R K Kumar

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Dimeric S100A8 in human neutrophils is diminished after phagocytosis
    R K Kumar
    School of Pathology, University of New South Wales, Sydney, Australia
    J Leukoc Biol 70:59-64. 2001
  2. ncbi request reprint Integrating histology and histopathology teaching in practical classes using virtual slides
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    Anat Rec B New Anat 289:128-33. 2006
  3. doi request reprint Epigenetic changes in childhood asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney NSW, Australia
    Dis Model Mech 2:549-53. 2009
  4. pmc Interleukin-33 drives activation of alveolar macrophages and airway inflammation in a mouse model of acute exacerbation of chronic asthma
    Melissa M Bunting
    Department of Pathology, Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Biomed Res Int 2013:250938. 2013
  5. pmc Responses of airway epithelium to environmental injury: role in the induction phase of childhood asthma
    Rakesh K Kumar
    Inflammation and Infection Research Centre, School of Medial Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    J Allergy (Cairo) 2011:257017. 2011
  6. pmc Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?
    Rakesh K Kumar
    Department of Pathology, School of Medical Sciences, University of New South Wales Sydney, NSW, Australia
    Front Physiol 3:312. 2012
  7. pmc Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge
    Cristan Herbert
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, 2052, Australia
    Dis Model Mech 6:479-88. 2013
  8. pmc Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma
    Adam Collison
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW 2308, Australia
    Dis Model Mech 6:993-1000. 2013
  9. pmc Anti-inflammatory and anti-remodelling effects of ISU201, a modified form of the extracellular domain of human BST2, in experimental models of asthma: association with inhibition of histone acetylation
    Cristan Herbert
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, Australia
    PLoS ONE 9:e90436. 2014
  10. pmc Impact on learning of an e-learning module on leukaemia: a randomised controlled trial
    Yuri Morgulis
    Department of Pathology, School of Medical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia
    BMC Med Educ 12:36. 2012

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Dimeric S100A8 in human neutrophils is diminished after phagocytosis
    R K Kumar
    School of Pathology, University of New South Wales, Sydney, Australia
    J Leukoc Biol 70:59-64. 2001
    ..In vitro, phagocytosis is associated with rapid diminution of immunostaining without loss of viability. Loss of immunoreactivity for S100A8 may serve as a marker of localized neutrophil activation in tissues...
  2. ncbi request reprint Integrating histology and histopathology teaching in practical classes using virtual slides
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    Anat Rec B New Anat 289:128-33. 2006
    ..We believe that the approach we have developed should help to minimize the potential adverse impact of curriculum reform on the teaching of morphology, while ensuring that learning remains both meaningful and interesting...
  3. doi request reprint Epigenetic changes in childhood asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney NSW, Australia
    Dis Model Mech 2:549-53. 2009
    ..Thus, an understanding of epigenetic mechanisms in asthma has the potential to reveal new approaches for primary prevention or therapeutic intervention in childhood asthma...
  4. pmc Interleukin-33 drives activation of alveolar macrophages and airway inflammation in a mouse model of acute exacerbation of chronic asthma
    Melissa M Bunting
    Department of Pathology, Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Biomed Res Int 2013:250938. 2013
    ..Collectively, these data indicate that in this model of an acute exacerbation of chronic asthma, IL-33 drives activation of AM and has an important role in the pathogenesis of airway inflammation. ..
  5. pmc Responses of airway epithelium to environmental injury: role in the induction phase of childhood asthma
    Rakesh K Kumar
    Inflammation and Infection Research Centre, School of Medial Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    J Allergy (Cairo) 2011:257017. 2011
    ..To date, however, few investigations have employed models of the induction phase of childhood asthma. Further research may help to identify interventions that could reduce the risk of allergic asthma...
  6. pmc Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?
    Rakesh K Kumar
    Department of Pathology, School of Medical Sciences, University of New South Wales Sydney, NSW, Australia
    Front Physiol 3:312. 2012
    ....
  7. pmc Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge
    Cristan Herbert
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, 2052, Australia
    Dis Model Mech 6:479-88. 2013
    ..These findings are likely to be relevant to the induction of childhood asthma...
  8. pmc Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma
    Adam Collison
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW 2308, Australia
    Dis Model Mech 6:993-1000. 2013
    ..Epigenetic changes associated with this pattern of gene activation might play a role in the development of childhood asthma. ..
  9. pmc Anti-inflammatory and anti-remodelling effects of ISU201, a modified form of the extracellular domain of human BST2, in experimental models of asthma: association with inhibition of histone acetylation
    Cristan Herbert
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, Australia
    PLoS ONE 9:e90436. 2014
    ..Thus, unlike drugs which target specific mediators, it could potentially be an alternative or an adjunct to glucocorticoids for the treatment of asthma. ..
  10. pmc Impact on learning of an e-learning module on leukaemia: a randomised controlled trial
    Yuri Morgulis
    Department of Pathology, School of Medical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia
    BMC Med Educ 12:36. 2012
    ..This study compared the learning impact on senior medical students of a purpose-built e-learning module on leukaemia, compared with existing online resources...
  11. ncbi request reprint Interferon-γ, pulmonary macrophages and airway responsiveness in asthma
    Rakesh K Kumar
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, 2052, Australia
    Inflamm Allergy Drug Targets 11:292-7. 2012
    ..Targeting the effects of IFN-γ on pulmonary macrophages may be particularly relevant to the treatment of steroid-resistant acute exacerbations of asthma...
  12. pmc Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cells
    Xiu M Wei
    School of Pathology, Faculty of Medicine, UNSW, Sydney, Australia
    Respir Res 6:108. 2005
    ..Thus, some of the inhibitory effects of CSS appear to be via oxidative free radicals rather than a NOX-related negative feedback...
  13. pmc Mass spectrometric analysis of electrophoretically separated allergens and proteases in grass pollen diffusates
    Mark J Raftery
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia 2052
    Respir Res 4:10. 2003
    ..Disruption of mucosal epithelial integrity by proteases released by inhaled pollens could promote allergic sensitisation...
  14. pmc Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice
    Jessica S Siegle
    Department of Pathology, University of New South Wales, Sydney, NSW, Australia
    Respir Res 11:14. 2010
    ..The purpose of this study was to assess whether early-life infection with a species-specific model of RSV and subsequent allergen exposure predisposed to the development of features of asthma...
  15. pmc Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target
    Adam Collison
    Inflammation and Infection Research Centre, University of New South Wales, Sydney, Australia
    BMC Pulm Med 11:29. 2011
    ..In the present study, we extended investigation of the therapeutic potential of miRNA inhibition to our well-established model of chronic asthma...
  16. pmc Integrated online formative assessments in the biomedical sciences for medical students: benefits for learning
    Gary M Velan
    Department of Pathology, School of Medical Sciences, Faculty of Medicine, The University of New South Wales, Sydney 2052, Australia
    BMC Med Educ 8:52. 2008
    ..This study attempts to determine whether participation and performance in integrated online formative assessments in the biomedical sciences has measurable effects on learning by junior medical students...
  17. ncbi request reprint Interferon-gamma as a possible target in chronic asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    Inflamm Allergy Drug Targets 5:253-6. 2006
    ..This may be particularly relevant to acute exacerbations of asthma, in which setting there may be justification for therapeutic inhibition of IFN-gamma...
  18. ncbi request reprint Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosis
    R K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    Clin Exp Allergy 34:567-75. 2004
    ..Growth factors produced by airway epithelial cells may be important in the pathogenesis of subepithelial fibrosis, a distinctive lesion of chronic human asthma...
  19. ncbi request reprint Effects of anticytokine therapy in a mouse model of chronic asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    Am J Respir Crit Care Med 170:1043-8. 2004
    ....
  20. ncbi request reprint Virtual microscopy for learning and assessment in pathology
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, NSW 2052, Australia
    J Pathol 204:613-8. 2004
    ..We believe that the use of high-quality learning resources such as virtual slides can ensure that microscopic examination of tissues remains both meaningful and interesting...
  21. ncbi request reprint Reversibility of airway inflammation and remodelling following cessation of antigenic challenge in a model of chronic asthma
    R K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    Clin Exp Allergy 34:1796-802. 2004
    ..The role of ongoing exposure to allergens in their pathogenesis remains unclear...
  22. ncbi request reprint The "classical" ovalbumin challenge model of asthma in mice
    Rakesh K Kumar
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Curr Drug Targets 9:485-94. 2008
    ..Nevertheless, careful use of well-defined models allows investigators to answer specific questions that are otherwise difficult to address...
  23. ncbi request reprint Understanding airway wall remodeling in asthma: a basis for improvements in therapy?
    R K Kumar
    Inflammation Research Unit, School of Pathology, The University of New South Wales, Sydney, Australia 2052
    Pharmacol Ther 91:93-104. 2001
    ....
  24. ncbi request reprint Serum-free culture of mouse tracheal epithelial cells
    R K Kumar
    School of Pathology, University of New South Wales, Sydney, Australia
    Exp Lung Res 23:427-40. 1997
    ..In parallel, secretion of immunoreactive transforming growth factor-beta by the epithelial cells was strikingly increased, but could be partially down-regulated in the presence of mitogenic growth factors...
  25. ncbi request reprint Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    J Pharmacol Exp Ther 307:349-55. 2003
    ..Roflumilast did not diminish accumulation of transforming growth factor-beta1, suggesting that it might affect remodeling by mechanisms distinct from glucocorticoids...
  26. ncbi request reprint Murine model of chronic human asthma
    R K Kumar
    Inflammation Research Unit, School of Pathology, University of New South Wales, Sydney, New South Wales, Australia
    Immunol Cell Biol 79:141-4. 2001
    ..This model has considerable potential for the investigation of pathogenetic mechanisms and potential treatments of chronic human asthma...
  27. ncbi request reprint Modeling allergic asthma in mice: pitfalls and opportunities
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    Am J Respir Cell Mol Biol 27:267-72. 2002
    ..This more realistic model of asthma offers a number of opportunities for investigation of pathogenetic mechanisms and novel therapeutic agents...
  28. ncbi request reprint Eotaxin expression by epithelial cells and plasma cells in chronic asthma
    Rakesh K Kumar
    Inflammation Research Unit, Department of Pathology, University of New South Wales, Sydney, Australia
    Lab Invest 82:495-504. 2002
    ..Although high eotaxin levels alone are not sufficient to cause recruitment of eosinophils into the airways, recurrent exposure may generate or up-regulate additional signals required for eosinophil chemotaxis...
  29. ncbi request reprint Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma
    R K Kumar
    Inflammation Research Unit, Department of Pathology, University of New South Wales, Sydney, Australia
    Clin Exp Allergy 32:1104-11. 2002
    ..Interleukin-13 is believed to be important in asthmatic inflammation and airway hyper-reactivity...
  30. doi request reprint Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma
    C Herbert
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Clin Exp Allergy 38:847-56. 2008
    ..In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase-4 inhibitor)...
  31. pmc Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma
    J S Siegle
    Inflammation and Infection Research Centre, University of New South Wales, Sydney
    Clin Exp Immunol 165:19-28. 2011
    ....
  32. doi request reprint Interferon-gamma and pulmonary macrophages contribute to the mechanisms underlying prolonged airway hyperresponsiveness
    M Yang
    Centre for Asthma and Respiratory Disease, School of Biomedical Sciences, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW 2300, Australia
    Clin Exp Allergy 40:163-73. 2010
    ..This may be dissociated from inflammatory cell recruitment, implying a role for resident pulmonary cells in regulating the response...
  33. ncbi request reprint Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation
    Jessica S Siegle
    Department of Pathology, University of New South Wales, Sydney, Australia
    Am J Respir Cell Mol Biol 35:565-70. 2006
    ..The inflammatory response involves distal airways and is associated with a distinct pattern of AHR, which develops independent of the enhanced eosinophilic inflammation...
  34. ncbi request reprint Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells
    M V Apte
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals, NSW, Sydney, Australia
    Pancreas 29:179-87. 2004
    ....
  35. pmc The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation
    Bennett O V Shum
    Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    J Clin Invest 116:2183-2192. 2006
    ..Thus, aP2 regulates allergic airway inflammation and may provide a link between fatty acid metabolism and asthma...
  36. ncbi request reprint The pathology of human and murine pulmonary infection with Cryptococcus neoformans var. gattii
    A Torda
    Inflammation Research Unit, School of Pathology, University of New South Wales, Randwick, Australia
    Pathology 33:475-8. 2001
    ..We also established a murine model of pulmonary infection by Cryptococcus neoformans var. gattii, which reproduced most of these features. This model is likely to prove useful in studies of the pathogenesis of this infection...
  37. ncbi request reprint Teaching pathology using 'hotspotted' digital images
    Mark Dziegielewski
    School of Medical Sciences, University of New South Wales, Sydney 2052, Australia
    Med Educ 37:1047-8. 2003
  38. ncbi request reprint UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cells
    Nick Di Girolamo
    Inflammation Research Unit, School of Medical Sciences, Department of Pathology, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Invest Ophthalmol Vis Sci 43:3430-7. 2002
    ..The hypothesis tested in the current study is that UV radiation modulates the expression of interleukin (IL)-6 and -8, which could promote the neovascularization and chronic inflammation regularly observed in pterygia...
  39. doi request reprint IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    Jing Jing Li
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    J Immunol 185:4401-9. 2010
    ....
  40. ncbi request reprint Web-based self-assessments in pathology with Questionmark Perception
    Gary M Velan
    Department of Pathology, University of New South Wales, Sydney, Australia
    Pathology 34:282-4. 2002
    ..The potential of on-line formative self-assessments for postgraduate training and continuing education in pathology so far remains untapped...
  41. ncbi request reprint Development and evaluation of a computer-assisted learning module on glomerulonephritis for medical students
    Gary M Velan
    School of Pathology, University of New South Wales, Sydney, Australia
    Med Teach 24:412-6. 2002
    ..It is concluded that the module is an effective learning tool, but important caveats are noted associated with using CAL modules in redesigned medical curricula...
  42. pmc Cell migration: a novel aspect of pancreatic stellate cell biology
    P A Phillips
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia
    Gut 52:677-82. 2003
    ..The ability of PSCs to proliferate has been well established but their potential for migration has not been examined...
  43. pmc Expression and distribution of matrix metalloproteinases and their inhibitors in the human iris and ciliary body
    J Lan
    The Inflammation Research Unit, School of Medical Sciences, Department of Pathology, University of New South Wales, Sydney 2052, Australia
    Br J Ophthalmol 87:208-11. 2003
    ..To determine the expression and distribution of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the normal human iris and ciliary body...
  44. ncbi request reprint Cisapride and caesarean section: their role in babies with gastroschisis
    R K Kumar
    Department of Paediatric Intensive Care, Sydney Children s Hospital, Randwick, New South Wales, Australia
    J Paediatr Child Health 35:181-4. 1999
    ..The objective of this study was to compare the neonatal postoperative course and morbidity for patients with gastroschisis who received cisapride with those who did not receive cisapride...
  45. ncbi request reprint Morphological methods for assessment of fibrosis
    Rakesh K Kumar
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Methods Mol Med 117:179-88. 2005
    ..Issues related to sampling and the use of interactive computer-assisted measurement are discussed, and pitfalls associated with automated measurement are examined...
  46. ncbi request reprint Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammation
    Charles E Harvey
    Department of Gastroenterology, Prince of Wales Hospital, Sydney, New South Wales, Australia
    J Leukoc Biol 74:360-9. 2003
    ....
  47. ncbi request reprint Neuropeptides and nerve growth in inflammatory bowel diseases: a quantitative immunohistochemical study
    C M Y Lee
    Department of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
    Dig Dis Sci 47:495-502. 2002
    ..These data indicate a link between the immunologic and nervous systems in IBD...
  48. ncbi request reprint Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model
    Alain Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School, Sydney, Australia
    Gastroenterology 133:1293-303. 2007
    ....
  49. ncbi request reprint Interleukin-5 and eosinophils as therapeutic targets for asthma
    Paul S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
    Trends Mol Med 8:162-7. 2002
    ..The contribution of these IL-5-independent pathways should be considered when assessing the role of eosinophils in disease processes...
  50. ncbi request reprint CD4(+) T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma
    Paul S Foster
    Department of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Lab Invest 82:455-62. 2002
    ....
  51. pmc Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Cell Mol Biol 39:543-50. 2008
    ..We conclude that impaired nuclear recruitment of HDAC2 could be an important mechanism of steroid resistance of the neutrophilic inflammation in exacerbations of asthma. Oxidative stress may contribute to decreased HDAC2 activity...
  52. ncbi request reprint Site of inflammation influences site of hyperresponsiveness in experimental asthma
    Rachel A Collins
    Division of Clinical Sciences, TVW Telethon Institute for Child Health Research, West Perth 6872, Australia
    Respir Physiol Neurobiol 139:51-61. 2003
    ..Our recently developed murine asthma model is capable of inducing airway-specific chronic inflammatory changes and remodeling, features of human asthma commonly missing in conventional animal models...
  53. ncbi request reprint Differential expression of transforming growth factors-beta 1, -beta 2, -beta 3 and the type I, II, III receptors in the lining epithelia of inflamed gingiva
    Ping Ye
    Institute of Dental Research, Westmead Centre for Oral Health, Westmead, NSW, Australia
    Pathology 35:384-92. 2003
    ..To investigate the distribution of transforming growth factor-beta isoforms in chronically inflamed periodontal tissues...
  54. pmc Targeting eosinophils in asthma
    Paul S Foster
    Discipline of Immunology and Microbiology, Faculty of Health, University of Newcastle, Newcastle NSW, Australia
    Curr Mol Med 8:585-90. 2008
    ..This may predispose to the development of acute exacerbations of asthma, an outcome that would have significant clinical implications...