Peter Lock

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
    Isobel D Lawrenson
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Sci 115:1059-72. 2002
  2. pmc Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites
    Raffi Gugasyan
    Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3050, Australia
    J Cell Biol 158:115-25. 2002
  3. ncbi request reprint Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination
    Peter Lock
    Cell Signaling Laboratory, Department of Surgery, University of Melbourne, Royal Melbourne Hospital, Parkville 3050, Australia
    Biochem Biophys Res Commun 351:1018-23. 2006
  4. pmc Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation
    Stanley S Stylli
    Department of Surgery, University of Melbourne, Level 5, Clinical Sciences Building, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Cell Sci 122:2727-40. 2009
  5. pmc Distinct requirements for the Sprouty domain for functional activity of Spred proteins
    James A J King
    Department of Surgery, 5th Floor Clinical Sciences Building, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Biochem J 388:445-54. 2005
  6. ncbi request reprint Eve-3: a liver enriched suppressor of Ras/MAPK signaling
    James A J King
    Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Clinical Sciences Building, Parkville, VIC 3050, Australia
    J Hepatol 44:758-67. 2006
  7. ncbi request reprint ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner
    Stacey T T I
    Department of Surgery, University of Melbourne, Level 5 Clinical Sciences Building, Royal Melbourne Hospital, VIC 3050, Australia
    J Cell Sci 117:6071-84. 2004
  8. doi request reprint Prognostic significance of Tks5 expression in gliomas
    Stanley S Stylli
    Department of Surgery, The University of Melbourne, Level 5, Clinical Sciences Building, The Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Clin Neurosci 19:436-42. 2012
  9. doi request reprint Invadopodia: at the cutting edge of tumour invasion
    Stanley S Stylli
    Department of Surgery, University of Melbourne, Cell Signaling Laboratory, Level 5, Clinical Sciences Building, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Clin Neurosci 15:725-37. 2008
  10. ncbi request reprint Efficient gene transfer into the epithelial cell layer of embryonic mouse intestine using low-voltage electroporation
    Helen E Abud
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Gastroenterology 126:1779-87. 2004

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
    Isobel D Lawrenson
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Sci 115:1059-72. 2002
    ....
  2. pmc Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites
    Raffi Gugasyan
    Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3050, Australia
    J Cell Biol 158:115-25. 2002
    ..In contrast, a minimal effect on B cell and myeloid lineage development was observed. Importantly, functional RasGAP and Nck binding sites were found to be essential for the biological effects of DokR in vitro and in vivo...
  3. ncbi request reprint Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination
    Peter Lock
    Cell Signaling Laboratory, Department of Surgery, University of Melbourne, Royal Melbourne Hospital, Parkville 3050, Australia
    Biochem Biophys Res Commun 351:1018-23. 2006
    ..These results suggest a role for Spred-2 tyrosine phosphorylation and ubiquitination in controlling Spred-2 expression levels...
  4. pmc Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation
    Stanley S Stylli
    Department of Surgery, University of Melbourne, Level 5, Clinical Sciences Building, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Cell Sci 122:2727-40. 2009
    ..These results identify a Src-Tks5-Nck pathway in ECM-degrading invadopodia that shows parallels with pathways linking several mammalian and pathogen-derived proteins to local actin regulation...
  5. pmc Distinct requirements for the Sprouty domain for functional activity of Spred proteins
    James A J King
    Department of Surgery, 5th Floor Clinical Sciences Building, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Biochem J 388:445-54. 2005
    ....
  6. ncbi request reprint Eve-3: a liver enriched suppressor of Ras/MAPK signaling
    James A J King
    Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Clinical Sciences Building, Parkville, VIC 3050, Australia
    J Hepatol 44:758-67. 2006
    ..This suggests that growth inhibitors may be involved in the control of liver growth. We analyzed the role of the Spred-family of growth inhibitors in the liver...
  7. ncbi request reprint ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner
    Stacey T T I
    Department of Surgery, University of Melbourne, Level 5 Clinical Sciences Building, Royal Melbourne Hospital, VIC 3050, Australia
    J Cell Sci 117:6071-84. 2004
    ..These results implicate ARAP3 in integrin-mediated tyrosine kinase signalling pathways controlling Rho GTPases and cell spreading...
  8. doi request reprint Prognostic significance of Tks5 expression in gliomas
    Stanley S Stylli
    Department of Surgery, The University of Melbourne, Level 5, Clinical Sciences Building, The Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Clin Neurosci 19:436-42. 2012
    ..This association was clearest in patients with low-grade astrocytomas and oligoastrocytomas. These results suggest a prognostic relevance for the Tks5 invadopodial protein in glial-derived brain tumours...
  9. doi request reprint Invadopodia: at the cutting edge of tumour invasion
    Stanley S Stylli
    Department of Surgery, University of Melbourne, Cell Signaling Laboratory, Level 5, Clinical Sciences Building, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Clin Neurosci 15:725-37. 2008
    ....
  10. ncbi request reprint Efficient gene transfer into the epithelial cell layer of embryonic mouse intestine using low-voltage electroporation
    Helen E Abud
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Gastroenterology 126:1779-87. 2004
    ....