Rita Machaalani

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi Distribution of nicotinic acetylcholine receptor subunits alpha7 and beta2 in the human brainstem and hippocampal formation
    Rita Machaalani
    Department of Medicine, The University of Sydney, NSW 2006, Australia
    J Chem Neuroanat 40:223-31. 2010
  2. ncbi Serotoninergic receptor 1A in the sudden infant death syndrome brainstem medulla and associations with clinical risk factors
    Rita Machaalani
    Department of Medicine, The Bosch Institute, University of Sydney, NSW, Australia
    Acta Neuropathol 117:257-65. 2009
  3. ncbi Tissue fixation effects on immunohistochemical staining of caspase-3 in brain tissue
    Rita Machaalani
    Department of Medicine, The University of Sydney, NSW 2006, Australia
    Appl Immunohistochem Mol Morphol 15:463-70. 2007
  4. ncbi The effects of nicotine on the alpha-7 and beta-2 nicotinic acetycholine receptor subunits in the developing piglet brainstem
    Cherylea J Browne
    Department of Pathology, University of Sydney, NSW 2006, Australia
    Int J Dev Neurosci 28:1-7. 2010
  5. ncbi Brain-derived neurotrophic factor (BDNF) and TrkB in the piglet brainstem after post-natal nicotine and intermittent hypercapnic hypoxia
    Samantha Tang
    Department of Paediatrics and Child Health, The University of Sydney, and The Children s Hospital, Westmead Sydney, NSW 2006, Australia
    Brain Res 1232:195-205. 2008
  6. ncbi Intermittent hypercapnic hypoxia induced protein changes in the piglet hippocampus identified by MALDI-TOF-MS
    Samantha Tang
    Discipline of Pediatrics and Child Health, University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 34:2215-25. 2009
  7. ncbi Changes in serotoninergic receptors 1A and 2A in the piglet brainstem after intermittent hypercapnic hypoxia (IHH) and nicotine
    Meichien Say
    Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia
    Brain Res 1152:17-26. 2007
  8. ncbi Expression of brain-derived neurotrophic factor and TrkB receptor in the sudden infant death syndrome brainstem
    Samantha Tang
    Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia Bosch Institute, The University of Sydney, NSW 2006, Australia
    Respir Physiol Neurobiol 180:25-33. 2012
  9. ncbi Effects of cigarette smoke exposure on nicotinic acetylcholine receptor subunits α7 and β2 in the sudden infant death syndrome (SIDS) brainstem
    Rita Machaalani
    Department of Medicine, The University of Sydney, NSW 2006, Australia
    Toxicol Appl Pharmacol 257:396-404. 2011
  10. ncbi Neuronal cell death in the Sudden Infant Death Syndrome brainstem and associations with risk factors
    Rita Machaalani
    Department of Medicine, Room 206, Blackburn Building, D06, The University of Sydney, NSW 2006, Australia
    Brain 131:218-28. 2008

Collaborators

Detail Information

Publications21

  1. ncbi Distribution of nicotinic acetylcholine receptor subunits alpha7 and beta2 in the human brainstem and hippocampal formation
    Rita Machaalani
    Department of Medicine, The University of Sydney, NSW 2006, Australia
    J Chem Neuroanat 40:223-31. 2010
    ..We conclude that both alpha7 and beta2 containing nAChRs play an important role in many nuclei of the human infant and adult brainstem, and that the alpha7 subunit may have a more prominent role in the infant than adult hippocampus...
  2. ncbi Serotoninergic receptor 1A in the sudden infant death syndrome brainstem medulla and associations with clinical risk factors
    Rita Machaalani
    Department of Medicine, The Bosch Institute, University of Sydney, NSW, Australia
    Acta Neuropathol 117:257-65. 2009
    ..This study not only provides further evidence of abnormalities within the brainstem serotoninergic system of SIDS infants, but also shows that these changes may be associated with exposure to clinical risk factors...
  3. ncbi Tissue fixation effects on immunohistochemical staining of caspase-3 in brain tissue
    Rita Machaalani
    Department of Medicine, The University of Sydney, NSW 2006, Australia
    Appl Immunohistochem Mol Morphol 15:463-70. 2007
    ..This study characterizes differences in immunohistochemical outcomes using commercially available antibodies for caspase-3, according to tissue fixation method and species...
  4. ncbi The effects of nicotine on the alpha-7 and beta-2 nicotinic acetycholine receptor subunits in the developing piglet brainstem
    Cherylea J Browne
    Department of Pathology, University of Sydney, NSW 2006, Australia
    Int J Dev Neurosci 28:1-7. 2010
    ..Changes in beta2 were more widespread but showed gender-specific effects. These findings provide evidence that early postnatal exposure to nicotine significantly affects nAChR subunit expressions in the developing brainstem...
  5. ncbi Brain-derived neurotrophic factor (BDNF) and TrkB in the piglet brainstem after post-natal nicotine and intermittent hypercapnic hypoxia
    Samantha Tang
    Department of Paediatrics and Child Health, The University of Sydney, and The Children s Hospital, Westmead Sydney, NSW 2006, Australia
    Brain Res 1232:195-205. 2008
    ....
  6. ncbi Intermittent hypercapnic hypoxia induced protein changes in the piglet hippocampus identified by MALDI-TOF-MS
    Samantha Tang
    Discipline of Pediatrics and Child Health, University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 34:2215-25. 2009
    ....
  7. ncbi Changes in serotoninergic receptors 1A and 2A in the piglet brainstem after intermittent hypercapnic hypoxia (IHH) and nicotine
    Meichien Say
    Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia
    Brain Res 1152:17-26. 2007
    ..The findings support our hypothesis that 5-HT receptor abnormalities may be caused by postnatal exposures to clinically-relevant stimuli such as cigarette smoke exposure and/or prone sleeping...
  8. ncbi Expression of brain-derived neurotrophic factor and TrkB receptor in the sudden infant death syndrome brainstem
    Samantha Tang
    Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia Bosch Institute, The University of Sydney, NSW 2006, Australia
    Respir Physiol Neurobiol 180:25-33. 2012
    ..Abnormal expression of BDNF and TrkB suggests that neuroprotective functions of the BDNF/TrkB system may be reduced in respiratory-related nuclei of SIDS infants...
  9. ncbi Effects of cigarette smoke exposure on nicotinic acetylcholine receptor subunits α7 and β2 in the sudden infant death syndrome (SIDS) brainstem
    Rita Machaalani
    Department of Medicine, The University of Sydney, NSW 2006, Australia
    Toxicol Appl Pharmacol 257:396-404. 2011
    ....
  10. ncbi Neuronal cell death in the Sudden Infant Death Syndrome brainstem and associations with risk factors
    Rita Machaalani
    Department of Medicine, Room 206, Blackburn Building, D06, The University of Sydney, NSW 2006, Australia
    Brain 131:218-28. 2008
    ....
  11. ncbi Increased neuronal cell death after intermittent hypercapnic hypoxia in the developing piglet brainstem
    Rita Machaalani
    Department of Medicine, Room 206, Blackburn Building, D06, University of Sydney, Sydney, NSW 2006, Australia
    Brain Res 985:127-34. 2003
    ..This could have important implications for clinical conditions including obstructive apnea and prone sleeping as a risk for SIDS...
  12. ncbi NMDA receptor 1 expression in the brainstem of human infants and its relevance to the sudden infant death syndrome (SIDS)
    Rita Machaalani
    Department of Medicine, The University of Sydney, Westmead, Sydney, Australia
    J Neuropathol Exp Neurol 62:1076-85. 2003
    ..Further studies will be required to delineate these abnormalities and to investigate potential underlying mechanisms and sequelae...
  13. ncbi NMDA receptors in the developing brain and effects of noxious insults
    Karen A Waters
    Department of Medicine, Room 206, Blackburn Building, D06, The University of Sydney, Sydney, NSW 2006, Australia
    Neurosignals 13:162-74. 2004
    ..By highlighting knowledge gaps in this field, we hope to encourage future research focusing on clinically relevant problems and outcomes in this area...
  14. ncbi Brain-derived neurotrophic factor mRNA and protein in the piglet brainstem and effects of Intermittent Hypercapnic Hypoxia
    Tanya Shyami Peiris
    Department of Pathology, Room 206, Blackburn Building, DO6, University of Sydney, Sydney, NSW 2006, Australia
    Brain Res 1029:11-23. 2004
    ..Implications of the wide distribution of BDNF in the piglet caudal medulla and increased expression after IHH exposure are discussed, with particular reference to roles for BDNF-dependent neurons at this stage of development...
  15. ncbi Immunolocalization of pro- and mature-brain derived neurotrophic factor (BDNF) and receptor TrkB in the human brainstem and hippocampus
    Samantha Tang
    Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia
    Brain Res 1354:1-14. 2010
    ..We conclude that BDNF and TrkB play important roles in controlling respiration, movement, balance and feeding in the brainstem and that the TrkB receptor is the most age-sensitive component of this system, especially in the hippocampus...
  16. ncbi Role of NMDA receptors in development of respiratory control
    Karen A Waters
    Department of Medicine, Room 206, Blackburn Building, DO6, University of Sydney, NSW 2006, Australia
    Respir Physiol Neurobiol 149:123-30. 2005
    ..NMDA receptor expression has also been measured histologically, and more recently knockout animal models have been used to provide additional functional information...
  17. ncbi Effects of post-mortem intervals on regional brain protein profiles in rats using SELDI-TOF-MS analysis
    Rita Machaalani
    Department of Medicine, The University of Sydney, NSW 2006, Australia
    Neurochem Int 57:655-61. 2010
    ....
  18. ncbi Distribution and quantification of NMDA R1 mRNA and protein in the piglet brainstem and effects of intermittent hypercapnic hypoxia (IHH)
    Rita Machaalani
    Department of Medicine, Room 206 Blackburn Building, DO6, University of Sydney, Sydney, NSW 2006, Australia
    Brain Res 951:293-300. 2002
    ..NR1 mRNA expression increased while the number of neurons expressing NR1 protein showed no change. This finding suggests that NMDA pathways are activated by exposure to IHH...
  19. ncbi Comparative proteomics in the corpus callosal sub-regions of postmortem human brain
    Mohammed A Kashem
    University of Sydney, NSW, Australia
    Neurochem Int 55:483-90. 2009
    ..Protein expression maps of these regions can be used as a reference source for future studies to investigate the molecular basis of functional differences and degree of pathogenesis of various neurodegenerative diseases of the CC...
  20. ncbi The dorsal motor nucleus of the vagus (DMNV) in sudden infant death syndrome (SIDS): pathways leading to apoptosis
    Charbel Bejjani
    Sydney Medical Program, University of Sydney, NSW 2006, Australia Australia
    Respir Physiol Neurobiol 185:203-10. 2013
    ....
  21. ncbi Vascular endothelial growth factor receptor 1 (Flt1) and apoptosis in the preeclamptic placenta and effects of in vivo anti-hypertensive exposure
    Rita Machaalani
    Department of Medicine, University of Sydney, NSW, Australia
    Hypertens Pregnancy 27:361-73. 2008
    ..To test the hypothesis that vascular endothelial growth factor receptor 1 (Flt1) is negatively correlated with apoptosis in preeclampsia placentae, and to examine the effects of antihypertensive medication on apoptosis...