Sharon R Lewin

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations
    Sharon R Lewin
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY
    Blood 100:2235-42. 2002
  2. ncbi request reprint Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infection
    Sharon R Lewin
    Department of Microbiology and Immunology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Immunol 169:4657-66. 2002
  3. ncbi request reprint Highly reproducible transient transfections for the study of hepatitis B virus replication based on an internal GFP reporter system
    Theo Gouskos
    Department of Medicine RMH, University of Melbourne, Vic, Australia
    J Virol Methods 121:65-72. 2004
  4. doi request reprint Increased intrahepatic apoptosis but reduced immune activation in HIV-HBV co-infected patients with advanced immunosuppression
    David M Iser
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Australia
    AIDS 25:197-205. 2011
  5. ncbi request reprint The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infection
    J Judy Chang
    Department of Microbiology and Immunology, University of Melbourne, Australia
    Hepatology 46:1332-40. 2007
  6. pmc Impaired quality of the hepatitis B virus (HBV)-specific T-cell response in human immunodeficiency virus type 1-HBV coinfection
    J Judy Chang
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia
    J Virol 83:7649-58. 2009
  7. pmc Coinfection of hepatic cell lines with human immunodeficiency virus and hepatitis B virus leads to an increase in intracellular hepatitis B surface antigen
    David M Iser
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
    J Virol 84:5860-7. 2010
  8. ncbi request reprint Immunopathogenesis of hepatitis B virus infection
    J Judy Chang
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    Immunol Cell Biol 85:16-23. 2007
  9. doi request reprint Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocation
    Reena Rajasuriar
    Department of Medicine, Monash University, Burnet Institute, University of Melbourne, Melbourne, Australia
    J Infect Dis 202:1254-64. 2010
  10. ncbi request reprint Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene
    Joseph Torresi
    Department of Medicine RMH WH, University of Melbourne, Melbourne, Victoria 3050, Australia
    Virology 299:88-99. 2002

Detail Information

Publications48

  1. ncbi request reprint Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations
    Sharon R Lewin
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY
    Blood 100:2235-42. 2002
    ..T-cell neogenesis, appropriate to age but delayed in adult recipients of T-cell-depleted allografts, justifies interventions to hasten this process and to stimulate desirable cellular immune responses...
  2. ncbi request reprint Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infection
    Sharon R Lewin
    Department of Microbiology and Immunology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Immunol 169:4657-66. 2002
    ....
  3. ncbi request reprint Highly reproducible transient transfections for the study of hepatitis B virus replication based on an internal GFP reporter system
    Theo Gouskos
    Department of Medicine RMH, University of Melbourne, Vic, Australia
    J Virol Methods 121:65-72. 2004
    ..The presence of an internal GFP reporter increased the efficiency of generating highly reproducible results and facilitated multiple forms of analysis from a single transfection accurately...
  4. doi request reprint Increased intrahepatic apoptosis but reduced immune activation in HIV-HBV co-infected patients with advanced immunosuppression
    David M Iser
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Australia
    AIDS 25:197-205. 2011
    ....
  5. ncbi request reprint The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infection
    J Judy Chang
    Department of Microbiology and Immunology, University of Melbourne, Australia
    Hepatology 46:1332-40. 2007
    ....
  6. pmc Impaired quality of the hepatitis B virus (HBV)-specific T-cell response in human immunodeficiency virus type 1-HBV coinfection
    J Judy Chang
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia
    J Virol 83:7649-58. 2009
    ..The quality of the HBV-specific T-cell response is impaired in the setting of HIV-1-HBV coinfection and is related to the CD4+ T-cell count...
  7. pmc Coinfection of hepatic cell lines with human immunodeficiency virus and hepatitis B virus leads to an increase in intracellular hepatitis B surface antigen
    David M Iser
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
    J Virol 84:5860-7. 2010
    ....
  8. ncbi request reprint Immunopathogenesis of hepatitis B virus infection
    J Judy Chang
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    Immunol Cell Biol 85:16-23. 2007
    ..In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease...
  9. doi request reprint Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocation
    Reena Rajasuriar
    Department of Medicine, Monash University, Burnet Institute, University of Melbourne, Melbourne, Australia
    J Infect Dis 202:1254-64. 2010
    ..We hypothesized that residual immune activation and polymorphisms in the interleukin 7 (IL-7) receptor α (IL-7Rα) gene were important for immune recovery...
  10. ncbi request reprint Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene
    Joseph Torresi
    Department of Medicine RMH WH, University of Melbourne, Melbourne, Victoria 3050, Australia
    Virology 299:88-99. 2002
    ..Since these viruses carry mutations in the a determinant of HBsAg that may potentially decrease the ability of anti-HBs antibody to neutralize these viruses, these HBV mutants also have the potential to behave as vaccine escape mutants...
  11. ncbi request reprint Sexually transmissible infection and HIV management among men who have sex with men with and without HIV: survey of medical practitioners who are members of the Australasian Society for HIV Medicine
    Christopher K Fairley
    Melbourne Sexual Health Centre, 580 Swanston Street, Carlton, VIC 3053, Australia
    Sex Health 5:155-9. 2008
    ..Our aim was to determine if the use of suppressive treatment for genital herpes, the treatment of HIV or STI screening practices were different between states in Australia...
  12. ncbi request reprint Immunological and virological failure after antiretroviral therapy is associated with enhanced peripheral and thymic pathogenicity
    Ajantha Solomon
    Department of Microbiology and Immunology, University of Melbourne, and Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia
    J Infect Dis 187:1915-23. 2003
    ..Although there was a high prevalence of mutations in the protease and reverse transcriptase genes in discordant immunological responders, these changes were also observed in nonresponders...
  13. doi request reprint The search for an HIV cure: tackling latent infection
    Stephen J Kent
    Department of Microbiology and Immunology, University of Melbourne, Vic, Australia
    Lancet Infect Dis 13:614-21. 2013
    ..Clinical studies that use a longer duration of drug dosing, alternative agents, combination approaches, gene therapy, and immune-modulation approaches are all underway. ..
  14. doi request reprint Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation
    Jessica M Moffat
    Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    Eur J Immunol 43:595-605. 2013
    ..In summary, BST-2 is a useful receptor to target with antigen, given its broad expression pattern and ability to access both MHCI and MHCII presentation pathways with relative efficiency...
  15. ncbi request reprint Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient
    Theo Gouskos
    Department of Medicine RMH, University of Melbourne, Melbourne, Australia
    AIDS 18:1734-7. 2004
    ..However, a strong HBV-specific CD8 T-cell response was identified and may have resulted in the severe hepatitis...
  16. ncbi request reprint Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, 3001 Victoria, Australia Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    Virology 337:384-98. 2005
    ..Thus, reduced CD4/CCR5 dependence is a phenotype of R5 HIV-1 associated with M-tropism and late stage infection, which may affect the efficacy of HIV-1 entry inhibitors...
  17. ncbi request reprint HIV-1 cell entry and advances in viral entry inhibitor therapy
    Louise A Cooley
    Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Parkville, Vic, Australia
    J Clin Virol 26:121-32. 2003
    ..A greater number of HIV-1 entry inhibitors are in preclinical development. This review outlines the mechanisms involved in HIV-1 entry and the sites of action of specific HIV-1 inhibitors...
  18. ncbi request reprint Human thymic dendritic cells: regulators of T cell development in health and HIV-1 infection
    Vanessa A Evans
    Monash University, Department of Medicine, Central and Eastern Clinical School, Alfred Campus, Melbourne, Victoria, Australia
    Clin Immunol 126:1-12. 2008
    ..Here we review the phenotype and function of different DC subsets found within the human thymus and discuss potential mechanisms of how DCs may be important in CD4(+) T cell dysfunction in HIV-1 infection...
  19. ncbi request reprint Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individuals
    Peter A Revill
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, Victoria 3051, Australia
    AIDS 21:1701-10. 2007
    ..To test this hypothesis, we have analysed genome-length sequences of HBV DNA from patients both prior to and during antiviral therapy...
  20. ncbi request reprint What are the barriers to offering HIV testing in an antenatal setting? A national study of obstetricians
    Michelle L Giles
    Department of Medicine Monash University, and Centre for Epidemiology and Population Health Research, Macfarlane Burnet Institute, Melbourne, Victoria 3004, Australia
    AIDS 21:1601-6. 2007
    ..To investigate factors that influence the antenatal screening practice of obstetricians and identify barriers to the implementation of universal antenatal HIV screening...
  21. ncbi request reprint Incidence of putative HIV superinfection and sexual practices among HIV-infected men who have sex with men
    Mohsin M Sidat
    School of Population Health, The University of Melbourne, VIC 3010, Australia
    Sex Health 5:61-7. 2008
    ..To determine the upper limit for the incidence of clinically important HIV superinfection among HIV-infected men who have sex with men (MSM) and its relationship with engagement in unsafe sexual practices...
  22. pmc Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance
    Scott Preiss
    Victorian Infectious Diseases Reference Laboratories, Research and Molecular Development, North Melbourne, Victoria, Australia
    Hepatology 48:741-9. 2008
    ..0001), indicating that antiviral drug resistance alters the balance between defective and genomic length DNA in circulation. Experiments in vitro using HBV encoding LMV-R mutations confirmed these results...
  23. doi request reprint A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naïve individuals in Thailand
    Gail V Matthews
    Viral Hepatitis Program, National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Darlinghurst, Sydney, NSW, Australia
    Hepatology 48:1062-9. 2008
    ..Hepatitis B e antigen (HBeAg) loss was observed in 33% of HBeAg-positive subjects, and 8% experienced hepatitis B surface antigen loss. Hepatic flare was observed in 25% of subjects...
  24. pmc The anti-HIV activity of entecavir: a multicentre evaluation of lamivudine-experienced and lamivudine-naive patients
    Joe Sasadeusz
    The Alfred Hospital, Melbourne, Victoria, Australia
    AIDS 22:947-55. 2008
    ....
  25. ncbi request reprint The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo
    Philip J Ellery
    AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Immunol 178:6581-9. 2007
    ..Collectively, these data show that CD16+ monocytes are preferentially susceptible to HIV-1 entry, more permissive for replication, and constitute a continuing source of viral persistence during HAART...
  26. ncbi request reprint Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4(+) T cells in thymomas
    Philipp Strobel
    Institute of Pathology, University of Wuerzburg, Germany
    Blood 100:159-66. 2002
    ..The acquisition of the CD45RA(+) phenotype on CD4(+) T cells during terminal intratumorous thymopoiesis is associated with the presence of MG in most thymoma patients...
  27. pmc Reduced hepatitis B virus (HBV)-specific CD4+ T-cell responses in human immunodeficiency virus type 1-HBV-coinfected individuals receiving HBV-active antiretroviral therapy
    J Judy Chang
    Infectious Diseases Unit, Alfred Hospital, Commercial Rd, Melbourne, Victoria 3004, Australia
    J Virol 79:3038-51. 2005
    ..Therefore, HIV-1 infection has a significant and specific effect on HBV-specific T-cell immunity...
  28. ncbi request reprint Immunopathogenesis: role of innate and adaptive immune responses
    Kumar Visvanathan
    Department of Infectious Diseases, Monash Medical Centre, Clayton, Victoria, Australia
    Semin Liver Dis 26:104-15. 2006
    ..These arms may be divided broadly into innate and specific immune responses, and they have different roles and responses in acute and chronic infection...
  29. ncbi request reprint Enhanced replicative capacity and pathogenicity of HIV-1 isolated from individuals infected with drug-resistant virus and declining CD4+ T-cell counts
    Ajantha Solomon
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    J Acquir Immune Defic Syndr 40:140-8. 2005
    ..In summary, although drug resistance may lead to impaired viral fitness, the capacity of virus quasispecies from PBMCs to use CXCR4 may have significant consequences on viral replicative capacity and potentially on clinical outcome...
  30. ncbi request reprint Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty
    John M Murray
    School of Mathematics, University of NSW, Sydney, Australia
    Immunol Cell Biol 81:487-95. 2003
    ..7 year half-life of the productive thymus so that by age 55 only 5% of naive production arises from thymic export...
  31. pmc Comparison of sequence analysis and a novel discriminatory real-time PCR assay for detection and quantification of Lamivudine-resistant hepatitis B virus strains
    Fiona Wightman
    Department of Medicine, Monash University, Melbourne, Australia
    J Clin Microbiol 42:3809-12. 2004
    ..Excellent concordance was demonstrated between sequencing and the discriminatory real-time assay; however, a mixture of quasispecies was more frequently detected by discriminatory real-time PCR...
  32. pmc Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytes
    Paul U Cameron
    Department of Immunology, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia
    J Virol 81:2297-306. 2007
    ..Early selective infection of immature blood DCs by R5 virus and upregulation of viral expression during DC-T-cell interaction and transmission provide a potential pathway for R5 selection following parenteral transmission...
  33. ncbi request reprint Ten years of highly active antiretroviral therapy for HIV infection
    Luke F Chen
    Infectious Diseases Unit, The Alfred Hospital, Melbourne, Vic
    Med J Aust 186:146-51. 2007
    ..Drug-drug interactions are common and caution is required when prescribing ARVs that inhibit or induce the cytochrome P450 pathway...
  34. ncbi request reprint Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir
    Jennifer F Hoy
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    J Infect Dis 190:688-92. 2004
    ..During the 24-week study, there was no significant change in mtDNA copy numbers in PBMCs in either treatment group, despite improvement in peripheral lipoatrophy among patients whose treatment was switched to abacavir...
  35. ncbi request reprint HIV-1 down-modulates gamma signaling chain of Fc gamma R in human macrophages: a possible mechanism for inhibition of phagocytosis
    Katherine Kedzierska
    AIDS Pathogenesis Research Unit, Macfarlane Burnet Center, Victoria, Australia
    J Immunol 168:2895-903. 2002
    ....
  36. ncbi request reprint Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat
    Catherine L Cherry
    Department of Infectious Diseases and Microbiology, The Alfred Hospital, Melbourne, Australia
    J Acquir Immune Defic Syndr 30:271-7. 2002
    ..A reliable and valid laboratory test to detect this is not yet available. The objective of this study was to correlate tissue mtDNA quantification in HIV-infected patients with exposure to nucleoside analogs...
  37. ncbi request reprint Variable uptake of recommended interventions to reduce mother-to-child transmission of HIV in Australia, 1982-2005
    Michelle L Giles
    Department of Medicine, Monash University, Melbourne, Vic, Australia
    Med J Aust 189:151-4. 2008
    ..To analyse the uptake of interventions known to reduce the risk of perinatal HIV transmission among Australian women with HIV infection (who knew their HIV status before delivery), and identify predictors of uptake...
  38. ncbi request reprint A phase I study of the pharmacokinetics and safety of passive immunotherapy with caprine anti-HIV antibodies, (PE)HRG214, in HIV-1-infected individuals
    Sarah L Pett
    HIV, Immunology and Infectious Diseases Clinical Services, St Vincent s Hospital, Sydney, and National Centre in HIV Epidemiology and Clinical Research, University of NSW, Darlinghurst, Sydney, Australia
    HIV Clin Trials 5:91-8. 2004
    ..To establish the pharmacokinetics and safety of single-dose polyclonal caprine anti-HIV antibodies ((PE)HRG214)in HIV-1-infected individuals...
  39. ncbi request reprint A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics
    Christopher P Desmond
    Department of Gastroenterology, Alfred Hospital, Melbourne, Australia
    Antivir Ther 13:161-75. 2008
    ..The immune response to hepatitis B virus (HBV) is important for both viral control and disease pathogenesis. A detailed understanding of the HBV-specific T-cell responses may potentially lead to novel therapeutic strategies for HBV...
  40. pmc The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection
    Miranda Shehu-Xhilaga
    Infectious Diseases Unit, Alfred Hospital, Prahran, Australia
    Retrovirology 4:7. 2007
    ..Little is known about the progression and pathogenesis of HIV-1 infection within the male genital tract (MGT), particularly during the early stages of infection...
  41. ncbi request reprint CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency
    Suha Saleh
    Departments of Medicine, Alfred Hospital, Melbourne, Australia
    Blood 110:4161-4. 2007
    ..CCR7 ligands facilitate efficient entry of HIV-1 into resting CD4(+) T cells. These studies demonstrate a unique action of the chemokines CCL19 and CCL21 and provide a novel model with which to study HIV-1 latency in vitro...
  42. pmc Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:66. 2007
    ....
  43. pmc HIV research in Australia: linking basic research findings with clinical and public health outcomes
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    Retrovirology 3:86. 2006
    ..The meeting is expected to attract over 5000 participants and will have a dynamic and innovative programme within the three major themes of HIV basic science, clinical research and biomedical prevention...
  44. ncbi request reprint The evidence for a change in antenatal HIV screening policy in Australia
    Michelle L Giles
    Department of Medicine, Monash University, Melbourne, Victoria, Australia
    Med J Aust 185:217-20. 2006
    ..A universal antenatal HIV screening program meets many of the Wilson and Jungner criteria for population-based screening programs. This should be considered in the current review of Australia's HIV testing policy...
  45. ncbi request reprint Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infection
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    J Acquir Immune Defic Syndr 47:140-47. 2008
    ..Commencing ARVs during primary HIV-1 infection (PHI) may limit the size of the latent pool and lead to improved control of viral replication during structured treatment interruption (STI)...
  46. ncbi request reprint Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapy
    Sonia Fernandez
    School of Surgery and Pathology, University of Western Australia, Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, The University of Melbourne, Melbourne, Australia
    AIDS Res Hum Retroviruses 22:163-70. 2006
    ..However, the data are consistent with extrathymic T cell production contributing to the naive T cell pool in some patients...
  47. ncbi request reprint Phase 1 single dose studies to optimize the pharmacokinetics of DG17, a novel HIV-protease inhibitor pro-drug, using sodium bicarbonate and ritonavir
    Catherine L Cherry
    Burnet Institute, Melbourne, Australia
    Curr HIV Res 6:272-5. 2008
    ..No significant adverse events occurred. Single dose DG17 is safe and best administered in a manner preventing gastric acid degradation and with low-dose ritonavir...
  48. ncbi request reprint Immune recovery uveitis in an HIV-negative individual
    Michelle L Baker
    Clin Experiment Ophthalmol 35:189-90. 2007
    ..The visual acuity (VA) at presentation of IRU was limited to counting fingers bilaterally. The IRU resolved with the re-intensification of the immunosuppression. VA restored to right 6/18 and left 6/12...