M Lappas

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. doi request reprint Effect of pre-existing maternal obesity, gestational diabetes and adipokines on the expression of genes involved in lipid metabolism in adipose tissue
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia Electronic address
    Metabolism 63:250-62. 2014
  2. doi request reprint Activation of inflammasomes in adipose tissue of women with gestational diabetes
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia Electronic address
    Mol Cell Endocrinol 382:74-83. 2014
  3. doi request reprint Forkhead box O1 (FOXO1) in pregnant human myometrial cells: a role as a pro-inflammatory mediator in human parturition
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia Electronic address
    J Reprod Immunol 99:24-32. 2013
  4. pmc Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study
    Mathis Grossmann
    Department of Medicine, Austin Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia
    Reprod Biol Endocrinol 11:40. 2013
  5. pmc Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer
    Ratana Lim
    Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic, Australia
    J Ovarian Res 6:5. 2013
  6. doi request reprint NOD1 and NOD2 regulate proinflammatory and prolabor mediators in human fetal membranes and myometrium via nuclear factor-kappa B
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, 163 Studley Rd, Melbourne, VIC 3084, Australia
    Biol Reprod 89:14. 2013
  7. pmc Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Heidelberg, VIC 3084, Australia
    Mediators Inflamm 2012:597514. 2012
  8. doi request reprint Nuclear factor-κB mediates placental growth factor induced pro-labour mediators in human placenta
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Level 4 163 Studley Road, Heidelberg, VIC 3084, Australia
    Mol Hum Reprod 18:354-61. 2012
  9. doi request reprint Complement C5A regulates prolabor mediators in human placenta
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia
    Biol Reprod 86:190. 2012
  10. doi request reprint Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta
    Martha Lappas
    Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Level 4 163 Studley Road, Heidelberg, Victoria, Australia
    J Endocrinol 213:49-57. 2012

Collaborators

Detail Information

Publications53

  1. doi request reprint Effect of pre-existing maternal obesity, gestational diabetes and adipokines on the expression of genes involved in lipid metabolism in adipose tissue
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia Electronic address
    Metabolism 63:250-62. 2014
    ..To determine the effect of maternal obesity, gestational diabetes mellitus (GDM) and adipokines on the expression of genes involved in fatty acid uptake, transport, synthesis and metabolism...
  2. doi request reprint Activation of inflammasomes in adipose tissue of women with gestational diabetes
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia Electronic address
    Mol Cell Endocrinol 382:74-83. 2014
    ..In conclusion, the present findings describe an important role for adipose tissue inflammasome activation in the development of insulin resistance associated in pregnancies complicated by GDM. ..
  3. doi request reprint Forkhead box O1 (FOXO1) in pregnant human myometrial cells: a role as a pro-inflammatory mediator in human parturition
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia Electronic address
    J Reprod Immunol 99:24-32. 2013
    ....
  4. pmc Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study
    Mathis Grossmann
    Department of Medicine, Austin Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia
    Reprod Biol Endocrinol 11:40. 2013
    ..Given its potential role in immunomodulation, we also measured Vitamin D levels...
  5. pmc Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer
    Ratana Lim
    Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic, Australia
    J Ovarian Res 6:5. 2013
    ..abstract:..
  6. doi request reprint NOD1 and NOD2 regulate proinflammatory and prolabor mediators in human fetal membranes and myometrium via nuclear factor-kappa B
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, 163 Studley Rd, Melbourne, VIC 3084, Australia
    Biol Reprod 89:14. 2013
    ..NOD1 and NOD2 may thus represent therapeutic targets for the treatment and/or management of preterm birth. ..
  7. pmc Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Heidelberg, VIC 3084, Australia
    Mediators Inflamm 2012:597514. 2012
    ..SIRT6 may be a potential pharmacological target for inflammatory vascular diseases...
  8. doi request reprint Nuclear factor-κB mediates placental growth factor induced pro-labour mediators in human placenta
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Level 4 163 Studley Road, Heidelberg, VIC 3084, Australia
    Mol Hum Reprod 18:354-61. 2012
    ..The PLGF-induced pro-labour responses were abrogated by co-treatment with the NF-κB inhibitor BAY 11-7082. In summary, the pro-inflammatory and pro-labour effects of PLGF in human placenta are mediated by NF-κB...
  9. doi request reprint Complement C5A regulates prolabor mediators in human placenta
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia
    Biol Reprod 86:190. 2012
    ..We conclude that C5a upregulates prolabor mediators in human gestational tissues via CD88-mediated NFKB activation...
  10. doi request reprint Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta
    Martha Lappas
    Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Level 4 163 Studley Road, Heidelberg, Victoria, Australia
    J Endocrinol 213:49-57. 2012
    ..Collectively, the data presented here demonstrate that oxidative stress reduces placental glucose uptake and GLUT1 expression by a SIRT1-dependent mechanism...
  11. doi request reprint MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: regulation of enzymes involved in the degradation of fetal membranes
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Level 4 163 Studley Road, Heidelberg, Victoria 3084, Australia
    Placenta 32:1016-25. 2011
    ..Thus, the MAPK/AP-1 pathway may play a role in the degradation of the ECM at the SCS making it more susceptible to membrane rupture...
  12. doi request reprint Transcriptional regulation of the processes of human labour and delivery
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia
    Placenta 30:S90-5. 2009
    ..We also propose that coordination of these different pathways is achieved by competition for common cofactors that control the activity of NRs in human gestational tissues...
  13. doi request reprint Localisation and expression of FoxO1 proteins in human gestational tissues
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Level 4 163 Studley Road, Heidelberg 3084, Victoria, Australia
    Placenta 30:256-62. 2009
    ..The exact role of FoxO1 proteins in human pregnancy are unknown, however the finding that they are expressed in human gestational tissues warrants further research into their function in these tissues...
  14. ncbi request reprint Regulation of phospholipase isozymes by nuclear factor-kappaB in human gestational tissues in vitro
    Martha Lappas
    Department of Obstetrics and Gynaecology, The University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, East Melbourne, Victoria, Australia 3002
    J Clin Endocrinol Metab 89:2365-72. 2004
    ..In addition, SASP concentrations of 5 mM or greater significantly suppressed NF-kappaB DNA binding activity. These data are consistent with the hypothesis that NF-kappaB regulates the expression and release of phospholipase isozymes...
  15. doi request reprint Increased expression of ac-FoxO1 protein in prelabor fetal membranes overlying the cervix: possible role in human fetal membrane rupture
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, and Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg
    Reprod Sci 16:635-41. 2009
    ..Although the precise role and contribution of acetylated-forkhead box O1 in the process of human fetal membrane rupture are unknown, it has been implicated in apoptosis and/or cell cycle regulation...
  16. doi request reprint In response to oxidative stress, the expression of inflammatory cytokines and antioxidant enzymes are impaired in placenta, but not adipose tissue, of women with gestational diabetes
    Martha Lappas
    Department of Obstetrics and Gynaecology Mercy Perinatal Research Centre, Mercy Hospital for Women, University of Melbourne, Level 4 163 Studley Road, Heidelberg 3084, Victoria, Australia
    J Endocrinol 204:75-84. 2010
    ..This may represent a protective or adaptive mechanism to prevent damage from further oxidative insult in utero as indicated by increased tissue antioxidant expression...
  17. doi request reprint Expression and localisation of FoxO3 and FoxO4 in human placenta and fetal membranes
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital forWomen, 163 Studley Road, Heidelberg 3084, Victoria, Australia
    Placenta 31:1043-50. 2010
    ..Presence of FoxO3 and FoxO4 are expected to contribute to apoptosis and/or cell cycle regulation associated with fetal membrane rupture...
  18. doi request reprint The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B(3) derivative, are elicited by FoxO3 in human gestational tissues: implications for preterm birth
    Martha Lappas
    Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia
    J Nutr Biochem 22:1195-201. 2011
    ..Further studies should be undertaken to define a possible implication of vitamin B(3) derivatives in the management of preterm labour and delivery...
  19. doi request reprint Lower circulating levels of complement split proteins C3a and C4a in maternal plasma of women with gestational diabetes mellitus
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Vic, Australia
    Diabet Med 28:906-11. 2011
    ..The aim of this study was to determine the effect of gestational diabetes mellitus on maternal circulating levels of C3a, C4a and C5a...
  20. doi request reprint The role of oxidative stress in the pathophysiology of gestational diabetes mellitus
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia
    Antioxid Redox Signal 15:3061-100. 2011
    ..This review provides an overview and updated data on our current understanding of the complications associated with oxidative changes in GDM...
  21. doi request reprint Visfatin regulates the terminal processes of human labour and delivery via activation of the nuclear factor-κB pathway
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    Mol Cell Endocrinol 348:128-34. 2012
    ..Thus, visfatin represents a novel cytokine linked to the events of human labour initiation...
  22. doi request reprint Pre-labour fetal membranes overlying the cervix display alterations in inflammation and NF-kappaB signalling pathways
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    Placenta 29:995-1002. 2008
    ..In summary, data from this study confirm that supracervical fetal membranes display altered structural and biochemical characteristics...
  23. ncbi request reprint Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro
    Martha Lappas
    Department of Obstetrics and Gynecology, University of Melbourne and Mercy Perinatal Research Center, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia
    Endocrinology 146:1491-7. 2005
    ..Control of the IKK-beta/NF-kappa B pathway may therefore provide an alternative therapeutic strategy for regulating aberrant cytokine release and thereby alleviating insulin resistance in type 2 diabetes mellitus...
  24. ncbi request reprint 15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, 163 Studley Road, Heidelberg 3084, Victoria, Australia
    Placenta 27:1060-72. 2006
    ..The data demonstrated in this study suggest that the 15d-PGJ(2) and troglitazone exhibit anti-inflammatory properties in human gestational tissues via PPAR-gamma independent actions...
  25. ncbi request reprint Effect of nuclear factor-kappa B inhibitors and peroxisome proliferator-activated receptor-gamma ligands on PTHrP release from human fetal membranes
    M Lappas
    Department of Obstetrics and Gynaecology, The University of Melbourne and Mercy Perinatal Research Center, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, Victoria, Australia 3002
    Placenta 25:699-704. 2004
    ..05). This study demonstrates that PTHrP release from human fetal membranes is regulated by inhibitors of NF-kappaB, and ligands of PPAR-gamma...
  26. ncbi request reprint The role and regulation of the nuclear factor kappa B signalling pathway in human labour
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, 4th Floor, 163 Studley Road, Heidelberg, Victoria 3084, Australia
    Placenta 28:543-56. 2007
    ....
  27. ncbi request reprint Decidual activation: abundance and localization of prostaglandin F2alpha receptor (FP) mRNA and protein and uterine activation proteins in human decidua at preterm birth and term birth
    S Makino
    Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan
    Placenta 28:557-65. 2007
    ....
  28. ncbi request reprint Phospholipase A2 isozymes in pregnancy and parturition
    M Lappas
    Mercy Perinatal Research Center, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne 3002, Australia
    Prostaglandins Leukot Essent Fatty Acids 70:87-100. 2004
    ....
  29. ncbi request reprint Lipopolysaccharide and TNF-alpha activate the nuclear factor kappa B pathway in the human placental JEG-3 cells
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, Victoria 3002, Australia
    Placenta 27:568-75. 2006
    ....
  30. ncbi request reprint Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated kinase
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, East Melbourne, Victoria, Australia
    Endocrinology 146:3334-42. 2005
    ....
  31. ncbi request reprint N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro
    Martha Lappas
    Department of Obstetrics and Gynecology, University of Melbourne, and Mercy Perinatal Research Center, Mercy Hospital for Women, East Melbourne, 3002 Victoria, Australia
    J Clin Endocrinol Metab 88:1723-9. 2003
    ..05). The data presented in this study demonstrate that NAC inhibits an NF-kappaB-activated pathway and subsequent phospholipid metabolism, proinflammatory cytokine release, and protease activity in human fetal membranes...
  32. ncbi request reprint Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Perinatal Research Centre, Mercy Hospital for Women, East Melbourne, Victoria, Australia 3002
    J Clin Endocrinol Metab 87:4667-72. 2002
    ..The data presented in this study demonstrate that the formation of proinflammatory mediators can be modulated by currently available therapeutic agents and may therefore be of therapeutic potential in human labor...
  33. ncbi request reprint Mitogen-activated protein kinase proteins regulate LPS-stimulated release of pro-inflammatory cytokines and prostaglandins from human gestational tissues
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, 4th Floor, 163 Studley Road, Heidelberg 3084, Victoria, Australia
    Placenta 28:936-45. 2007
    ....
  34. ncbi request reprint Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro
    Martha Lappas
    Department of Obstetrics and Gynaecology, Melbourne University, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, Victoria 3002, Australia
    Biol Reprod 67:668-73. 2002
    ..The control of NF-kappaB activation may therefore provide an alternative therapeutic strategy for reducing the release of proinflammatory mediators in infection associated preterm labor...
  35. ncbi request reprint Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-kappaB and extracellular signal-regulated kinase 1/2
    Martha Lappas
    Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Level 4 163 Studley Road, Heidelberg, Victoria, Australia
    J Endocrinol 193:269-77. 2007
    ..In conclusion, AGE mediates inflammatory actions in human gestational tissues. Protein kinases and the NF-kappaB pathway play an essential role in AGE signalling in human gestational tissues...
  36. ncbi request reprint Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia
    J Endocrinol 186:457-65. 2005
    ..Furthermore, resistin release is greatly affected by a variety of inflammatory mediators and hormones...
  37. doi request reprint SIRT1 is a novel regulator of key pathways of human labor
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia
    Biol Reprod 84:167-78. 2011
    ..In conclusion, SIRT1 possesses anti-inflammatory actions and thus may play a role in regulating pregnancy and parturition...
  38. ncbi request reprint Release of proinflammatory cytokines and 8-isoprostane from placenta, adipose tissue, and skeletal muscle from normal pregnant women and women with gestational diabetes mellitus
    Martha Lappas
    Department of Obstetrics and Gynecology, University of Melboure and Mercy Perinatal Research Center, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia
    J Clin Endocrinol Metab 89:5627-33. 2004
    ..These data are consistent with the hypothesis that oxidative stress may be involved in the progression and/or pathogenesis of GDM...
  39. doi request reprint Human labour is associated with decreased cytoplasmic FoxO4
    R Lim
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    Placenta 33:52-9. 2012
    ..Although the exact role of FoxO4 in human pregnancy remains to be fully elucidated, our data demonstrate that it can regulate COX-2 expression and subsequent prostaglandin expression...
  40. doi request reprint Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia
    S J Holdsworth-Carson
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia
    Placenta 31:222-9. 2010
    ..Peroxisome proliferator-activated receptors (PPARs), and their partner retinoid X receptor a (RXRalpha), mediate trophoblast differentiation and thus may offer insight into the pathophysiology of these diseases...
  41. doi request reprint Increased oxidative stress in human fetal membranes overlying the cervix from term non-labouring and post labour deliveries
    M Chai
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    Placenta 33:604-10. 2012
    ..In summary, non-labouring SC fetal membranes are characterised by reduced antioxidant enzyme activity when compared to distal membranes, and, as such, may be more susceptible to oxidative damage and thus membrane rupture...
  42. ncbi request reprint Type II phospholipase A2 in preterm human gestational tissues
    M Lappas
    Department of Obstetrics and Gynecology, Melbourne University, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002, Victoria, Australia
    Placenta 22:64-9. 2001
    ..The data obtained in this study support a role for Type II PLA2 in association with spontaneous rupture of membranes...
  43. ncbi request reprint Antiinflammatory effects of the cyclopentenone isoprostane 15-A(2)-IsoP in human gestational tissues
    Martha Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia
    Free Radic Biol Med 42:1791-6. 2007
    ..Cyclopentenone IsoPs may serve as negative feedback regulators of the inflammatory response in human gestational tissues...
  44. doi request reprint Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia
    C L Whitehead
    Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg 3084, Victoria, Australia
    J Perinatol 33:600-4. 2013
    ....
  45. ncbi request reprint Antisense oligonucleotide inhibition of type II phospholipase A2 expression, release and activity in vitro
    M Lappas
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, East Melbourne, Victoria, Australia
    Placenta 22:418-24. 2001
    ..05). This data demonstrates the efficacy of antisense oligonucleotide inhibition of secretory PLA2 (sPLA2) expression and activity, and the contribution of sPLA2 to placental prostaglandin production...
  46. doi request reprint Peroxisome proliferator-activated receptors and retinoid X receptor-alpha in term human gestational tissues: tissue specific and labour-associated changes
    S J Holdsworth-Carson
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria 3084, Australia
    Placenta 30:176-86. 2009
    ..This data is consistent with the hypothesis that PPAR:RXR are involved in regulating of the processes of human term parturition...
  47. doi request reprint Diabetes and obesity during pregnancy alter insulin signalling and glucose transporter expression in maternal skeletal muscle and subcutaneous adipose tissue
    Michelle Colomiere
    Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Mercy Hospital for Women, University of Melbourne, 4th Floor, 163 Studley Road, Heidelberg 3084, Victoria, Australia
    J Mol Endocrinol 44:213-23. 2010
    ..Collectively, our results suggest that diabetes and obesity during pregnancy cause defects in insulin-signalling transduction in adipose tissue and skeletal muscle and may be the underlying cause of GDM...
  48. doi request reprint Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus
    Michelle Colomiere
    Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne and Mercy Perinatal Research Centre, Heidelberg 3084, Victoria, Australia
    Eur J Endocrinol 160:567-78. 2009
    ..The present study tested the hypothesis that endogenous expression levels in the human term placenta of insulin signaling components are altered in placental tissue from GDM women in comparison with normal controls and maternal obesity...
  49. ncbi request reprint Effect of high oxygen on placental function in short-term explant cultures
    Nicole G Reti
    Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia
    Cell Tissue Res 328:607-16. 2007
    ..These data are consistent with the hypothesis that hyperoxia activates pathways and mechanisms involved in cellular metabolism, necrosis and apoptosis, thereby shifting the balance from a steady state towards cell death...
  50. doi request reprint Screening for biomarkers predictive of gestational diabetes mellitus
    Harry M Georgiou
    Department of Obstetrics and Gynecology, University of Melbourne, Parkville, Vic, Australia
    Acta Diabetol 45:157-65. 2008
    ..Plasma insulin and adiponectin concentrations, when measured at 11 weeks, may be predictive of impending gestational diabetes. Further studies are warranted to determine the reliability of these biomarkers...
  51. doi request reprint Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia
    C L Whitehead
    Translational Obstetrics Group, The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Vic, Australia
    BJOG 118:1268-71. 2011
    ..We conclude that the novel primate-specific splice variant of sFlt-1 is highly expressed in both severe pre-eclampsia and HELLP...
  52. pmc Rational design of immunostimulatory siRNAs
    Michael P Gantier
    Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Victoria, Australia
    Mol Ther 18:785-95. 2010
    ..Our data suggest that this sequence modification coupled with structural modification differentially recruits human TLR8 over TLR7, and could have potential application in antiviral therapies...
  53. ncbi request reprint Why do membranes rupture at term? Evidence of increased cellular apoptosis in the supracervical fetal membranes
    Nicole G Reti
    Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia
    Am J Obstet Gynecol 196:484.e1-10. 2007
    ..Membrane apoptosis would provide a mechanism for the reduced tensile strength that presumably precedes spontaneous intrapartum rupture of the membranes...