Fabio Luciani

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. doi request reprint Next generation deep sequencing and vaccine design: today and tomorrow
    Fabio Luciani
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Trends Biotechnol 30:443-52. 2012
  2. doi request reprint Interpreting genotype cluster sizes of Mycobacterium tuberculosis isolates typed with IS6110 and spoligotyping
    Fabio Luciani
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW, Australia
    Infect Genet Evol 8:182-90. 2008
  3. pmc The evolutionary dynamics of a rapidly mutating virus within and between hosts: the case of hepatitis C virus
    Fabio Luciani
    Centre for Infection and Inflammation Research CIIR, School of Medical Sciences, University of New South Wales, Sydney, Australia
    PLoS Comput Biol 5:e1000565. 2009
  4. pmc Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection
    Rowena A Bull
    School of Medical Sciences, University of New South Wales, Australia
    PLoS Pathog 7:e1002243. 2011
  5. pmc Transmitted/Founder Viruses Rapidly Escape from CD8+ T Cell Responses in Acute Hepatitis C Virus Infection
    Rowena A Bull
    Systems Medicine, Inflammation and Infection Research Centre, School of Medical Sciences, Faculty of Medicine, UNSW Australia, Sydney, New South Wales, Australia
    J Virol 89:5478-90. 2015
  6. doi request reprint A prospective study of hepatitis C incidence in Australian prisoners
    Fabio Luciani
    Inflammation and Infection Research Centre, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales, Australia
    Addiction 109:1695-706. 2014
  7. pmc Accurate single nucleotide variant detection in viral populations by combining probabilistic clustering with a statistical test of strand bias
    Kerensa McElroy
    Centre for Marine Bioinnovation and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    BMC Genomics 14:501. 2013
  8. pmc Contribution of intra- and interhost dynamics to norovirus evolution
    Rowena A Bull
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, a and School of Medical Sciences, Faculty of Medicine, b University of New South Wales, Sydney, Australia
    J Virol 86:3219-29. 2012
  9. pmc The epidemiological fitness cost of drug resistance in Mycobacterium tuberculosis
    Fabio Luciani
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2052, Australia
    Proc Natl Acad Sci U S A 106:14711-5. 2009
  10. pmc Using approximate Bayesian computation to estimate tuberculosis transmission parameters from genotype data
    Mark M Tanaka
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
    Genetics 173:1511-20. 2006

Detail Information

Publications20

  1. doi request reprint Next generation deep sequencing and vaccine design: today and tomorrow
    Fabio Luciani
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Trends Biotechnol 30:443-52. 2012
    ..NGS is unraveling the complex dynamics of viral evolution and host responses against these viruses, thus contributing substantially to the likelihood of successful vaccine development...
  2. doi request reprint Interpreting genotype cluster sizes of Mycobacterium tuberculosis isolates typed with IS6110 and spoligotyping
    Fabio Luciani
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW, Australia
    Infect Genet Evol 8:182-90. 2008
    ..This study illustrates the utility of examining the full distribution of genotype cluster sizes from a given region, in the light of population genetic models...
  3. pmc The evolutionary dynamics of a rapidly mutating virus within and between hosts: the case of hepatitis C virus
    Fabio Luciani
    Centre for Infection and Inflammation Research CIIR, School of Medical Sciences, University of New South Wales, Sydney, Australia
    PLoS Comput Biol 5:e1000565. 2009
    ..This model raises questions that can be tested experimentally and underlines the necessity to consider the evolution of quantitative traits to understand the outcome and the fitness of an infection...
  4. pmc Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection
    Rowena A Bull
    School of Medical Sciences, University of New South Wales, Australia
    PLoS Pathog 7:e1002243. 2011
    ..These results provide the first detailed analysis of early within-host evolution of HCV, indicating strong selective forces limit viral evolution in the acute phase of infection...
  5. pmc Transmitted/Founder Viruses Rapidly Escape from CD8+ T Cell Responses in Acute Hepatitis C Virus Infection
    Rowena A Bull
    Systems Medicine, Inflammation and Infection Research Centre, School of Medical Sciences, Faculty of Medicine, UNSW Australia, Sydney, New South Wales, Australia
    J Virol 89:5478-90. 2015
    ..These findings raise questions regarding optimal selection of immunogens for HCV vaccine development and suggest that detailed analysis of individual epitopes may be required...
  6. doi request reprint A prospective study of hepatitis C incidence in Australian prisoners
    Fabio Luciani
    Inflammation and Infection Research Centre, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales, Australia
    Addiction 109:1695-706. 2014
    ..To document the relationships between injecting drug use, imprisonment and hepatitis C virus (HCV) infection...
  7. pmc Accurate single nucleotide variant detection in viral populations by combining probabilistic clustering with a statistical test of strand bias
    Kerensa McElroy
    Centre for Marine Bioinnovation and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    BMC Genomics 14:501. 2013
    ..Distinguishing true single nucleotide variants (SNVs) from sequencing errors remains challenging, however. Current protocols are characterised by high false positive rates, with results requiring time consuming manual checking...
  8. pmc Contribution of intra- and interhost dynamics to norovirus evolution
    Rowena A Bull
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, a and School of Medical Sciences, Faculty of Medicine, b University of New South Wales, Sydney, Australia
    J Virol 86:3219-29. 2012
    ..In contrast, in a typical acute NoV infection, the viral population was highly homogenous and relatively stable. These results indicate that the evolution of NoV occurs through multiple mechanisms...
  9. pmc The epidemiological fitness cost of drug resistance in Mycobacterium tuberculosis
    Fabio Luciani
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2052, Australia
    Proc Natl Acad Sci U S A 106:14711-5. 2009
    ..For instance, projections using our estimates suggest that the prevalence of tuberculosis may decline with successful treatment, but the proportion of cases associated with resistance is likely to increase...
  10. pmc Using approximate Bayesian computation to estimate tuberculosis transmission parameters from genotype data
    Mark M Tanaka
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
    Genetics 173:1511-20. 2006
    ..I. 0.64, 1.82); and reproductive value 3.4 (95% C.I. 1.4, 79.7). These figures suggest a rapidly spreading epidemic, consistent with observations of the resurgence of tuberculosis in the United States in the 1980s and 1990s...
  11. doi request reprint spolTools: online utilities for analyzing spoligotypes of the Mycobacterium tuberculosis complex
    Chaka Tang
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW, Australia
    Bioinformatics 24:2414-5. 2008
    ....
  12. ncbi request reprint Effects and interactions in an environmentally relevant mixture of pharmaceuticals
    Francesco Pomati
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, Australia
    Toxicol Sci 102:129-37. 2008
    ..Hazard identification for micropollutants depends heavily on appropriate study designs, and we indicate the use of in vitro cytotoxicity threshold and statistical design of experiments (DOEs) as a valid approach...
  13. doi request reprint Resistance to hepatitis C virus: potential genetic and immunological determinants
    Michael M Mina
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia Electronic address
    Lancet Infect Dis 15:451-60. 2015
    ....
  14. pmc Per-event probability of hepatitis C infection during sharing of injecting equipment
    Lies Boelen
    Inflammation and Infection Research Centre, School of Medical Sciences, The University of New South Wales, Sydney, Australia Section of Immunology, School of Medicine, Imperial College, London, United Kingdom
    PLoS ONE 9:e100749. 2014
    ..Shared injecting apparatus during drug use is the premier risk factor for hepatitis C virus (HCV) transmission...
  15. pmc Incidence of primary hepatitis C infection and risk factors for transmission in an Australian prisoner cohort
    Suzy Teutsch
    School of Medical Sciences, The University of New South Wales, Sydney, New South Wales, Australia
    BMC Public Health 10:633. 2010
    ..Previous studies of HCV incidence have been based on small case numbers and have not distinguished risk events in prison from those in the community...
  16. doi request reprint Trade-offs in resource allocation in the intracellular life-cycle of hepatitis C virus
    Alison K McLean
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    J Theor Biol 267:565-72. 2010
    ..The most productive strategy is a form of the Free Movement model in which genomes are allocated entirely to the replication-translation cycle while allowing some genomes to be packaged through reallocation...
  17. doi request reprint Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas
    Peter Zarzour
    Adult Cancer Program, Prince of Wales Clinical School, Lowy Cancer Research Centre, UNSW, Sydney, NSW 2052, Australia
    Genes Chromosomes Cancer 54:303-14. 2015
    ..Deletion of the corresponding region is sometimes present in adenomas, suggesting that LOH at these loci may play an important role in tumor initiation...
  18. pmc A bioinformatics pipeline for the analyses of viral escape dynamics and host immune responses during an infection
    Preston Leung
    Inflammation and Infection Research Centre, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    Biomed Res Int 2014:264519. 2014
    ..We provide a statistical and visual explanation of the relationship between cooccurring mutations on the viral genome and the parallel adaptive immune response against HCV. ..
  19. pmc GemSIM: general, error-model based simulator of next-generation sequencing data
    Kerensa E McElroy
    Centre for Marine Bio Innovation and School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, NSW, Australia
    BMC Genomics 13:74. 2012
    ..Empirical fragment length and quality score distributions are also used. Reads may be drawn from one or more genomes or haplotype sets, facilitating simulation of deep sequencing, metagenomic, and resequencing projects...
  20. doi request reprint Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics
    Michele Mishto
    Interdepartmental Center for Studies on Biophysics, Bioinformatics and Biocomplexity L Galvani CIG, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    J Mol Biol 377:1607-17. 2008
    ..ProteaMAlg is publicly available on the web (http://www.proteamalg.com)...