V G Macefield

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint The discharge behaviour of single sympathetic neurones supplying human sweat glands
    V G Macefield
    Department of Clinical Neuroscience, Sahlgren s Hospital, University of Goteborg, Sweden
    J Auton Nerv Syst 61:277-86. 1996
  2. ncbi request reprint Physiological characteristics of low-threshold mechanoreceptors in joints, muscle and skin in human subjects
    Vaughan G Macefield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 32:135-44. 2005
  3. ncbi request reprint Comparison of the firing patterns of human postganglionic sympathetic neurones and spinal alpha motoneurones during brief bursts
    Vaughan G Macefield
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
    Exp Physiol 89:82-8. 2004
  4. ncbi request reprint Cardiovascular and respiratory modulation of tactile afferents in the human finger pad
    Vaughan G Macefield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW 2052, Australia
    Exp Physiol 88:617-25. 2003
  5. pmc Resting discharge of human muscle spindles is not modulated by increases in sympathetic drive
    Vaughan G Macefield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    J Physiol 551:1005-11. 2003
  6. ncbi request reprint Loads applied tangential to a fingertip during an object restraint task can trigger short-latency as well as long-latency EMG responses in hand muscles
    Vaughan G Macefield
    Prince of Wales Medical Research Institute, UNSW, Barker St, Randwick, Sydney, NSW 2031, Australia
    Exp Brain Res 152:143-9. 2003
  7. ncbi request reprint Firing properties of single postganglionic sympathetic neurones recorded in awake human subjects
    Vaughan G Macefield
    Prince of Wales Medical Research Institute, NSW, Sydney, Australia
    Auton Neurosci 95:146-59. 2002
  8. pmc Discharge behaviour of single motor units during maximal voluntary contractions of a human toe extensor
    V G Macefield
    John B Pierce Laboratory, New Haven, CT 06519, USA
    J Physiol 528:227-34. 2000
  9. ncbi request reprint Inhibition of muscle sympathetic outflow following transcranial cortical stimulation
    V G Macefield
    The Prince of Wales Medical Research Institute, Randwick NSW, Australia
    J Auton Nerv Syst 68:49-57. 1998
  10. ncbi request reprint Sustained activation of muscle sympathetic outflow during static lung inflation depends on a high intrathoracic pressure
    V G Macefield
    Prince of Wales Medical Research Institute, Randwick, NSW, Australia
    J Auton Nerv Syst 68:135-9. 1998

Collaborators

Detail Information

Publications48

  1. ncbi request reprint The discharge behaviour of single sympathetic neurones supplying human sweat glands
    V G Macefield
    Department of Clinical Neuroscience, Sahlgren s Hospital, University of Goteborg, Sweden
    J Auton Nerv Syst 61:277-86. 1996
    ..We conclude that the discharge of human sudomotor neurones is modulated by baroreceptor input...
  2. ncbi request reprint Physiological characteristics of low-threshold mechanoreceptors in joints, muscle and skin in human subjects
    Vaughan G Macefield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 32:135-44. 2005
    ....
  3. ncbi request reprint Comparison of the firing patterns of human postganglionic sympathetic neurones and spinal alpha motoneurones during brief bursts
    Vaughan G Macefield
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
    Exp Physiol 89:82-8. 2004
    ....
  4. ncbi request reprint Cardiovascular and respiratory modulation of tactile afferents in the human finger pad
    Vaughan G Macefield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW 2052, Australia
    Exp Physiol 88:617-25. 2003
    ..It is concluded that cardiac modulation is common for both classes of slowly adapting tactile afferents (but less common for the rapidly adapting afferents), which may have implications for the sensory signalling of tactile information...
  5. pmc Resting discharge of human muscle spindles is not modulated by increases in sympathetic drive
    Vaughan G Macefield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    J Physiol 551:1005-11. 2003
    ....
  6. ncbi request reprint Loads applied tangential to a fingertip during an object restraint task can trigger short-latency as well as long-latency EMG responses in hand muscles
    Vaughan G Macefield
    Prince of Wales Medical Research Institute, UNSW, Barker St, Randwick, Sydney, NSW 2031, Australia
    Exp Brain Res 152:143-9. 2003
    ....
  7. ncbi request reprint Firing properties of single postganglionic sympathetic neurones recorded in awake human subjects
    Vaughan G Macefield
    Prince of Wales Medical Research Institute, NSW, Sydney, Australia
    Auton Neurosci 95:146-59. 2002
    ..In this review, we describe our methodology for analyzing unitary sympathetic activity and discuss the similarities in the firing properties of individual muscle vasoconstrictor, cutaneous vasoconstrictor and sudomotor neurones...
  8. pmc Discharge behaviour of single motor units during maximal voluntary contractions of a human toe extensor
    V G Macefield
    John B Pierce Laboratory, New Haven, CT 06519, USA
    J Physiol 528:227-34. 2000
    ....
  9. ncbi request reprint Inhibition of muscle sympathetic outflow following transcranial cortical stimulation
    V G Macefield
    The Prince of Wales Medical Research Institute, Randwick NSW, Australia
    J Auton Nerv Syst 68:49-57. 1998
    ....
  10. ncbi request reprint Sustained activation of muscle sympathetic outflow during static lung inflation depends on a high intrathoracic pressure
    V G Macefield
    Prince of Wales Medical Research Institute, Randwick, NSW, Australia
    J Auton Nerv Syst 68:135-9. 1998
    ....
  11. pmc Respiratory and cardiac modulation of single sympathetic vasoconstrictor and sudomotor neurones to human skin
    V G Macefield
    Institute of Clinical Neurosciences, Department of Clinical Neurophysiology, University of Goteborg, Sahlgren University Hospital, S 413 45 Goteborg, Sweden
    J Physiol 516:303-14. 1999
    ....
  12. pmc Effects of deep and superficial experimentally induced acute pain on muscle sympathetic nerve activity in human subjects
    A R Burton
    Prince of Wales Medical Research Institute, Sydney, NSW 2031, Australia
    J Physiol 587:183-93. 2009
    ..Whether this holds true for longer lasting experimental pain remains to be seen...
  13. doi request reprint Selective activation of muscle and skin nociceptors does not trigger exaggerated sympathetic responses in spinal-injured subjects
    A R Burton
    Spinal Injuries Research Centre, Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
    Spinal Cord 46:660-5. 2008
    ..Measurement of sympathetic effector organ responses to selective activation of muscle and skin nociceptors below lesion in spinal cord-injured (SCI) subjects...
  14. pmc Evidence for strong synaptic coupling between single tactile afferents and motoneurones supplying the human hand
    P A McNulty
    Prince of Wales Medical Research Institute, Randwick, Sydney, NSW 2031, Australia
    J Physiol 518:883-93. 1999
    ..The potent short-latency response we found supports the important role of cutaneous mechanoreceptors in fine motor control of the human hand...
  15. pmc Modulation of ongoing EMG by different classes of low-threshold mechanoreceptors in the human hand
    P A McNulty
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
    J Physiol 537:1021-32. 2001
    ..Conversely, we saw no evidence of such modulation by SA I, muscle spindle or joint afferents...
  16. ncbi request reprint Force-frequency and fatigue properties of motor units in muscles that control digits of the human hand
    A J Fuglevand
    John B Pierce Laboratory, New Haven, Connecticut 06519, USA
    J Neurophysiol 81:1718-29. 1999
    ..Questions regarding classification of motor units and possible mechanisms by which fatigue-related slowing might coexist with a shift in the force-frequency curve toward higher frequencies are discussed...
  17. pmc Firing properties of single vasoconstrictor neurones in human subjects with high levels of muscle sympathetic activity
    V G Macefield
    Institute of Clinical Neurosciences, Department of Clinical Neurophysiology, University of Goteborg, Sahlgren University Hospital, S 413 45 Goteborg, Sweden
    J Physiol 516:293-301. 1999
    ..During acute increases of multi-unit activity, both increases in discharge frequency and recruitment of additional neurones contribute to the increased intensity of an individual sympathetic burst...
  18. pmc Comparison of contractile properties of single motor units in human intrinsic and extrinsic finger muscles
    P A McNulty
    Prince of Wales Medical Research Institute, Randwick, NSW 2031, Australia
    J Physiol 526:445-56. 2000
    ..This reflects the important role of the intrinsic hand muscles in the fine manipulation of objects...
  19. doi request reprint Assessing the capacity of the sympathetic nervous system to respond to a cardiovascular challenge in human spinal cord injury
    R Brown
    Spinal Injuries Research Centre, Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    Spinal Cord 46:666-72. 2008
    ..Measurement of haemodynamic responses and cutaneous blood flow during an inspiratory-capacity apnoea following spinal cord injury (SCI)...
  20. ncbi request reprint Pathological sympathoexcitation: how is it achieved?
    M Elam
    Department of Clinical Neurophysiology, Inst for Clinical Neuroscience, Sahlgrenska University Hospital, Götenburg, Sweden
    Acta Physiol Scand 177:405-11. 2003
    ....
  21. ncbi request reprint Axonal changes in spinal cord injured patients distal to the site of injury
    Cindy Shin Yi Lin
    Prince of Wales Medical Research Institute and Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    Brain 130:985-94. 2007
    ..Changes in axonal structure and ion channel function, but perhaps more critically decentralization and consequent inactivity, are likely to underlie the complex changes observed in axonal excitability in SCI patients...
  22. ncbi request reprint Somatotopic organization of the processing of muscle and cutaneous pain in the left and right insula cortex: a single-trial fMRI study
    L A Henderson
    Department of Anatomy and Histology, University of Sydney, Sydney, NSW 2006, Australia
    Pain 128:20-30. 2007
    ..This study reveals that the insula is organized somatopically with respect to muscle and cutaneous pain and that this organization is further separated according to the tissue in which the pain originates...
  23. doi request reprint Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjects
    A R Burton
    Prince of Wales Medical Research Institute, Sydney NSW, Australia
    Exp Brain Res 195:317-24. 2009
    ..We conclude that both acute muscle and skin pain cause an increase in SSNA, sweat release and gender-dependent changes in skin blood flow...
  24. ncbi request reprint Why do human postganglionic neurones primarily only fire once during a sympathetic burst?
    V G Macefield
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
    Acta Physiol Scand 177:247-53. 2003
    ....
  25. pmc Cortically evoked neural volleys to the human hand are increased during ischaemic block of the forearm
    P A McNulty
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW, Australia
    J Physiol 538:279-88. 2002
    ..Thus, we conclude that the increased response of biceps to TMS during distal ischaemia is not accompanied by a corresponding decrease in the motor cortical representation of the hand...
  26. doi request reprint Cutaneous vasoconstriction as a measure of incipient autonomic dysreflexia during penile vibratory stimulation in spinal cord injury
    R Brown
    Spinal Injuries Research Centre, Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    Spinal Cord 47:538-44. 2009
    ..Measurement of haemodynamic responses, cutaneous blood flow and sweat release during penile vibratory stimulation (PVS) in spinal cord-injured men...
  27. ncbi request reprint Evidence for strong synaptic coupling between single tactile afferents from the sole of the foot and motoneurons supplying leg muscles
    James B Fallon
    Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    J Neurophysiol 94:3795-804. 2005
    ....
  28. ncbi request reprint Intraneural microstimulation of motor axons in the study of human single motor units
    Penelope A McNulty
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW, Australia
    Muscle Nerve 32:119-39. 2005
    ....
  29. ncbi request reprint Mechanically evoked sensory and motor responses to dynamic compression of the ulnar nerve
    Elizabeth C Clarke
    School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, Australia
    Muscle Nerve 35:303-11. 2007
    ..Cutaneous axons had lower mechanical thresholds than motor axons. We relate these findings to the viscoelastic properties of peripheral nerves and differences in biophysical properties of cutaneous and motor axons...
  30. ncbi request reprint Does sympathetic nerve discharge affect the firing of myelinated cutaneous afferents in humans?
    Mikael Elam
    Institute of Clinical Neuroscience, Sahlgren University Hospital, S 413 45 Goteborg, Sweden
    Auton Neurosci 111:116-26. 2004
    ..e. secondary to changes in the mechanoreceptors' tissue environment rather than to a direct sympathetic effect on the endings...
  31. ncbi request reprint Neural sites involved in the sustained increase in muscle sympathetic nerve activity induced by inspiratory capacity apnea: a fMRI study
    V G Macefield
    Prince of Wales Medical Research Institute and University of New South Wales, Australia
    J Appl Physiol 100:266-73. 2006
    ..Given that many of these sites have roles in cardiovascular control, the sustained increase in MSNA during an inspiratory capacity apnea is likely to originate from a distributed set of discrete areas...
  32. doi request reprint Bilateral activation of the trigeminothalamic tract by acute orofacial cutaneous and muscle pain in humans
    P G Nash
    Department of Anatomy and Histology, University of Sydney, Sydney, NSW, Australia
    Pain 151:384-93. 2010
    ..These data indicate that, in contrast to innocuous inputs from the face, noxious information ascends bilaterally to the face SI through the ventroposterior thalamus in humans...
  33. doi request reprint Frequency-dependent modulation of muscle sympathetic nerve activity by sinusoidal galvanic vestibular stimulation in human subjects
    Tarandeep Grewal
    School of Medicine, University of Western Sydney, Locked Bag 1797, Penrith South DC, Sydney, NSW, 1797, Australia
    Exp Brain Res 197:379-86. 2009
    ..8 Hz), with vestibular modulation of MSNA being greater when this competition with the baroreceptors is reduced...
  34. doi request reprint Input-output relationships of a somatosympathetic reflex in human spinal injury
    Rachael Brown
    Spinal Injuries Research Centre, Prince of Wales Medical Research Institute, Sydney, NSW 2031, Australia
    Clin Auton Res 19:213-20. 2009
    ....
  35. pmc The effects of experimental muscle and skin pain on the static stretch sensitivity of human muscle spindles in relaxed leg muscles
    Ingvars Birznieks
    Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Sydney, Australia
    J Physiol 586:2713-23. 2008
    ..Rather, our results are more aligned with the pain adaptation model, based on clinical studies predicting pain-induced reductions of agonist muscle activity...
  36. ncbi request reprint Vibration sensitivity of human muscle spindles and Golgi tendon organs
    James B Fallon
    Prince of Wales Medical Research Institute, Sydney, NSW, Australia
    Muscle Nerve 36:21-9. 2007
    ....
  37. ncbi request reprint Gender differences in brain activity evoked by muscle and cutaneous pain: a retrospective study of single-trial fMRI data
    Luke A Henderson
    Department of Anatomy and Histology, University of Sydney, Sydney, NSW, Australia
    Neuroimage 39:1867-76. 2008
    ..These differences may reflect differences in emotional processing of noxious information in men and women and may underlie the gender bias that exists in many chronic pain conditions...
  38. pmc Firing probability and mean firing rates of human muscle vasoconstrictor neurones are elevated during chronic asphyxia
    Cynthia Ashley
    Prince of Wales Medical Research Institute, Sydney, Australia
    J Physiol 588:701-12. 2010
    ....
  39. doi request reprint Real-time imaging of the medullary circuitry involved in the generation of spontaneous muscle sympathetic nerve activity in awake subjects
    Vaughan G Macefield
    School of Medicine, University of Western Sydney, and Prince of Wales Medical Research Institute, Sydney, Australia
    Hum Brain Mapp 31:539-49. 2010
    ....
  40. doi request reprint Slowly adapting mechanoreceptors in the borders of the human fingernail encode fingertip forces
    Ingvars Birznieks
    Prince of Wales Medical Research Institute, Sydney, New South Wales 2031, Australia
    J Neurosci 29:9370-9. 2009
    ..The particular tactile features of contacted surfaces would less influence force-related signals in SA-IInail afferents than force-related signals present in afferents terminating in the volar skin areas that directly contact objects...
  41. ncbi request reprint Prolonged surges of baroreflex-resistant muscle sympathetic drive during periodic breathing
    Vaughan G Macefield
    Prince of Wales Medical Research Institute, Randwick, NSW, Australia
    Clin Auton Res 12:165-9. 2002
    ....
  42. doi request reprint Firing properties of sudomotor neurones in hyperhidrosis and thermal sweating
    Vaughan G Macefield
    Prince of Wales Medical Research Institute, Sydney, Australia
    Clin Auton Res 18:325-30. 2008
    ....
  43. doi request reprint Effects of intramuscular anesthesia on the expression of primary and referred pain induced by intramuscular injection of hypertonic saline
    Troy K Rubin
    Prince of Wales Medical Research Institute, Sydney NSW, Australia
    J Pain 10:829-35. 2009
    ..It is important to know the primary source of the pain so that treatment can be directed to this site rather to the site of referral...
  44. ncbi request reprint Discrete changes in cortical activation during experimentally induced referred muscle pain: a single-trial fMRI study
    Vaughan G Macefield
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, NSW, Australia
    Cereb Cortex 17:2050-9. 2007
    ..Interestingly, differential signal changes also occurred in anterior cingulate, cerebellar, and insular cortices. This is the first study to provide evidence of cortical differentiation in the processing of primary and referred pain...
  45. doi request reprint Changes in the spatiotemporal expression of local and referred pain following repeated intramuscular injections of hypertonic saline: a longitudinal study
    Troy K Rubin
    Prince of Wales Medical Research Institute, Sydney, NSW, Australia
    J Pain 11:737-45. 2010
    ..We conclude that the decrease in perceived local pain and increase in perceived referred pain reflects plastic processes occurring centrally...
  46. doi request reprint Differential activation of the human trigeminal nuclear complex by noxious and non-noxious orofacial stimulation
    Paul G Nash
    Department of Anatomy and Histology, University of Sydney, New South Wales, Australia
    Hum Brain Mapp 30:3772-82. 2009
    ..We speculate that the differential activation evoked by cutaneous and muscle noxious stimuli within the trigeminal sensory complex may contribute to the neural basis for these differences...
  47. ncbi request reprint Modulation of muscle sympathetic bursts by sinusoidal galvanic vestibular stimulation in human subjects
    Leah R Bent
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Exp Brain Res 174:701-11. 2006
    ..This demonstrates that the human vestibular apparatus exerts a potent facilitatory influence on MSNA that potentially operates independently of the baroreceptor system...
  48. ncbi request reprint Absence of short-term vestibular modulation of muscle sympathetic outflow, assessed by brief galvanic vestibular stimulation in awake human subjects
    Philip S Bolton
    School of Biomedical Science, Faculty of Health, University of Newcastle, NSW 2287, Callaghan, Australia
    Exp Brain Res 154:39-43. 2004
    ..Conversely, phasic vestibular inputs do excite cutaneous sympathetic neurones, consistent with the observation that motion sickness is accompanied by pallor and sweating...