Research Topics
| D J KennawaySummaryAffiliation: University of Adelaide Country: Australia Publications
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Publications
Adipokines and adipocyte function in Clock mutant mice that retain melatonin rhythmicityDavid J Kennaway
Robinson Institute, Research Centre for Reproductive Health Discipline of Obstetrics and Gynaecology, University of Adelaide, Medical School, Adelaide, South Australia, Australia
Obesity (Silver Spring) 20:295-305. 2012....
Programming of the fetal suprachiasmatic nucleus and subsequent adult rhythmicityDavid J Kennaway
Dept Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, 5005, Adelaide, Australia
Trends Endocrinol Metab 13:398-402. 2002..The nature of these changes in adult rhythmicity is similar to those commonly associated with depression in humans. Thus, abnormal fetal programming might predispose adults to depressive illness...- Rhythmic expression of clock and clock-controlled genes in the rat oviductD J Kennaway
Department of Obstetrics and Gynaecology, Reproductive Medicine Unit, University of Adelaide, Frome Road, Adelaide, South Australia, 5005, Australia
Mol Hum Reprod 9:503-7. 2003.... - Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolismD J Kennaway
Department of Obstetrics and Gynaecology, Adelaide University, Medical School, Adelaide, South Australia 5005
Am J Physiol Regul Integr Comp Physiol 282:R358-65. 2002..These studies have shown that the appropriate methodological tools are now available for studying melatonin rhythms in mice... - Resetting the suprachiasmatic nucleus clockDavid J Kennaway
Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, Adelaide, South Australia, 5005
Front Biosci 9:56-62. 2004..Also the effects of different experimental paradigms on outcomes, for example phase response curves and skeleton photoperiods, are discussed... - The impact of fetal size and length of gestation on 6-sulphatoxymelatonin excretion in adult lifeD J Kennaway
Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, South Australia
J Pineal Res 30:188-92. 2001..These data suggest that urinary 6-sulphatoxymelatonin excretion was impaired in adults who were growth restricted prenatally or were delivered after 40 weeks gestation... - Serotonin, excitatory amino acids and the photic control of melatonin rhythms and SCN c-FOS in the ratD J Kennaway
Department of Obstetrics and Gynaecology, Adelaide University, Medical School, Frome Road, South Australia, 5005, Adelaide, Australia
Brain Res 897:36-43. 2001..These results provide further evidence that serotonin plays a role in the mediation of light effects on rhythms in the rat... - The role of circadian rhythmicity in reproductionDavid J Kennaway
Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, Adelaide, South Australia, Australia, 5005
Hum Reprod Update 11:91-101. 2005..The challenge issued here is for researchers to probe their function and the consequences of their disruption in both animal and human reproduction... - Reproductive performance in female Clock Delta19 mutant miceDavid J Kennaway
Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Adelaide, SA, Australia
Reprod Fertil Dev 16:801-10. 2004..It would appear that redundancy in genes in the circadian system allows the reproductive cyclicity to persist in mice, albeit at a suboptimal level... - Functional central rhythmicity and light entrainment, but not liver and muscle rhythmicity, are Clock independentDavid J Kennaway
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, Medical School, University of Adelaide, Frome Rd, Adelaide, South Australia 5000, Australia
Am J Physiol Regul Integr Comp Physiol 291:R1172-80. 2006..Therefore, liver and muscle, but not SCN, have an absolute requirement for CLOCK, with as yet unknown Clock-independent factors able to generate the latter... - Metabolic homeostasis in mice with disrupted Clock gene expression in peripheral tissuesDavid J Kennaway
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Univ of Adelaide, Medical School, Frome Road, Adelaide, South Australia, 5005
Am J Physiol Regul Integr Comp Physiol 293:R1528-37. 2007..It is, however, premature to declare that clock-gene disruption causes the full metabolic syndrome... - Clock genes at the heart of depressionDavid J Kennaway
Robinson Institute, Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Australia
J Psychopharmacol 24:5-14. 2010..With this increasing knowledge we may predict that new antidepressant drugs will emerge that, as a primary or secondary mechanism of action, target and correct abnormalities in the circadian timing system... - Circadian rhythms and fertilityDavid J Kennaway
Robinson Institute, Research Centre for Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
Mol Cell Endocrinol 349:56-61. 2012.... - Melatonin and activity rhythm responses to light pulses in mice with the Clock mutationDavid J Kennaway
Department of Obstetrics and Gynaecology, University of Adelaide Medical School, Adelaide, South Australia 5005, Australia
Am J Physiol Regul Integr Comp Physiol 284:R1231-40. 2003..They also raise important questions about the role of Clock in rhythmicity and the usefulness of monitoring behavioral rhythms compared with hormonal rhythms... - Nicotine phase shifts the 6-sulphatoxymelatonin rhythm and induces c-Fos in the SCN of ratsS A Ferguson
Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, South Australia, Australia
Brain Res Bull 48:527-38. 1999..These data indicate that cholinergic neurons may alter the timing of the onset of melatonin excretion by a direct or indirect effect on the SCN possibly mediated by the nicotinic receptor... - Effect of variable temperatures, darkness and light on the secretion of melatonin by pineal explants in the gecko, Christinus marmoratusR W Moyer
Department of Anatomy and Histology, University of Adelaide, SA, Australia
Brain Res 747:230-5. 1997..It was concluded that both light and temperature are important modulators of pineal function although their combined effects on pineal melatonin production is complex and unclear... - Emergence of altered circadian timing in a cholinergically supersensitive rat lineS A Ferguson
Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Adelaide, South Australia 5005
Am J Physiol 277:R1171-8. 1999..3 +/- 0.1 h, respectively, P < 0.05). The results suggest that the altered circadian timing of the S(ox) rats may be related to the cholinergic supersensitivity, intimating a role for acetylcholine in the circadian timing system... - Estrogenic effects on urinary 6-sulphatoxymelatonin excretion in the female ratR M White
Department of Obstetrics and Gynaecology, University of Adelaide, South Australia, Australia
J Pineal Res 22:124-9. 1997..6S excretion throughout the estrous cycle may provide a basis for a functional relationship between pineal activity and reproduction in this species... - Immunohistochemical localization of serotonin receptors in the rat suprachiasmatic nucleusR W Moyer
Department of Obstetrics and Gynaecology, Medical School University of Adelaide, South Australia, Australia
Neurosci Lett 271:147-50. 1999.... - Prenatal exposure to the dopamine agonist SKF-38393 disrupts the timing of the initial response of the suprachiasmatic nucleus to lightS A Ferguson
Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, Frome Road, Adelaide, Australia
Brain Res 858:284-9. 2000..The exposure to dopaminergic stimulation during gestation may have altered the timing of development of afferent connections to the fetal SCN, resulting in alteration of the initial response of the circadian timing system to light... - Thermocyclic entrainment of lizard blood plasma melatonin rhythms in constant and cyclic photic environmentsB T Firth
Department of Anatomical Sciences, University of Adelaide, Adelaide, SA 5005, Australia
Am J Physiol 277:R1620-6. 1999..Taken together, these results support the notion that there is an interaction between the external light and temperature cycle and a circadian clock in determining melatonin rhythms in Tiliqua rugosa... - Circadian rhythms and reproductionMichael J Boden
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
Reproduction 132:379-92. 2006..With the role of Clock and Bmal1 in fertility becoming clearer, it may be time to pursue the effect of polymorphisms in these genes in relation to the various types of infertility in humans... - Phase response relationships between light pulses and the melatonin rhythm in ratsJ M Stepien
Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, South Australia
J Biol Rhythms 16:234-42. 2001..It is concluded that phase response curves conducted under Type I and Type II conditions are comparable... - Activation of 5-HT2C receptors acutely induces Per1 gene expression in the rat SCN in vitroTamara J Varcoe
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia
Brain Res 1209:19-28. 2008..This response was similar to that previously observed in vivo. This provides support for the hypothesis that the actions of 5-HT2C receptor agonists are on cells located within the SCN... 
Pinealectomy in the chicken: a good model of scoliosis?Andrew B Fagan
Discipline of Orthopaedics and Trauma, The University of Adelaide, Royal Adelaide Hospital, Adelaide, SA, 5000, Australia
Eur Spine J 18:1154-9. 2009..This study highlights important differences between the chicken and the human, and between their respective spinal deformities. Caution is advised when drawing conclusions regarding the pathogenesis of AIS from this model...- Melatonin rhythms in the Australian freshwater crocodile (Crocodylus johnstoni): a reptile lacking a pineal complex?Bruce T Firth
Discipline of Anatomical Sciences, Faculty of Health Sciences, School of Medical Sciences, University of Adelaide, Adelaide, SA, 5005, Australia
J Comp Physiol B 180:67-72. 2010..Further studies are needed to determine why the melatonin rhythm is intermittently expressed and whether this may be related to seasonal changes in the expression of the rhythm linked to tropical environments... - Activation of 5-HT2C receptors acutely induces Per gene expression in the rat suprachiasmatic nucleus at nightTamara J Varcoe
Department of Obstetrics and Gynaecology, University of Adelaide Medical School, Frome Road, Adelaide 5005, South Australia, Australia
Brain Res Mol Brain Res 119:192-200. 2003..The drug increased both Per1 and Per2 expression at ZT16, but had no effect at ZT22. These results provide evidence for 5-HT2C receptors being involved in the modulation of circadian rhythms during early night... - Persistence of a plasma melatonin rhythm in constant darkness and its inhibition by constant light in the sleepy lizard, Tiliqua rugosaBruce T Firth
Department of Anatomical Sciences, University of Adelaide, Adelaide, Australia
J Pineal Res 41:15-20. 2006..Therefore, the sleepy lizard pineal gland may be an independent oscillator capable of driving the melatonin rhythm and be a transducer of the seasonally changing external photothermal environment... - Maternal fluoxetine infusion does not alter fetal endocrine and biophysical circadian rhythms in pregnant sheepJanna L Morrison
Department of Obstetrics and Gynecology, BC Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, BC, Canada
J Soc Gynecol Investig 12:356-64. 2005..We have therefore investigated the effect of chronic administration of FX on maternal and fetal circadian rhythms in sheep... - Generation and entrainment of circadian rhythmsD J Kennaway
Department of Obstetrics and Gynaecology, University of Adelaide, Medical School, South Australia, Australia
Clin Exp Pharmacol Physiol 25:862-5. 1998..How the re-setting is achieved at the cellular level is not known... - Melatonin in rat milk and the likelihood of its role in postnatal maternal entrainment of rhythmsShawn A Rowe
Department of Obstetrics and Gynaecology, University of Adelaide Medical School, Adelaide, South Australia 5005, Australia
Am J Physiol Regul Integr Comp Physiol 282:R797-804. 2002..Propranolol administration to 2- and 5-day lactating dams inhibited plasma and milk melatonin at night but had no effect on their suckling pups. Transfer of melatonin via the milk is unlikely to provide an entraining signal for rat pups... - Melatonin and circadian rhythmsDavid J Kennaway
Department of Obstetrics and Gynaecology, Adelaide University, Medical School, South Australia
Curr Top Med Chem 2:199-209. 2002..We also review the role of melatonin rhythmicity in sleep timing and sleep initiation... - Differential effects of light wavelength in phase advancing the melatonin rhythmHelen R Wright
School of Psychology, Flinders University, Adelaide, South Australia, Australia
J Pineal Res 36:140-4. 2004..These results strengthen earlier findings that the human circadian system is more sensitive to the short wavelengths of light than the longer wavelengths... - Reproductive biology of female Bmal1 null miceMichael J Boden
School of Paediatrics and Reproductive Health, Robinson Institute, Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, South Australia 5005, Australia
Reproduction 139:1077-90. 2010..The loss of Bmal1 gene expression resulted in a loss of rhythmicity of many genes in the ovary and downregulation of Star. In conclusion, it is clear that the profound infertility of Bmal1 null mice is multifactorial... - Potential action of melatonin in insomniaNaomi L Rogers
The University of Pennsylvania School of Medicine, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Philadelphia 19104-6021, USA
Sleep 26:1058-9. 2003 - Neurobehavioural performance effects of daytime melatonin and temazepam administrationNaomi L Rogers
Division of Sleep and Chronobiology, Unit for Experimental Psychiatry, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Sleep Res 12:207-12. 2003..Given melatonin's soporific and chronobiotic properties, these results suggest that melatonin may be preferable to benzodiazepines in the management of circadian and sleep disorders...