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Genomes and Genes | Nicole L La GrutaSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
Multiplexed combinatorial tetramer staining in a mouse model of virus infectionTania Cukalac
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
J Immunol Methods 360:157-61. 2010....
A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responsesNicole L La Gruta
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
Eur J Immunol 36:2951-9. 2006..Furthermore, this study shows that different indicators of avidity do not necessarily provide similar information and should be used in combination to obtain an overall picture of the characteristics of TCR binding...
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansionNicole L La Gruta
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Clin Invest 120:1885-94. 2010..These findings suggest possibilities for enhancing protective immune memory by maximizing both the size and diversity of typically subdominant T cell responses through rational vaccine design...- Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidityNicole L La Gruta
Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
J Immunol 172:5553-60. 2004.... - A question of self-preservation: immunopathology in influenza virus infectionNicole L La Gruta
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
Immunol Cell Biol 85:85-92. 2007.... - A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequenciesNicole L La Gruta
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
Proc Natl Acad Sci U S A 103:994-9. 2006..Thus, this immunodominance hierarchy is a direct function of antigen dose and T cell numbers... - Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation thresholdSophie A Valkenburg
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
PLoS Pathog 6:e1001039. 2010..Our study does not support vaccine strategies that include immunization against commonly selected cross-reactive variants with mutations at partially-solvent exposed residues that have characteristics comparable to NPN3A... - Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptidesNicole L La Gruta
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Victoria, Australia
Proc Natl Acad Sci U S A 105:2034-9. 2008..Thus, whereas a diverse repertoire may be important for recognition of epitope variants, its effect on the response to cognate pMHC recognition appears minimal... - Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responsesE Bridie Day
Department of Microbiology and Immunology, Bio21, Department of Biochemistry, University of Melbourne, Parkville, VIC 3010, Australia
Proc Natl Acad Sci U S A 108:9536-41. 2011..Overall, these data provide an explanation for the combination of TCRV region bias and diversity within selected repertoires, even as they maintain exquisite pMHCI specificity... - Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responsesKatherine Kedzierska
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
J Immunol 181:2556-62. 2008..The key finding is thus that the role of TdT in ensuring enhanced diversity and the selection of private TCR repertoires promotes optimal CD8(+) T cell immunity, both within individuals and across the species as a whole... - Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cellsMisty R Jenkins
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Immunol 181:3818-22. 2008..Thus, while effector gene expression can be acquired early, maturation of cytotoxic capacity requires extended differentiation... - Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunityShirley G K Seah
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
Eur J Immunol 42:1744-54. 2012..We suggest that direct CD28 costimulation of CD8(+) T cells is more critical in their priming during primary influenza infection than previously appreciated... - Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populationsStephen J Turner
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
Nat Immunol 6:382-9. 2005..Thus, the lack of prominent features in an antigenic complex of peptide and major histocompatibility complex class I is associated with a diminished spectrum of TCR usage... - Functional implications of T cell receptor diversityStephen J Turner
Department of Microbiology and Immunology, The University of Melbourne, Victoria, Australia
Curr Opin Immunol 21:286-90. 2009..Here, we review recent advances demonstrating a link between T cell repertoire diversity and immunity to infection, and consider the potential mechanisms at play... - Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversityKatherine Kedzierska
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
Mol Immunol 45:607-18. 2008.... - Establishment and recall of CD8+ T-cell memory in a model of localized transient infectionKatherine Kedzierska
Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
Immunol Rev 211:133-45. 2006.... - Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infectionStephen J Turner
Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia
Semin Immunol 16:179-84. 2004..The approach offers novel insights into the factors determining the selection of immune repertoires, and their functional consequences for CD8(+) T cell-mediated immunity... - Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responsesKatherine Kedzierska
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
Proc Natl Acad Sci U S A 102:11432-7. 2005..Thus, whereas TCR sequence (or affinity) appears to contribute substantially to the avidity profile of diverse virus-specific CD8+ populations, other mechanisms may be prominent where the TCR spectrum is more limited... - Influenza epitope-specific CD8+ T cell avidity, but not cytokine polyfunctionality, can be determined by TCRβ clonotypeJessica M Moffat
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Immunol 185:6850-6. 2010..These data suggest that factors other than TCRβ sequence influence cytokine profiles and demonstrate no link between differential avidity and polyfunctionality... - IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cellsAlice E Denton
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
Eur J Immunol 37:368-75. 2007..Together, our results suggest that IL-18, but not IL-12, induces optimal, antigen-specific production of key cytokines by CD8+ T cells for the efficient clearance of influenza virus from the lungs of infected mice... - Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigensLouise J Young
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 104:17753-8. 2007..These observations have important implications for the design of prophylactic and therapeutic DC vaccines and contribute to the understanding of the mechanisms causing immunosuppression during systemic blood infections... - Killer T cells in influenzaJohn Stambas
Department of Microbiology and Immunology, University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia
Pharmacol Ther 120:186-96. 2008..Understanding the complexities of CD8+ T cell mediated immunity and memory has the potential for improving vaccine design, particularly to combat pandemics caused by newly emerging influenza viruses... - Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector functionE Bridie Day
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
J Immunol 186:6319-28. 2011..Such findings illustrate the difficulties of predicting and defining the effects of MHC class I diversification on epitope-specific responses... - A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivoZi Zhao Lieu
Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute and Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
Proc Natl Acad Sci U S A 105:3351-6. 2008..Also, we have demonstrated a previously undescribed approach to control cytokine secretion by the specific silencing of trafficking machinery... - Precursor frequency and competition dictate the HLA-A2-restricted CD8+ T cell responses to influenza A infection and vaccination in HLA-A2.1 transgenic miceAmabel C L Tan
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Victoria, Australia
J Immunol 187:1895-902. 2011.... - The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responsesShirley G K Seah
The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Eur J Immunol 41:1499-500. 2011 - Thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic T cellsKaren L Laurie
Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Australia. Division of Immunobiology, University of Bonn, Bonn, Germany
J Immunol 172:5994-6002. 2004..These findings also suggest that the precise level of tissue-specific Ags in the thymus may be an important consideration in protection against autoimmune disease and that perturbation of the levels of self-Ags may be detrimental... - Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritisIan R van Driel
The Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
Autoimmun Rev 1:290-7. 2002..The highlights of these recent advances are the subject of this review... - Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cellsStephen J Turner
Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
Proc Natl Acad Sci U S A 101:3545-50. 2004..Therefore, the massive difference in magnitude for the secondary, although not the primary, response to these D(b)NP(366) and D(b)PA(224) epitopes cannot be considered to reflect differential TNFR2-mediated T cell editing... - Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expressionDana R Marshall
Department of Immunology, Hartwell Center for Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
Proc Natl Acad Sci U S A 102:6074-9. 2005.... - Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cellsPaula Y Arnold
Department of Immunology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA
J Immunol Methods 271:137-51. 2002..Furthermore, we have successfully used these reagents to stain T cells generated following viral infection. Thus, MHC class II:gamma2aFc multimers are robust and reliable reagents for the analysis of MHC class II-restricted T cells... - Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130Meegan Howlett
Department of Medicine, University of Melbourne at Western Hospital, Footscray, Australia
Gastroenterology 129:1005-18. 2005..This model recapitulates many characteristics of intestinal-type gastric cancer in humans... - The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residuesPaula Y Arnold
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
J Immunol 169:739-49. 2002..This key feature, which is not shared by MHC class I-restricted responses, may underlie the broad functional diversity displayed by MHC class II-restricted T cells... - Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligationNicole L La Gruta
Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Immunol 172:3662-9. 2004..These data suggest a mechanism by which ligated TCR may be differentiated from unligated TCR and selectively down-modulated...