Simon J G Lewis

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc Quality of life in Parkinson's disease caregivers: the contribution of personality traits
    Eloise H Tew
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
    Biomed Res Int 2013:151872. 2013
  2. pmc Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease
    Samuel J Bolitho
    Parkinson s Disease Clinic, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e81233. 2013
  3. pmc The relationship between thermoregulation and REM sleep behaviour disorder in Parkinson's disease
    George Zhong
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e72661. 2013
  4. pmc Autonomous identification of freezing of gait in Parkinson's disease from lower-body segmental accelerometry
    Steven T Moore
    Department of Neurology, Mount Sinai School of Medicine, Human Aerospace Laboratory, 10029, New York, NY, USA
    J Neuroeng Rehabil 10:19. 2013
  5. doi Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease
    Simon J G Lewis
    Ageing Brain Center, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    Mov Disord 27:1262-7. 2012
  6. doi Commentary: an evaluation of mechanisms underlying the influence of step cues on gait in Parkinson's disease
    Simon J G Lewis
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, Camperdown, New South Wales 2050, Australia
    J Clin Neurosci 18:803. 2011
  7. doi A pathophysiological model of freezing of gait in Parkinson's disease
    Simon J G Lewis
    Department of Neurology, Royal Prince Alfred Hospital, Sydney 2050, Australia
    Parkinsonism Relat Disord 15:333-8. 2009
  8. doi Understanding the dopaminergic deficits in Parkinson's disease: insights into disease heterogeneity
    Simon J G Lewis
    Department of Neurology, Royal Prince Alfred Hospital, Sydney 2050, Australia
    J Clin Neurosci 16:620-5. 2009
  9. doi Exploring the cortical and subcortical functional magnetic resonance imaging changes associated with freezing in Parkinson's disease
    James M Shine
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, NSW 2050, Australia
    Brain 136:1204-15. 2013
  10. pmc Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load
    James M Shine
    Parkinson s Disease Clinic, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e52602. 2013

Collaborators

Detail Information

Publications47

  1. pmc Quality of life in Parkinson's disease caregivers: the contribution of personality traits
    Eloise H Tew
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
    Biomed Res Int 2013:151872. 2013
    ..Thus, screening for neuroticism may help identify those caregivers who would benefit from intervention strategies, which could in the long term help reduce the need for nursing home placement of Parkinson's disease patients. ..
  2. pmc Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease
    Samuel J Bolitho
    Parkinson s Disease Clinic, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e81233. 2013
    ..Furthermore this study aimed to identify patients with PD who may benefit from pharmacologic and behavioural intervention to improve these symptoms...
  3. pmc The relationship between thermoregulation and REM sleep behaviour disorder in Parkinson's disease
    George Zhong
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e72661. 2013
    ..This study explored the relationship between symptoms of rapid eye movement sleep behaviour disorder, thermoregulation and sleep in Parkinson's Disease...
  4. pmc Autonomous identification of freezing of gait in Parkinson's disease from lower-body segmental accelerometry
    Steven T Moore
    Department of Neurology, Mount Sinai School of Medicine, Human Aerospace Laboratory, 10029, New York, NY, USA
    J Neuroeng Rehabil 10:19. 2013
    ..Here we extend this approach to evaluate the optimal configuration of sensor placement and signal processing parameters using seven sensors attached to the lumbar back, thighs, shanks and feet...
  5. doi Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease
    Simon J G Lewis
    Ageing Brain Center, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    Mov Disord 27:1262-7. 2012
    ..These results suggest that loss of neuronal integrity within the ACC plays an important role in the pathophysiology underlying executive functioning and visual hallucinations in PD. © 2012 Movement Disorder Society...
  6. doi Commentary: an evaluation of mechanisms underlying the influence of step cues on gait in Parkinson's disease
    Simon J G Lewis
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, Camperdown, New South Wales 2050, Australia
    J Clin Neurosci 18:803. 2011
    ..This study highlights the potential therapeutic benefits of strategies that could tap into this mechanism...
  7. doi A pathophysiological model of freezing of gait in Parkinson's disease
    Simon J G Lewis
    Department of Neurology, Royal Prince Alfred Hospital, Sydney 2050, Australia
    Parkinsonism Relat Disord 15:333-8. 2009
    ..It is further postulated that this phenomenon may be acting via a transient period of increased synchronization within the basal ganglia oscillations...
  8. doi Understanding the dopaminergic deficits in Parkinson's disease: insights into disease heterogeneity
    Simon J G Lewis
    Department of Neurology, Royal Prince Alfred Hospital, Sydney 2050, Australia
    J Clin Neurosci 16:620-5. 2009
    ..It is further postulated that this phenomenon may be acting via increased synchronization within the basal ganglia circuitry...
  9. doi Exploring the cortical and subcortical functional magnetic resonance imaging changes associated with freezing in Parkinson's disease
    James M Shine
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, NSW 2050, Australia
    Brain 136:1204-15. 2013
    ..These results provide novel insights into the pathophysiology underlying freezing of gait and lend support to models of freezing of gait that implicate dysfunction across coordinated neural networks...
  10. pmc Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load
    James M Shine
    Parkinson s Disease Clinic, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e52602. 2013
    ....
  11. doi Sleep disturbance relates to neuropsychological functioning in late-life depression
    Sharon L Naismith
    Clinical Research Unit, Brain and Mind Research Institute, Australia
    J Affect Disord 132:139-45. 2011
    ..Sleep-wake disturbance in older people is a risk factor for depression onset and recurrence. The aim of this study was to determine if objective sleep-wake disturbance in late-life depression relates to neuropsychological functioning...
  12. ncbi Freezing of gait in Parkinson's disease is associated with functional decoupling between the cognitive control network and the basal ganglia
    James M Shine
    1 Parkinson s Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, NSW, Australia
    Brain 136:3671-81. 2013
    ..These results support the hypothesis that freezing behaviour in Parkinson's disease is because of impaired communication between complimentary yet competing neural networks. ..
  13. doi Emotion recognition in mild cognitive impairment: relationship to psychosocial disability and caregiver burden
    Donna McCade
    Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, New South Wales, Australia
    J Geriatr Psychiatry Neurol 26:165-73. 2013
    ..Emerging evidence supports the presence of very early emotion recognition difficulties in mild cognitive impairment (MCI); however, the relationship between these impairments and psychosocial measures is not yet explored...
  14. doi Reduced mismatch negativity in mild cognitive impairment: associations with neuropsychological performance
    Loren Mowszowski
    Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia
    J Alzheimers Dis 30:209-19. 2012
    ..These findings overall suggest that MMN may be a viable neurophysiological biomarker of underlying disease in this 'at risk' group...
  15. doi Investigating visual misperceptions in Parkinson's disease: a novel behavioral paradigm
    James M Shine
    Parkinson s Disease Clinic, Brain and Mind Research Institute, The University of Sydney, New South Wales, Australia
    Mov Disord 27:500-5. 2012
    ..We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD...
  16. doi How well do caregivers detect mild cognitive change in Parkinson's disease?
    Sharon L Naismith
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
    Mov Disord 26:161-4. 2011
    ..The capacity for caregivers to rate mild cognitive change in PD may be useful to assist in early screening and intervention approaches...
  17. doi Improving memory in Parkinson's disease: a healthy brain ageing cognitive training program
    Sharon L Naismith
    Healthy Brain Ageing Clinic, Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
    Mov Disord 28:1097-103. 2013
    ..It also appeared successful for increasing awareness of adaptive and/or compensatory cognitive strategies, as well as modifiable risk factors to optimize brain functioning...
  18. doi Sleep well, think well: sleep-wake disturbance in mild cognitive impairment
    Sharon L Naismith
    Ageing Brain Centre, Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    J Geriatr Psychiatry Neurol 23:123-30. 2010
    ..This preliminary data suggests that sleep-wake disturbance in nonamnestic forms of MCI is related to cognitive functioning and may be indicative of shared neurobiological underpinnings...
  19. doi Neuropsychological functioning in Parkinson's disease: differential relationships with self-reported sleep-wake disturbances
    Sharon L Naismith
    Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
    Mov Disord 26:1537-41. 2011
    ..However, prior studies exploring the association between specific sleep-wake disturbances and neuropsychological functions have been limited...
  20. doi The contribution of nocturnal sleep to the consolidation of motor skill learning in healthy ageing and Parkinson's disease
    Zoe Terpening
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia
    J Sleep Res 22:398-405. 2013
    ..Slow wave sleep microarchitecture and the use of dopaminergic medications may contribute to impaired sleep-dependent multi-session acquisition of motor skill learning in Parkinson's disease. ..
  21. doi Using informant reports to detect cognitive decline in mild cognitive impairment
    Ruby S M Tsang
    Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Int Psychogeriatr 24:967-73. 2012
    ....
  22. doi Sleep disturbances in Parkinson disease and their potential role in heterogeneity
    David G Gunn
    Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
    J Geriatr Psychiatry Neurol 23:131-7. 2010
    ..It also emphasizes the need for further studies that explore the heterogeneity of all disease features in PD...
  23. ncbi The specific contributions of set-shifting to freezing of gait in Parkinson's disease
    Sharon L Naismith
    Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Mov Disord 25:1000-4. 2010
    ..This was apparent even after controlling for slowed processing speed, disease stage and depressive symptoms. The results support the recently proposed hypothesis for the pathophysiology underlying FOG in PD...
  24. doi Reduced temporal mismatch negativity in late-life depression: an event-related potential index of cognitive deficit and functional disability?
    Sharon L Naismith
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Australia
    J Affect Disord 138:71-8. 2012
    ..This study examined MMN elicited by duration deviant stimuli in older people with lifetime depression, and explored its relationship with neuropsychological functioning and disability...
  25. doi Emotion recognition deficits exist in mild cognitive impairment, but only in the amnestic subtype
    Donna McCade
    Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney
    Psychol Aging 28:840-52. 2013
    ..These findings may have implications for early diagnosis, prognosis, and clinical management...
  26. ncbi Investigating rapid eye movement sleep without atonia in Parkinson's disease using the rapid eye movement sleep behavior disorder screening questionnaire
    Samuel J Bolitho
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia
    Mov Disord 29:736-42. 2014
    ..Further studies are needed to develop accurate determination and quantification of RWA in RBD to improve management of patients with PD in the future...
  27. ncbi The role of dysfunctional attentional control networks in visual misperceptions in Parkinson's disease
    James M Shine
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, New South Wales, Australia
    Hum Brain Mapp 35:2206-19. 2014
    ..These findings are consistent with specific predictions from a recently proposed hypothesis that implicates dysfunction within attentional networks in Parkinsonian hallucinations...
  28. doi "DASH" symptoms in patients with Parkinson's disease: red flags for early cognitive decline
    Sharon L Naismith
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia
    J Clin Neurosci 18:352-5. 2011
    ..The DASH score may represent a simple screening method for highlighting early cognitive decline, which in turn is associated with the development of dementia in PD...
  29. doi Enhancing memory in late-life depression: the effects of a combined psychoeducation and cognitive training program
    Sharon L Naismith
    Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Am J Geriatr Psychiatry 19:240-8. 2011
    ..To evaluate the efficacy of a multifactorial cognitive training (CT) program for older people with a lifetime history of depressive disorder...
  30. doi Sleep-wake changes and cognition in neurodegenerative disease
    Sharon L Naismith
    Healthy Brain Ageing Clinic, Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia
    Prog Brain Res 190:21-52. 2011
    ..Such research will hopefully lead to targeted early intervention approaches for cognitive decline in older people...
  31. doi Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson's disease versus behavioural variant frontotemporal dementia
    Claire O'Callaghan
    Neuroscience Research Australia, Sydney, Australia
    Cortex 49:1833-43. 2013
    ..Instead, there is the suggestion that dopaminergic therapy interacts with existing neuroanatomical and/or neurochemical abnormalities, to produce impulsive behaviour in certain vulnerable patients...
  32. ncbi Using virtual reality to explore the role of conflict resolution and environmental salience in freezing of gait in Parkinson's disease
    Elie Matar
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, Level 4, Building F, 94 Mallett St, Camperdown, New South Wales 2050, Australia
    Parkinsonism Relat Disord 19:937-42. 2013
    ..Recent studies have suggested that freezing is related to both impairments in conflict resolution as well as the processing of environmentally salient information...
  33. ncbi Circadian misalignment and sleep disruption in mild cognitive impairment
    Sharon L Naismith
    Healthy Brain Ageing Clinic, Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia
    J Alzheimers Dis 38:857-66. 2014
    ..While it is evident that Alzheimer's disease is associated with disturbed sleep and circadian rhythms, the extent to which such changes are evident in older people 'at risk' of developing dementia is unknown...
  34. doi Visual misperceptions and hallucinations in Parkinson's disease: dysfunction of attentional control networks?
    James M Shine
    Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia
    Mov Disord 26:2154-9. 2011
    ....
  35. pmc Cognitive impairment with and without depression history: an analysis of white matter microstructure
    Shantel L Duffy
    Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Camperdown, Australia, and the Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
    J Psychiatry Neurosci 39:135-43. 2014
    ..The present study examined white matter microstructure in patients with MCI with and without a history of major depression compared with healthy controls...
  36. doi The detection of Freezing of Gait in Parkinson's disease patients using EEG signals based on Wavelet decomposition
    A M Ardi Handojoseno
    Faculty of Engineering and Information Technology, University of Technology, Sydney, Broadway, NSW 2007, Australia
    Conf Proc IEEE Eng Med Biol Soc 2012:69-72. 2012
    ..This results have proved the feasibility of utilized EEG in future treatment of FOG...
  37. doi The role of mild depression in sleep disturbance and quality of life in Parkinson's disease
    Sharon L Naismith
    Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
    J Neuropsychiatry Clin Neurosci 22:384-9. 2010
    ..Overall, these data highlight the need to screen patients for even mild levels of depression because its relationship with sleep and quality of life are evident early in the disease course...
  38. doi A novel paradigm for modelling freezing of gait in Parkinson's disease
    Sharon L Naismith
    Brain and Mind Research Institute, The University of Sydney, Level 4, Building F, 94 Mallett Street, Camperdown, New South Wales 2050, Australia
    J Clin Neurosci 17:984-7. 2010
    ..We believe this paradigm is capable of accurately modelling FOG and will have validity in future functional neuroimaging and therapeutic intervention studies...
  39. doi Utilising functional MRI (fMRI) to explore the freezing phenomenon in Parkinson's disease
    James M Shine
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales 2050, Australia
    J Clin Neurosci 18:807-10. 2011
    ..The results of this single study highlight the potential utility of this approach in elucidating the underlying neural correlate of freezing behaviour in PD...
  40. ncbi Actigraphically-defined sleep disturbance in Parkinson's disease is associated with differential aspects of cognitive functioning
    David G Gunn
    Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia
    J Clin Neurosci 21:1112-5. 2014
    ..This may in part reflect common neural underpinnings...
  41. ncbi Tricks of the mind: Visual hallucinations as disorders of attention
    James M Shine
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, NSW, Australia Electronic address
    Prog Neurobiol 116:58-65. 2014
    ..The review concludes by showing that a variety of pathological processes can ultimately manifest in any of these three categories, depending on the precise location of the impairment. ..
  42. ncbi Freezing of gait in Parkinson's disease: Current treatments and the potential role for cognitive training
    Courtney C Walton
    Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, NSW, Australia Healthy Brain Ageing Program, Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Restor Neurol Neurosci 32:411-22. 2014
    ..This article focuses on the existing evidence for such intervention strategies and proposes that targeted cognitive training may offer a novel treatment option for FOG that is worthy of an increased research focus. ..
  43. doi Glutathione relates to neuropsychological functioning in mild cognitive impairment
    Shantel L Duffy
    Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia Clinical Research Unit, Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
    Alzheimers Dement 10:67-75. 2014
    ..This study aims to assess in vivo levels of glutathione via proton magnetic resonance spectroscopy in patients with MCI and to determine how glutathione relates to cognitive decline...
  44. doi The relationship between actigraphically defined sleep disturbance and REM sleep behaviour disorder in Parkinson's Disease
    Sharon L Naismith
    Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, 94 Mallett St, Camperdown, NSW 2050, Australia
    Clin Neurol Neurosurg 112:420-3. 2010
    ..In this study, we sought to evaluate the utility of actigraphy for examining symptoms of rapid eye movement sleep behaviour disorder (RSBD)...
  45. doi Cognitive training in affective disorders improves memory: a preliminary study using the NEAR approach
    Sharon L Naismith
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, NSW, Australia
    J Affect Disord 121:258-62. 2010
    ..Some of these changes persist despite antidepressant treatment. While research in other areas of psychiatry has shown cognitive training techniques to be effective, only one study has evaluated this approach in depression...