Research Topics
| V G MacefieldSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
The discharge behaviour of single sympathetic neurones supplying human sweat glandsV G Macefield
Department of Clinical Neuroscience, Sahlgren s Hospital, University of Goteborg, Sweden
J Auton Nerv Syst 61:277-86. 1996..We conclude that the discharge of human sudomotor neurones is modulated by baroreceptor input...- Physiological characteristics of low-threshold mechanoreceptors in joints, muscle and skin in human subjectsVaughan G Macefield
Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
Clin Exp Pharmacol Physiol 32:135-44. 2005.... - Comparison of the firing patterns of human postganglionic sympathetic neurones and spinal alpha motoneurones during brief burstsVaughan G Macefield
Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
Exp Physiol 89:82-8. 2004.... - Cardiovascular and respiratory modulation of tactile afferents in the human finger padVaughan G Macefield
Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW 2052, Australia
Exp Physiol 88:617-25. 2003..It is concluded that cardiac modulation is common for both classes of slowly adapting tactile afferents (but less common for the rapidly adapting afferents), which may have implications for the sensory signalling of tactile information... 
Resting discharge of human muscle spindles is not modulated by increases in sympathetic driveVaughan G Macefield
Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
J Physiol 551:1005-11. 2003....- Loads applied tangential to a fingertip during an object restraint task can trigger short-latency as well as long-latency EMG responses in hand musclesVaughan G Macefield
Prince of Wales Medical Research Institute, UNSW, Barker St, Randwick, Sydney, NSW 2031, Australia
Exp Brain Res 152:143-9. 2003.... - Firing properties of single postganglionic sympathetic neurones recorded in awake human subjectsVaughan G Macefield
Prince of Wales Medical Research Institute, NSW, Sydney, Australia
Auton Neurosci 95:146-59. 2002..In this review, we describe our methodology for analyzing unitary sympathetic activity and discuss the similarities in the firing properties of individual muscle vasoconstrictor, cutaneous vasoconstrictor and sudomotor neurones... - Discharge behaviour of single motor units during maximal voluntary contractions of a human toe extensorV G Macefield
John B Pierce Laboratory, New Haven, CT 06519, USA
J Physiol 528:227-34. 2000.... - Inhibition of muscle sympathetic outflow following transcranial cortical stimulationV G Macefield
The Prince of Wales Medical Research Institute, Randwick NSW, Australia
J Auton Nerv Syst 68:49-57. 1998.... - Sustained activation of muscle sympathetic outflow during static lung inflation depends on a high intrathoracic pressureV G Macefield
Prince of Wales Medical Research Institute, Randwick, NSW, Australia
J Auton Nerv Syst 68:135-9. 1998.... - Respiratory and cardiac modulation of single sympathetic vasoconstrictor and sudomotor neurones to human skinV G Macefield
Institute of Clinical Neurosciences, Department of Clinical Neurophysiology, University of Goteborg, Sahlgren University Hospital, S 413 45 Goteborg, Sweden
J Physiol 516:303-14. 1999.... - Effects of deep and superficial experimentally induced acute pain on muscle sympathetic nerve activity in human subjectsA R Burton
Prince of Wales Medical Research Institute, Sydney, NSW 2031, Australia
J Physiol 587:183-93. 2009..Whether this holds true for longer lasting experimental pain remains to be seen... 
Selective activation of muscle and skin nociceptors does not trigger exaggerated sympathetic responses in spinal-injured subjectsA R Burton
Spinal Injuries Research Centre, Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
Spinal Cord 46:660-5. 2008..Measurement of sympathetic effector organ responses to selective activation of muscle and skin nociceptors below lesion in spinal cord-injured (SCI) subjects...- Evidence for strong synaptic coupling between single tactile afferents and motoneurones supplying the human handP A McNulty
Prince of Wales Medical Research Institute, Randwick, Sydney, NSW 2031, Australia
J Physiol 518:883-93. 1999..The potent short-latency response we found supports the important role of cutaneous mechanoreceptors in fine motor control of the human hand... - Modulation of ongoing EMG by different classes of low-threshold mechanoreceptors in the human handP A McNulty
Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
J Physiol 537:1021-32. 2001..Conversely, we saw no evidence of such modulation by SA I, muscle spindle or joint afferents... - Force-frequency and fatigue properties of motor units in muscles that control digits of the human handA J Fuglevand
John B Pierce Laboratory, New Haven, Connecticut 06519, USA
J Neurophysiol 81:1718-29. 1999..Questions regarding classification of motor units and possible mechanisms by which fatigue-related slowing might coexist with a shift in the force-frequency curve toward higher frequencies are discussed... - Firing properties of single vasoconstrictor neurones in human subjects with high levels of muscle sympathetic activityV G Macefield
Institute of Clinical Neurosciences, Department of Clinical Neurophysiology, University of Goteborg, Sahlgren University Hospital, S 413 45 Goteborg, Sweden
J Physiol 516:293-301. 1999..During acute increases of multi-unit activity, both increases in discharge frequency and recruitment of additional neurones contribute to the increased intensity of an individual sympathetic burst... - Comparison of contractile properties of single motor units in human intrinsic and extrinsic finger musclesP A McNulty
Prince of Wales Medical Research Institute, Randwick, NSW 2031, Australia
J Physiol 526:445-56. 2000..This reflects the important role of the intrinsic hand muscles in the fine manipulation of objects... - Assessing the capacity of the sympathetic nervous system to respond to a cardiovascular challenge in human spinal cord injuryR Brown
Spinal Injuries Research Centre, Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
Spinal Cord 46:666-72. 2008..Measurement of haemodynamic responses and cutaneous blood flow during an inspiratory-capacity apnoea following spinal cord injury (SCI)... - Pathological sympathoexcitation: how is it achieved?M Elam
Department of Clinical Neurophysiology, Inst for Clinical Neuroscience, Sahlgrenska University Hospital, Götenburg, Sweden
Acta Physiol Scand 177:405-11. 2003.... - Axonal changes in spinal cord injured patients distal to the site of injuryCindy Shin Yi Lin
Prince of Wales Medical Research Institute and Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
Brain 130:985-94. 2007..Changes in axonal structure and ion channel function, but perhaps more critically decentralization and consequent inactivity, are likely to underlie the complex changes observed in axonal excitability in SCI patients... - Somatotopic organization of the processing of muscle and cutaneous pain in the left and right insula cortex: a single-trial fMRI studyL A Henderson
Department of Anatomy and Histology, University of Sydney, Sydney, NSW 2006, Australia
Pain 128:20-30. 2007..This study reveals that the insula is organized somatopically with respect to muscle and cutaneous pain and that this organization is further separated according to the tissue in which the pain originates... - Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjectsA R Burton
Prince of Wales Medical Research Institute, Sydney NSW, Australia
Exp Brain Res 195:317-24. 2009..We conclude that both acute muscle and skin pain cause an increase in SSNA, sweat release and gender-dependent changes in skin blood flow... - Why do human postganglionic neurones primarily only fire once during a sympathetic burst?V G Macefield
Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
Acta Physiol Scand 177:247-53. 2003.... - Cortically evoked neural volleys to the human hand are increased during ischaemic block of the forearmP A McNulty
Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW, Australia
J Physiol 538:279-88. 2002..Thus, we conclude that the increased response of biceps to TMS during distal ischaemia is not accompanied by a corresponding decrease in the motor cortical representation of the hand... - Cutaneous vasoconstriction as a measure of incipient autonomic dysreflexia during penile vibratory stimulation in spinal cord injuryR Brown
Spinal Injuries Research Centre, Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
Spinal Cord 47:538-44. 2009..Measurement of haemodynamic responses, cutaneous blood flow and sweat release during penile vibratory stimulation (PVS) in spinal cord-injured men... - Evidence for strong synaptic coupling between single tactile afferents from the sole of the foot and motoneurons supplying leg musclesJames B Fallon
Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
J Neurophysiol 94:3795-804. 2005.... - Intraneural microstimulation of motor axons in the study of human single motor unitsPenelope A McNulty
Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW, Australia
Muscle Nerve 32:119-39. 2005.... - Mechanically evoked sensory and motor responses to dynamic compression of the ulnar nerveElizabeth C Clarke
School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, Australia
Muscle Nerve 35:303-11. 2007..Cutaneous axons had lower mechanical thresholds than motor axons. We relate these findings to the viscoelastic properties of peripheral nerves and differences in biophysical properties of cutaneous and motor axons... - Does sympathetic nerve discharge affect the firing of myelinated cutaneous afferents in humans?Mikael Elam
Institute of Clinical Neuroscience, Sahlgren University Hospital, S 413 45 Goteborg, Sweden
Auton Neurosci 111:116-26. 2004..e. secondary to changes in the mechanoreceptors' tissue environment rather than to a direct sympathetic effect on the endings... - Neural sites involved in the sustained increase in muscle sympathetic nerve activity induced by inspiratory capacity apnea: a fMRI studyV G Macefield
Prince of Wales Medical Research Institute and University of New South Wales, Australia
J Appl Physiol 100:266-73. 2006..Given that many of these sites have roles in cardiovascular control, the sustained increase in MSNA during an inspiratory capacity apnea is likely to originate from a distributed set of discrete areas... - Bilateral activation of the trigeminothalamic tract by acute orofacial cutaneous and muscle pain in humansP G Nash
Department of Anatomy and Histology, University of Sydney, Sydney, NSW, Australia
Pain 151:384-93. 2010..These data indicate that, in contrast to innocuous inputs from the face, noxious information ascends bilaterally to the face SI through the ventroposterior thalamus in humans... - Frequency-dependent modulation of muscle sympathetic nerve activity by sinusoidal galvanic vestibular stimulation in human subjectsTarandeep Grewal
School of Medicine, University of Western Sydney, Locked Bag 1797, Penrith South DC, Sydney, NSW, 1797, Australia
Exp Brain Res 197:379-86. 2009..8 Hz), with vestibular modulation of MSNA being greater when this competition with the baroreceptors is reduced... - Input-output relationships of a somatosympathetic reflex in human spinal injuryRachael Brown
Spinal Injuries Research Centre, Prince of Wales Medical Research Institute, Sydney, NSW 2031, Australia
Clin Auton Res 19:213-20. 2009.... - The effects of experimental muscle and skin pain on the static stretch sensitivity of human muscle spindles in relaxed leg musclesIngvars Birznieks
Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Sydney, Australia
J Physiol 586:2713-23. 2008..Rather, our results are more aligned with the pain adaptation model, based on clinical studies predicting pain-induced reductions of agonist muscle activity... - Vibration sensitivity of human muscle spindles and Golgi tendon organsJames B Fallon
Prince of Wales Medical Research Institute, Sydney, NSW, Australia
Muscle Nerve 36:21-9. 2007.... - Gender differences in brain activity evoked by muscle and cutaneous pain: a retrospective study of single-trial fMRI dataLuke A Henderson
Department of Anatomy and Histology, University of Sydney, Sydney, NSW, Australia
Neuroimage 39:1867-76. 2008..These differences may reflect differences in emotional processing of noxious information in men and women and may underlie the gender bias that exists in many chronic pain conditions... - Firing probability and mean firing rates of human muscle vasoconstrictor neurones are elevated during chronic asphyxiaCynthia Ashley
Prince of Wales Medical Research Institute, Sydney, Australia
J Physiol 588:701-12. 2010.... - Real-time imaging of the medullary circuitry involved in the generation of spontaneous muscle sympathetic nerve activity in awake subjectsVaughan G Macefield
School of Medicine, University of Western Sydney, and Prince of Wales Medical Research Institute, Sydney, Australia
Hum Brain Mapp 31:539-49. 2010.... - Slowly adapting mechanoreceptors in the borders of the human fingernail encode fingertip forcesIngvars Birznieks
Prince of Wales Medical Research Institute, Sydney, New South Wales 2031, Australia
J Neurosci 29:9370-9. 2009..The particular tactile features of contacted surfaces would less influence force-related signals in SA-IInail afferents than force-related signals present in afferents terminating in the volar skin areas that directly contact objects... - Prolonged surges of baroreflex-resistant muscle sympathetic drive during periodic breathingVaughan G Macefield
Prince of Wales Medical Research Institute, Randwick, NSW, Australia
Clin Auton Res 12:165-9. 2002.... - Firing properties of sudomotor neurones in hyperhidrosis and thermal sweatingVaughan G Macefield
Prince of Wales Medical Research Institute, Sydney, Australia
Clin Auton Res 18:325-30. 2008.... - Effects of intramuscular anesthesia on the expression of primary and referred pain induced by intramuscular injection of hypertonic salineTroy K Rubin
Prince of Wales Medical Research Institute, Sydney NSW, Australia
J Pain 10:829-35. 2009..It is important to know the primary source of the pain so that treatment can be directed to this site rather to the site of referral... - Discrete changes in cortical activation during experimentally induced referred muscle pain: a single-trial fMRI studyVaughan G Macefield
Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, NSW, Australia
Cereb Cortex 17:2050-9. 2007..Interestingly, differential signal changes also occurred in anterior cingulate, cerebellar, and insular cortices. This is the first study to provide evidence of cortical differentiation in the processing of primary and referred pain... - Changes in the spatiotemporal expression of local and referred pain following repeated intramuscular injections of hypertonic saline: a longitudinal studyTroy K Rubin
Prince of Wales Medical Research Institute, Sydney, NSW, Australia
J Pain 11:737-45. 2010.... - Differential activation of the human trigeminal nuclear complex by noxious and non-noxious orofacial stimulationPaul G Nash
Department of Anatomy and Histology, University of Sydney, New South Wales, Australia
Hum Brain Mapp 30:3772-82. 2009..We speculate that the differential activation evoked by cutaneous and muscle noxious stimuli within the trigeminal sensory complex may contribute to the neural basis for these differences... - Modulation of muscle sympathetic bursts by sinusoidal galvanic vestibular stimulation in human subjectsLeah R Bent
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
Exp Brain Res 174:701-11. 2006..This demonstrates that the human vestibular apparatus exerts a potent facilitatory influence on MSNA that potentially operates independently of the baroreceptor system... - Absence of short-term vestibular modulation of muscle sympathetic outflow, assessed by brief galvanic vestibular stimulation in awake human subjectsPhilip S Bolton
School of Biomedical Science, Faculty of Health, University of Newcastle, NSW 2287, Callaghan, Australia
Exp Brain Res 154:39-43. 2004..Conversely, phasic vestibular inputs do excite cutaneous sympathetic neurones, consistent with the observation that motion sickness is accompanied by pallor and sweating...