Affiliation: University of Western Australia
- Cell surface markers of regulatory T cells are not associated with increased forkhead box p3 expression in blood CD4+ T cells from HIV-infected patients responding to antiretroviral therapyAndrew Y F Lim
School of Surgery and Pathology, University of Western Australia, Perth, WA, Australia
Immunol Cell Biol 84:530-6. 2006..Hence, none of the putative Treg cell surface markers identified T-cell populations in peripheral blood that mirrored the effects of HIV infection and antiretroviral therapy on Foxp3 expression...
- Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapyAndrew Lim
School of Surgery and Pathology, University of Western Australia, Rear 50 Murray Street, Perth 6000, Western Australia
AIDS 21:1525-34. 2007..Data were compared with established Treg cell markers (FoxP3, CTLA-4 and GITR)...
- CD4+ and CD8+ T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapyAndrew Lim
School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Perth, Western Australia 6000, Australia
J Acquir Immune Defic Syndr 51:248-57. 2009..We assessed whether FoxP3 expression in CD8 T cells is associated with suppressive potential and/or with HIV-associated immune activation...
- Robust interferon-α and IL-12 responses by dendritic cells are related to efficient CD4+ T-cell recovery in HIV patients on ARTDino Bee Aik Tan
School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Australia
Clin Immunol 139:115-21. 2011..Patients with good recovery of CD4(+) T-cells had robust TLR-mediated interferon-α responses by plasmacytoid DC and IL-12 responses by myeloid DC during early ART (1-3 months)...
- TLR2-induced cytokine responses may characterize HIV-infected patients experiencing mycobacterial immune restoration diseaseDino B A Tan
School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
AIDS 25:1455-60. 2011..Recognition of mycobacteria-associated molecular patterns through toll-like receptors (TLRs) on dendritic cells and monocytes induces cytokine production. Here, we investigate TLR-induced responses in IRD...
- Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infectionAndrew Lim
School of Pathology and Laboratory Medicine, University of Western Australia, Australia
AIDS 25:1379-83. 2011..To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection...
- Vaccine-induced IgG2 anti-HIV p24 is associated with control of HIV in patients with a 'high-affinity' FcgammaRIIa genotypeMartyn A French
School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia
AIDS 24:1983-90. 2010....
- Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiencyAndrew Lim
University of Western Australia, School of Pathology and Laboratory Medicine Royal Perth Hospital campus, Level 2 Medical Research Foundation Building, Rear of 50 Murray Street, Perth, Western Australia, Australia, 6000
Clin Immunol 137:296-302. 2010..05), but IL-10-producing CD4(+) T cells were undetectable. NTMLD is not associated with deficient IFNγ production, but may be associated with reduced Th17 immunity and/or a predisposition towards IL-10 production from non-CD4(+) T cells...
- Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfectionVivek Naranbhai
aCentre for the AIDS Programme of Research in South Africa bHIV Pathogenesis Programme, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa cNuffield Department of Medicine, University of Oxford, Oxford, UK dDepartment of Infectious Diseases, Monash University and Alfred Hospital eCentre for Biomedical Research, Burnet Institute, Melbourne fSchool of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia gDepartment of Infectious Diseases, Nelson R Mandela School of Medicine hKwaZulu Natal Research Institute for Tuberculosis and HIV K RITH, University of KwaZulu Natal, Durban, South Africa iMax Planck Institute for Infection Biology, Berlin, Germany jMedgar Evers College City University of New York, Brooklyn, New York, USA Vivek Naranbhai and Christina C Chang contributed equally to the writing of the article
AIDS 28:657-66. 2014....
- TB-IRIS after initiation of antiretroviral therapy is associated with expansion of preexistent Th1 responses against Mycobacterium tuberculosis antigensRamachandran Vignesh
Infectious Diseases Laboratory, YR Gaitonde Centre for AIDS Research and Education YRG CARE, Chennai, India School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD HIV Prevention Research, Beth Israel Deaconess Medical Center, Boston, MA Division of Infectious Diseases, University of California, San Diego, CA and Medical Centre, Centre for AIDS Research and Education, Chennai, India
J Acquir Immune Defic Syndr 64:241-8. 2013..The role of T-cell responses against Mycobacterium tuberculosis antigens in tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is unclear...
- Immunological markers of lung disease due to non-tuberculous mycobacteriaAndrew Lim
School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia
Dis Markers 29:103-9. 2010..Compared with responders, patients who responded poorly to treatment generally had higher plasma levels of CXCL10 and IL-18, and higher frequencies of activated CD8(+) T cells...