Research Topics
| R K KumarSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Dimeric S100A8 in human neutrophils is diminished after phagocytosisR K Kumar
School of Pathology, University of New South Wales, Sydney, Australia
J Leukoc Biol 70:59-64. 2001..In vitro, phagocytosis is associated with rapid diminution of immunostaining without loss of viability. Loss of immunoreactivity for S100A8 may serve as a marker of localized neutrophil activation in tissues...- Integrating histology and histopathology teaching in practical classes using virtual slidesRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Anat Rec B New Anat 289:128-33. 2006..We believe that the approach we have developed should help to minimize the potential adverse impact of curriculum reform on the teaching of morphology, while ensuring that learning remains both meaningful and interesting... 
Epigenetic changes in childhood asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney NSW, Australia
Dis Model Mech 2:549-53. 2009..Thus, an understanding of epigenetic mechanisms in asthma has the potential to reveal new approaches for primary prevention or therapeutic intervention in childhood asthma...- Interferon-γ, pulmonary macrophages and airway responsiveness in asthmaRakesh K Kumar
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, 2052, Australia
Inflamm Allergy Drug Targets 11:292-7. 2012..Targeting the effects of IFN-γ on pulmonary macrophages may be particularly relevant to the treatment of steroid-resistant acute exacerbations of asthma... 
Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cellsXiu M Wei
School of Pathology, Faculty of Medicine, UNSW, Sydney, Australia
Respir Res 6:108. 2005..Thus, some of the inhibitory effects of CSS appear to be via oxidative free radicals rather than a NOX-related negative feedback...- Mass spectrometric analysis of electrophoretically separated allergens and proteases in grass pollen diffusatesMark J Raftery
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia 2052
Respir Res 4:10. 2003..Disruption of mucosal epithelial integrity by proteases released by inhaled pollens could promote allergic sensitisation... 
Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in miceJessica S Siegle
Department of Pathology, University of New South Wales, Sydney, NSW, Australia
Respir Res 11:14. 2010..The purpose of this study was to assess whether early-life infection with a species-specific model of RSV and subsequent allergen exposure predisposed to the development of features of asthma...- Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic targetAdam Collison
Inflammation and Infection Research Centre, University of New South Wales, Sydney, Australia
BMC Pulm Med 11:29. 2011..In the present study, we extended investigation of the therapeutic potential of miRNA inhibition to our well-established model of chronic asthma... - Integrated online formative assessments in the biomedical sciences for medical students: benefits for learningGary M Velan
Department of Pathology, School of Medical Sciences, Faculty of Medicine, The University of New South Wales, Sydney 2052, Australia
BMC Med Educ 8:52. 2008..This study attempts to determine whether participation and performance in integrated online formative assessments in the biomedical sciences has measurable effects on learning by junior medical students... - Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosisR K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Clin Exp Allergy 34:567-75. 2004..Growth factors produced by airway epithelial cells may be important in the pathogenesis of subepithelial fibrosis, a distinctive lesion of chronic human asthma... - Effects of anticytokine therapy in a mouse model of chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Am J Respir Crit Care Med 170:1043-8. 2004.... - Virtual microscopy for learning and assessment in pathologyRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, NSW 2052, Australia
J Pathol 204:613-8. 2004..We believe that the use of high-quality learning resources such as virtual slides can ensure that microscopic examination of tissues remains both meaningful and interesting... - Reversibility of airway inflammation and remodelling following cessation of antigenic challenge in a model of chronic asthmaR K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Clin Exp Allergy 34:1796-802. 2004..The role of ongoing exposure to allergens in their pathogenesis remains unclear... - Interferon-gamma as a possible target in chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Inflamm Allergy Drug Targets 5:253-6. 2006..This may be particularly relevant to acute exacerbations of asthma, in which setting there may be justification for therapeutic inhibition of IFN-gamma... - The "classical" ovalbumin challenge model of asthma in miceRakesh K Kumar
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
Curr Drug Targets 9:485-94. 2008..Nevertheless, careful use of well-defined models allows investigators to answer specific questions that are otherwise difficult to address... - Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
J Pharmacol Exp Ther 307:349-55. 2003..Roflumilast did not diminish accumulation of transforming growth factor-beta1, suggesting that it might affect remodeling by mechanisms distinct from glucocorticoids... - Serum-free culture of mouse tracheal epithelial cellsR K Kumar
School of Pathology, University of New South Wales, Sydney, Australia
Exp Lung Res 23:427-40. 1997..In parallel, secretion of immunoreactive transforming growth factor-beta by the epithelial cells was strikingly increased, but could be partially down-regulated in the presence of mitogenic growth factors... - Murine model of chronic human asthmaR K Kumar
Inflammation Research Unit, School of Pathology, University of New South Wales, Sydney, New South Wales, Australia
Immunol Cell Biol 79:141-4. 2001..This model has considerable potential for the investigation of pathogenetic mechanisms and potential treatments of chronic human asthma... - Understanding airway wall remodeling in asthma: a basis for improvements in therapy?R K Kumar
Inflammation Research Unit, School of Pathology, The University of New South Wales, Sydney, Australia 2052
Pharmacol Ther 91:93-104. 2001.... - Modeling allergic asthma in mice: pitfalls and opportunitiesRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Am J Respir Cell Mol Biol 27:267-72. 2002..This more realistic model of asthma offers a number of opportunities for investigation of pathogenetic mechanisms and novel therapeutic agents... - Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthmaR K Kumar
Inflammation Research Unit, Department of Pathology, University of New South Wales, Sydney, Australia
Clin Exp Allergy 32:1104-11. 2002..Interleukin-13 is believed to be important in asthmatic inflammation and airway hyper-reactivity... - Eotaxin expression by epithelial cells and plasma cells in chronic asthmaRakesh K Kumar
Inflammation Research Unit, Department of Pathology, University of New South Wales, Sydney, Australia
Lab Invest 82:495-504. 2002..Although high eotaxin levels alone are not sufficient to cause recruitment of eosinophils into the airways, recurrent exposure may generate or up-regulate additional signals required for eosinophil chemotaxis... - Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthmaC Herbert
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
Clin Exp Allergy 38:847-56. 2008..In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase-4 inhibitor)... - Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammationJessica S Siegle
Department of Pathology, University of New South Wales, Sydney, Australia
Am J Respir Cell Mol Biol 35:565-70. 2006..The inflammatory response involves distal airways and is associated with a distinct pattern of AHR, which develops independent of the enhanced eosinophilic inflammation... - Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cellsM V Apte
Pancreatic Research Group, Department of Gastroenterology, Bankstown-Lidcombe and Liverpool Hospitals, NSW, Sydney, Australia
Pancreas 29:179-87. 2004..PSC function is influenced by pancreatic cancer cells. Interactions between tumor cells and stromal cells (PSCs) may play an important role in the pathobiology of pancreatic cancer... - Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthmaJ S Siegle
Inflammation and Infection Research Centre, University of New South Wales, Sydney
Clin Exp Immunol 165:19-28. 2011.... - The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammationBennett O V Shum
Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
J Clin Invest 116:2183-2192. 2006..Thus, aP2 regulates allergic airway inflammation and may provide a link between fatty acid metabolism and asthma... - Web-based self-assessments in pathology with Questionmark PerceptionGary M Velan
Department of Pathology, University of New South Wales, Sydney, Australia
Pathology 34:282-4. 2002..The potential of on-line formative self-assessments for postgraduate training and continuing education in pathology so far remains untapped... - IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophagesJing Jing Li
Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
J Immunol 185:4401-9. 2010.... - UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cellsNick Di Girolamo
Inflammation Research Unit, School of Medical Sciences, Department of Pathology, Faculty of Medicine, University of New South Wales, Sydney, Australia
Invest Ophthalmol Vis Sci 43:3430-7. 2002..The hypothesis tested in the current study is that UV radiation modulates the expression of interleukin (IL)-6 and -8, which could promote the neovascularization and chronic inflammation regularly observed in pterygia... - Teaching pathology using 'hotspotted' digital imagesMark Dziegielewski
School of Medical Sciences, University of New South Wales, Sydney 2052, Australia
Med Educ 37:1047-8. 2003 - Development and evaluation of a computer-assisted learning module on glomerulonephritis for medical studentsGary M Velan
School of Pathology, University of New South Wales, Sydney, Australia
Med Teach 24:412-6. 2002..It is concluded that the module is an effective learning tool, but important caveats are noted associated with using CAL modules in redesigned medical curricula... - The pathology of human and murine pulmonary infection with Cryptococcus neoformans var. gattiiA Torda
Inflammation Research Unit, School of Pathology, University of New South Wales, Randwick, Australia
Pathology 33:475-8. 2001..We also established a murine model of pulmonary infection by Cryptococcus neoformans var. gattii, which reproduced most of these features. This model is likely to prove useful in studies of the pathogenesis of this infection... - Expression and distribution of matrix metalloproteinases and their inhibitors in the human iris and ciliary bodyJ Lan
The Inflammation Research Unit, School of Medical Sciences, Department of Pathology, University of New South Wales, Sydney 2052, Australia
Br J Ophthalmol 87:208-11. 2003..Their differential localisation in the ciliary body suggests they may have a role in maintaining homeostasis in the uveal tract... - Cell migration: a novel aspect of pancreatic stellate cell biologyP A Phillips
Pancreatic Research Group, Department of Gastroenterology, Bankstown-Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia
Gut 52:677-82. 2003..IMPLICATION: Chemotactic factors released during pancreatic injury may stimulate the migration of PSCs through surrounding basement membrane towards affected areas of the gland... - Cisapride and caesarean section: their role in babies with gastroschisisR K Kumar
Department of Paediatric Intensive Care, Sydney Children s Hospital, Randwick, New South Wales, Australia
J Paediatr Child Health 35:181-4. 1999..The objective of this study was to compare the neonatal postoperative course and morbidity for patients with gastroschisis who received cisapride with those who did not receive cisapride... - Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammationCharles E Harvey
Department of Gastroenterology, Prince of Wales Hospital, Sydney, New South Wales, Australia
J Leukoc Biol 74:360-9. 2003.... - Morphological methods for assessment of fibrosisRakesh K Kumar
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
Methods Mol Med 117:179-88. 2005..Issues related to sampling and the use of interactive computer-assisted measurement are discussed, and pitfalls associated with automated measurement are examined... - Neuropeptides and nerve growth in inflammatory bowel diseases: a quantitative immunohistochemical studyC M Y Lee
Department of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
Dig Dis Sci 47:495-502. 2002..These data indicate a link between the immunologic and nervous systems in IBD... - Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal modelAlain Vonlaufen
Pancreatic Research Group, South Western Sydney Clinical School, Sydney, Australia
Gastroenterology 133:1293-303. 2007.... - Site of inflammation influences site of hyperresponsiveness in experimental asthmaRachel A Collins
Division of Clinical Sciences, TVW Telethon Institute for Child Health Research, West Perth 6872, Australia
Respir Physiol Neurobiol 139:51-61. 2003..CONCLUSIONS: Chronic inhalational exposure of sensitized mice to low-mass concentrations of OVA induces airway-specific hyperresponsiveness... - Differential expression of transforming growth factors-beta 1, -beta 2, -beta 3 and the type I, II, III receptors in the lining epithelia of inflamed gingivaPing Ye
Institute of Dental Research, Westmead Centre for Oral Health, Westmead, NSW, Australia
Pathology 35:384-92. 2003..These findings provide a basis for evaluation of the role of these growth factors in the pathogenesis of periodontitis... - Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthmaKazuhiro Ito
Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
Am J Respir Cell Mol Biol 39:543-50. 2008..We conclude that impaired nuclear recruitment of HDAC2 could be an important mechanism of steroid resistance of the neutrophilic inflammation in exacerbations of asthma. Oxidative stress may contribute to decreased HDAC2 activity... - CD4(+) T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthmaPaul S Foster
Department of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Lab Invest 82:455-62. 2002.... - Interleukin-5 and eosinophils as therapeutic targets for asthmaPaul S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
Trends Mol Med 8:162-7. 2002..The contribution of these IL-5-independent pathways should be considered when assessing the role of eosinophils in disease processes... - Targeting eosinophils in asthmaPaul S Foster
Discipline of Immunology and Microbiology, Faculty of Health, University of Newcastle, Newcastle NSW, Australia
Curr Mol Med 8:585-90. 2008..This may predispose to the development of acute exacerbations of asthma, an outcome that would have significant clinical implications...