Dorothy M Keefe

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi Developing evidence-based guidelines for management of alimentary mucositis: process and pitfalls
    Dorothy M Keefe
    Department of Medical Oncology, Royal Adelaide Hospital Cancer Centre, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, 5000, Australia
    Support Care Cancer 14:492-8. 2006
  2. ncbi Irinotecan-induced alterations in intestinal cell kinetics and extracellular matrix component expression in the dark agouti rat
    Noor Al-Dasooqi
    Department of Medicine, University of Adelaide, North Terrace, Adelaide, SA, Australia
    Int J Exp Pathol 92:357-65. 2011
  3. ncbi Selection of housekeeping genes for gene expression studies in a rat model of irinotecan-induced mucositis
    Noor Al-Dasooqi
    Department of Medicine, University of Adelaide, Adelaide, S A, Australia
    Chemotherapy 57:43-53. 2011
  4. ncbi Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat
    Noor Al-Dasooqi
    Department of Medicine, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
    Exp Biol Med (Maywood) 235:1244-56. 2010
  5. ncbi Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis?
    Noor Al-Dasooqi
    Department of Medicine, University of Adelaide, Adelaide, SA, Australia
    Cancer Chemother Pharmacol 64:1-9. 2009
  6. ncbi Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans
    Joanne M Bowen
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia
    Pathology 37:56-62. 2005
  7. ncbi Trastuzumab induces gastrointestinal side effects in HER2-overexpressing breast cancer patients
    Noor Al-Dasooqi
    Department of Physiology, University of Adelaide, North Terrace, Adelaide, SA, Australia
    Invest New Drugs 27:173-8. 2009
  8. ncbi Emerging drugs for chemotherapy-induced mucositis
    Dorothy M Keefe
    Royal Adelaide Hospital, RAH Cancer Centre, North Terrace, Adelaide, SA 5000, Australia
    Expert Opin Emerg Drugs 13:511-22. 2008
  9. ncbi Updated clinical practice guidelines for the prevention and treatment of mucositis
    Dorothy M Keefe
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, Australia
    Cancer 109:820-31. 2007
  10. ncbi Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis
    Zhi Yi Ong
    School of Medicine, University of Adelaide, Adelaide, South Australia
    Radiat Oncol 5:22. 2010

Detail Information

Publications14

  1. ncbi Developing evidence-based guidelines for management of alimentary mucositis: process and pitfalls
    Dorothy M Keefe
    Department of Medical Oncology, Royal Adelaide Hospital Cancer Centre, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, 5000, Australia
    Support Care Cancer 14:492-8. 2006
    ....
  2. ncbi Irinotecan-induced alterations in intestinal cell kinetics and extracellular matrix component expression in the dark agouti rat
    Noor Al-Dasooqi
    Department of Medicine, University of Adelaide, North Terrace, Adelaide, SA, Australia
    Int J Exp Pathol 92:357-65. 2011
    ..Changes in ECM expression may have a direct impact on the loss of mucosal layer integrity evident in chemotherapy-induced mucositis...
  3. ncbi Selection of housekeeping genes for gene expression studies in a rat model of irinotecan-induced mucositis
    Noor Al-Dasooqi
    Department of Medicine, University of Adelaide, Adelaide, S A, Australia
    Chemotherapy 57:43-53. 2011
    ..As this method relies on the use of a validated endogenous control, this study aims to validate commonly used housekeeping genes in an irinotecan-induced mucositis model...
  4. ncbi Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat
    Noor Al-Dasooqi
    Department of Medicine, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
    Exp Biol Med (Maywood) 235:1244-56. 2010
    ..This prompts the consideration of MMPs as possible mediators of chemotherapy-induced mucositis...
  5. ncbi Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis?
    Noor Al-Dasooqi
    Department of Medicine, University of Adelaide, Adelaide, SA, Australia
    Cancer Chemother Pharmacol 64:1-9. 2009
    ..This prompts the consideration of MMPs as possibly being key mediators in mucositis development...
  6. ncbi Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans
    Joanne M Bowen
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia
    Pathology 37:56-62. 2005
    ..The aim of this study was to examine the effect of cytotoxic treatment on Bcl-2 protein expression in patients and rats with tumours...
  7. ncbi Trastuzumab induces gastrointestinal side effects in HER2-overexpressing breast cancer patients
    Noor Al-Dasooqi
    Department of Physiology, University of Adelaide, North Terrace, Adelaide, SA, Australia
    Invest New Drugs 27:173-8. 2009
    ..To characterise the gastrointestinal toxicities associated with Trastuzumab administration in HER2-overexpressing breast cancer patients...
  8. ncbi Emerging drugs for chemotherapy-induced mucositis
    Dorothy M Keefe
    Royal Adelaide Hospital, RAH Cancer Centre, North Terrace, Adelaide, SA 5000, Australia
    Expert Opin Emerg Drugs 13:511-22. 2008
    ..The pathobiology of mucositis is complex, and agents that target mechanisms to prevent mucositis or accelerate healing are in high demand...
  9. ncbi Updated clinical practice guidelines for the prevention and treatment of mucositis
    Dorothy M Keefe
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, Australia
    Cancer 109:820-31. 2007
    ..These efforts are likely to have significant clinical and economic impact on the treatment of cancer patients. Cancer 2007;109:820-31. (c) 2007 American Cancer Society...
  10. ncbi Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis
    Zhi Yi Ong
    School of Medicine, University of Adelaide, Adelaide, South Australia
    Radiat Oncol 5:22. 2010
    ..Therefore, the aim of the present study was to characterise the expression of pro-inflammatory cytokines in the gastrointestinal tract using a rat model of fractionated radiotherapy-induced toxicity...
  11. ncbi Severe mucositis: how can nutrition help?
    Dorothy M Keefe
    Royal Adelaide Hospital Cancer Centre, Royal Adelaide Hospital, South Australia
    Curr Opin Clin Nutr Metab Care 10:627-31. 2007
    ..To review the recent evidence on the effect of nutrition on the incidence and severity of mucositis following anticancer treatment...
  12. ncbi Intestinal mucositis: mechanisms and management
    Dorothy M Keefe
    Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Curr Opin Oncol 19:323-7. 2007
    ..To describe the advances in the rapidly evolving field of intestinal (or alimentary) mucositis during the past year...
  13. ncbi The combination of oral and small intestinal mucositis, pediatrics and biomarkers: a particularly tricky problem!
    Dorothy M Keefe
    Department of Medical Oncology, Royal Adelaide Hospital and Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South, Australia
    Cancer Biol Ther 5:1282-4. 2006
  14. ncbi Alimentary tract mucositis in cancer patients: impact of terminology and assessment on research and clinical practice
    Douglas E Peterson
    Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, 06030 1605, USA
    Support Care Cancer 14:499-504. 2006
    ..OBJECTIVES: This paper will review history, current status, and new research directions associated with terminology and assessment of mucosal injury in cancer patients in the context described above...