Research Topics
Genomes and Genes
Species | M LappasSummaryAffiliation: University of Melbourne Country: Australia Publications
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Detail Information
Publications
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cellsMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Heidelberg, VIC 3084, Australia
Mediators Inflamm 2012:597514. 2012..SIRT6 may be a potential pharmacological target for inflammatory vascular diseases...
Nuclear factor-κB mediates placental growth factor induced pro-labour mediators in human placentaMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Level 4 163 Studley Road, Heidelberg, VIC 3084, Australia
Mol Hum Reprod 18:354-61. 2012..The PLGF-induced pro-labour responses were abrogated by co-treatment with the NF-κB inhibitor BAY 11-7082. In summary, the pro-inflammatory and pro-labour effects of PLGF in human placenta are mediated by NF-κB...- Complement C5A regulates prolabor mediators in human placentaMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Biol Reprod 86:190. 2012..We conclude that C5a upregulates prolabor mediators in human gestational tissues via CD88-mediated NFKB activation... - Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placentaMartha Lappas
Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Level 4 163 Studley Road, Heidelberg, Victoria, Australia
J Endocrinol 213:49-57. 2012..Collectively, the data presented here demonstrate that oxidative stress reduces placental glucose uptake and GLUT1 expression by a SIRT1-dependent mechanism... - MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: regulation of enzymes involved in the degradation of fetal membranesM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Level 4 163 Studley Road, Heidelberg, Victoria 3084, Australia
Placenta 32:1016-25. 2011..Thus, the MAPK/AP-1 pathway may play a role in the degradation of the ECM at the SCS making it more susceptible to membrane rupture... - Localisation and expression of FoxO1 proteins in human gestational tissuesM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Level 4 163 Studley Road, Heidelberg 3084, Victoria, Australia
Placenta 30:256-62. 2009..The exact role of FoxO1 proteins in human pregnancy are unknown, however the finding that they are expressed in human gestational tissues warrants further research into their function in these tissues... - Transcriptional regulation of the processes of human labour and deliveryM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia
Placenta 30:S90-5. 2009..We also propose that coordination of these different pathways is achieved by competition for common cofactors that control the activity of NRs in human gestational tissues... - Pre-labour fetal membranes overlying the cervix display alterations in inflammation and NF-kappaB signalling pathwaysM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
Placenta 29:995-1002. 2008..In summary, data from this study confirm that supracervical fetal membranes display altered structural and biochemical characteristics... 
Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-kappaB and extracellular signal-regulated kinase 1/2Martha Lappas
Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Level 4 163 Studley Road, Heidelberg, Victoria, Australia
J Endocrinol 193:269-77. 2007..In conclusion, AGE mediates inflammatory actions in human gestational tissues. Protein kinases and the NF-kappaB pathway play an essential role in AGE signalling in human gestational tissues...- Increased expression of ac-FoxO1 protein in prelabor fetal membranes overlying the cervix: possible role in human fetal membrane ruptureMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, and Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg
Reprod Sci 16:635-41. 2009..Although the precise role and contribution of acetylated-forkhead box O1 in the process of human fetal membrane rupture are unknown, it has been implicated in apoptosis and/or cell cycle regulation... - SIRT1 is a novel regulator of key pathways of human laborMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia
Biol Reprod 84:167-78. 2011..In conclusion, SIRT1 possesses anti-inflammatory actions and thus may play a role in regulating pregnancy and parturition... - Expression and localisation of FoxO3 and FoxO4 in human placenta and fetal membranesM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital forWomen, 163 Studley Road, Heidelberg 3084, Victoria, Australia
Placenta 31:1043-50. 2010..Presence of FoxO3 and FoxO4 are expected to contribute to apoptosis and/or cell cycle regulation associated with fetal membrane rupture... - The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B(3) derivative, are elicited by FoxO3 in human gestational tissues: implications for preterm birthMartha Lappas
Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia
J Nutr Biochem 22:1195-201. 2011..Further studies should be undertaken to define a possible implication of vitamin B(3) derivatives in the management of preterm labour and delivery... - Lower circulating levels of complement split proteins C3a and C4a in maternal plasma of women with gestational diabetes mellitusM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Vic, Australia
Diabet Med 28:906-11. 2011..The aim of this study was to determine the effect of gestational diabetes mellitus on maternal circulating levels of C3a, C4a and C5a... - The role of oxidative stress in the pathophysiology of gestational diabetes mellitusMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Antioxid Redox Signal 15:3061-100. 2011..This review provides an overview and updated data on our current understanding of the complications associated with oxidative changes in GDM... - Visfatin regulates the terminal processes of human labour and delivery via activation of the nuclear factor-κB pathwayMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
Mol Cell Endocrinol 348:128-34. 2012..Thus, visfatin represents a novel cytokine linked to the events of human labour initiation... - In response to oxidative stress, the expression of inflammatory cytokines and antioxidant enzymes are impaired in placenta, but not adipose tissue, of women with gestational diabetesMartha Lappas
Department of Obstetrics and Gynaecology Mercy Perinatal Research Centre, Mercy Hospital for Women, University of Melbourne, Level 4 163 Studley Road, Heidelberg 3084, Victoria, Australia
J Endocrinol 204:75-84. 2010..This may represent a protective or adaptive mechanism to prevent damage from further oxidative insult in utero as indicated by increased tissue antioxidant expression... - Mitogen-activated protein kinase proteins regulate LPS-stimulated release of pro-inflammatory cytokines and prostaglandins from human gestational tissuesM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, 4th Floor, 163 Studley Road, Heidelberg 3084, Victoria, Australia
Placenta 28:936-45. 2007.... - N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitroMartha Lappas
Department of Obstetrics and Gynecology, University of Melbourne, and Mercy Perinatal Research Center, Mercy Hospital for Women, East Melbourne, 3002 Victoria, Australia
J Clin Endocrinol Metab 88:1723-9. 2003..05). The data presented in this study demonstrate that NAC inhibits an NF-kappaB-activated pathway and subsequent phospholipid metabolism, proinflammatory cytokine release, and protease activity in human fetal membranes... - Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitroMartha Lappas
Department of Obstetrics and Gynecology, University of Melbourne and Mercy Perinatal Research Center, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia
Endocrinology 146:1491-7. 2005..Control of the IKK-beta/NF-kappa B pathway may therefore provide an alternative therapeutic strategy for regulating aberrant cytokine release and thereby alleviating insulin resistance in type 2 diabetes mellitus... - Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazoneMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Perinatal Research Centre, Mercy Hospital for Women, East Melbourne, Victoria, Australia 3002
J Clin Endocrinol Metab 87:4667-72. 2002..The data presented in this study demonstrate that the formation of proinflammatory mediators can be modulated by currently available therapeutic agents and may therefore be of therapeutic potential in human labor... - Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitroMartha Lappas
Department of Obstetrics and Gynaecology, Melbourne University, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, Victoria 3002, Australia
Biol Reprod 67:668-73. 2002..The control of NF-kappaB activation may therefore provide an alternative therapeutic strategy for reducing the release of proinflammatory mediators in infection associated preterm labor... - Effect of nuclear factor-kappa B inhibitors and peroxisome proliferator-activated receptor-gamma ligands on PTHrP release from human fetal membranesM Lappas
Department of Obstetrics and Gynaecology, The University of Melbourne and Mercy Perinatal Research Center, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, Victoria, Australia 3002
Placenta 25:699-704. 2004..05). This study demonstrates that PTHrP release from human fetal membranes is regulated by inhibitors of NF-kappaB, and ligands of PPAR-gamma... - Lipopolysaccharide and TNF-alpha activate the nuclear factor kappa B pathway in the human placental JEG-3 cellsM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, Victoria 3002, Australia
Placenta 27:568-75. 2006.... - Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated kinase Martha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, East Melbourne, Victoria, Australia
Endocrinology 146:3334-42. 2005.... - Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnanciesMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia
J Endocrinol 186:457-65. 2005..Furthermore, resistin release is greatly affected by a variety of inflammatory mediators and hormones... - Regulation of phospholipase isozymes by nuclear factor-kappaB in human gestational tissues in vitroMartha Lappas
Department of Obstetrics and Gynaecology, The University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, East Melbourne, Victoria, Australia 3002
J Clin Endocrinol Metab 89:2365-72. 2004..In addition, SASP concentrations of 5 mM or greater significantly suppressed NF-kappaB DNA binding activity. These data are consistent with the hypothesis that NF-kappaB regulates the expression and release of phospholipase isozymes... - 15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissuesM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, 163 Studley Road, Heidelberg 3084, Victoria, Australia
Placenta 27:1060-72. 2006..The data demonstrated in this study suggest that the 15d-PGJ(2) and troglitazone exhibit anti-inflammatory properties in human gestational tissues via PPAR-gamma independent actions... - The role and regulation of the nuclear factor kappa B signalling pathway in human labourM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, 4th Floor, 163 Studley Road, Heidelberg, Victoria 3084, Australia
Placenta 28:543-56. 2007.... - Phospholipase A2 isozymes in pregnancy and parturitionM Lappas
Mercy Perinatal Research Center, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne 3002, Australia
Prostaglandins Leukot Essent Fatty Acids 70:87-100. 2004.... - Decidual activation: abundance and localization of prostaglandin F2alpha receptor (FP) mRNA and protein and uterine activation proteins in human decidua at preterm birth and term birthS Makino
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan
Placenta 28:557-65. 2007.... - Release of proinflammatory cytokines and 8-isoprostane from placenta, adipose tissue, and skeletal muscle from normal pregnant women and women with gestational diabetes mellitusMartha Lappas
Department of Obstetrics and Gynecology, University of Melboure and Mercy Perinatal Research Center, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia
J Clin Endocrinol Metab 89:5627-33. 2004..These data are consistent with the hypothesis that oxidative stress may be involved in the progression and/or pathogenesis of GDM... - Human labour is associated with decreased cytoplasmic FoxO4R Lim
Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
Placenta 33:52-9. 2012..Although the exact role of FoxO4 in human pregnancy remains to be fully elucidated, our data demonstrate that it can regulate COX-2 expression and subsequent prostaglandin expression... - Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsiaS J Holdsworth-Carson
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Placenta 31:222-9. 2010..Peroxisome proliferator-activated receptors (PPARs), and their partner retinoid X receptor a (RXRalpha), mediate trophoblast differentiation and thus may offer insight into the pathophysiology of these diseases... - Increased oxidative stress in human fetal membranes overlying the cervix from term non-labouring and post labour deliveriesM Chai
Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
Placenta 33:604-10. 2012..In summary, non-labouring SC fetal membranes are characterised by reduced antioxidant enzyme activity when compared to distal membranes, and, as such, may be more susceptible to oxidative damage and thus membrane rupture... - Type II phospholipase A2 in preterm human gestational tissuesM Lappas
Department of Obstetrics and Gynecology, Melbourne University, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002, Victoria, Australia
Placenta 22:64-9. 2001..The data obtained in this study support a role for Type II PLA2 in association with spontaneous rupture of membranes... - Antiinflammatory effects of the cyclopentenone isoprostane 15-A(2)-IsoP in human gestational tissuesMartha Lappas
Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Free Radic Biol Med 42:1791-6. 2007..Cyclopentenone IsoPs may serve as negative feedback regulators of the inflammatory response in human gestational tissues... - Peroxisome proliferator-activated receptors and retinoid X receptor-alpha in term human gestational tissues: tissue specific and labour-associated changesS J Holdsworth-Carson
Department of Obstetrics and Gynaecology, University of Melbourne, Victoria 3084, Australia
Placenta 30:176-86. 2009..This data is consistent with the hypothesis that PPAR:RXR are involved in regulating of the processes of human term parturition... - Antisense oligonucleotide inhibition of type II phospholipase A2 expression, release and activity in vitroM Lappas
Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, East Melbourne, Victoria, Australia
Placenta 22:418-24. 2001..05). This data demonstrates the efficacy of antisense oligonucleotide inhibition of secretory PLA2 (sPLA2) expression and activity, and the contribution of sPLA2 to placental prostaglandin production... - Effect of high oxygen on placental function in short-term explant culturesNicole G Reti
Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia
Cell Tissue Res 328:607-16. 2007..These data are consistent with the hypothesis that hyperoxia activates pathways and mechanisms involved in cellular metabolism, necrosis and apoptosis, thereby shifting the balance from a steady state towards cell death... - Diabetes and obesity during pregnancy alter insulin signalling and glucose transporter expression in maternal skeletal muscle and subcutaneous adipose tissueMichelle Colomiere
Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Mercy Hospital for Women, University of Melbourne, 4th Floor, 163 Studley Road, Heidelberg 3084, Victoria, Australia
J Mol Endocrinol 44:213-23. 2010..Collectively, our results suggest that diabetes and obesity during pregnancy cause defects in insulin-signalling transduction in adipose tissue and skeletal muscle and may be the underlying cause of GDM... - Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitusMichelle Colomiere
Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne and Mercy Perinatal Research Centre, Heidelberg 3084, Victoria, Australia
Eur J Endocrinol 160:567-78. 2009..The present study tested the hypothesis that endogenous expression levels in the human term placenta of insulin signaling components are altered in placental tissue from GDM women in comparison with normal controls and maternal obesity... - Screening for biomarkers predictive of gestational diabetes mellitusHarry M Georgiou
Department of Obstetrics and Gynecology, University of Melbourne, Parkville, Vic, Australia
Acta Diabetol 45:157-65. 2008..Plasma insulin and adiponectin concentrations, when measured at 11 weeks, may be predictive of impending gestational diabetes. Further studies are warranted to determine the reliability of these biomarkers... - Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsiaC L Whitehead
Translational Obstetrics Group, The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Vic, Australia
BJOG 118:1268-71. 2011..We conclude that the novel primate-specific splice variant of sFlt-1 is highly expressed in both severe pre-eclampsia and HELLP... - Rational design of immunostimulatory siRNAsMichael P Gantier
Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Victoria, Australia
Mol Ther 18:785-95. 2010..Our data suggest that this sequence modification coupled with structural modification differentially recruits human TLR8 over TLR7, and could have potential application in antiviral therapies... - Why do membranes rupture at term? Evidence of increased cellular apoptosis in the supracervical fetal membranesNicole G Reti
Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Am J Obstet Gynecol 196:484.e1-10. 2007..Membrane apoptosis would provide a mechanism for the reduced tensile strength that presumably precedes spontaneous intrapartum rupture of the membranes...