Research Topics
Species | Sharon R LewinSummaryAffiliation: University of Melbourne Country: Australia Publications
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Detail Information
Publications
Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infectionSharon R Lewin
Department of Microbiology and Immunology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
J Immunol 169:4657-66. 2002....- Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantationsSharon R Lewin
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY
Blood 100:2235-42. 2002..T-cell neogenesis, appropriate to age but delayed in adult recipients of T-cell-depleted allografts, justifies interventions to hasten this process and to stimulate desirable cellular immune responses... - Highly reproducible transient transfections for the study of hepatitis B virus replication based on an internal GFP reporter systemTheo Gouskos
Department of Medicine (RMH, University of Melbourne, Vic, Australia
J Virol Methods 121:65-72. 2004..The presence of an internal GFP reporter increased the efficiency of generating highly reproducible results and facilitated multiple forms of analysis from a single transfection accurately... 
Increased intrahepatic apoptosis but reduced immune activation in HIV-HBV co-infected patients with advanced immunosuppressionDavid M Iser
Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Australia
AIDS 25:197-205. 2011....
Impaired quality of the hepatitis B virus (HBV)-specific T-cell response in human immunodeficiency virus type 1-HBV coinfectionJ Judy Chang
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia
J Virol 83:7649-58. 2009..The quality of the HBV-specific T-cell response is impaired in the setting of HIV-1-HBV coinfection and is related to the CD4+ T-cell count...- The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infectionJ Judy Chang
Department of Microbiology and Immunology, University of Melbourne, Australia
Hepatology 46:1332-40. 2007.... - Coinfection of hepatic cell lines with human immunodeficiency virus and hepatitis B virus leads to an increase in intracellular hepatitis B surface antigenDavid M Iser
Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
J Virol 84:5860-7. 2010.... - Immunopathogenesis of hepatitis B virus infectionJ Judy Chang
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
Immunol Cell Biol 85:16-23. 2007..In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease... - Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocationReena Rajasuriar
Department of Medicine, Monash University, Burnet Institute, University of Melbourne, Melbourne, Australia
J Infect Dis 202:1254-64. 2010..We hypothesized that residual immune activation and polymorphisms in the interleukin 7 (IL-7) receptor α (IL-7Rα) gene were important for immune recovery... - Sexually transmissible infection and HIV management among men who have sex with men with and without HIV: survey of medical practitioners who are members of the Australasian Society for HIV MedicineChristopher K Fairley
Melbourne Sexual Health Centre, 580 Swanston Street, Carlton, VIC 3053, Australia
Sex Health 5:155-9. 2008..Our aim was to determine if the use of suppressive treatment for genital herpes, the treatment of HIV or STI screening practices were different between states in Australia... - Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S geneJoseph Torresi
Department of Medicine RMH WH, University of Melbourne, Melbourne, Victoria 3050, Australia
Virology 299:88-99. 2002..Since these viruses carry mutations in the a determinant of HBsAg that may potentially decrease the ability of anti-HBs antibody to neutralize these viruses, these HBV mutants also have the potential to behave as vaccine escape mutants... - Immunological and virological failure after antiretroviral therapy is associated with enhanced peripheral and thymic pathogenicityAjantha Solomon
Department of Microbiology and Immunology, University of Melbourne, and Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia
J Infect Dis 187:1915-23. 2003..Although there was a high prevalence of mutations in the protease and reverse transcriptase genes in discordant immunological responders, these changes were also observed in nonresponders... - Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndromeLachlan Gray
Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, 3001 Victoria, Australia Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
Virology 337:384-98. 2005..Thus, reduced CD4/CCR5 dependence is a phenotype of R5 HIV-1 associated with M-tropism and late stage infection, which may affect the efficacy of HIV-1 entry inhibitors... - Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patientTheo Gouskos
Department of Medicine (RMH, University of Melbourne, Melbourne, Australia
AIDS 18:1734-7. 2004..However, a strong HBV-specific CD8 T-cell response was identified and may have resulted in the severe hepatitis... - Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentationJessica M Moffat
Walter and Eliza Hall Institute, Parkville, Victoria, Australia
Eur J Immunol 43:595-605. 2013..In summary, BST-2 is a useful receptor to target with antigen, given its broad expression pattern and ability to access both MHCI and MHCII presentation pathways with relative efficiency... - HIV-1 cell entry and advances in viral entry inhibitor therapyLouise A Cooley
Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Parkville, Vic, Australia
J Clin Virol 26:121-32. 2003..A greater number of HIV-1 entry inhibitors are in preclinical development. This review outlines the mechanisms involved in HIV-1 entry and the sites of action of specific HIV-1 inhibitors... - The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivoPhilip J Ellery
AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
J Immunol 178:6581-9. 2007..Collectively, these data show that CD16+ monocytes are preferentially susceptible to HIV-1 entry, more permissive for replication, and constitute a continuing source of viral persistence during HAART... - What are the barriers to offering HIV testing in an antenatal setting? A national study of obstetriciansMichelle L Giles
Department of Medicine Monash University, and Centre for Epidemiology and Population Health Research, Macfarlane Burnet Institute, Melbourne, Victoria 3004, Australia
AIDS 21:1601-6. 2007..To investigate factors that influence the antenatal screening practice of obstetricians and identify barriers to the implementation of universal antenatal HIV screening... - Human thymic dendritic cells: regulators of T cell development in health and HIV-1 infectionVanessa A Evans
Monash University, Department of Medicine, Central and Eastern Clinical School, Alfred Campus, Melbourne, Victoria, Australia
Clin Immunol 126:1-12. 2008..Here we review the phenotype and function of different DC subsets found within the human thymus and discuss potential mechanisms of how DCs may be important in CD4(+) T cell dysfunction in HIV-1 infection... - Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistanceScott Preiss
Victorian Infectious Diseases Reference Laboratories, Research and Molecular Development, North Melbourne, Victoria, Australia
Hepatology 48:741-9. 2008.... - Incidence of putative HIV superinfection and sexual practices among HIV-infected men who have sex with menMohsin M Sidat
School of Population Health, The University of Melbourne, VIC 3010, Australia
Sex Health 5:61-7. 2008..To determine the upper limit for the incidence of clinically important HIV superinfection among HIV-infected men who have sex with men (MSM) and its relationship with engagement in unsafe sexual practices... - The anti-HIV activity of entecavir: a multicentre evaluation of lamivudine-experienced and lamivudine-naive patientsJoe Sasadeusz
The Alfred Hospital, Melbourne, Victoria, Australia
AIDS 22:947-55. 2008.... - Ten years of highly active antiretroviral therapy for HIV infectionLuke F Chen
Infectious Diseases Unit, The Alfred Hospital, Melbourne, Vic
Med J Aust 186:146-51. 2007..Drug-drug interactions are common and caution is required when prescribing ARVs that inhibit or induce the cytochrome P450 pathway... - Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individualsPeter A Revill
Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, Victoria 3051, Australia
AIDS 21:1701-10. 2007..To test this hypothesis, we have analysed genome-length sequences of HBV DNA from patients both prior to and during antiviral therapy... - Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytesPaul U Cameron
Department of Immunology, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia
J Virol 81:2297-306. 2007..Early selective infection of immature blood DCs by R5 virus and upregulation of viral expression during DC-T-cell interaction and transmission provide a potential pathway for R5 selection following parenteral transmission... - Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4(+) T cells in thymomasPhilipp Strobel
Institute of Pathology, University of Wuerzburg, Germany
Blood 100:159-66. 2002..The acquisition of the CD45RA(+) phenotype on CD4(+) T cells during terminal intratumorous thymopoiesis is associated with the presence of MG in most thymoma patients... - A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naïve individuals in ThailandGail V Matthews
Viral Hepatitis Program, National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Darlinghurst, Sydney, NSW, Australia
Hepatology 48:1062-9. 2008..This study confirms current treatment guidelines that recommend a TDF-based regimen as the treatment of choice for HIV/HBV coinfection, but does not demonstrate any advantage of HBV combination therapy in this short-term setting... - Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twentyJohn M Murray
School of Mathematics, University of NSW, Sydney, Australia
Immunol Cell Biol 81:487-95. 2003..7 year half-life of the productive thymus so that by age 55 only 5% of naive production arises from thymic export... - Comparison of sequence analysis and a novel discriminatory real-time PCR assay for detection and quantification of Lamivudine-resistant hepatitis B virus strainsFiona Wightman
Department of Medicine, Monash University, Melbourne, Australia
J Clin Microbiol 42:3809-12. 2004..Excellent concordance was demonstrated between sequencing and the discriminatory real-time assay; however, a mixture of quasispecies was more frequently detected by discriminatory real-time PCR... - Reduced hepatitis B virus (HBV)-specific CD4+ T-cell responses in human immunodeficiency virus type 1-HBV-coinfected individuals receiving HBV-active antiretroviral therapyJ Judy Chang
Infectious Diseases Unit, Alfred Hospital, Commercial Rd, Melbourne, Victoria 3004, Australia
J Virol 79:3038-51. 2005..Therefore, HIV-1 infection has a significant and specific effect on HBV-specific T-cell immunity... - Enhanced replicative capacity and pathogenicity of HIV-1 isolated from individuals infected with drug-resistant virus and declining CD4+ T-cell countsAjantha Solomon
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
J Acquir Immune Defic Syndr 40:140-8. 2005..In summary, although drug resistance may lead to impaired viral fitness, the capacity of virus quasispecies from PBMCs to use CXCR4 may have significant consequences on viral replicative capacity and potentially on clinical outcome... - Immunopathogenesis: role of innate and adaptive immune responsesKumar Visvanathan
Department of Infectious Diseases, Monash Medical Centre, Clayton, Victoria, Australia
Semin Liver Dis 26:104-15. 2006..These arms may be divided broadly into innate and specific immune responses, and they have different roles and responses in acute and chronic infection... - Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapySonia Fernandez
School of Surgery and Pathology, University of Western Australia, Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, The University of Melbourne, Melbourne, Australia
AIDS Res Hum Retroviruses 22:163-70. 2006..However, the data are consistent with extrathymic T cell production contributing to the naive T cell pool in some patients... - Immune recovery uveitis in an HIV-negative individualMichelle L Baker
Clin Experiment Ophthalmol 35:189-90. 2007..The visual acuity (VA) at presentation of IRU was limited to counting fingers bilaterally. The IRU resolved with the re-intensification of the immunosuppression. VA restored to right 6/18 and left 6/12... - Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fatCatherine L Cherry
Department of Infectious Diseases and Microbiology, The Alfred Hospital, Melbourne, Australia
J Acquir Immune Defic Syndr 30:271-7. 2002..A reliable and valid laboratory test to detect this is not yet available. The objective of this study was to correlate tissue mtDNA quantification in HIV-infected patients with exposure to nucleoside analogs... - HIV research in Australia: linking basic research findings with clinical and public health outcomesSharon R Lewin
Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
Retrovirology 3:86. 2006..The meeting is expected to attract over 5000 participants and will have a dynamic and innovative programme within the three major themes of HIV basic science, clinical research and biomedical prevention... - The evidence for a change in antenatal HIV screening policy in AustraliaMichelle L Giles
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Med J Aust 185:217-20. 2006..A universal antenatal HIV screening program meets many of the Wilson and Jungner criteria for population-based screening programs. This should be considered in the current review of Australia's HIV testing policy... - HIV-1 down-modulates gamma signaling chain of Fc gamma R in human macrophages: a possible mechanism for inhibition of phagocytosisKatherine Kedzierska
AIDS Pathogenesis Research Unit, Macfarlane Burnet Center, Victoria, Australia
J Immunol 168:2895-903. 2002.... - Variable uptake of recommended interventions to reduce mother-to-child transmission of HIV in Australia, 1982-2005Michelle L Giles
Department of Medicine, Monash University, Melbourne, Vic, Australia
Med J Aust 189:151-4. 2008..To analyse the uptake of interventions known to reduce the risk of perinatal HIV transmission among Australian women with HIV infection (who knew their HIV status before delivery), and identify predictors of uptake... - A phase I study of the pharmacokinetics and safety of passive immunotherapy with caprine anti-HIV antibodies, (PE)HRG214, in HIV-1-infected individualsSarah L Pett
HIV, Immunology and Infectious Diseases Clinical Services, St Vincent s Hospital, Sydney, and National Centre in HIV Epidemiology and Clinical Research, University of NSW, Darlinghurst, Sydney, Australia
HIV Clin Trials 5:91-8. 2004..To establish the pharmacokinetics and safety of single-dose polyclonal caprine anti-HIV antibodies ((PE)HRG214)in HIV-1-infected individuals... - Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavirJennifer F Hoy
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
J Infect Dis 190:688-92. 2004..During the 24-week study, there was no significant change in mtDNA copy numbers in PBMCs in either treatment group, despite improvement in peripheral lipoatrophy among patients whose treatment was switched to abacavir... - A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeuticsChristopher P Desmond
Department of Gastroenterology, Alfred Hospital, Melbourne, Australia
Antivir Ther 13:161-75. 2008..The immune response to hepatitis B virus (HBV) is important for both viral control and disease pathogenesis. A detailed understanding of the HBV-specific T-cell responses may potentially lead to novel therapeutic strategies for HBV... - The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infectionMiranda Shehu-Xhilaga
Infectious Diseases Unit, Alfred Hospital, Prahran, Australia
Retrovirology 4:7. 2007..Little is known about the progression and pathogenesis of HIV-1 infection within the male genital tract (MGT), particularly during the early stages of infection... - CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latencySuha Saleh
Departments of Medicine, Alfred Hospital, Melbourne, Australia
Blood 110:4161-4. 2007..CCR7 ligands facilitate efficient entry of HIV-1 into resting CD4(+) T cells. These studies demonstrate a unique action of the chemokines CCL19 and CCL21 and provide a novel model with which to study HIV-1 latency in vitro... - Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivoPaul R Gorry
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Retrovirology 4:66. 2007.... - Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infectionSharon R Lewin
Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
J Acquir Immune Defic Syndr 47:140-47. 2008..Commencing ARVs during primary HIV-1 infection (PHI) may limit the size of the latent pool and lead to improved control of viral replication during structured treatment interruption (STI)... - Phase 1 single dose studies to optimize the pharmacokinetics of DG17, a novel HIV-protease inhibitor pro-drug, using sodium bicarbonate and ritonavirCatherine L Cherry
Burnet Institute, Melbourne, Australia
Curr HIV Res 6:272-5. 2008..No significant adverse events occurred. Single dose DG17 is safe and best administered in a manner preventing gastric acid degradation and with low-dose ritonavir...