Research Topics
| Deborah LehmannSummaryAffiliation: University of Western Australia Country: Australia Publications
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Detail Information
Publications
Maternal immunization with pneumococcal polysaccharide vaccine in the highlands of Papua New GuineaDeborah Lehmann
Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
Vaccine 20:1837-45. 2002..The findings of this study and those in several other developing countries provide support for the concept of Pnc PS maternal immunization and justify the planning of large-scale efficacy trials...
The changing epidemiology of invasive pneumococcal disease in aboriginal and non-aboriginal western Australians from 1997 through 2007 and emergence of nonvaccine serotypesDeborah Lehmann
Telethon Institute for Child Health Research, Centre for Child Health Research, Queensland, Australia
Clin Infect Dis 50:1477-86. 2010..However, IPD due to non-7vPCV serotypes has increased and is of particular concern among young Aboriginal adults, for whom an intensive 23vPPV campaign is needed. An immunization register covering all age groups should be established...
Association between early bacterial carriage and otitis media in Aboriginal and non-Aboriginal children in a semi-arid area of Western Australia: a cohort studyWenxing Sun
Division of Population Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA 6872, Australia
BMC Infect Dis 12:366. 2012..We investigated associations between early onset of URT bacterial carriage and subsequent diagnosis of OM in Aboriginal and non-Aboriginal children living in the Kalgoorlie-Boulder region located in a semi-arid zone of Western Australia...- Absent otoacoustic emissions predict otitis media in young Aboriginal children: a birth cohort study in Aboriginal and non-Aboriginal children in an arid zone of Western AustraliaDeborah Lehmann
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Australia
BMC Pediatr 8:32. 2008..Absent transient evoked otoacoustic emissions (TEOAEs) may predict subsequent risk of OM... - The Kalgoorlie Otitis Media Research Project: rationale, methods, population characteristics and ethical considerationsDeborah Lehmann
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, West Perth, WA, Australia
Paediatr Perinat Epidemiol 22:60-71. 2008..Early consultation, provision of a service while undertaking research, inclusion of Aboriginal people as active members of a research team and appropriate acknowledgement will assist in ensuring successful completion of the research... - Benefits of routine immunizations on childhood survival in Tari, Southern Highlands Province, Papua New GuineaDeborah Lehmann
Papua New Guinea Institute of Medical Research, Goroka and Tari, Papua New Guinea
Int J Epidemiol 34:138-48. 2005..This study aimed to determine the effects of diphtheria-tetanus-whole-cell-pertussis (DTP), BCG, hepatitis B, and measles vaccines on mortality in the highlands of Papua New Guinea (PNG)... - Benefits of swimming pools in two remote Aboriginal communities in Western Australia: intervention studyDeborah Lehmann
Centre for Child Health Research, University of Western Australia, Telethon Institute for Child Health Research, PO Box 855, West Perth, WA 6872, Australia
BMJ 327:415-9. 2003..To determine the health impact of swimming pools built with the aim of improving quality of life and reducing high rates of pyoderma and otitis media... - Studies of maternal immunisation with pneumococcal polysaccharide vaccine in Papua New GuineaDeborah Lehmann
Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
Vaccine 21:3446-50. 2003..Given results from several developing countries, large-scale safety and efficacy trials are now justified. Postpartum maternal immunisation is another intervention under consideration... - Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteria in Australian Aboriginal and non-Aboriginal childrenPeter Jacoby
Centre for Child Health Research, Telethon Institute for Child Health Research, The University of Western Australia, Perth, Australia
Pediatr Infect Dis J 30:480-5. 2011..Data are limited on risk factors for carriage of these pathogens, particularly for Indigenous populations. We investigated predictors of nasopharyngeal carriage in Australian Aboriginal and non-Aboriginal children... - Effect of early carriage of Streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancyAnita H J van den Biggelaar
Division of Cell Biology, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth WA, Australia
Pediatr Infect Dis J 31:243-8. 2012..The aim of this study was to examine the relationship between nasopharyngeal pneumococcal colonization in early life and the subsequent development of pneumococcal-specific T cell responses... - The interaction between respiratory viruses and pathogenic bacteria in the upper respiratory tract of asymptomatic Aboriginal and non-Aboriginal childrenHannah C Moore
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
Pediatr Infect Dis J 29:540-5. 2010..However, data on asymptomatic identification rates of respiratory viruses are limited, particularly in Indigenous populations, who suffer a high burden of OM... - Pneumococcal conjugate vaccination at birth in a high-risk setting: no evidence for neonatal T-cell toleranceAnita H J van den Biggelaar
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, West Perth WA 6872, Australia
Vaccine 29:5414-20. 2011..Neonatal immunisation schedules should therefore be considered in high-risk areas where this may result in improved vaccine coverage and the earliest possible protection against pneumococcal disease and death... - Diverging trends for lower respiratory infections in non-Aboriginal and Aboriginal childrenHannah Moore
Telethon Institute for Child Health Research, Centre for Child Health Research, Perth, WA, Australia
J Paediatr Child Health 43:451-7. 2007..To investigate temporal trends in admission rates for acute lower respiratory infections (ALRI) in a total population birth cohort of non-Aboriginal and Aboriginal children... - Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tractPeter Jacoby
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, WA, Australia
Vaccine 25:2458-64. 2007..Viral vaccines may assist in reducing the burden of bacterial disease... - Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: a randomized controlled trial in Papua New GuineaAnita H J van den Biggelaar
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, West Perth, WA 6872, Australia
Vaccine 27:1340-7. 2009..Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses... - Can linked emergency department data help assess the out-of-hospital burden of acute lower respiratory infections? A population-based cohort studyHannah C Moore
Division of Population Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
BMC Public Health 12:703. 2012..There is a lack of data on the out-of-hospital burden of acute lower respiratory infections (ALRI) in developed countries. Administrative datasets from emergency departments (ED) may assist in addressing this... - Upper respiratory tract bacterial carriage in Aboriginal and non-Aboriginal children in a semi-arid area of Western AustraliaKelly Watson
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Western Australia, Australia
Pediatr Infect Dis J 25:782-90. 2006..CONCLUSIONS: Interventions are needed to reduce high transmission and carriage rates, particularly in Aboriginal communities, to avoid the serious consequences of OM... - Use of data linkage to investigate the aetiology of acute lower respiratory infection hospitalisations in childrenHannah C Moore
Telethon Institute for Child Health Research, Centre for Child Health Research, Schools of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia
J Paediatr Child Health 48:520-8. 2012..To document the aetiology of acute lower respiratory infection (ALRI) hospitalisations in Western Australian children by linking population-based laboratory data with hospital morbidity data... - Maternal antibodies to pneumolysin but not to pneumococcal surface protein A delay early pneumococcal carriage in high-risk Papua New Guinean infantsJacinta P Francis
Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
Clin Vaccine Immunol 16:1633-8. 2009..57; 95% CI, 1.03 to 2.40). Maternal vaccination with a pneumococcal protein-based vaccine should be considered as a strategy to protect high-risk infants against pneumococcal disease by reducing carriage risks in both mothers and infants... - Seasonality of respiratory viral identification varies with age and Aboriginality in metropolitan Western AustraliaHannah C Moore
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
Pediatr Infect Dis J 28:598-603. 2009..Viral respiratory infections are a major cause of pediatric illness. It is not known whether seasonality of viruses differs between Aboriginal and non-Aboriginal children of varying ages... - Infection is the major component of the disease burden in aboriginal and non-aboriginal Australian children: a population-based studyKylie S Carville
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
Pediatr Infect Dis J 26:210-6. 2007..We investigated reasons for hospitalization before age 2 years in a birth cohort of Western Australian Aboriginal and non-Aboriginal children... - Effect of swimming pools on antibiotic use and clinic attendance for infections in two Aboriginal communities in Western AustraliaDesiree T Silva
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
Med J Aust 188:594-8. 2008..To determine whether installation of swimming pools in remote Aboriginal communities reduces infection-related outpatient attendances and prescription of antibiotics... - Reduction in disparity for pneumonia hospitalisations between Australian Indigenous and non-Indigenous childrenHannah C Moore
Division of Population Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Western Australia, Australia
J Epidemiol Community Health 66:489-94. 2012..We investigated population trends for pneumonia hospitalisations between 1996 and 2005... - A retrospective population-based cohort study identifying target areas for prevention of acute lower respiratory infections in childrenHannah C Moore
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
BMC Public Health 10:757. 2010..This study investigates population attributable fractions of known infant and maternal risk factors for ALRI to inform prevention strategies that target high-risk groups or particular risk factors... - The effect of passive smoking on the risk of otitis media in Aboriginal and non-Aboriginal children in the Kalgoorlie-Boulder region of Western AustraliaPeter A Jacoby
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
Med J Aust 188:599-603. 2008..To determine the risk of otitis media (OM) associated with passive smoking in young children, and any competing effect between passive smoking and childcare attendance... - Prevalence of and risk factors for human rhinovirus infection in healthy aboriginal and non-aboriginal Western Australian childrenAlicia A Annamalay
School of Paediatrics and Child Health, The University of Western Australia, Perth, Australia
Pediatr Infect Dis J 31:673-9. 2012..The prevalence of HRV-C among healthy children and whether this varies with ethnicity is unknown... - Hospitalisation for bronchiolitis in infants is more common after elective caesarean deliveryHannah C Moore
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
Arch Dis Child 97:410-4. 2012..In view of increasing rates of elective caesarean delivery, this association warranted further investigation... - Antimicrobial susceptibility of Moraxella catarrhalis isolated from children in Kalgoorlie-Boulder, Western AustraliaNevada M Pingault
School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia
Pathology 42:273-9. 2010..To investigate antimicrobial susceptibility of Moraxella catarrhalis isolated from a cohort of children being followed in a study of the natural history of otitis media in a semi-arid region of Western Australia... - Chlamydia trachomatis infection and distribution of serovars in the Eastern Highlands Province, Papua New GuineaDagwin L Suarkia
Papua New Guinea Institute of Medical Research, Goroka
P N G Med J 50:134-44. 2007..However, the association of L3 also with childhood infection indicates that it may be causing the same pathology as the serovars D-K that are associated with non-ulcerative sexually transmitted infections... - Comparison between nasal swabs and nasopharyngeal aspirates for, and effect of time in transit on, isolation of Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Moraxella catarrhalisKylie S Carville
The University of Western Australia, Australia
J Clin Microbiol 45:244-5. 2007..influenzae as those in transit for < or =3 days. There was no statistically significant difference for either Moraxella catarrhalis or Staphylococcus aureus... - Are you listening? The inaugural Australian Otitis Media (OMOZ) workshop--towards a better understanding of otitis mediaLea Ann S Kirkham
School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia
Med J Aust 193:569-71. 2010 - Respiratory viral pathogens associated with lower respiratory tract disease among young children in the highlands of Papua New GuineaGlenys R Chidlow
Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, Australia
J Clin Virol 54:235-9. 2012..However, comprehensive studies of the viral aetiology of ALRI have not been conducted in PNG for almost 30 years... - Demography and causes of death among the Huli in the Tari BasinDeborah Lehmann
Centre for Child Health Research, University of Western Australia, Telethon Institute for Child Health Research, Perth, WA, Australia
P N G Med J 45:51-62. 2002..If restored, the Tari Research Unit could continue to play a key role in assisting the Department of Health in making decisions on appropriate interventions to improve the quality of life of Papua New Guineans... - Improved pulsed field gel electrophoresis method for Moraxella catarrhalisNevada M Pingault
School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Western Australia, Australia
J Microbiol Methods 75:344-5. 2008.... - Neonatal innate cytokine responses to BCG controlling T-cell development vary between populationsAnita H J van den Biggelaar
Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 124:544-50, 550.e1-2. 2009..The protective effect of Mycobacterium bovis BCG vaccination against infection and atopy varies between populations... - The relationship between undernutrition and humoral immune status in children with pneumonia in Papua New GuineaAllan W Cripps
School of Medicine, Griffith University, Gold Coast, Queensland, Australia
P N G Med J 51:120-30. 2008..In conclusion, undernutrition was associated with hypoalbuminaemia and reduced humoral immune responses in children with pneumonia but its immunological effects varied with age in an unpredictable way... - Has the seven-valent pneumococcal conjugate vaccine had an impact on invasive pneumococcal disease in Western Australia?Carolien Giele
Communicable Disease Control Directorate, Department of Health, P O Box 8172, Perth Business Centre, WA 6849, Australia
Vaccine 25:2379-84. 2007..Continued surveillance is essential to measure the impact of the childhood pneumococcal conjugate vaccination program on IPD incidence and to identify the emergence of disease due to non-vaccine serotypes... - Fifth International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs, Central Australia, 2-6 April 2006Allan W Cripps
Griffith Health, Griffith University, PMB50, Gold Coast Mail Centre, QLD 9726, Australia
Vaccine 25:2361-5. 2007 - Predictors of neonatal sepsis in developing countriesMartin W Weber
Medical Research Council Laboratories, Fajara, The Gambia
Pediatr Infect Dis J 22:711-7. 2003..Neonatal infections are a major cause of death worldwide. Simple procedures for identifying infants with infection that need referral for treatment are therefore of major public health importance... - Re: DTP vaccination and child survival in observational studies with incomplete vaccination dataDeborah Lehmann
Trop Med Int Health 12:1269-70; author reply 1270-1. 2007 - Re: DTP vaccination and child survival in observational studies with incomplete vaccination dataDeborah Lehmann
Trop Med Int Health 12:1134-5. 2007 - Decline in meningitis admissions in young children: vaccines make a differenceHannah C Moore
Med J Aust 185:404. 2006 - Pneumococcal vaccination in developing countriesAllan W Cripps
Lancet 368:644. 2006 - Nutrition and morbidity: acute lower respiratory tract infections, diarrhoea and malaria. 1988Deborah Lehmann
P N G Med J 48:87-94. 2005 - Long-term outcomes of middle-ear surgery in Aboriginal childrenDonna B Mak
Med J Aust 179:324-5. 2003