Research Topics
| Allan O LanglandsSummaryAffiliation: University of Sydney Country: Australia Publications
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Detail Information
Publications
Modelling interrupted time series to evaluate prevention and control of infection in healthcareV Gebski
Division of Healthcare Quality Promotion, Centres for Disease Control and Prevention, Atlanta, GA, USA
Epidemiol Infect 140:2131-41. 2012..Both approaches yielded consistent results. Where feasible, a model adjusting for the unit effect should be fitted, or if there is heterogeneity, an analysis incorporating a random effect for units may be appropriate...
Clinical trial design in oncology: assessment of outcomesVal Gebski
NHMRC Clinical Trials Centre, University of Sydney, Australia
Lancet Oncol 5:761-3. 2004- Statistical methods in clinical trialsVal J Gebski
NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown, NSW 1450
Med J Aust 178:182-4. 2003 - Survival effects of postmastectomy adjuvant radiation therapy using biologically equivalent doses: a clinical perspectiveVal Gebski
National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Australia
J Natl Cancer Inst 98:26-38. 2006..We reanalyzed the results from 36 unconfounded trials (i.e., addition of radiation therapy was the sole discriminant between treatments being compared) that were identified in previous meta-analyses, which provided 38 comparisons... - Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysisVal Gebski
National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia
Lancet Oncol 8:226-34. 2007..We aimed to clarify the benefits of neoadjuvant chemoradiotherapy or chemotherapy versus surgery alone by a meta-analysis of randomised trial data... - Radiotherapy in the treatment of breast cancer: a personal retrospectiveAllan O Langlands
Breast 15:698-703. 2006..The incorporation of evidence from the clinical trials in breast cancer management, changes in radiation therapy techniques and incorporation of patient choice in treatment decisions are discussed... - Uterine papillary serous carcinoma: patterns of failure and survivalWei Wang
Department of Radiation Oncology, Westmead Hospital, Sydney, New South Wales, Australia
Aust N Z J Obstet Gynaecol 49:419-25. 2009..To evaluate the outcome in patients with uterine papillary serous carcinoma (UPSC)... - Factorial designs: a graphical aid for choosing study designs accounting for interactionKaren Byth
NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW, Australia
Clin Trials 1:315-25. 2004..The method is illustrated with respect to a published 2 x 2 factorial study. In this study, interaction reduced the power of the final analysis to detect significant main effects... - Dynamic balancing randomization in controlled clinical trialsStephane Heritier
National Health and Medical Research Council NHMRC Clinical Trials Centre, University of Sydney, NSW, Australia
Stat Med 24:3729-41. 2005..A comparison of DBR with minimization and a biased coin design is carried out by simulation on two simulated trials... - Managing the resource demands of a large sample size in clinical trials: can you succeed with fewer subjects?Anthony C Keech
NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown, NSW 1450, Australia
Med J Aust 177:445-7. 2002 - What is the value of computered tomography colonography in patients screening positive for fecal occult blood? A systematic review and economic evaluationSilke Walleser
National Health and Medical Research Council Clinical Trials Centre, University of Sydney, New South Wales, Australia
Clin Gastroenterol Hepatol 5:1439-46; quiz 1368. 2007..Because of high false-positive rates for FOBT, concerns have been raised about patient uptake and access to colonoscopy services. This study assessed the value of CTC as an alternative to colonoscopy in FOBT-positive individuals... - Specifying objectives and outcomes for clinical trialsVal Gebski
NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown, NSW 1450, Australia
Med J Aust 176:491-2. 2002 - Comparing patients' and clinicians' assessment of outcomes in a randomised trial of sentinel node biopsy for breast cancer (the RACS SNAC trial)Michaella J Smith
NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, NSW, Australia
Breast Cancer Res Treat 117:99-109. 2009..6). Patients' ratings on single items were 3-5 times more efficient than clinicians' measurements. Primary endpoints based on patient-rated outcome measures could reduce the required sample size in future surgical trials... - Selective mastectomy in the management of locally advanced breast cancerVerity Ahern
Department of Radiation Oncology, Westmead Hospital, NSW 2145, Sydney, Australia
Int J Radiat Oncol Biol Phys 68:1010-7. 2007..To evaluate local control for patients with locally advanced noninflammatory breast cancer (LABC) managed by selective mastectomy... - Merkel cell carcinoma: improved outcome with adjuvant radiotherapyMichael J Veness
Head and Neck Cancer Service, Westmead Hospital, Sydney, Australia
ANZ J Surg 75:275-81. 2005..Patients remain at high risk of locoregional and distant relapse despite treatment. Most studies support the incorporation of locoregional adjuvant radiotherapy in reducing the risk of relapse... - Outcome and patterns of recurrence for International Federation of Gynecology and Obstetrics (FIGO) stages I and II squamous cell vulvar cancerCharuwan Tantipalakorn
Gynaecological Cancer Centre, Royal Hospital for Women and University of New South Wales, Sydney, Australia
Obstet Gynecol 113:895-901. 2009.... - Surgery and adjuvant radiotherapy in patients with cutaneous head and neck squamous cell carcinoma metastatic to lymph nodes: combined treatment should be considered best practiceMichael J Veness
Head and Neck Cancer Service, Westmead Hospital, University of Sydney, Sydney, Australia. michael.radonc.wsahs.nsw.gov.au
Laryngoscope 115:870-5. 2005..004) compared to surgery alone. CONCLUSIONS: In patients with metastatic cutaneous head and neck SCC, surgery and adjuvant radiotherapy provide the best chance of achieving locoregional control and should be considered best practice... - Parotid lymph-node metastases from cutaneous squamous-cell carcinomas: treatment outcome and prognostic factors following surgery and adjuvant radiotherapyMargaret S-T Chua
Joint Radiation Oncology Centre, Westmead and Nepean Hospitals, Westmead, Sydney, Australia
Australas Radiol 46:174-9. 2002..The role of altered fractionation after surgery as a means to further enhance locoregional control warrants further investigation... - Secondary cytoreductive surgery for recurrent epithelial ovarian cancerEng Hseon Tay
Gynaecological Cancer Centre, Royal Hospital for Women, Department of Obstetrics and Gynaecology, University of New South Wales, Sydney, Australia
Obstet Gynecol 99:1008-13. 2002.... - Anterior tongue cancer: age is not a predictor of outcome and should not alter treatmentMichael J Veness
Head and Neck Unit, Westmead Hospital, Sydney, New South Wales, Australia
ANZ J Surg 73:899-904. 2003..The aetiology remains unclear and the anterior tongue is a prevalent site. Prognosis has been reported as worse in young patients and some have proposed a more aggressive treatment approach... - Anterior tongue cancer and the incidence of cervical lymph node metastases with increasing tumour thickness: should elective treatment to the neck be standard practice in all patients?Michael J Veness
Head and Neck Cancer Service, Westmead Hospital, Sydney, New South Wales, Australia
ANZ J Surg 75:101-5. 2005..There is an increasing risk of cervical lymph node metastases as tumour thickness increases in patients with anterior tongue squamous cell carcinoma (SCC). The role of elective neck treatment in early anterior tongue cancer in unclear... - Adjuvant locoregional radiotherapy as best practice in patients with Merkel cell carcinoma of the head and neckMichael J Veness
Head and Neck Cancer Service, Westmead Hospital, Westmead, NSW, 2145, Sydney, Australia
Head Neck 27:208-16. 2005..The purpose of this study was to report the patterns of recurrence after initial treatment, the outcomes, and any predictors for survival... - The role of radiotherapy alone in patients with merkel cell carcinoma: reporting the Australian experience of 43 patientsMichael Veness
Department of Radiation Oncology, Westmead Hospital, University of Sydney, Sydney, Australia
Int J Radiat Oncol Biol Phys 78:703-9. 2010..To review the role of radiotherapy (RTx) alone in patients with Merkel cell carcinoma (MCC)... - Determining the sample size in a clinical trialAdrienne Kirby
NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW
Med J Aust 177:256-7. 2002 - The Chinese herbal formulation biminne in management of perennial allergic rhinitis: a randomized, double-blind, placebo-controlled, 12-week clinical trialGuorang Hu
Department of Medicine, University of Sydney, Australia
Ann Allergy Asthma Immunol 88:478-87. 2002..Total serum immunoglobulin E was reduced after the herbal treatment. CONCLUSIONS: Our results suggest the Biminne formulation is effective in treatment of perennial AR. Its mode of action is unknown... - Australian prostate-specific antigen outcome and toxicity following radiation therapy for localized prostate cancerAndrew Kneebone
Collaboration for Cancer Outcomes Research and Evaluation, Liverpool Health Service, Sydney, New South Wales, Australia
Australas Radiol 47:422-7. 2003..Long-term toxicity was very acceptable. However, further improvement in outcome is desirable, and with the adoption of new technology allowing escalation of radiotherapy doses such an expectation might be achieved... - Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trialBryan H Burmeister
University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Lancet Oncol 6:659-68. 2005..We aimed to assess whether a short preoperative chemoradiotherapy regimen improves outcomes for patients with resectable oesophageal cancer... - Randomisation in clinical trialsElaine M Beller
Queensland Clinical Trials Centre, University of Queensland, Herston, QLD, Australia
Med J Aust 177:565-7. 2002 - Participation in the RACS sentinel node biopsy versus axillary clearance trialNeil R Wetzig
Wesley Medical Centre, Brisbane, Queensland, Australia
ANZ J Surg 75:98-100. 2005..The Royal Australasian College of Surgeons (RACS) SNAC trial is a randomized controlled trial of sentinel node biopsy (SNB) versus axillary clearance (AC). It opened in May 2001 and is recruiting rapidly with good acceptance by consumers... - A pilot study of preoperative and postoperative chemotherapy in patients with operable gastric cancer: Australasian Gastrointestinal Trials Group Study 9601Michael Findlay
Wellington Cancer Centre, Wellington Hospital, Wellington, New Zealand
ANZ J Surg 77:247-52. 2007..With poor cure rates in gastric cancer using surgery alone, the safety, efficacy and feasibility of preoperative and postoperative chemotherapy was investigated... - On the issue of 'multiple' first failures in competing risks analysisBee Choo Tai
NMRC Clinical Trials and Epidemiology Research Unit, 10 College Road, Singapore 169851
Stat Med 21:2243-55. 2002..However, it takes a longer computer running time, especially when the number of replicates is large. The weighted Cox approach is the method of choice where statistical software allows its implementation without extra programming effort... - Influence of the way results are presented on research interpretation and medical decision making: the PRIMER collaboration randomized studiesThomas Philip Shakespeare
North Coast Cancer Institute, Coffs Harbour Health Campus, Coffs Harbour, New South Wales, Australia
Med Decis Making 28:127-37. 2008..The authors evaluate whether the use of confidence levels improve research interpretation and decision making compared with P values and 95% confidence intervals... - Evaluation of the quality of radiotherapy randomized trials for painful bone metastasesThomas P Shakespeare
Department of Radiation Oncology, Tan Tock Seng Hospital, Singapore
Cancer 103:1976-81. 2005..The goals of the current study were to evaluate the quality of randomized studies using a validated checklist and to discuss implications and future directions... - First-event or marginal estimation of cause-specific hazards for analysing correlated multivariate failure-time data?Bee Choo Tai
Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Stat Med 27:922-36. 2008..Although the coverage is poor for a correlation of 0.7 and beyond, such a high correlation between competing event times may be biologically rather implausible... - Estimating risks of radiotherapy complications as part of informed consent: the high degree of variability between radiation oncologists may be related to experienceThomas Philip Shakespeare
National University Hospital, Singapore, Singapore
Int J Radiat Oncol Biol Phys 54:647-53. 2002..Estimating the risks of radiotherapy (RT) toxicity is important for informed consent; however, the consistency in estimates has not been studied. This study aimed to explore the variability and factors affecting risk estimates (REs)... - Guidelines for statistical analysis of percentage of syllables stuttered dataMark Jones
School of Population Health, University of Queensland, Brisbane, Australia
J Speech Lang Hear Res 49:867-78. 2006..Under these circumstances, analyses should be based on standard methods, with a suitable transformation performed prior to analysis... - Patterns of metastases in familial and non-familial melanomaJoanne Hornbuckle
Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, NSW 2145, Australia
Melanoma Res 13:105-9. 2003..Genetic susceptibility for melanoma may lower the threshold for entering an otherwise common molecular pathway for tumour development and evolution... - A randomized trial evaluating rigid immobilization for pelvic irradiationAndrew Kneebone
Cancer Therapy Centre, Liverpool Hospital, Liverpool, Australia
Int J Radiat Oncol Biol Phys 56:1105-11. 2003..In recent years, a number of pelvic immobilization techniques have been developed. Few have been evaluated in randomized trials, and many of these studies have produced contradictory and inconclusive results... - Presenting symptoms of epithelial ovarian cancerIsam Lataifeh
Gynaecological Cancer Centre, Royal Hospital for Women, University of New South Wales, Australia
Aust N Z J Obstet Gynaecol 45:211-4. 2005..CONCLUSION: Patients with early stage ovarian cancer are likely to be younger and to have larger, better differentiated tumours that are more often non-serous histologically. Advanced disease is not invariably due to delayed diagnosis... - Statistical power in stuttering research: a tutorialMark Jones
National Health and Medical Research Council of Australia, Clinical Trials Centre, The University of Sydney
J Speech Lang Hear Res 45:243-55. 2002..With this in mind, the paper concludes with an attempt to open discussion about ways to redress the problems associated with statistical power...