Paul A Keller

Summary

Affiliation: University of Wollongong
Country: Australia

Publications

  1. ncbi request reprint The first syntheses of enantiopure 2,2'-biindoline
    Steven M Wales
    School of Chemistry, University of Wollongong, Wollongong, Australia
    Chem Commun (Camb) 46:9226-8. 2010
  2. ncbi request reprint The role of the HPA axis in psychiatric disorders and CRF antagonists as potential treatments
    Paul A Keller
    Chemistry School of Environmental and Life Sciences, University of Newcastle, Callaghan, Australia
    Arch Pharm (Weinheim) 339:346-55. 2006
  3. doi request reprint Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 18:4793-800. 2010
  4. doi request reprint Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives
    Mark Robertson
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Eur J Med Chem 46:4201-11. 2011
  5. doi request reprint Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    J Ethnopharmacol 143:310-3. 2012
  6. doi request reprint Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid
    Daniel R Coghlan
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 19:3549-57. 2011
  7. doi request reprint Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 18:2611-20. 2010
  8. ncbi request reprint Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia
    Nat Prod Commun 7:575-80. 2012
  9. ncbi request reprint GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Nat Prod Commun 8:1305-8. 2013
  10. pmc Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Beilstein J Org Chem 8:1265-70. 2012

Collaborators

  • Phurpa Wangchuk
  • John B Bremner
  • R Griffith
  • Adam McCluskey
  • A Katsifis
  • Thanapat Sastraruji
  • John Deadman
  • Stephen G Pyne
  • David I Rhodes
  • Jonathan Coates
  • Kittiya Somphol
  • Alireza Shakoori
  • Anthony C Willis
  • Daniel R Coghlan
  • Mark Robertson
  • Allan B Gamble
  • Steven M Wales
  • Adel Garas
  • Timothy P Boyle
  • James Garner
  • Nageshwar R Yepuri
  • Taryn P Homes
  • Christopher P Gordon
  • Rachada Haritakul
  • Jody Morgan
  • Glenn A Burley
  • Rachada Haritakun
  • Dean Baylis
  • Alan D Robertson
  • Dorothy M David
  • Jonathan A Coates
  • David Rhodes
  • Scott P Leach
  • Filomena Mattner
  • Graham E Ball

Detail Information

Publications31

  1. ncbi request reprint The first syntheses of enantiopure 2,2'-biindoline
    Steven M Wales
    School of Chemistry, University of Wollongong, Wollongong, Australia
    Chem Commun (Camb) 46:9226-8. 2010
    ..The first two syntheses of chiral 2,2'-biindoline are reported either in five steps from 2,2'-bioxirane, or three steps from 2,2'-biaziridine, both with exceptional enantiopurity...
  2. ncbi request reprint The role of the HPA axis in psychiatric disorders and CRF antagonists as potential treatments
    Paul A Keller
    Chemistry School of Environmental and Life Sciences, University of Newcastle, Callaghan, Australia
    Arch Pharm (Weinheim) 339:346-55. 2006
    ..The association of the corticotrophin releasing factor (CRF) and the HPA axis indicates that CRF antagonists should be beneficial as potential therapeutics...
  3. doi request reprint Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 18:4793-800. 2010
    ....
  4. doi request reprint Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives
    Mark Robertson
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Eur J Med Chem 46:4201-11. 2011
    ....
  5. doi request reprint Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    J Ethnopharmacol 143:310-3. 2012
    ..Corydalis dubia is used in Bhutanese traditional medicine as a febrifuge and for treating infections in the blood, liver and bile which correlate to the signs and symptoms of malarial and microbial infections...
  6. doi request reprint Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid
    Daniel R Coghlan
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 19:3549-57. 2011
    ..This paper presents some structure-activity relationship studies with additional macrocycles based on this lead compound against Staphylococcus aureus together with the antibacterial activity of two related acyclic compounds...
  7. doi request reprint Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 18:2611-20. 2010
    ..9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE)...
  8. ncbi request reprint Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia
    Nat Prod Commun 7:575-80. 2012
    ..This study also identified compound 5 as potential new antimalarial lead compound...
  9. ncbi request reprint GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Nat Prod Commun 8:1305-8. 2013
    ..2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). They exhibited mild antibacterial activity against Bacillus subtilis. None of the test samples showed cytotoxicity...
  10. pmc Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Beilstein J Org Chem 8:1265-70. 2012
    ....
  11. doi request reprint Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    J Ethnopharmacol 137:730-42. 2011
    ..We have focused our study only on seven species of these plants...
  12. ncbi request reprint The synthesis and testing of arenearylpyrimidylmethanes as antimalarial agents
    Nageshwar R Yepuri
    Department of Chemistry, University of Wollongong, Wollongong, 2522, Australia
    ChemMedChem 1:715-7. 2006
  13. ncbi request reprint A new methodology for the simulation of flexible protein-ligand interactions
    James Garner
    Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    J Mol Graph Model 26:187-97. 2007
    ..Short simulation times are sufficient to achieve good refinement of docking poses resulting from exchange of structurally dissimilar inhibitors between crystal structures...
  14. doi request reprint Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials
    Timothy P Boyle
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Eur J Med Chem 44:1001-9. 2009
    ..An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 microg/mL against Staphylococcus aureus...
  15. doi request reprint A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain
    Phurpa Wangchuk
    Menjong Sorig Pharmaceuticals, Ministry of Health, Thimphu, Bhutan School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia Electronic address
    J Ethnopharmacol 150:953-9. 2013
    ..This study is to validate the ethnopharmacological uses of this plant and also identify potent antimalarial drug leads through bioassays of its crude extracts and phytochemical constituents...
  16. ncbi request reprint Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists
    Adam McCluskey
    Chemistry, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia
    Org Biomol Chem 1:3353-61. 2003
    ..Additionally we have utilized these data and that recently reported by others to refine our original CRH1 pharmacophore (J Med. Chem., 1999, 42, 2351-2357)...
  17. doi request reprint An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: Textual understanding and the current practices
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, NSW 2500, Australia
    J Ethnopharmacol 148:305-10. 2013
    ..It caters to 20-30% of the daily out-patients within 49 traditional medicine units attached to 20 district modern hospitals and 29 Basic Health Units in the country...
  18. ncbi request reprint Combining structure-based drug design and pharmacophores
    Renate Griffith
    School of Environmental and Life Sciences, University of Newcastle, NSW 2308, Australia
    J Mol Graph Model 23:439-46. 2005
    ..Various types of novel pharmacophores are discussed and compared, using HIV-1 reverse transcriptase (RT) as the target protein, and their application in database searching is presented...
  19. ncbi request reprint Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites
    Taryn P Homes
    Department of Chemistry, University of Wollongong, NSW 2500, Wollongong, Australia
    Bioorg Med Chem 14:3938-46. 2006
    ..This high affinity and selective radioligand may be useful for imaging neurodegeneration, inflammation and tumours using single photon emission computed tomography...
  20. ncbi request reprint Novel pharmacophore-based methods reveal gossypol as a reverse transcriptase inhibitor
    Paul A Keller
    Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    J Mol Graph Model 21:365-73. 2003
    ..These results suggest that at least a part of its anti-HIV activity is due to gossypol targeting the non-nucleoside inhibitor binding pocket of RT...
  21. ncbi request reprint New anti-malarial compounds from database searching
    Renate Griffith
    School of Biological and Chemical Sciences, University of Newcastle, 2308, Callaghan, NSW, Australia
    Bioorg Med Chem Lett 12:539-42. 2002
    ....
  22. doi request reprint Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    J Ethnopharmacol 148:1013-7. 2013
    ....
  23. ncbi request reprint Mining the Chemical Abstracts database with pharmacophore-based queries
    John B Bremner
    Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    J Mol Graph Model 21:185-94. 2002
    ..Several structurally novel rigid ring skeletons were found with this new database mining technique which are potentially useful as leads in the design of alpha1B selective adrenergic receptor antagonists...
  24. doi request reprint Rapid cascade synthesis of poly-heterocyclic architectures from indigo
    Alireza Shakoori
    School of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia
    J Org Chem 78:7639-47. 2013
    ....
  25. ncbi request reprint Control of hepatitis C: a medicinal chemistry perspective
    Christopher P Gordon
    Department of Chemistry, University of Wollongong, Wollongong 2522, Australia
    J Med Chem 48:1-20. 2005
  26. doi request reprint Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities
    Adel Garas
    School of Chemistry, University of Wollongong, Wollongong, NSW, Australia
    Bioorg Med Chem Lett 19:3010-3. 2009
    ..An efficient synthesis of four new acyclic and four new cyclic binaphthyl-based cationic peptoids is described. These compounds had anti-bacterial activities with MIC values of 4-62 microg/mL against Staphylococcus aureus...
  27. doi request reprint Ethnobotanical authentication and identification of Khrog-sman (Lower Elevation Medicinal Plants) of Bhutan
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
    J Ethnopharmacol 134:813-23. 2011
    ..Our study reports the botanical identification of 'Lower Elevation Medicinal Plants' and their ethnomedical uses...
  28. doi request reprint Synthesis of reaction-ready 6,6'-biindole and 6,6'-biisatin via palladium(II)-catalysed intramolecular C-H functionalisation
    Allan B Gamble
    School of Chemistry, University of Wollongong, 2522, Wollongong, Australia
    Chem Commun (Camb) 46:4076-8. 2010
    ....
  29. ncbi request reprint Bioactive Discovery in the New Millennium--A Joint RACI, JMGM, FACS and MM2003 Conference. 5-9 February 2003, Lorne, Australia
    Paul A Keller
    Department of Chemistry, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
    IDrugs 6:315-7. 2003
  30. ncbi request reprint Anilinopyrimidines as novel antituberculosis agents
    Jody Morgan
    Department of Chemistry, University of Wollongong, NSW 2522, Australia
    Bioorg Med Chem Lett 13:1755-7. 2003
    ..A selection of novel anilinopyrimidine analogues have been found to have micromolar activity against Mycobacterium tuberculosis. This could potentially generate new lead compounds in the fight against multi-drug resistant tuberculosis...
  31. ncbi request reprint Synthesis and characterization of mono- and bis-methano[60]fullerenyl amino acid derivatives and their reductive ring-opening retro-bingel reactions
    Glenn A Burley
    Department of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia
    J Org Chem 67:8316-30. 2002
    ..Thus, it was concluded that the tether was not the driving force for the reductive elimination of one of the methano groups...