Sunil R Lakhani

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 11:5175-80. 2005
  2. pmc Rare variants in the ATM gene and risk of breast cancer
    David E Goldgar
    Department of Dermatology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2101, USA
    Breast Cancer Res 13:R73. 2011
  3. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010
  4. pmc Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines
    Annika N Alexopoulou
    University of Oxford Branch, Ludwig Institute for Cancer Research, Old Road Campus, off Roosevelt Drive, Oxford OX3 7DQ, UK
    Breast Cancer Res 12:R51. 2010
  5. pmc Incorporating tumour pathology information into breast cancer risk prediction algorithms
    Nasim Mavaddat
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK
    Breast Cancer Res 12:R28. 2010
  6. pmc Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival
    Laura G Fulford
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res 9:R4. 2007
  7. pmc Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?
    Paul K Lovelock
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston Road, Queensland 4029, Australia
    Breast Cancer Res 9:R82. 2007
  8. pmc Breast cancer stem cells: implications for therapy of breast cancer
    Brian J Morrison
    Queensland Institute of Medical Research, Royal Brisbane Hospital Post Office, Brisbane 4029, Australia
    Breast Cancer Res 10:210. 2008
  9. ncbi request reprint The management of lobular carcinoma in situ (LCIS). Is LCIS the same as ductal carcinoma in situ (DCIS)?
    Sunil R Lakhani
    Molecular and Cellular Pathology, School of Medicine, The University of Queensland, Mayne Medical School, Brisbane, QLD 4006, Australia
    Eur J Cancer 42:2205-11. 2006
  10. doi request reprint Aberrant expression of E-cadherin in lobular carcinomas of the breast
    Leonard Da Silva
    Molecular and Cellular Pathology, Mayne Medical School, University of Queensland, Brisbane, Australia
    Am J Surg Pathol 32:773-83. 2008

Detail Information

Publications69

  1. ncbi request reprint Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 11:5175-80. 2005
    ..To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients...
  2. pmc Rare variants in the ATM gene and risk of breast cancer
    David E Goldgar
    Department of Dermatology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2101, USA
    Breast Cancer Res 13:R73. 2011
    ..However, the magnitude of risk and the subset of variants that are pathogenic for breast cancer remain unresolved...
  3. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010
    ....
  4. pmc Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines
    Annika N Alexopoulou
    University of Oxford Branch, Ludwig Institute for Cancer Research, Old Road Campus, off Roosevelt Drive, Oxford OX3 7DQ, UK
    Breast Cancer Res 12:R51. 2010
    ..The purpose of the study was to identify the role of NR4A1 in normal mammary epithelial and breast cancer cell biology...
  5. pmc Incorporating tumour pathology information into breast cancer risk prediction algorithms
    Nasim Mavaddat
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK
    Breast Cancer Res 12:R28. 2010
    ..In particular, oestrogen receptor (ER)-negative status, triple-negative (TN) status, and expression of basal markers are predictive of BRCA1 mutation carrier status...
  6. pmc Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival
    Laura G Fulford
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res 9:R4. 2007
    ..Previous studies have suggested that expression of such 'basal' markers predicts different biological behaviour, with more frequent lung and brain metastases and poorer prognosis than other carcinomas...
  7. pmc Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?
    Paul K Lovelock
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston Road, Queensland 4029, Australia
    Breast Cancer Res 9:R82. 2007
    ....
  8. pmc Breast cancer stem cells: implications for therapy of breast cancer
    Brian J Morrison
    Queensland Institute of Medical Research, Royal Brisbane Hospital Post Office, Brisbane 4029, Australia
    Breast Cancer Res 10:210. 2008
    ..Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells...
  9. ncbi request reprint The management of lobular carcinoma in situ (LCIS). Is LCIS the same as ductal carcinoma in situ (DCIS)?
    Sunil R Lakhani
    Molecular and Cellular Pathology, School of Medicine, The University of Queensland, Mayne Medical School, Brisbane, QLD 4006, Australia
    Eur J Cancer 42:2205-11. 2006
    ..In this review, the working group on behalf of EUSOMA has attempted to summarise the current thinking and management of this interesting lesion...
  10. doi request reprint Aberrant expression of E-cadherin in lobular carcinomas of the breast
    Leonard Da Silva
    Molecular and Cellular Pathology, Mayne Medical School, University of Queensland, Brisbane, Australia
    Am J Surg Pathol 32:773-83. 2008
    ..Misclassification of tumors may lead to mismanagement of patients in clinical practice, particularly in the context of in situ disease at margins...
  11. ncbi request reprint FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas
    Jorge Sergio Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 12:6652-62. 2006
    ..However, little is known about the putative therapeutic targets for these tumors. The aim of this study was to characterize CLCs at the molecular genetic level and identify putative therapeutic targets...
  12. doi request reprint Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assay
    Nic Waddell
    The Queensland Institute of Medical Research, Brisbane, Australia
    J Pathol 221:452-61. 2010
    ....
  13. ncbi request reprint Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK
    J Pathol 207:1-13. 2005
    ..Taken together, these data suggest that at least some PLCs may evolve from the same precursor or through the same genetic pathway as classic lobular carcinomas...
  14. doi request reprint Subtypes of familial breast tumours revealed by expression and copy number profiling
    Nic Waddell
    Queensland Institute of Medical Research, Brisbane, Australia
    Breast Cancer Res Treat 123:661-77. 2010
    ..This study highlights the heterogeneity of familial tumours and the clinical consequences for treatment and prognosis...
  15. doi request reprint Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary
    Phillip J Whiley
    Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mutat 32:678-87. 2011
    ....
  16. doi request reprint Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression
    Ana Cristina Vargas
    UQ Centre for Clinical Research, The University of Queensland, Herston, Brisbane, QLD, Australia
    Breast Cancer Res Treat 135:153-65. 2012
    ..We propose that these expression changes could be involved in facilitating the transition from in situ disease to invasive cancer and may thus mark a critical point in disease development...
  17. ncbi request reprint Pathology of ovarian cancers in BRCA1 and BRCA2 carriers
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 10:2473-81. 2004
    ..Our aim was to evaluate the morphologies and immunophenotypes in a large cohort of patients with familial ovarian cancer...
  18. pmc MicroRNA-182-5p targets a network of genes involved in DNA repair
    Keerthana Krishnan
    Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
    RNA 19:230-42. 2013
    ..Finally, we show that miR-182-5p is highly expressed in a panel of human breast cancer samples, highlighting its role as a potential oncomir in breast cancer...
  19. ncbi request reprint Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis
    Peter T Simpson
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Am J Surg Pathol 29:734-46. 2005
    ..These data further support the hypothesis that CCLs are a nonobligate, intermediary step in the development of some forms of low grade in situ and invasive carcinoma...
  20. ncbi request reprint Molecular cytogenetic identification of subgroups of grade III invasive ductal breast carcinomas with different clinical outcomes
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Clin Cancer Res 10:5988-97. 2004
    ..Robust characterization of this basal group is necessary if it is to have a major impact on management of patients with breast cancer...
  21. ncbi request reprint The molecular genetics of breast cancer: the contribution of comparative genomic hybridization
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Pathol Res Pract 201:713-25. 2005
    ..CGH has been instrumental in dissecting distinct molecular pathways toward breast malignancy and in establishing a direct relationship between genotype and clinical pathological features...
  22. doi request reprint Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer
    Amelia A Peters
    The University of Queensland, School of Pharmacy, Brisbane, Queensland, Australia, 4072
    Mol Cancer Ther 11:2158-68. 2012
    ..Our findings suggest that inhibitors of TRPV6 may offer a novel therapeutic strategy for the treatment of ER-negative breast cancers...
  23. pmc Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors
    Chanel E Smart
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 7:e40742. 2012
    ..These data indicate that PTPRJ may regulate differentiation of normal mammary epithelia and that dysregulation of protein localisation may be associated with tumorigenesis...
  24. pmc HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
    Breast Cancer Res 12:R46. 2010
    ..Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear...
  25. doi request reprint Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis
    Leonard Da Silva
    University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Level 6, Building 71 918, Herston, Brisbane, 4029, Australia
    Virchows Arch 454:107-14. 2009
    ..These molecular data highlight the genomic instability of TA, a benign florid proliferation intermingled with ACC, and do not provide evidence of molecular evolution from TA to ACC...
  26. ncbi request reprint Myoepithelial cells: pathology, cell separation and markers of myoepithelial differentiation
    Catherine Clarke
    Molecular and Cellular Pathology, Mayne Medical School, Queensland Institute of Medical Research and The Royal Brisbane and Women s Hospital, University of Queensland, Brisbane, QLD, Australia
    J Mammary Gland Biol Neoplasia 10:273-80. 2005
    ..These immunohistochemical data, combined with genomic studies, may lead to better identification and management of patients with 'basal' tumors...
  27. ncbi request reprint Distribution and significance of 14-3-3sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 202:274-85. 2004
    ..This analysis demonstrates the utility of 14-3-3sigma as a new adjunct antibody for characterization of myoepithelial cells and myoepithelial lesions and it may be a novel prognostic factor for breast cancer patients...
  28. pmc Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
    Jorge S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 7:R1028-35. 2005
    ..We investigated whether HER2 and EGFR overexpression was present and evaluated gene amplification in a series of metaplastic breast carcinomas...
  29. pmc Bayes analysis provides evidence of pathogenicity for the BRCA1 c.135-1G>T (IVS3-1) and BRCA2 c.7977-1G>C (IVS17-1) variants displaying in vitro splicing results of equivocal clinical significance
    Amanda B Spurdle
    Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mutat 31:E1141-5. 2010
    ..Multifactorial likelihood analysis indicates that the BRCA1 c.135-1G>T and BRCA2 c.7977-1G>C variants are disease-associated mutations which should be managed clinically in the same fashion as classical truncating mutations...
  30. ncbi request reprint Molecular evolution of breast cancer
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 205:248-54. 2005
    ..However, only through the combination of comprehensive morphological analysis and cutting-edge molecular tools can this knowledge be translated into clinical practice and patient management...
  31. pmc Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity
    Logan C Walker
    Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mutat 31:E1484-505. 2010
    ..Arg3052Trp), supporting experimentally derived evidence. These findings highlight the need for improved bioinformatic prediction of splicing aberrations and to refine multifactorial likelihood models used to assess clinical significance...
  32. doi request reprint The contribution of breast cancer pathology to statistical models to predict mutation risk in BRCA carriers
    Ana Cristina Vargas
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Building 71 918, Brisbane, QLD 4029, Australia
    Fam Cancer 9:545-53. 2010
    ..Here we review the pathology of familial breast cancer and assess the evidence to justify the use of pathology in refining risk assessment models...
  33. doi request reprint Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization
    Leonard Da Silva
    The University of Queensland, UQ Centre for Clinical Research, Herston, Building 918 B71, Royal Brisbane and Women s Hospital, Herston, QLD, 4029, Australia
    Endocr Pathol 22:103-7. 2011
    ....
  34. ncbi request reprint Cytokeratin 5/6 in normal human breast: lack of evidence for a stem cell phenotype
    Catherine L Clarke
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 204:147-52. 2004
    ..This study brings into question the previously described profile of breast 'stem cells' based on CK5/6 staining and hence the breast cancer progression model and classification based on this phenotype...
  35. pmc In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity
    Chanel E Smart
    UQ Centre for Clinical Research UQCCR, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 8:e64388. 2013
    ..Sphere culture may represent an alternative 3-dimensional culture system which rather than universally 'enriching' for stem cells, has utility as one of a suite of functional assays that provide a read-out of progenitor activity...
  36. pmc The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 5:313-9. 2003
    ..We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and pre-invasive lesions...
  37. ncbi request reprint Breast pathology: beyond morphology
    Peter T Simpson
    University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia
    Semin Diagn Pathol 27:91-6. 2010
    ....
  38. doi request reprint Pathology of hereditary breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia
    Mod Pathol 23:S46-51. 2010
    ..A number of low-to-moderate-penetrant genes/loci have also been identified, but their role and contribution in breast cancer development is still under investigation...
  39. doi request reprint Breast cancer stem cells: treatment resistance and therapeutic opportunities
    Fares Al-Ejeh
    Signal Transduction Lab, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia
    Carcinogenesis 32:650-8. 2011
    ..As a means to increase the rates of breast cancer cure, several approaches to specific targeting of the treatment-resistant cell population exist and include methods for addressing the problem of radioresistance in particular...
  40. doi request reprint Phenotype-genotype correlation in familial breast cancer
    Ana Cristina Vargas
    UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia
    J Mammary Gland Biol Neoplasia 16:27-40. 2011
    ..Here we review the current understanding of phenotype-genotype correlation in familial breast cancer...
  41. doi request reprint Application of molecular findings to the diagnosis and management of breast disease: recent advances and challenges
    Peter T Simpson
    Molecular and Cellular Pathology, The University of Queensland, UQ Centre for Clinical Research, Herston, 4029 Brisbane, Australia
    Hum Pathol 42:153-65. 2011
    ..The integration of these multiple layers of new knowledge will have a major impact in clinical oncology, leading to significant breakthroughs in diagnosis and treatment...
  42. ncbi request reprint Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Res 64:3037-45. 2004
    ..These data provide a framework for the interpretation of breast cancer molecular profiling experiments, the identification of potential new diagnostic markers, and development of novel indicators of prognosis...
  43. doi request reprint Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor
    Fares Al-Ejeh
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Nucl Med 54:913-21. 2013
    ....
  44. doi request reprint Current and future approach to the pathologist's assessment for targeted therapy in breast cancer
    Pria Pakkiri
    School of Medicine, The University of Queensland, Queensland, Australia
    Pathology 41:89-99. 2009
    ....
  45. doi request reprint Metastatic progression of breast cancer: insights from 50 years of autopsies
    Margaret C Cummings
    The University of Queensland, UQ Centre for Clinical Research, Herston, Brisbane, QLD, Australia Pathology Queensland, Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia The University of Queensland, School of Medicine, Herston, Brisbane, QLD, Australia
    J Pathol 232:23-31. 2014
    ..2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. ..
  46. doi request reprint Intraoperative imprint cytology for breast cancer sentinel nodes: is it worth it?
    Angela D M Richards
    University of Queensland School of Medicine, Brisbane, Queensland, Australia
    ANZ J Surg 83:539-44. 2013
    ..The aim of this study was to determine whether touch imprint cytology (TIC) could reduce returns to theatre without compromising patient safety and pathology department and operating theatre efficiency...
  47. ncbi request reprint The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2
    Sunil R Lakhani
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research and the Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 20:2310-8. 2002
    ..This study evaluates the immunohistochemical profiles of tumors arising in patients with mutations in these genes...
  48. pmc The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 5:258-62. 2003
    ..LCIS is now considered a risk factor and a non-obligate precursor for the subsequent development of invasive cancer...
  49. ncbi request reprint Pathologic quiz case: a 62-year-old woman with a 4.5-cm nodule in the right breast. Lipid-rich breast carcinoma
    Jorge S Reis-Filho
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Arch Pathol Lab Med 127:e396-8. 2003
  50. doi request reprint What's in a cancer syndrome? Genes, phenotype and pathology
    Nicola Wayte
    The Queensland Institute of Medical Research, Brisbane, Australia
    Pathology 40:247-59. 2008
    ....
  51. ncbi request reprint Mutation analysis of five candidate genes in familial breast cancer
    Anna Marsh
    Cancer and Cell Biology, Queensland Institute of Medical Research, c o RBH Post Office, Herston, Brisbane, QLD, 4029, Australia
    Breast Cancer Res Treat 105:377-89. 2007
    ..Although we identified many novel variants, we found no evidence that highly penetrant germline mutations in these five genes contribute to familial breast cancer susceptibility...
  52. doi request reprint Molecular classification of breast cancer: is it time to pack up our microscopes?
    Margaret C Cummings
    The University of Queensland, UQ Centre for Clinical Research, Herston, Australia
    Pathology 43:1-8. 2011
    ..Whether the molecular classification is as useful for special subtypes of breast cancers as it has been for ductal carcinoma, no special type, remains to be determined...
  53. ncbi request reprint Pathologic quiz case: a 93-year-old woman with an enlarged and tender left breast. Histiocytoid variant of lobular breast carcinoma
    Jorge S Reis-Filho
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, England
    Arch Pathol Lab Med 127:1626-8. 2003
  54. ncbi request reprint In situ carcinoma - can we predict which patient will come back with a recurrence?
    Peter T Simpson
    Molecular and Cellular Pathology, School of Medicine, University of Queensland, Herston QLD 4006, Australia
    Cancer Cell 12:409-11. 2007
    ..In this issue of Cancer Cell, Gauthier and colleagues suggest that abrogated response to cell stress measured by analysis of p16 and the proliferation marker Ki67 accurately predicts recurrence in ductal carcinoma in situ...
  55. doi request reprint Pleomorphic lobular carcinoma of the breast: molecular pathology and clinical impact
    Ana Cristina Vargas
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, Brisbane, Australia
    Future Oncol 5:233-43. 2009
    ..It is now important to define the most appropriate management strategy for patients diagnosed with pleomorphic lobular carcinoma...
  56. doi request reprint Fibroadenoma and intraduct papilloma--a common pathogenesis?
    Margaret C Cummings
    Molecular and Cellular Pathology, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia
    Virchows Arch 455:271-5. 2009
    ..That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed...
  57. pmc Molecular aspects of breast cancer metastasis to the brain
    Jodi M Saunus
    UQ Centre for Clinical Research, The University of Queensland, Herston, QLD 4029, Australia
    Genet Res Int 2011:219189. 2011
    ....
  58. ncbi request reprint In-situ lobular neoplasia: time for an awakening
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, and Royal Marsden Hospital, SW3 6JB, London, UK
    Lancet 361:96. 2003
  59. ncbi request reprint Comparative genomic hybridization analysis of bilateral hyperplasia of usual type of the breast
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 199:152-6. 2003
    ..The limited data from these experiments do not reveal a specific predisposition locus...
  60. ncbi request reprint Typical medullary breast carcinomas have a basal/myoepithelial phenotype
    Jocelyne Jacquemier
    Marseille Cancer Institute, Molecular Oncology Department, UMR599 INSERM and Paoli Calmettes Institute, Marseille, France
    J Pathol 207:260-8. 2005
    ..In multivariate analysis with logistic regression, TMBC was defined by the association of P-cadherin (R=2.29), MIB1 > 50 (R=3.80), ERBB2 negativity (R=2.24) and p53 positivity (RR=1.45)...
  61. doi request reprint Clinical classification of BRCA1 and BRCA2 DNA sequence variants: the value of cytokeratin profiles and evolutionary analysis--a report from the kConFab Investigators
    Amanda B Spurdle
    Queensland Institute of Medical Research, c o Royal Brisbane Hospital Post Office, Herston, Queensland 4029, Australia
    J Clin Oncol 26:1657-63. 2008
    ..We assessed the value of tumor immunohistochemical markers in conjunction with genetic and evolutionary approaches for investigating the clinical significance of unclassified variants...
  62. ncbi request reprint A test of performance of breast MRI interpretation in a multicentre screening study
    Ruth Warren
    Department of Radiology, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Magn Reson Imaging 24:917-29. 2006
    ..The aim of this study was to assess the consistency and performance of radiologists interpreting breast magnetic resonance imaging (MRI) examinations...
  63. ncbi request reprint Evaluation of a prospective scoring system designed for a multicenter breast MR imaging screening study
    Ruth M L Warren
    Department of Radiology, Addenbrooke s Hospital, Cambridge, England, and Department of Radiology, University of Aberdeen, Aberdeen, Scotland
    Radiology 239:677-85. 2006
    ..To evaluate prospectively the accuracy of a lesion classification system designed for use in a magnetic resonance (MR) imaging high-breast-cancer-risk screening study...
  64. ncbi request reprint Expression profiling using cDNA microarrays
    Chris Jones
    The Breakthrough Toby Robins Breast Research Centre at the Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Methods Mol Med 120:403-14. 2006
    ....
  65. ncbi request reprint The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours
    Elinor J Sawyer
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Pathol 196:437-44. 2002
    ..In the progression to malignancy, the stromal proliferation appears to become independent of the Wnt pathway and, presumably, of the epithelial component of these tumours...
  66. ncbi request reprint Malignant adenomyoepithelioma of the breast metastasizing to the liver
    Chris Jones
    Virchows Arch 442:504-6. 2003
  67. ncbi request reprint cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells
    Alan Mackay
    LICR UCL Breast Cancer Laboratory, University College London, London, UK
    Oncogene 22:2680-8. 2003
    ..These data represent profiles of the transcriptional changes associated with ERBB2-related pathways in the breast, and identify novel and potentially useful targets for prognosis and therapy...
  68. pmc The diagnosis and management of pre-invasive breast disease--current challenges, future hopes
    Sunil R Lakhani
    Breast Cancer Res 5:248-9. 2003
  69. ncbi request reprint Somatic mutations of the protein kinase gene family in human lung cancer
    Helen Davies
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, United Kingdom
    Cancer Res 65:7591-5. 2005
    ..The results suggest that several mutated protein kinases may be contributing to lung cancer development, but that mutations in each one are infrequent...