A S Leong

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi Refinement of immunohistologic parameters for Her2/neu scoring validation by FISH and CISH
    Anthony S Y Leong
    Immunohistology Unit, Division of Anatomical Pathology, Hunter Area Pathology Service, Newcastle, Australia
    Appl Immunohistochem Mol Morphol 14:384-9. 2006
  2. ncbi Quantitation in immunohistology: fact or fiction? A discussion of variables that influence results
    Anthony S Y Leong
    Appl Immunohistochem Mol Morphol 12:1-7. 2004
  3. ncbi Incorporation of microwave tissue processing into a routine pathology laboratory: impact on turnaround times and laboratory work patterns
    Anthony S Y Leong
    Division of Anatomical Pathology, Hunter Area Pathology Service, Newcastle, NSW 2310, Australia
    Pathology 36:321-4. 2004
  4. ncbi Strategies for laboratory cost containment and for pathologist shortage: centralised pathology laboratories with microwave-stimulated histoprocessing and telepathology
    Anthony S Y Leong
    Hunter Area Pathology Service, Newcastle, NSW, Australia
    Pathology 37:5-9. 2005
  5. ncbi Newer developments in immunohistology
    A S Y Leong
    Discipline of Anatomical Pathology, University of Newcastle, Newcastle, Australia
    J Clin Pathol 59:1117-26. 2006
  6. ncbi An advanced digital image-capture computer system for gross specimens: a substitute for gross description
    A S Leong
    Hunter Area Pathology Services, Hunter Region Mail Centre, Newcastle 2310, Australia
    Pathology 32:131-5. 2000
  7. ncbi Basal lamina visualization using color image processing and pattern recognition
    F Joel W M Leong
    Mirada Solutions, Oxford Centre for Innovation and Oxford University Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom
    Appl Immunohistochem Mol Morphol 13:273-6. 2005
  8. ncbi Diagnostic 'errors' in anatomical pathology: relevance to Australian laboratories
    Anthony S Y Leong
    Division of Anatomical Pathology, Hunter Area Pathology Service, Newcastle, New South Wales, Australia
    Pathology 38:490-7. 2006
  9. ncbi Microwave enhancement of CISH for HER2 oncogene
    Anthony S Y Leong
    Immunohistology Unit, Division of Anatomical Pathology, Hunter Area Pathology Service, Locked Bag 1, HRMC, Newcastle 2310, Australia
    Appl Immunohistochem Mol Morphol 15:88-93. 2007
  10. ncbi Apoptosis is a major cause of so-called "caseous necrosis" in mycobacterial granulomas in HIV-infected patients
    A S Y Leong
    Division of Anatomical Pathology, Hunter Area Pathology Service and University of Newcastle, Australia 2310
    J Clin Pathol 61:366-72. 2008

Collaborators

Detail Information

Publications28

  1. ncbi Refinement of immunohistologic parameters for Her2/neu scoring validation by FISH and CISH
    Anthony S Y Leong
    Immunohistology Unit, Division of Anatomical Pathology, Hunter Area Pathology Service, Newcastle, Australia
    Appl Immunohistochem Mol Morphol 14:384-9. 2006
    ..FISH and CISH testing in selected cases from the other categories validated the revised scoring method. These criteria reduced the numbers of equivocal staining cases that required FISH testing...
  2. ncbi Quantitation in immunohistology: fact or fiction? A discussion of variables that influence results
    Anthony S Y Leong
    Appl Immunohistochem Mol Morphol 12:1-7. 2004
  3. ncbi Incorporation of microwave tissue processing into a routine pathology laboratory: impact on turnaround times and laboratory work patterns
    Anthony S Y Leong
    Division of Anatomical Pathology, Hunter Area Pathology Service, Newcastle, NSW 2310, Australia
    Pathology 36:321-4. 2004
    ..To examine the impact of microwave (MW) tissue processing on turnaround times (TATs) in a routine diagnostic laboratory...
  4. ncbi Strategies for laboratory cost containment and for pathologist shortage: centralised pathology laboratories with microwave-stimulated histoprocessing and telepathology
    Anthony S Y Leong
    Hunter Area Pathology Service, Newcastle, NSW, Australia
    Pathology 37:5-9. 2005
    ....
  5. ncbi Newer developments in immunohistology
    A S Y Leong
    Discipline of Anatomical Pathology, University of Newcastle, Newcastle, Australia
    J Clin Pathol 59:1117-26. 2006
    ..The mechanism of antigen retrieval remains debated. The absence of optimal controls continues to hinder standardisation of immunostaining and invalidates current attempts at quantification of immunostaining...
  6. ncbi An advanced digital image-capture computer system for gross specimens: a substitute for gross description
    A S Leong
    Hunter Area Pathology Services, Hunter Region Mail Centre, Newcastle 2310, Australia
    Pathology 32:131-5. 2000
    ..The stored images form a powerful database for teaching and research. Connection to remote transmission facilities allows teleconferencing and telepathology consultations...
  7. ncbi Basal lamina visualization using color image processing and pattern recognition
    F Joel W M Leong
    Mirada Solutions, Oxford Centre for Innovation and Oxford University Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom
    Appl Immunohistochem Mol Morphol 13:273-6. 2005
    ..In addition, digital visualization of basal lamina is readily amenable to quantitative assessment, and the method provides a basis for the development of computer-based cancer diagnosis...
  8. ncbi Diagnostic 'errors' in anatomical pathology: relevance to Australian laboratories
    Anthony S Y Leong
    Division of Anatomical Pathology, Hunter Area Pathology Service, Newcastle, New South Wales, Australia
    Pathology 38:490-7. 2006
    ....
  9. ncbi Microwave enhancement of CISH for HER2 oncogene
    Anthony S Y Leong
    Immunohistology Unit, Division of Anatomical Pathology, Hunter Area Pathology Service, Locked Bag 1, HRMC, Newcastle 2310, Australia
    Appl Immunohistochem Mol Morphol 15:88-93. 2007
    ..MW exposed sections showed larger numbers of large and small clusters that often allowed identification of amplified tumors without having to count single dots with crisp staining and absence of background precipitation...
  10. ncbi Apoptosis is a major cause of so-called "caseous necrosis" in mycobacterial granulomas in HIV-infected patients
    A S Y Leong
    Division of Anatomical Pathology, Hunter Area Pathology Service and University of Newcastle, Australia 2310
    J Clin Pathol 61:366-72. 2008
    ..To demonstrate that so-called "caseous necrosis" is the result of apoptosis and investigate the association of B and T cells, and macrophages with the granulomas and their relationship to some apoptosis-related proteins...
  11. ncbi The pathology of dengue hemorrhagic fever
    Anthony S Y Leong
    Hunter Area Pathology Service, Newcastle, NSW, Australia
    Semin Diagn Pathol 24:227-36. 2007
    ..The role of genetics in relation to resistance to DHF/DSS also requires clarification...
  12. ncbi Citraconic anhydride: a new antigen retrieval solution
    Anthony S Y Leong
    Immunohistology Unit, Hunter Area Pathology Service and University of Newcastle, Newcastle, New South Wales, Australia
    Pathology 42:77-81. 2010
    ..Citrate buffer at pH 6.0 has become widely embraced as the universal fixative but some antibodies remain capricious and yield poor staining results...
  13. ncbi Standardization in immunohistology
    Anthony S Y Leong
    University of Newcastle, Newcastle, NSW, Australia
    Methods Mol Biol 724:37-68. 2011
    ....
  14. ncbi Microwaves for chromogenic in situ hybridization
    Anthony S Y Leong
    University of Newcastle, Newcastle, NSW, Australia
    Methods Mol Biol 724:79-89. 2011
    ..The same procedure is performed following enzyme digestion to produce consistent signals in amplified and nonamplified cells that are both larger in size and numbers when compared with those produced by the conventional protocol...
  15. ncbi The changing role of pathology in breast cancer diagnosis and treatment
    Anthony S Y Leong
    Hunter Area Pathology Service, Anatomical Pathology, University of Newcastle, Australia
    Pathobiology 78:99-114. 2011
    ....
  16. ncbi Synoptic/checklist reporting of breast biopsies: has the time come?
    A S Leong
    Hunter Area Pathology Services and Department of Anatomical Pathology, University of Newcastle, Newcastle, New South Wales, Australia
    Breast J 7:271-4. 2001
    ..The reproducibility of morphologic descriptions is thus a matter of some concern...
  17. ncbi Pitfalls in diagnostic immunohistology
    Anthony S Y Leong
    Hunter Area Pathology Service and Discipline of Anatomical Pathology, University of Newcastle, Australia
    Adv Anat Pathol 11:86-93. 2004
    ..Proper utilization of immunostaining requires that it is employed as a morphology-based technique and not interpreted in isolation...
  18. ncbi Patterns of immunoglobulin staining in paraffin-embedded malignant lymphomas
    Anthony S Y Leong
    Division of Anatomical Pathology, Hunter Area Pathology Services, University of Newcastle, New South Wales, Australia
    Appl Immunohistochem Mol Morphol 10:110-4. 2002
    ..Perinuclear staining occurred in combination with cytoplasmic staining in 12 cases and membrane staining in 8 cases with 12 lymphomas showing more than two patterns of staining...
  19. ncbi Biologic markers in ductal carcinoma in situ and concurrent infiltrating carcinoma. A comparison of eight contemporary grading systems
    A S Leong
    Hunter Area Pathology Services and the Discipline of Anatomical Pathology, University of Newcastle, Newcastle, Australia
    Am J Clin Pathol 115:709-18. 2001
    ....
  20. ncbi Digital photography in anatomical pathology
    F J Leong
    Mirada Solutions, Oxford, UK
    J Postgrad Med 50:62-9. 2004
    ..Early reports indicate that medical vision systems are a reality and can provide for automated computer-generated histopathological diagnosis and quality assurance...
  21. ncbi Significance and assessment of margin status in ductal carcinoma in situ of the breast
    E K Millar
    Division of Anatomical Pathology, Hunter Area Pathology Service, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia
    Adv Anat Pathol 8:338-44. 2001
    ..Criteria for margin adequacy and the relevance of margin status in the selection of cases for breast conservation are discussed in the context of other important risk factors for local failure...
  22. ncbi Accuracy and reproducibility of telecytology diagnosis of cervical smears. A tool for quality assurance programs
    Eung Seok Lee
    Division of Anatomical Pathology, Hunter Area Pathology Service and Discipline of Anatomical Pathology, University of Newcastle, Newcastle, New South Wales, Australia
    Am J Clin Pathol 119:356-60. 2003
    ..Digital images are suitable substitutes for glass slides; telecytology can be used as an alternative method for the cytologic diagnosis of cervical smears, particularly in quality assurance programs...
  23. ncbi Histologic grading of noninvasive papillary urothelial tumors: validation of the 1998 WHO/ISUP system by immunophenotyping and follow-up
    Hui Yin
    Division of Anatomical Pathology, Hunter Area Pathology Service, Newcastle, NSW, Australia
    Am J Clin Pathol 121:679-87. 2004
    ....
  24. ncbi Digital imaging in pathology: theoretical and practical considerations, and applications
    F Joel W-M Leong
    Mirada Solutions, Oxford, United Kingdom
    Pathology 36:234-41. 2004
    ....
  25. ncbi CDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus
    Xue Ying Shi
    Division of Anatomical Pathology, Hunter Area Pathology Service, Newcastle, Australia
    Am J Clin Pathol 129:571-7. 2008
    ..CDX2 and villin are sensitive markers for early-stage IM and can supplement the histologic identification of this premalignant condition in the esophagus...
  26. ncbi p16, cyclin D1, Ki-67, and AMACR as markers for dysplasia in Barrett esophagus
    Xue Ying Shi
    Division of Anatomical Pathology, Hunter Area of Pathology Service, Newcastle, Australia
    Appl Immunohistochem Mol Morphol 16:447-52. 2008
    ..Cytoplasmic staining of p16 is specific. It may represent a different pathway of p16 dysfunction. The pattern and extent of Ki-67 staining and AMACR overexpression are useful additional parameters for identifying dysplasia in BE...
  27. ncbi Immunohistologic parameters in minimal morphologic change duodenal biopsies from patients with clinically suspected gluten-sensitive enteropathy
    Jongkolnee Settakorn
    Division of Anatomical Pathology, Hunter Area Pathology Service, Newcastle, Australia
    Appl Immunohistochem Mol Morphol 12:198-204. 2004
    ..The few S-H+ cases seen most likely represented false-negative serology, because the assessed parameters of this group and S+H+ cases were indistinguishable...
  28. ncbi Microwaves and turnaround times in histoprocessing: is this a new era in histotechnology?
    Anthony S Y Leong
    Am J Clin Pathol 121:460-2. 2004