Peter Lock

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
    Isobel D Lawrenson
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Sci 115:1059-72. 2002
  2. ncbi Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination
    Peter Lock
    Cell Signaling Laboratory, Department of Surgery, University of Melbourne, Royal Melbourne Hospital, Parkville 3050, Australia
    Biochem Biophys Res Commun 351:1018-23. 2006
  3. ncbi Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation
    Stanley S Stylli
    Department of Surgery, University of Melbourne, Level 5, Clinical Sciences Building, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Cell Sci 122:2727-40. 2009
  4. ncbi Distinct requirements for the Sprouty domain for functional activity of Spred proteins
    James A J King
    Department of Surgery, 5th Floor Clinical Sciences Building, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Biochem J 388:445-54. 2005
  5. ncbi Eve-3: a liver enriched suppressor of Ras/MAPK signaling
    James A J King
    Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Clinical Sciences Building, Parkville, VIC 3050, Australia
    J Hepatol 44:758-67. 2006
  6. ncbi ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner
    Stacey T T I
    Department of Surgery, University of Melbourne, Level 5 Clinical Sciences Building, Royal Melbourne Hospital, VIC 3050, Australia
    J Cell Sci 117:6071-84. 2004
  7. ncbi Prognostic significance of Tks5 expression in gliomas
    Stanley S Stylli
    Department of Surgery, The University of Melbourne, Level 5, Clinical Sciences Building, The Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Clin Neurosci 19:436-42. 2012
  8. ncbi Efficient gene transfer into the epithelial cell layer of embryonic mouse intestine using low-voltage electroporation
    Helen E Abud
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Gastroenterology 126:1779-87. 2004
  9. ncbi Invadopodia: at the cutting edge of tumour invasion
    Stanley S Stylli
    Department of Surgery, University of Melbourne, Cell Signaling Laboratory, Level 5, Clinical Sciences Building, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Clin Neurosci 15:725-37. 2008
  10. ncbi Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites
    Raffi Gugasyan
    Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3050, Australia
    J Cell Biol 158:115-25. 2002

Collaborators

Detail Information

Publications10

  1. ncbi Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
    Isobel D Lawrenson
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Sci 115:1059-72. 2002
    ....
  2. ncbi Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination
    Peter Lock
    Cell Signaling Laboratory, Department of Surgery, University of Melbourne, Royal Melbourne Hospital, Parkville 3050, Australia
    Biochem Biophys Res Commun 351:1018-23. 2006
    ..These results suggest a role for Spred-2 tyrosine phosphorylation and ubiquitination in controlling Spred-2 expression levels...
  3. ncbi Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation
    Stanley S Stylli
    Department of Surgery, University of Melbourne, Level 5, Clinical Sciences Building, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Cell Sci 122:2727-40. 2009
    ..These results identify a Src-Tks5-Nck pathway in ECM-degrading invadopodia that shows parallels with pathways linking several mammalian and pathogen-derived proteins to local actin regulation...
  4. ncbi Distinct requirements for the Sprouty domain for functional activity of Spred proteins
    James A J King
    Department of Surgery, 5th Floor Clinical Sciences Building, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Biochem J 388:445-54. 2005
    ....
  5. ncbi Eve-3: a liver enriched suppressor of Ras/MAPK signaling
    James A J King
    Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Clinical Sciences Building, Parkville, VIC 3050, Australia
    J Hepatol 44:758-67. 2006
    ..This suggests that growth inhibitors may be involved in the control of liver growth. We analyzed the role of the Spred-family of growth inhibitors in the liver...
  6. ncbi ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner
    Stacey T T I
    Department of Surgery, University of Melbourne, Level 5 Clinical Sciences Building, Royal Melbourne Hospital, VIC 3050, Australia
    J Cell Sci 117:6071-84. 2004
    ..These results implicate ARAP3 in integrin-mediated tyrosine kinase signalling pathways controlling Rho GTPases and cell spreading...
  7. ncbi Prognostic significance of Tks5 expression in gliomas
    Stanley S Stylli
    Department of Surgery, The University of Melbourne, Level 5, Clinical Sciences Building, The Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Clin Neurosci 19:436-42. 2012
    ..This association was clearest in patients with low-grade astrocytomas and oligoastrocytomas. These results suggest a prognostic relevance for the Tks5 invadopodial protein in glial-derived brain tumours...
  8. ncbi Efficient gene transfer into the epithelial cell layer of embryonic mouse intestine using low-voltage electroporation
    Helen E Abud
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Gastroenterology 126:1779-87. 2004
    ....
  9. ncbi Invadopodia: at the cutting edge of tumour invasion
    Stanley S Stylli
    Department of Surgery, University of Melbourne, Cell Signaling Laboratory, Level 5, Clinical Sciences Building, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Clin Neurosci 15:725-37. 2008
    ....
  10. ncbi Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites
    Raffi Gugasyan
    Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3050, Australia
    J Cell Biol 158:115-25. 2002
    ..In contrast, a minimal effect on B cell and myeloid lineage development was observed. Importantly, functional RasGAP and Nck binding sites were found to be essential for the biological effects of DokR in vitro and in vivo...