Peter Y Liu

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint The short-term effects of high-dose testosterone on sleep, breathing, and function in older men
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute and Concord Hospital, University of Sydney, Sydney, 2139 Australia
    J Clin Endocrinol Metab 88:3605-13. 2003
  2. ncbi request reprint Contraceptive efficacy of a depot progestin and androgen combination in men
    Leo Turner
    Department of Andrology, Concord Hospital, and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 88:4659-67. 2003
  3. doi request reprint Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute, University of Sydney and Concord Hospital, Concord, New South Wales 2139, Australia
    J Clin Endocrinol Metab 93:1774-83. 2008
  4. ncbi request reprint Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis
    Peter Y Liu
    Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA
    Lancet 367:1412-20. 2006
  5. ncbi request reprint Early markers of metabolic syndrome in nonoverweight, middle-aged men
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute, Concord, NSW, Australia
    Nat Clin Pract Urol 3:524-5. 2006
  6. doi request reprint Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 94:801-8. 2009
  7. pmc Genetic and hormonal control of bone volume, architecture, and remodeling in XXY mice
    Peter Y Liu
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute LA BioMed at Harbor UCLA Medical Center, Torrance, CA, USA
    J Bone Miner Res 25:2148-54. 2010
  8. pmc Genetic, hormonal, and metabolomic influences on social behavior and sex preference of XXY mice
    Peter Y Liu
    Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California, USA
    Am J Physiol Endocrinol Metab 299:E446-55. 2010
  9. doi request reprint Randomized cross-over clinical trial of injectable vs. implantable depot testosterone for maintenance of testosterone replacement therapy in androgen deficient men
    Carolyn Fennell
    Andrology Department, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Clin Endocrinol (Oxf) 73:102-9. 2010
  10. doi request reprint Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: a randomised sham-controlled study
    Camilla M Hoyos
    Endocrine and Cardiometabolic Research Group, Woolcock Institute of Medical Research, University of Sydney, Glebe, Australia
    Thorax 67:1081-9. 2012

Collaborators

Detail Information

Publications58

  1. ncbi request reprint The short-term effects of high-dose testosterone on sleep, breathing, and function in older men
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute and Concord Hospital, University of Sydney, Sydney, 2139 Australia
    J Clin Endocrinol Metab 88:3605-13. 2003
    ..These changes did not appear to be due to upper airway narrowing. Further study of longer-term lower-dose androgen therapy on sleep and breathing is needed to evaluate its safety in older men...
  2. ncbi request reprint Contraceptive efficacy of a depot progestin and androgen combination in men
    Leo Turner
    Department of Andrology, Concord Hospital, and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 88:4659-67. 2003
    ..Further studies of purpose-developed products are required to extend the overall safety and efficacy experience with depot androgen/progestin combinations, the most promising approach to hormonal male contraception...
  3. doi request reprint Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute, University of Sydney and Concord Hospital, Concord, New South Wales 2139, Australia
    J Clin Endocrinol Metab 93:1774-83. 2008
    ..Male hormonal contraceptive methods require effective suppression of sperm output...
  4. ncbi request reprint Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis
    Peter Y Liu
    Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA
    Lancet 367:1412-20. 2006
    ..We have investigated the rate, extent, and predictors of reversibility of hormonal male contraception...
  5. ncbi request reprint Early markers of metabolic syndrome in nonoverweight, middle-aged men
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute, Concord, NSW, Australia
    Nat Clin Pract Urol 3:524-5. 2006
  6. doi request reprint Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 94:801-8. 2009
    ..Understanding the predictors of response would inform clinical practice but requires multivariate analyses in sufficiently large clinical cohorts that are suitably detailed and frequently assessed...
  7. pmc Genetic and hormonal control of bone volume, architecture, and remodeling in XXY mice
    Peter Y Liu
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute LA BioMed at Harbor UCLA Medical Center, Torrance, CA, USA
    J Bone Miner Res 25:2148-54. 2010
    ..Testosterone deficiency does not explain the bone phenotype because testosterone-replaced XXY mice show reduced bone volume despite similar blood testosterone levels...
  8. pmc Genetic, hormonal, and metabolomic influences on social behavior and sex preference of XXY mice
    Peter Y Liu
    Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California, USA
    Am J Physiol Endocrinol Metab 299:E446-55. 2010
    ..Specific metabolic changes in brain lipids, which are also regulated by androgens, are observed in brain regions that are involved in these behaviors...
  9. doi request reprint Randomized cross-over clinical trial of injectable vs. implantable depot testosterone for maintenance of testosterone replacement therapy in androgen deficient men
    Carolyn Fennell
    Andrology Department, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Clin Endocrinol (Oxf) 73:102-9. 2010
    ..This study compared directly the two long-acting depot T products, subdermal T implants (TI) and injectable T undecanoate (TU) for maintenance of TRT...
  10. doi request reprint Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: a randomised sham-controlled study
    Camilla M Hoyos
    Endocrine and Cardiometabolic Research Group, Woolcock Institute of Medical Research, University of Sydney, Glebe, Australia
    Thorax 67:1081-9. 2012
    ..The reversibility of these observed changes with continuous positive airway pressure (CPAP) treatment in men with OSA has not been systematically studied in a randomised sham-controlled fashion...
  11. doi request reprint Endogenous glucocorticoid signalling in osteoblasts is necessary to maintain normal bone structure in mice
    Robert Kalak
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
    Bone 45:61-7. 2009
    ..Taken together, our results demonstrate that endogenous glucocorticoids may be required for normal bone growth but that their effect on bone structure and strength varies according to the skeletal site and sexual maturity of the animals...
  12. doi request reprint Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial
    Camilla M Hoyos
    Endocrine and Cardiometabolic Research Group, NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, University of Sydney, Glebe, Australia
    Eur J Endocrinol 167:531-41. 2012
    ..There has been no systematic study evaluating whether testosterone therapy can improve cardiometabolic health in obese men with OSA by improving body composition, visceral abdominal fat and insulin sensitivity...
  13. ncbi request reprint Endocrine regulation of bone turnover in men
    Christian Meier
    Bone Research Program, ANZAC Research Institute, University of Sydney, Concord, New South Wales, Australia
    Clin Endocrinol (Oxf) 63:603-16. 2005
  14. pmc Does ethnicity matter in male hormonal contraceptive efficacy?
    Niloufar Ilani
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA 90509, USA
    Asian J Androl 13:579-84. 2011
    ..This goal mandates further investment and large clinical trials in multiethnic populations to better define safety and efficacy...
  15. pmc Fate of bone marrow stem cells transplanted into the testis: potential implication for men with testicular failure
    Yanhe Lue
    Department of Medicine, Division of Endocrinology, David Geffen School of Medicine at University of California, Los Angeles, CA 90509, USA
    Am J Pathol 170:899-908. 2007
    ..This clinically relevant finding raises the possibility for treatment of male infertility and testosterone deficiency through the therapeutic use of stem cells...
  16. pmc Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study
    Nathaniel S Marshall
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    Sleep 31:1079-85. 2008
    ..However, it is unknown whether sleep apnea is an independent risk factor for all-cause mortality in a community-based sample free from clinical referral bias...
  17. ncbi request reprint Rates of suppression and recovery of human sperm output in testosterone-based hormonal contraceptive regimens
    Lam P Ly
    Departments of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney NSW 2139, Australia
    Hum Reprod 20:1733-40. 2005
    ....
  18. doi request reprint Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets
    Flora F Ip
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    Eur J Endocrinol 162:385-90. 2010
    ..We, therefore, sought to define the prevalence, predictors, and proximate basis (role of erythropoietin) for polycythemia (hematocrit >0.50) in hypogonadal men receiving testosterone implants long term...
  19. ncbi request reprint Recombinant human chorionic gonadotropin but not dihydrotestosterone alone stimulates osteoblastic collagen synthesis in older men with partial age-related androgen deficiency
    Christian Meier
    Bone Research Program, ANZAC Research Institute, University of Sydney, Concord, NSW 2139, Australia
    J Clin Endocrinol Metab 89:3033-41. 2004
    ..If androgen supplementation is required for aging men, aromatizable androgens with sufficient endogenous estrogenic activity may have the most beneficial effects on bone...
  20. doi request reprint Mouse model for men with klinefelter syndrome: a multifaceted fit for a complex disorder
    Ronald S Swerdloff
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA
    Acta Paediatr 100:892-9. 2011
    ..The similarities in phenotype between 47XXY men and 41XXY mice suggest that the clinical manifestations in XXY men may be because of gene-dosage effect from genes that escape X inactivation in mouse...
  21. doi request reprint Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo-controlled trial
    Camilla M Hoyos
    Endocrine and Cardiometabolic Research Group, NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
    Clin Endocrinol (Oxf) 77:599-607. 2012
    ..We assessed sleep and breathing effects of near-conventional testosterone treatment as an adjunct to weight loss in obese men with severe OSA...
  22. pmc Is sleep apnea an independent risk factor for prevalent and incident diabetes in the Busselton Health Study?
    Nathaniel S Marshall
    Woolcock Institute of Medical Research, University of Sydney, Australia
    J Clin Sleep Med 5:15-20. 2009
    ..However, this observation has yet to be replicated outside the USA or be observed lonigitudinally...
  23. pmc Assessment of sleep and breathing in adults with prader-willi syndrome: a case control series
    Brendon J Yee
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, Australia
    J Clin Sleep Med 3:713-8. 2007
    ....
  24. doi request reprint Continuous positive airway pressure reduces postprandial lipidemia in obstructive sleep apnea: a randomized, placebo-controlled crossover trial
    Craig L Phillips
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    Am J Respir Crit Care Med 184:355-61. 2011
    ..Dyslipidemia is common in Obstructive Sleep Apnea (OSA). Postprandial lipidemia (PPL) is a strong marker of cardiovascular risk. Evidence that OSA treatment improves PPL is lacking...
  25. doi request reprint Modafinil effects during acute continuous positive airway pressure withdrawal: a randomized crossover double-blind placebo-controlled trial
    Shaun C Williams
    Sleep and Circadian Research Group NHMRC Centre for Sleep Medicine, Woolcock Institute, University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia
    Am J Respir Crit Care Med 181:825-31. 2010
    ..However, interruption of CPAP therapy is common and is associated with a decline in daytime function...
  26. ncbi request reprint Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 92:3599-603. 2007
    ..Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time...
  27. pmc Recent methodological advances in male hormonal contraception
    Peter Y Liu
    Division of Endocrinology, Department of Medicine, General Clinical Research Center, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute LA BioMed at Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Contraception 82:471-5. 2010
    ..These are the best data available and will provide guidance and reassurance for the larger-scale Phase III specific regimen efficacy studies that will be required to bring MHC to the population (market)...
  28. ncbi request reprint Do reproductive hormones modify insulin sensitivity and metabolism in older men? A randomized, placebo-controlled clinical trial of recombinant human chorionic gonadotropin
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, Concord, New South Wales 2139, Australia
    Eur J Endocrinol 148:55-66. 2003
    ....
  29. ncbi request reprint Joint synchrony of reciprocal hormonal signaling in human paradigms of both ACTH excess and cortisol depletion
    Peter Y Liu
    Division of Endocrinology, Department of Internal Medicine, Endocrine Research Unit and General Clinical Research Center, Mayo Clinic, Mayo Medical and Graduate Schools of Medicine, 200 First St Southwest, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 289:E160-5. 2005
    ..Thus quantification of directionally defined joint synchrony of biologically coupled signals offers a noninvasive strategy to dissect feedforward- and feedback-selective adaptations in an interactive axis...
  30. doi request reprint Implications of sleep restriction and recovery on metabolic outcomes
    Roo Killick
    David Geffen School of Medicine at University of California Los Angeles UCLA, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, 1124 West Carson Street, Torrance, California 90502, USA
    J Clin Endocrinol Metab 97:3876-90. 2012
    ..Whether recovery sleep is sufficient to offset these detriments is an area of ongoing research...
  31. ncbi request reprint Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axes
    Peter Y Liu
    Division of Endocrinology, Department of Internal Medicine, Endocrine Research Unit and General Clinical Research Center, Mayo Clinic, Mayo Medical and Graduate Schools of Medicine, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 288:R440-6. 2005
    ..The linking of relevant biological input to output signals and vice versa should be useful in the dissection of the reciprocal control of neuroendocrine systems or even in the analysis of other nonendocrine networks...
  32. ncbi request reprint Insights into the pathogenesis of XXY phenotype from comparison of the clinical syndrome with an experimental XXY mouse model
    Yan He Lue
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA
    Pediatr Endocrinol Rev 8:140-4. 2010
    ..The phenotypic similarities between XXY mouse and men suggest that the common genes that escape the X inactivation between XXY mouse and men may be responsible for the clinical manifestations in men with Klinefelter syndrome...
  33. ncbi request reprint Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment
    Bronwyn A L Crawford
    Department of Endocrinology, ANZAC Research Institute, Royal Prince Alfred Hospital and University of Sydney, Sydney, New South Wales, Australia
    J Clin Endocrinol Metab 88:3167-76. 2003
    ..001). These results suggest that androgen therapy may have a role in ameliorating adverse effects of glucocorticoid therapy such as muscle and bone loss and aromatization is necessary for androgen action on bone but not on muscle...
  34. doi request reprint The effects of testosterone on ventilatory responses in men with obstructive sleep apnea: a randomised, placebo-controlled trial
    Roo Killick
    NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
    J Sleep Res 22:331-6. 2013
    ..57, P = 0.03) at 6-7 weeks, but not at 18 weeks. Time-dependent alterations in ventilatory recruitment threshold may therefore mediate the time-dependent changes in sleep breathing observed with testosterone...
  35. ncbi request reprint The present and future state of hormonal treatment for male infertility
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, New South Wales, Australia
    Hum Reprod Update 9:9-23. 2003
    ..How such novel hormonal methods will develop in conjunction with improved ICSI/IVF or cloning technologies, and the potential role of adjunctive hormonal therapy remains to be clarified...
  36. ncbi request reprint Male sex matters
    Peter Y Liu
    Division of Endocrinology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute, Los Angeles, CA 90502, USA
    Clin Endocrinol (Oxf) 63:601-2. 2005
  37. ncbi request reprint Androgens, obesity, and sleep-disordered breathing in men
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute, Concord Hospital C64, University of Sydney, Sydney NSW 2139, Australia
    Endocrinol Metab Clin North Am 36:349-63. 2007
    ..In addition, avoiding excessive weight may maintain optimal male reproductive health...
  38. ncbi request reprint Relative testosterone deficiency in older men: clinical definition and presentation
    Peter Y Liu
    Division of Endocrinology, Department of Medicine, Los Angeles Biomedical Research Institute, Harbor University of California at Los Angeles Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
    Endocrinol Metab Clin North Am 34:957-72, x. 2005
  39. ncbi request reprint Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea
    Sheila Sivam
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, PO Box M77, Missenden Road, NSW 2050, Australia
    Eur Respir J 40:913-8. 2012
    ..Longer duration of CPAP use may be necessary to demonstrate a difference...
  40. doi request reprint Rapid eye movement and slow-wave sleep rebound after one night of continuous positive airway pressure for obstructive sleep apnoea
    Ruby Brillante
    Department of Thoracic and Sleep Medicine, Concord Repatriation General Hospital, Concord, New South Wales, Australia
    Respirology 17:547-53. 2012
    ..The pressure titration study often represents the first recovery sleep period for patients with OSA. Our aim was to objectively define and identify predictors of SWS and REM sleep rebound following CPAP titration...
  41. ncbi request reprint Clinical review 171: The rationale, efficacy and safety of androgen therapy in older men: future research and current practice recommendations
    Peter Y Liu
    Division of Endocrinology, Department of Internal Medicine, Endocrine Research Unit, Mayo Clinic, Mayo Medical and Graduate Schools of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:4789-96. 2004
    ..However, interim recommendations are available to help guide appropriate and curb unnecessary androgen prescription for symptomatic older men with low serum testosterone levels...
  42. ncbi request reprint Andropause: invention, prevention, rejuvenation
    David J Handelsman
    Department of Andrology, Concord Hospital, ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia
    Trends Endocrinol Metab 16:39-45. 2005
    ..This review appraises current knowledge with a focus on the questionable basis for using androgen therapy to improve male reproductive health during aging...
  43. ncbi request reprint Androgens and cardiovascular disease
    Peter Y Liu
    ANZAC Research Institute, Concord Hospital and Department of Medicine, University of Sydney, New South Wales, Australia
    Endocr Rev 24:313-40. 2003
    ....
  44. ncbi request reprint A double-blind, placebo-controlled, randomized clinical trial of recombinant human chorionic gonadotropin on muscle strength and physical function and activity in older men with partial age-related androgen deficiency
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Concord NSW 2139, Australia
    J Clin Endocrinol Metab 87:3125-35. 2002
    ..We conclude that 3 months of treatment with twice weekly r-hCG demonstrates sustained androgenic effects on hormones and muscle mass but has no effect on muscle strength or physical functioning...
  45. ncbi request reprint Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease
    Peter Y Liu
    Division of Endocrinology, Metabolism, Diabetes and Nutrition, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:1041-6. 2005
    ..We therefore examined AR, ER alpha, and ER beta expression as a function of key components of atherosclerosis, namely plaque and calcium area, in male human coronary arteries...
  46. ncbi request reprint Does individual response to androgen replacement therapy affect bone density?
    Peter Y Liu
    Harbor UCLA Medical Center, Los Angeles 90502, USA
    Nat Clin Pract Endocrinol Metab 2:76-7. 2006
  47. doi request reprint Male hormonal contraception: so near and yet so far
    Peter Y Liu
    J Clin Endocrinol Metab 93:2474-6. 2008
  48. ncbi request reprint Prospective study of effect of androgens on serum inflammatory markers in men
    Martin K C Ng
    Department of Cardiology, Royal Prince Alfred Hospital and The Heart Research Institute
    Arterioscler Thromb Vasc Biol 22:1136-41. 2002
    ..Because levels of serum inflammatory markers predict cardiovascular outcomes, we prospectively assessed the effects of androgen therapy on these markers in older men...
  49. ncbi request reprint Age or factors associated with aging attenuate testosterone's concentration-dependent enhancement of the regularity of luteinizing hormone secretion in healthy men
    Peter Y Liu
    Endocrine Research Unit, Mayo Clinic School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Endocrinol Metab 91:4077-84. 2006
    ..Healthy older men have reduced testosterone (Te) production and frequent, small irregular LH pulses. Which is cause and which is effect are not known...
  50. ncbi request reprint An ensemble model of the male gonadal axis: illustrative application in aging men
    Daniel M Keenan
    Department of Statistics, University of Virginia, Charlottesville, Virginia 22903, USA
    Endocrinology 147:2817-28. 2006
    ..The generality of the present integrative model suggests utility in parsing interlinked adaptations in other physiological networks...
  51. ncbi request reprint Mechanisms of hypoandrogenemia in healthy aging men
    Peter Y Liu
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Education, General Clinical Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Endocrinol Metab Clin North Am 34:935-55, ix. 2005
  52. ncbi request reprint Of mice, men, and hormones
    Virginia M Miller
    Arterioscler Thromb Vasc Biol 24:995-7. 2004
  53. ncbi request reprint Predicting pregnancy and spermatogenesis by survival analysis during gonadotrophin treatment of gonadotrophin-deficient infertile men
    Peter Y Liu
    Department of Andrology and ANZAC Research Institute, Concord Hospital, Sydney NSW 2139, Australia
    Hum Reprod 17:625-33. 2002
    ..Predictors of fertility or spermatogenesis during gonadotrophin therapy of gonadotrophin-deficient men remain poorly defined...
  54. pmc Graded inhibition of pulsatile luteinizing hormone secretion by a selective gonadotropin-releasing hormone (GnRH)-receptor antagonist in healthy men: evidence that age attenuates hypothalamic GnRH outflow
    Paul Y Takahashi
    Endocrine Research Unit, Department of Internal Medicine, General Clinical Research Center, Mayo Medical and Graduate Schools of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:2768-74. 2005
    ..These joint outcomes support the clinical hypothesis that age diminishes hypothalamic GnRH outflow without impairing GnRH action in healthy men...
  55. ncbi request reprint Age-specific changes in the regulation of LH-dependent testosterone secretion: assessing responsiveness to varying endogenous gonadotropin output in normal men
    Peter Y Liu
    Endocrine Research Unit, Dept of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 289:R721-8. 2005
    ..The experimental strategy of graded suppression of neuroglandular outflow may have utility in estimating dose-response adaptations in other endocrine systems...
  56. ncbi request reprint Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade
    Peter Y Liu
    Endocrine Research Unit, Dept of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 290:E34-E41. 2006
    ..Thus the experimental strategy of stepwise silencing of an agonistic pathway may have utility in dissecting the bases of altered neurohormonal linkages in other systems...
  57. ncbi request reprint Aging in healthy men impairs recombinant human luteinizing hormone (LH)-stimulated testosterone secretion monitored under a two-day intravenous pulsatile LH clamp
    Peter Y Liu
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:5544-50. 2005
    ..Testosterone (Te) depletion in aging men in principle could reflect deficits in the hypothalamus, pituitary gland, or testis. Available pharmacological studies of possible failure of Leydig cell steroidogenesis remain inconclusive...
  58. ncbi request reprint Klinefelter's syndrome--a microcosm of male reproductive health
    David J Handelsman
    J Clin Endocrinol Metab 91:1220-2. 2006