Research Topics
| Pawel ListwanSummaryAffiliation: University of Queensland Country: Australia Publications
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Detail Information
Publications
Modification of recombinatorial cloning for small affinity tag fusion protein construct generationPawel Listwan
School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
Anal Biochem 346:327-9. 2005
Crystal structures of fusion proteins with large-affinity tagsDouglas R Smyth
Department of Biochemistry and Molecular Biology, Institute for Molecular Bioscience, and Special Research Centre for Functional and Applied Genomics, University of Queensland, St Lucia, Queensland 4072, Australia
Protein Sci 12:1313-22. 2003..g., membrane proteins). Structural genomics initiatives may also benefit from this approach as a way to crystallize problematic proteins of significant interest...
An automatable screen for the rapid identification of proteins amenable to refoldingNathan P Cowieson
Institute for Molecular Bioscience and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Brisbane, Queensland, Australia
Proteomics 6:1750-7. 2006..The efficacy of the screen is demonstrated on small-scale expression samples for 15 proteins. Refolding is then validated by large-scale expressions using SEC and circular dichroism...
Substrate specificity of protein kinases and computational prediction of substratesBostjan Kobe
School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
Biochim Biophys Acta 1754:200-9. 2005..We discuss the structural basis of substrate specificity of protein kinases and review the experimental and computational methods used to obtain specificity information...
Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression systemNathan P Cowieson
Institute for Molecular Bioscience, Australia
J Struct Funct Genomics 6:13-20. 2005..This success rate compares favourably with other protein screening projects, particularly for eukaryotic proteins, and could be further improved by modifications at the cloning step...
Overview of the pipeline for structural and functional characterization of macrophage proteins at the university of queenslandWeining Meng
School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
Methods Mol Biol 426:577-87. 2008..Jointly, the data sheds light on the molecular and cellular functions of macrophage proteins...
An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1Anna Aagaard
Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
Structure 13:309-17. 2005..The structure of the tumor suppressor protein TIG1 was modeled, revealing its putative membrane binding surface...
Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteinsMareike Kurz
Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
Protein Expr Purif 50:68-73. 2006..Our work suggests that one needs to be very careful when making modifications to expression vectors and combining different affinity and fusion tags and cleavage sites...
Focusing in on structural genomics: the University of Queensland structural biology pipelineMunish Puri
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
Biomol Eng 23:281-9. 2006..The structures from this pipeline will provide insights into the function of previously uncharacterized macrophage proteins and could lead to the validation of new drug targets for chronic obstructive pulmonary disease and arthritis...
A general target selection method for crystallographic proteomicsGautier Robin
Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
Methods Mol Biol 426:27-35. 2008..This novel procedure was designed to maximize selection efficiency, and its prevailing criteria categories make it suitable for a broad range of structural proteomics projects...
