Pawel Kuklik

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. pmc Attraction and repulsion of spiral waves by inhomogeneity of conduction anisotropy--a model of spiral wave interaction with electrical remodeling of heart tissue
    Pawel Kuklik
    Centre for Heart Rhythm Disorders, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
    J Biol Phys 39:67-80. 2013
  2. doi request reprint Role of spiral wave pinning in inhomogeneous active media in the termination of atrial fibrillation by electrical cardioversion
    Pawel Kuklik
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA 5000, Australia
    Comput Biol Med 40:363-72. 2010
  3. doi request reprint Quantitative description of the regional mechanics of the left atria by electroanatomical mapping
    Pawel Kuklik
    Cardiovascular Research Center, Department of Cardiology, Royal Adelaide Hospital, University of Adelaide, Australia
    Physiol Meas 31:555-64. 2010
  4. doi request reprint Spiral wave breakup in excitable media with an inhomogeneity of conduction anisotropy
    P Kuklik
    Physics of Complex Systems, Faculty of Physics, Warsaw University of Technology, ul Koszykowa 75, Warszawa, Poland
    Comput Biol Med 40:775-80. 2010
  5. doi request reprint Integration of the data from electroanatomical mapping system and CT imaging modality
    P Kuklik
    Faculty of Physics, Warsaw University of Technology, Warsaw, Poland
    Int J Cardiovasc Imaging 25:425-32. 2009
  6. doi request reprint High-density mapping of ventricular scar: a comparison of ventricular tachycardia (VT) supporting channels with channels that do not support VT
    Sachin Nayyar
    Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia
    Circ Arrhythm Electrophysiol 7:90-8. 2014
  7. doi request reprint Hypertension and atrial fibrillation: evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model
    Dennis H Lau
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital and Discipline of Medicine, University of Adelaide, Adelaide, Australia
    Heart Rhythm 7:1282-90. 2010
  8. pmc Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing
    Dennis H Lau
    Centre for Heart Rhythm Disorders CHRD, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia
    PLoS ONE 8:e72416. 2013
  9. doi request reprint Atrial protective effects of n-3 polyunsaturated fatty acids: a long-term study in ovine chronic heart failure
    Dennis H Lau
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia
    Heart Rhythm 8:575-82. 2011
  10. doi request reprint Direction-dependent conduction in lone atrial fibrillation
    Christopher X Wong
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital and Discipline of Medicine, University of Adelaide, Adelaide, Australia
    Heart Rhythm 7:1192-9. 2010

Collaborators

Detail Information

Publications30

  1. pmc Attraction and repulsion of spiral waves by inhomogeneity of conduction anisotropy--a model of spiral wave interaction with electrical remodeling of heart tissue
    Pawel Kuklik
    Centre for Heart Rhythm Disorders, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
    J Biol Phys 39:67-80. 2013
    ....
  2. doi request reprint Role of spiral wave pinning in inhomogeneous active media in the termination of atrial fibrillation by electrical cardioversion
    Pawel Kuklik
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA 5000, Australia
    Comput Biol Med 40:363-72. 2010
    ..We show that in inhomogeneous system delayed termination can be explained as the unpinning of a spiral wave from inhomogeneities and its termination after collision with the edge of the system...
  3. doi request reprint Quantitative description of the regional mechanics of the left atria by electroanatomical mapping
    Pawel Kuklik
    Cardiovascular Research Center, Department of Cardiology, Royal Adelaide Hospital, University of Adelaide, Australia
    Physiol Meas 31:555-64. 2010
    ..Therefore, we hypothesize that in order to minimize the impact on atrial mechanical function, an important determinant of thromboembolic risk, damage should be minimized to these atrial regions...
  4. doi request reprint Spiral wave breakup in excitable media with an inhomogeneity of conduction anisotropy
    P Kuklik
    Physics of Complex Systems, Faculty of Physics, Warsaw University of Technology, ul Koszykowa 75, Warszawa, Poland
    Comput Biol Med 40:775-80. 2010
    ..Our results suggest that the inhomogeneity of conduction anisotropy may promote wave breakup and hence play an important role in the initiation and perpetuation of the cardiac arrhythmias...
  5. doi request reprint Integration of the data from electroanatomical mapping system and CT imaging modality
    P Kuklik
    Faculty of Physics, Warsaw University of Technology, Warsaw, Poland
    Int J Cardiovasc Imaging 25:425-32. 2009
    ..25 mm. Bipolar viability and activation maps were reconstructed on the CT geometry. Our method allowed us to create maps of electrophysiological parameters of anatomically complex structures without the need for their detailed mapping...
  6. doi request reprint High-density mapping of ventricular scar: a comparison of ventricular tachycardia (VT) supporting channels with channels that do not support VT
    Sachin Nayyar
    Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia
    Circ Arrhythm Electrophysiol 7:90-8. 2014
    ..Surviving myocytes within scar may form channels that support ventricular tachycardia (VT) circuits. There are little data on the properties of channels that comprise VT circuits and those that are non-VT supporting channels...
  7. doi request reprint Hypertension and atrial fibrillation: evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model
    Dennis H Lau
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital and Discipline of Medicine, University of Adelaide, Adelaide, Australia
    Heart Rhythm 7:1282-90. 2010
    ..Hypertension accounts for more atrial fibrillation (AF) than any other predisposing factor...
  8. pmc Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing
    Dennis H Lau
    Centre for Heart Rhythm Disorders CHRD, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia
    PLoS ONE 8:e72416. 2013
    ..Here we aim to delineate the arrhythmogenic atrial substrate in mature spontaneously hypertensive rats (SHR)...
  9. doi request reprint Atrial protective effects of n-3 polyunsaturated fatty acids: a long-term study in ovine chronic heart failure
    Dennis H Lau
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia
    Heart Rhythm 8:575-82. 2011
    ..It has been suggested that omega-3 polyunsaturated fatty acids (n-3 PUFAs) may prevent the development of atrial fibrillation (AF)...
  10. doi request reprint Direction-dependent conduction in lone atrial fibrillation
    Christopher X Wong
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital and Discipline of Medicine, University of Adelaide, Adelaide, Australia
    Heart Rhythm 7:1192-9. 2010
    ..Patients with lone atrial fibrillation (AF) have an abnormal atrial substrate...
  11. doi request reprint Image integration using NavX Fusion: initial experience and validation
    Anthony G Brooks
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital and Disciplines of Medicine and Physiology, University of Adelaide, Adelaide, South Australia
    Heart Rhythm 5:526-35. 2008
    ..NavX Fusion software aims to mold the virtual anatomy to the patient's computed tomography (CT) image; however, the accuracy and clinical usefulness of this system have not been reported...
  12. doi request reprint High-density mapping of the sinus node in humans: role of preferential pathways and the effect of remodeling
    Martin K Stiles
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital and the Disciple of Medicine, University of Adelaide, Adelaide, Australia
    J Cardiovasc Electrophysiol 21:532-9. 2010
    ..We aimed to characterize the functional sinus node complex in health and disease with high-density simultaneous mapping...
  13. doi request reprint Bipolar electrogram shannon entropy at sites of rotational activation: implications for ablation of atrial fibrillation
    Anand N Ganesan
    Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia
    Circ Arrhythm Electrophysiol 6:48-57. 2013
    ..We aimed to determine whether Shannon entropy (ShEn), a measure of signal amplitude distribution, could differentiate the pivot from surrounding peripheral regions and thereby assist clinical rotor mapping...
  14. doi request reprint Direction-dependent conduction abnormalities in the chronically stretched atria
    Christopher X Wong
    Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia
    Europace 14:954-61. 2012
    ..We thus sought to characterize direction-dependent conduction in chronically stretched atria...
  15. doi request reprint High-density mapping of atrial fibrillation in humans: relationship between high-frequency activation and electrogram fractionation
    Martin K Stiles
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, Disciplines of Medicine and Physiology, University of Adelaide, Adelaide, Australia
    J Cardiovasc Electrophysiol 19:1245-53. 2008
    ..Sites of complex fractionated atrial electrograms (CFAE) and dominant frequency (DF) have been implicated in maintaining atrial fibrillation (AF); however, their relationship is poorly understood...
  16. doi request reprint Characterization of atrial remodeling studied remote from episodes of typical atrial flutter
    Martin K Stiles
    Department of Cardiology, University of Adelaide, Adelaide, South Australia, Australia
    Am J Cardiol 106:528-34. 2010
    ..These persisting abnormalities characterize the substrate underlying typical AFL and may account for the subsequent development of atrial fibrillation...
  17. doi request reprint Paroxysmal lone atrial fibrillation is associated with an abnormal atrial substrate: characterizing the "second factor"
    Martin K Stiles
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
    J Am Coll Cardiol 53:1182-91. 2009
    ..The purpose of this study was to determine whether patients with paroxysmal "lone" atrial fibrillation (AF) have an abnormal atrial substrate...
  18. doi request reprint Atrial remodeling in an ovine model of anthracycline-induced nonischemic cardiomyopathy: remodeling of the same sort
    Dennis H Lau
    Cardiovascular Research Centre, Departments of Cardiology and Cardiothoracic Surgery, Royal Adelaide Hospital and the Disciplines of Medicine and Physiology, University of Adelaide, Adelaide, Australia
    J Cardiovasc Electrophysiol 22:175-82. 2011
    ..To evaluate whether the atrial changes were specific to the model or represented an end result of HF, this study aimed to characterize atrial remodeling in an ovine model of doxorubicin-induced cardiomyopathy...
  19. pmc Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis
    Anand N Ganesan
    Centre for Heart Rhythm Disorders, Department of Cardiology, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
    J Am Heart Assoc 2:e004549. 2013
    ..We aimed to systematically review the medical literature to evaluate the long-term outcomes of AF ablation...
  20. doi request reprint Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation
    Hany S Abed
    Centre for Heart Rhythm Disorders, Discipline of Medicine, University of Adelaide and Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia
    Heart Rhythm 10:90-100. 2013
    ..Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown...
  21. doi request reprint Reverse remodeling of the atria after treatment of chronic stretch in humans: implications for the atrial fibrillation substrate
    Bobby John
    Department of Cardiology, Royal Adelaide Hospital and the Disciplines of Medicine and Physiology, University of Adelaide, Cardiovascular Research Center, Adelaide, Australia
    J Am Coll Cardiol 55:1217-26. 2010
    ..The aim of this report was to study the effect of chronic stretch reversal on the electrophysiological characteristics of the atria in humans...
  22. doi request reprint Atrial remodeling in obstructive sleep apnea: implications for atrial fibrillation
    Hany Dimitri
    Centre for Heart Rhythm Disorders CHRD, Discipline of Medicine, University of Adelaide, Adelaide, Australia
    Heart Rhythm 9:321-7. 2012
    ..There is a known association between obstructive sleep apnea (OSA) and atrial fibrillation (AF); however, how OSA affects the atrial myocardium is not well described...
  23. doi request reprint Left atrial remodeling in patients with atrial septal defects
    Kurt C Roberts-Thomson
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
    Heart Rhythm 6:1000-6. 2009
    ..Information regarding left atrial (LA) substrate in conditions predisposing to atrial fibrillation (AF) is limited...
  24. doi request reprint Feasibility of high-density electrophysiological study using multiple-electrode array in isolated small animal atria
    Dennis H Lau
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, Disciplines of Medicine and Physiology, University of Adelaide, Adelaide, Australia
    Clin Exp Pharmacol Physiol 37:1023-7. 2010
    ..In particular, it presents new research avenues to further explore the mechanisms of atrial arrhythmias in various transgenic and knockout rodent models...
  25. doi request reprint Outcomes of long-standing persistent atrial fibrillation ablation: a systematic review
    Anthony G Brooks
    Department of Cardiology, Royal Adelaide Hospital and the Disciplines of Medicine and Physiology, University of Adelaide, Cardiovascular Research Centre, Adelaide, Australia
    Heart Rhythm 7:835-46. 2010
    ..Ablation of long-standing persistent atrial fibrillation (AF) is highly variable, with differing techniques and outcomes...
  26. doi request reprint Electrical remodelling of the left and right atria due to rheumatic mitral stenosis
    Bobby John
    Cardiovascular Research Center, Department of Cardiology, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
    Eur Heart J 29:2234-43. 2008
    ..To characterize the atrial remodelling in mitral stenosis (MS)...
  27. ncbi request reprint Characteristics of ectopic triggers associated with paroxysmal and persistent atrial fibrillation: evidence for a changing role
    Anthony G Brooks
    Centre for Heart Rhythm Disorders, University of Adelaide, and Royal Adelaide Hospital, Adelaide, Australia
    Heart Rhythm 9:1367-74. 2012
    ..Atrial premature contractions (APCs) are well described to precede the initiation of paroxysmal atrial fibrillation (pAF). However, whether APC characteristics alter with progression of the arrhythmia is unknown...
  28. doi request reprint Short-term hypertension is associated with the development of atrial fibrillation substrate: a study in an ovine hypertensive model
    Dennis H Lau
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia
    Heart Rhythm 7:396-404. 2010
    ..However, the mechanisms of this link remain poorly understood. In addition, whether short-term hypertension can result in a substrate for AF is not known...
  29. doi request reprint The effect of electrogram duration on quantification of complex fractionated atrial electrograms and dominant frequency
    Martin K Stiles
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia
    J Cardiovasc Electrophysiol 19:252-8. 2008
    ..This study aimed to determine the minimum electrogram recording duration that accurately characterizes CFAE or DF sites for ablation without unduly lengthening the procedure...
  30. doi request reprint Concealed conduction effects in the atrium
    Jan J Zebrowski
    Physics of Complex Systems, Faculty of Physics, Warsaw University of Technology, Warszawa, ul Koszykowa 75, Poland
    IEEE Eng Med Biol Mag 28:24-9. 2009
    ..The effect of breathing modulation of heart rate and of a single deep breath can also be modeled. Finally, concealed conduction effects in the atrium are studied, yielding results comparable with recorded heart rate variability data...