Darryl A Knight

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells
    Nithiananthan Asokananthan
    Division of Inflammation and Infectious Diseases, Department of Microbiology, Asthma and Allergy Research Institute, University of Western Australia, Nedlands, Western Australia, Australia
    J Immunol 168:3577-85. 2002
  2. ncbi request reprint The airway epithelium: structural and functional properties in health and disease
    Darryl A Knight
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Respirology 8:432-46. 2003
  3. ncbi request reprint Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?
    Darryl A Knight
    Asthma and Allergy Research Institute and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009 Australia
    Curr Opin Pharmacol 4:251-6. 2004
  4. pmc Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium
    Anthony Kicic
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
    Am J Respir Crit Care Med 181:889-98. 2010
  5. ncbi request reprint Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma
    Anthony Kicic
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
    Am J Respir Crit Care Med 174:1110-8. 2006
  6. pmc A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium
    Markus Weichselbaum
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, 6009, Western Australia
    Respir Res 6:115. 2005
  7. ncbi request reprint The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression?
    Darryl A Knight
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Ground Floor, E Block, Verdun Street, Nedlands, Western Australia, 6009, Australia
    Pharmacol Ther 99:327-38. 2003
  8. ncbi request reprint Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2
    Mirjana Fogel-Petrovic
    Asthma and Allergy Research Institute and School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia
    Immunol Cell Biol 82:47-54. 2004
  9. doi request reprint Innate inflammatory responses of pediatric cystic fibrosis airway epithelial cells: effects of nonviral and viral stimulation
    Erika N Sutanto
    Division of Clinical Sciences, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Am J Respir Cell Mol Biol 44:761-7. 2011
  10. ncbi request reprint alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts
    Amelia K Scaffidi
    Asthma and Allergy Research Institute and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia
    J Biol Chem 279:37726-33. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells
    Nithiananthan Asokananthan
    Division of Inflammation and Infectious Diseases, Department of Microbiology, Asthma and Allergy Research Institute, University of Western Australia, Nedlands, Western Australia, Australia
    J Immunol 168:3577-85. 2002
    ..Combined, these data suggest an important role for PAR in the modulation of inflammation in the lung...
  2. ncbi request reprint The airway epithelium: structural and functional properties in health and disease
    Darryl A Knight
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Respirology 8:432-46. 2003
    ....
  3. ncbi request reprint Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?
    Darryl A Knight
    Asthma and Allergy Research Institute and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009 Australia
    Curr Opin Pharmacol 4:251-6. 2004
    ..These data have led an increasing number of investigators to ask the question whether the epithelial-mesenchymal trophic unit, central to lung development, becomes "re-activated" in asthma...
  4. pmc Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium
    Anthony Kicic
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
    Am J Respir Crit Care Med 181:889-98. 2010
    ..Damage to airway epithelium is followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial cells from children with asthma fail to heal a wound in vitro...
  5. ncbi request reprint Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma
    Anthony Kicic
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
    Am J Respir Crit Care Med 174:1110-8. 2006
    ..Convincing evidence of epithelial damage and aberrant repair exists in adult asthmatic airways, even in the absence of inflammation. However, comparable studies in children have been limited by access and availability of clinical samples...
  6. pmc A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium
    Markus Weichselbaum
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, 6009, Western Australia
    Respir Res 6:115. 2005
    ..Our aim was to characterize the three dimensional morphology of PNEC, their distribution, and their relationship to the epithelial nerves in whole mounts of adult human bronchi using confocal microscopy...
  7. ncbi request reprint The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression?
    Darryl A Knight
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Ground Floor, E Block, Verdun Street, Nedlands, Western Australia, 6009, Australia
    Pharmacol Ther 99:327-38. 2003
    ..This may provide guides for the development of novel pharmacological treatment for fibroproliferative diseases...
  8. ncbi request reprint Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2
    Mirjana Fogel-Petrovic
    Asthma and Allergy Research Institute and School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia
    Immunol Cell Biol 82:47-54. 2004
    ..PGE2 production by DC may therefore modulate DC and T-cell function, thereby shaping the character of the immune response...
  9. doi request reprint Innate inflammatory responses of pediatric cystic fibrosis airway epithelial cells: effects of nonviral and viral stimulation
    Erika N Sutanto
    Division of Clinical Sciences, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Am J Respir Cell Mol Biol 44:761-7. 2011
    ..The elevated IL-8, together with dampened apoptotic responses by CF cells to HRV, could contribute to augmented airway inflammation in the setting of recurrent viral infections early in life...
  10. ncbi request reprint alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts
    Amelia K Scaffidi
    Asthma and Allergy Research Institute and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia
    J Biol Chem 279:37726-33. 2004
    ..Our data provide a novel mechanism by which TGFbeta1 may contribute to abnormal wound healing and tissue fibrosis...
  11. ncbi request reprint Higher prostaglandin e2 production by dendritic cells from subjects with asthma compared with normal subjects
    Julie A Long
    Asthma and Allergy Research Institute, University of Western Australia, West Perth, WA, Australia
    Am J Respir Crit Care Med 170:485-91. 2004
    ..Increased PGE2 synthesis by DCs from subjects with asthma was associated with an increase in cyclooxygenase-2 messenger RNA expression. These findings support the notion that DC function is significantly altered in allergic asthma...
  12. doi request reprint Airway modeling and remodeling in the pathogenesis of asthma
    Stephanie M Warner
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Faculty of Medicine, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Curr Opin Allergy Clin Immunol 8:44-8. 2008
    ..In this review, we discuss the recent advancements in research targeting the role of airway remodeling in asthma...
  13. ncbi request reprint Concomitant activation of extracellular signal-regulated kinase and induction of COX-2 stimulates maximum prostaglandin E2 synthesis in human airway epithelial cells
    Nenad Petrovic
    Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, Australia
    Prostaglandins Other Lipid Mediat 81:126-35. 2006
    ....
  14. ncbi request reprint Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells
    Ralph McWhinnie
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Lung Cell Mol Physiol 292:L278-86. 2007
    ..These results suggest that ET-1 is a candidate mediator for the induction of increased smooth muscle mass in asthma and identify signaling pathways activated by this mediator...
  15. ncbi request reprint Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs
    Yuben P Moodley
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia
    Am J Respir Cell Mol Biol 29:490-8. 2003
    ..These results suggest that altered IL-6 signaling in IPF-Fb may enhance the resistance of these cells to apoptosis and contribute to a profibrotic effect of IL-6 in IPF...
  16. pmc Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation
    Yuben P Moodley
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Am J Pathol 163:345-54. 2003
    ..IL-11 was mitogenic for both normal and IPF fibroblasts. These results provide strong evidence for a fundamental abnormality in a cytokine-signaling pathway, as opposed to alterations in cytokine production, in the pathogenesis of IPF...
  17. ncbi request reprint Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis
    Yuben P Moodley
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    J Pathol 202:486-95. 2004
    ..These observations not only suggest that specific enzymatic effectors may be preferentially activated during fibroblast apoptosis, but also provide potential insights into the pathogenesis of IPF...
  18. ncbi request reprint The role of epithelial injury and repair in the origins of asthma
    Tillie Louise Hackett
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Curr Opin Allergy Clin Immunol 7:63-8. 2007
    ..We discuss the role of epithelial injury and wound repair in the origins of asthma...
  19. pmc Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF
    Sima Allahverdian
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 38:153-60. 2008
    ..Dysregulation of EGFR phosphorylation may contribute to a persistent repair phenotype and chronically increased IL-13 release, and in turn result in airway remodeling...
  20. doi request reprint Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway
    Dmitri V Pechkovsky
    University of British Columbia, Vancouver, British Columbia V6Z1Y6, Canada
    J Biol Chem 283:12898-908. 2008
    ..These data identify a novel mechanism for TGFbeta1 signaling in human lung fibroblasts by which they may contribute to normal and pathological wound healing...
  21. pmc Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts
    Amelia K Scaffidi
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital and Department of Medicine, University of Western Australia, Nedlands, Western Australia 6009
    Br J Pharmacol 136:793-801. 2002
    ..7. OSM significantly inhibited the spontaneous apoptosis of fibroblasts at 24 and 48 h. 8. These results provide evidence that OSM has pro-fibrotic properties and suggest that it may play a role in normal lung wound repair and fibrosis...
  22. ncbi request reprint Structural changes in the airways in asthma: observations and consequences
    Tony R Bai
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Clin Sci (Lond) 108:463-77. 2005
    ..Structural changes may increase airway narrowing by alteration of smooth muscle dynamics through limitation of the ability of the smooth muscle to periodically lengthen...