Research Topics
| Anthony KicicSummaryAffiliation: University of Western Australia Country: Australia Publications
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Detail Information
Publications
Successful establishment of primary small airway cell cultures in human lung transplantationBalarka Banerjee
Queensland Centre for Pulmonary Transplantation and Vascular Disease, The Prince Charles Hospital, Brisbane, 4032, Queensland, Australia
Respir Res 10:99. 2009..Our aims were to develop robust methods for sampling small airway epithelial cells (SAEC) and to establish submerged SAEC cultures for downstream experimentation...- Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epitheliumAnthony Kicic
Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
Am J Respir Crit Care Med 181:889-98. 2010..Damage to airway epithelium is followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial cells from children with asthma fail to heal a wound in vitro... 
Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthmaAnthony Kicic
Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
Am J Respir Crit Care Med 174:1110-8. 2006..Convincing evidence of epithelial damage and aberrant repair exists in adult asthmatic airways, even in the absence of inflammation. However, comparable studies in children have been limited by access and availability of clinical samples...- Are stem cell characteristics altered by disease state?Anthony Kicic
Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute and the University of Western Australia, Nedlands, 6009, Western Australia, Australia
Stem Cells Dev 14:15-28. 2005..This investigation has shown the existence of a large pool of undifferentiated stem cells derived from the disease state that have the potential to form the desired cell types when appropriately cued... 
Bronchial brushings for investigating airway inflammation and remodellingKevin Looi
School of Paediatrics and Child Health, Centre for Health Research, The University of Western Australia, Nedlands, Australia
Respirology 16:725-37. 2011..This review attempts to provide an overview of the currently used and recently developed/adapted techniques used to obtain lung tissue with specific reference to the airway epithelium...- Marrow stromal cells (MSC): a species comparisonAnthony Kicic
Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute, Centre of Ophthalmology and Visual Science, University of Western Australia, Nedlands, 6009, Western Australia, Australia
Adv Exp Med Biol 533:407-14. 2003 - Inflammatory responses to individual microorganisms in the lungs of children with cystic fibrosisCatherine Gangell
Telethon Institute for Child Health Research and the Centre for Child Health Research, University of Western Australia, Perth, Australia
Clin Infect Dis 53:425-32. 2011..We hypothesized that the inflammatory response in the lungs of children with cystic fibrosis (CF) would vary with the type of infecting organism, being greatest with Pseudomonas aeruginosa and Staphylococcus aureus... - Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screeningStephen M Stick
Department of Respiratory Medicine, Princess Margaret Hospital for Children, School of Paediatrics and Child Health, University of Western Australia, Melbourne, Australia
J Pediatr 155:623-8.e1. 2009..To determine the prevalence of bronchiectasis in young children with cystic fibrosis (CF) diagnosed after newborn screening (NBS) and the relationship of bronchiectasis to pulmonary inflammation and infection... - The airway epithelium is a direct source of matrix degrading enzymes in bronchiolitis obliterans syndromeBalarka Banerjee
School of Paediatrics and Child Health, University of Western Australia, Nedlands, Western Australia, Australia
J Heart Lung Transplant 30:1175-85. 2011..Because matrix metalloproteinase (MMP) -2 and MMP-9 secretion is integral to repair, we hypothesized that airway epithelial cells from patients with BOS would over-express these matrix-degrading enzymes... - Regional differences in susceptibiity of bronchial epithelium to mesenchymal transition and inhibition by the macrolide antibiotic azithromycinBalarka Banerjee
School of Paediatrics and Child Health, The University of Western Australia, Nedlands, Western Australia, Australia
PLoS ONE 7:e52309. 2012..Here we determined if regional variation in the EMT response to TGFβ1 underlies the bronchiolocentric fibrosis leading to BOS and whether EMT could be inhibited by azithromycin or mycophenolate... - Early bronchiectasis in cystic fibrosis detected by surveillance CTNaveen Pillarisetti
Department of Respiratory Medicine, Royal Children s Hospital, Melbourne, Victoria, Australia
Respirology 15:1009-11. 2010.... - Innate inflammatory responses of pediatric cystic fibrosis airway epithelial cells: effects of nonviral and viral stimulationErika N Sutanto
Division of Clinical Sciences, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
Am J Respir Cell Mol Biol 44:761-7. 2011..The elevated IL-8, together with dampened apoptotic responses by CF cells to HRV, could contribute to augmented airway inflammation in the setting of recurrent viral infections early in life... - Infection, inflammation, and lung function decline in infants with cystic fibrosisNaveen Pillarisetti
Department of Respiratory Medicine, Royal Children s Hospital Melbourne, Flemington Road, Parkville, 3052, Australia
Am J Respir Crit Care Med 184:75-81. 2011.... - Differentiation of marrow stromal cells into photoreceptors in the rat eyeAnthony Kicic
Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute, affiliated with the Center of Ophthalmology and Visual Science, University of Western Australia, Nedlands, 6009, Western Australia, Australia
J Neurosci 23:7742-9. 2003..Our results establish a proof of concept for CD90+ MSC differentiation with autologous transplantation, which may provide a promising therapeutic strategy for the treatment of some forms of genetically inherited retinal degenerations... - Stability of interleukin 8 and neutrophil elastase in bronchoalveolar lavage fluid following long-term storageLuke J Berry
Division of Clinical Sciences, Telethon Institute for Child Health Research, 100 Roberts Road, Subiaco, WA 6155 Australia and Centre for Child Health Research, University of Western Australia, Perth, Australia
J Cyst Fibros 9:346-50. 2010..Longitudinal analysis assumes uniform stability during storage, however the effect of extended low-temperature storage on these markers remains unclear... - The use of non-bronchoscopic brushings to study the paediatric airwayCatherine Lane
School of Paediatrics and Child Health, University of Western Australia, Nedlands, 6009, Western Australia, Australia
Respir Res 6:53. 2005.... - Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4Nina C Sturges
Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
Pediatr Pulmonol 45:883-9. 2010..930). The increased surface expression of TLR4 seen in young children with CF appears to be related to having CF per se and not related to current pulmonary infection... - Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screeningPeter D Sly
Division of Clinical Sciences, Telethon Institute for Child Health Research, PO Box 855, W Perth, WA 6872, Australia
Am J Respir Crit Care Med 180:146-52. 2009..The promise of newborn screening (NBS) for cystic fibrosis (CF) has not been fully realized, and the extent of improvement in respiratory outcomes is unclear. We hypothesized that significant lung disease was present at diagnosis... - Limbal stem cells: the search for a markerKevin Y H Chee
Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute, 2 Verdun Street, Nedlands, WA 6009, Australia
Clin Experiment Ophthalmol 34:64-73. 2006..Such a discovery will have far-reaching implications for the study of ocular surface biology and stratified squamous epithelia in general... - Cells of epithelial lineage are present in blood, engraft the bronchial epithelium, and are increased in human lung transplantationLeigh A May
Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia
J Heart Lung Transplant 28:550-7. 2009..In this study, in the setting of human lung transplantation, we sought to determine whether exogenous epithelial cells are able to engraft the transplanted organ and if cells of a similar phenotype could be detected in peripheral blood... - Interpretation of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine is adversely affected by methodological inaccuracies when using a commercial ELISALuke W Garratt
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, WA 6008, Australia
Free Radic Biol Med 48:1460-4. 2010..The implications of these findings for study outcomes add further support for chromatographic techniques, despite their cost and complexity, to remain the gold standard in urinary 8-oxodG assessment... - Desferrithiocin is a more potent antineoplastic agent than desferrioxamineAnthony Kicic
Department of Physiology, University of Western Australia, Nedlands 6907, Western Australia, Australia
Br J Pharmacol 135:1393-402. 2002..Further investigation into the DFT class of Fe chelators seems warranted, particularly in view of its high activity in relation to DFO, a chelator which is already in clinical trial for neuroblastoma... - Using stem cells to repair the degenerate retina. Stem cells in the context of retinal degenerationsChristine M Hall
Centre for Ophthalmology and Visual Science, The University of Western Australia, Australia
Adv Exp Med Biol 572:381-8. 2006