D J Kennaway

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. doi Adipokines and adipocyte function in Clock mutant mice that retain melatonin rhythmicity
    David J Kennaway
    Robinson Institute, Research Centre for Reproductive Health Discipline of Obstetrics and Gynaecology, University of Adelaide, Medical School, Adelaide, South Australia, Australia
    Obesity (Silver Spring) 20:295-305. 2012
  2. ncbi Programming of the fetal suprachiasmatic nucleus and subsequent adult rhythmicity
    David J Kennaway
    Dept Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, 5005, Adelaide, Australia
    Trends Endocrinol Metab 13:398-402. 2002
  3. ncbi Rhythmic expression of clock and clock-controlled genes in the rat oviduct
    D J Kennaway
    Department of Obstetrics and Gynaecology, Reproductive Medicine Unit, University of Adelaide, Frome Road, Adelaide, South Australia, 5005, Australia
    Mol Hum Reprod 9:503-7. 2003
  4. ncbi Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism
    D J Kennaway
    Department of Obstetrics and Gynaecology, Adelaide University, Medical School, Adelaide, South Australia 5005
    Am J Physiol Regul Integr Comp Physiol 282:R358-65. 2002
  5. ncbi Resetting the suprachiasmatic nucleus clock
    David J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, Adelaide, South Australia, 5005
    Front Biosci 9:56-62. 2004
  6. ncbi The impact of fetal size and length of gestation on 6-sulphatoxymelatonin excretion in adult life
    D J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, South Australia
    J Pineal Res 30:188-92. 2001
  7. ncbi Serotonin, excitatory amino acids and the photic control of melatonin rhythms and SCN c-FOS in the rat
    D J Kennaway
    Department of Obstetrics and Gynaecology, Adelaide University, Medical School, Frome Road, South Australia, 5005, Adelaide, Australia
    Brain Res 897:36-43. 2001
  8. ncbi The role of circadian rhythmicity in reproduction
    David J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, Adelaide, South Australia, Australia, 5005
    Hum Reprod Update 11:91-101. 2005
  9. ncbi Reproductive performance in female Clock Delta19 mutant mice
    David J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Adelaide, SA, Australia
    Reprod Fertil Dev 16:801-10. 2004
  10. ncbi Functional central rhythmicity and light entrainment, but not liver and muscle rhythmicity, are Clock independent
    David J Kennaway
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, Medical School, University of Adelaide, Frome Rd, Adelaide, South Australia 5000, Australia
    Am J Physiol Regul Integr Comp Physiol 291:R1172-80. 2006

Detail Information

Publications36

  1. doi Adipokines and adipocyte function in Clock mutant mice that retain melatonin rhythmicity
    David J Kennaway
    Robinson Institute, Research Centre for Reproductive Health Discipline of Obstetrics and Gynaecology, University of Adelaide, Medical School, Adelaide, South Australia, Australia
    Obesity (Silver Spring) 20:295-305. 2012
    ....
  2. ncbi Programming of the fetal suprachiasmatic nucleus and subsequent adult rhythmicity
    David J Kennaway
    Dept Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, 5005, Adelaide, Australia
    Trends Endocrinol Metab 13:398-402. 2002
    ..The nature of these changes in adult rhythmicity is similar to those commonly associated with depression in humans. Thus, abnormal fetal programming might predispose adults to depressive illness...
  3. ncbi Rhythmic expression of clock and clock-controlled genes in the rat oviduct
    D J Kennaway
    Department of Obstetrics and Gynaecology, Reproductive Medicine Unit, University of Adelaide, Frome Road, Adelaide, South Australia, 5005, Australia
    Mol Hum Reprod 9:503-7. 2003
    ....
  4. ncbi Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism
    D J Kennaway
    Department of Obstetrics and Gynaecology, Adelaide University, Medical School, Adelaide, South Australia 5005
    Am J Physiol Regul Integr Comp Physiol 282:R358-65. 2002
    ..These studies have shown that the appropriate methodological tools are now available for studying melatonin rhythms in mice...
  5. ncbi Resetting the suprachiasmatic nucleus clock
    David J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, Adelaide, South Australia, 5005
    Front Biosci 9:56-62. 2004
    ..Also the effects of different experimental paradigms on outcomes, for example phase response curves and skeleton photoperiods, are discussed...
  6. ncbi The impact of fetal size and length of gestation on 6-sulphatoxymelatonin excretion in adult life
    D J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, South Australia
    J Pineal Res 30:188-92. 2001
    ..These data suggest that urinary 6-sulphatoxymelatonin excretion was impaired in adults who were growth restricted prenatally or were delivered after 40 weeks gestation...
  7. ncbi Serotonin, excitatory amino acids and the photic control of melatonin rhythms and SCN c-FOS in the rat
    D J Kennaway
    Department of Obstetrics and Gynaecology, Adelaide University, Medical School, Frome Road, South Australia, 5005, Adelaide, Australia
    Brain Res 897:36-43. 2001
    ..These results provide further evidence that serotonin plays a role in the mediation of light effects on rhythms in the rat...
  8. ncbi The role of circadian rhythmicity in reproduction
    David J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, Adelaide, South Australia, Australia, 5005
    Hum Reprod Update 11:91-101. 2005
    ..The challenge issued here is for researchers to probe their function and the consequences of their disruption in both animal and human reproduction...
  9. ncbi Reproductive performance in female Clock Delta19 mutant mice
    David J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Adelaide, SA, Australia
    Reprod Fertil Dev 16:801-10. 2004
    ..It would appear that redundancy in genes in the circadian system allows the reproductive cyclicity to persist in mice, albeit at a suboptimal level...
  10. ncbi Functional central rhythmicity and light entrainment, but not liver and muscle rhythmicity, are Clock independent
    David J Kennaway
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, Medical School, University of Adelaide, Frome Rd, Adelaide, South Australia 5000, Australia
    Am J Physiol Regul Integr Comp Physiol 291:R1172-80. 2006
    ..Therefore, liver and muscle, but not SCN, have an absolute requirement for CLOCK, with as yet unknown Clock-independent factors able to generate the latter...
  11. ncbi Metabolic homeostasis in mice with disrupted Clock gene expression in peripheral tissues
    David J Kennaway
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Univ of Adelaide, Medical School, Frome Road, Adelaide, South Australia, 5005
    Am J Physiol Regul Integr Comp Physiol 293:R1528-37. 2007
    ..It is, however, premature to declare that clock-gene disruption causes the full metabolic syndrome...
  12. doi Clock genes at the heart of depression
    David J Kennaway
    Robinson Institute, Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Australia
    J Psychopharmacol 24:5-14. 2010
    ..With this increasing knowledge we may predict that new antidepressant drugs will emerge that, as a primary or secondary mechanism of action, target and correct abnormalities in the circadian timing system...
  13. doi Circadian rhythms and fertility
    David J Kennaway
    Robinson Institute, Research Centre for Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Mol Cell Endocrinol 349:56-61. 2012
    ....
  14. ncbi Melatonin and activity rhythm responses to light pulses in mice with the Clock mutation
    David J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide Medical School, Adelaide, South Australia 5005, Australia
    Am J Physiol Regul Integr Comp Physiol 284:R1231-40. 2003
    ..They also raise important questions about the role of Clock in rhythmicity and the usefulness of monitoring behavioral rhythms compared with hormonal rhythms...
  15. ncbi Nicotine phase shifts the 6-sulphatoxymelatonin rhythm and induces c-Fos in the SCN of rats
    S A Ferguson
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, South Australia, Australia
    Brain Res Bull 48:527-38. 1999
    ..These data indicate that cholinergic neurons may alter the timing of the onset of melatonin excretion by a direct or indirect effect on the SCN possibly mediated by the nicotinic receptor...
  16. ncbi Effect of variable temperatures, darkness and light on the secretion of melatonin by pineal explants in the gecko, Christinus marmoratus
    R W Moyer
    Department of Anatomy and Histology, University of Adelaide, SA, Australia
    Brain Res 747:230-5. 1997
    ..It was concluded that both light and temperature are important modulators of pineal function although their combined effects on pineal melatonin production is complex and unclear...
  17. ncbi Emergence of altered circadian timing in a cholinergically supersensitive rat line
    S A Ferguson
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Adelaide, South Australia 5005
    Am J Physiol 277:R1171-8. 1999
    ..3 +/- 0.1 h, respectively, P < 0.05). The results suggest that the altered circadian timing of the S(ox) rats may be related to the cholinergic supersensitivity, intimating a role for acetylcholine in the circadian timing system...
  18. ncbi Estrogenic effects on urinary 6-sulphatoxymelatonin excretion in the female rat
    R M White
    Department of Obstetrics and Gynaecology, University of Adelaide, South Australia, Australia
    J Pineal Res 22:124-9. 1997
    ..6S excretion throughout the estrous cycle may provide a basis for a functional relationship between pineal activity and reproduction in this species...
  19. ncbi Immunohistochemical localization of serotonin receptors in the rat suprachiasmatic nucleus
    R W Moyer
    Department of Obstetrics and Gynaecology, Medical School University of Adelaide, South Australia, Australia
    Neurosci Lett 271:147-50. 1999
    ....
  20. ncbi Prenatal exposure to the dopamine agonist SKF-38393 disrupts the timing of the initial response of the suprachiasmatic nucleus to light
    S A Ferguson
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, Adelaide, Australia
    Brain Res 858:284-9. 2000
    ..The exposure to dopaminergic stimulation during gestation may have altered the timing of development of afferent connections to the fetal SCN, resulting in alteration of the initial response of the circadian timing system to light...
  21. ncbi Thermocyclic entrainment of lizard blood plasma melatonin rhythms in constant and cyclic photic environments
    B T Firth
    Department of Anatomical Sciences, University of Adelaide, Adelaide, SA 5005, Australia
    Am J Physiol 277:R1620-6. 1999
    ..Taken together, these results support the notion that there is an interaction between the external light and temperature cycle and a circadian clock in determining melatonin rhythms in Tiliqua rugosa...
  22. ncbi Circadian rhythms and reproduction
    Michael J Boden
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Reproduction 132:379-92. 2006
    ..With the role of Clock and Bmal1 in fertility becoming clearer, it may be time to pursue the effect of polymorphisms in these genes in relation to the various types of infertility in humans...
  23. ncbi Phase response relationships between light pulses and the melatonin rhythm in rats
    J M Stepien
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, South Australia
    J Biol Rhythms 16:234-42. 2001
    ..It is concluded that phase response curves conducted under Type I and Type II conditions are comparable...
  24. doi Activation of 5-HT2C receptors acutely induces Per1 gene expression in the rat SCN in vitro
    Tamara J Varcoe
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia
    Brain Res 1209:19-28. 2008
    ..This response was similar to that previously observed in vivo. This provides support for the hypothesis that the actions of 5-HT2C receptor agonists are on cells located within the SCN...
  25. pmc Pinealectomy in the chicken: a good model of scoliosis?
    Andrew B Fagan
    Discipline of Orthopaedics and Trauma, The University of Adelaide, Royal Adelaide Hospital, Adelaide, SA, 5000, Australia
    Eur Spine J 18:1154-9. 2009
    ..This study highlights important differences between the chicken and the human, and between their respective spinal deformities. Caution is advised when drawing conclusions regarding the pathogenesis of AIS from this model...
  26. doi Melatonin rhythms in the Australian freshwater crocodile (Crocodylus johnstoni): a reptile lacking a pineal complex?
    Bruce T Firth
    Discipline of Anatomical Sciences, Faculty of Health Sciences, School of Medical Sciences, University of Adelaide, Adelaide, SA, 5005, Australia
    J Comp Physiol B 180:67-72. 2010
    ..Further studies are needed to determine why the melatonin rhythm is intermittently expressed and whether this may be related to seasonal changes in the expression of the rhythm linked to tropical environments...
  27. ncbi Activation of 5-HT2C receptors acutely induces Per gene expression in the rat suprachiasmatic nucleus at night
    Tamara J Varcoe
    Department of Obstetrics and Gynaecology, University of Adelaide Medical School, Frome Road, Adelaide 5005, South Australia, Australia
    Brain Res Mol Brain Res 119:192-200. 2003
    ..The drug increased both Per1 and Per2 expression at ZT16, but had no effect at ZT22. These results provide evidence for 5-HT2C receptors being involved in the modulation of circadian rhythms during early night...
  28. ncbi Persistence of a plasma melatonin rhythm in constant darkness and its inhibition by constant light in the sleepy lizard, Tiliqua rugosa
    Bruce T Firth
    Department of Anatomical Sciences, University of Adelaide, Adelaide, Australia
    J Pineal Res 41:15-20. 2006
    ..Therefore, the sleepy lizard pineal gland may be an independent oscillator capable of driving the melatonin rhythm and be a transducer of the seasonally changing external photothermal environment...
  29. ncbi Maternal fluoxetine infusion does not alter fetal endocrine and biophysical circadian rhythms in pregnant sheep
    Janna L Morrison
    Department of Obstetrics and Gynecology, BC Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, BC, Canada
    J Soc Gynecol Investig 12:356-64. 2005
    ..We have therefore investigated the effect of chronic administration of FX on maternal and fetal circadian rhythms in sheep...
  30. ncbi Generation and entrainment of circadian rhythms
    D J Kennaway
    Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, South Australia, Australia
    Clin Exp Pharmacol Physiol 25:862-5. 1998
    ..How the re-setting is achieved at the cellular level is not known...
  31. ncbi Melatonin in rat milk and the likelihood of its role in postnatal maternal entrainment of rhythms
    Shawn A Rowe
    Department of Obstetrics and Gynaecology, University of Adelaide Medical School, Adelaide, South Australia 5005, Australia
    Am J Physiol Regul Integr Comp Physiol 282:R797-804. 2002
    ..Propranolol administration to 2- and 5-day lactating dams inhibited plasma and milk melatonin at night but had no effect on their suckling pups. Transfer of melatonin via the milk is unlikely to provide an entraining signal for rat pups...
  32. ncbi Melatonin and circadian rhythms
    David J Kennaway
    Department of Obstetrics and Gynaecology, Adelaide University, Medical School, South Australia
    Curr Top Med Chem 2:199-209. 2002
    ..We also review the role of melatonin rhythmicity in sleep timing and sleep initiation...
  33. ncbi Differential effects of light wavelength in phase advancing the melatonin rhythm
    Helen R Wright
    School of Psychology, Flinders University, Adelaide, South Australia, Australia
    J Pineal Res 36:140-4. 2004
    ..These results strengthen earlier findings that the human circadian system is more sensitive to the short wavelengths of light than the longer wavelengths...
  34. doi Reproductive biology of female Bmal1 null mice
    Michael J Boden
    School of Paediatrics and Reproductive Health, Robinson Institute, Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Reproduction 139:1077-90. 2010
    ..The loss of Bmal1 gene expression resulted in a loss of rhythmicity of many genes in the ovary and downregulation of Star. In conclusion, it is clear that the profound infertility of Bmal1 null mice is multifactorial...
  35. ncbi Potential action of melatonin in insomnia
    Naomi L Rogers
    The University of Pennsylvania School of Medicine, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Philadelphia 19104 6021, USA
    Sleep 26:1058-9. 2003
  36. ncbi Neurobehavioural performance effects of daytime melatonin and temazepam administration
    Naomi L Rogers
    Division of Sleep and Chronobiology, Unit for Experimental Psychiatry, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Sleep Res 12:207-12. 2003
    ..Given melatonin's soporific and chronobiotic properties, these results suggest that melatonin may be preferable to benzodiazepines in the management of circadian and sleep disorders...