G R Kaufmann
Affiliation: University of New South Wales
- Antiretroviral therapy of HIV-1 infection: established treatment strategies and new therapeutic optionsG R Kaufmann
National Centre in HIV Epidemiology and Clinical Research, Level 2, 376 Victoria Street, NSW 2010, Sydney, Australia
Curr Opin Microbiol 3:508-14. 2000..Triple combination therapy that includes a non-nucleoside reverse transcriptase inhibitor can therefore be regarded as an effective alternative first-line treatment of HIV-1 infection...
- Long-term immunological response in HIV-1-infected subjects receiving potent antiretroviral therapyG R Kaufmann
National Centre in HIV Epidemiology and Clinical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
AIDS 14:959-69. 2000..To determine the long-term T-lymphocyte response to highly active antiretroviral therapy (HAART) and to define predictors of the immunological response...
- Impact of early HIV-1 RNA and T-lymphocyte dynamics during primary HIV-1 infection on the subsequent course of HIV-1 RNA levels and CD4+ T-lymphocyte counts in the first year of HIV-1 infection. Sydney Primary HIV Infection Study GroupG R Kaufmann
Centre for Immunology, St Vincent s Hospital, Sydney, New South Wales, Australia
J Acquir Immune Defic Syndr 22:437-44. 1999..Nadir viral load was the strongest predictor of HIV-1 RNA levels as well as of CD4+ counts at 6 to 12 months. An early decline of CD4+ T lymphocytes may be a useful clinical prognostic marker for rapid disease progression...
- Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremiaJ J Zaunders
Centre for Immunology, St Vincent s Hospital, UNSW, Darlinghurst, Australia 2010 Australia
J Infect Dis 180:320-9. 1999..The persistence of HIV-1 DNA together with increased CD8 T lymphocyte turnover and activation indicate continued expression of viral antigens...
- Phenotypic analysis of CD8+ T lymphocytes in a cohort of HIV type 1-infected patients treated with saquinavir, ritonavir, and two nucleoside analogs for 1 year, and association with plasma HIV type 1 RNAG R Kaufmann
Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
AIDS Res Hum Retroviruses 15:963-72. 1999..A complete normalization of immunologic changes of CD8+ T lymphocytes would therefore require a more potent drug regimen or a longer duration of therapy...
- Increased turnover of CCR5+ and redistribution of CCR5- CD4 T lymphocytes during primary human immunodeficiency virus type 1 infectionJ J Zaunders
Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
J Infect Dis 183:736-43. 2001..In contrast, in acute EBV infection, proliferating CCR5+ CD4 T cells accumulated to very high levels, suggesting they have an important role in the early antiviral response, which may be impaired in HIV-1 infection...
- Novel deletion of HIV type 1 reverse transcriptase residue 69 conferring selective high-level resistance to nevirapineK Suzuki
Centre for Immunology, St Vincent s Hospital, Sydney, NSW 2010, Australia
AIDS Res Hum Retroviruses 17:1293-6. 2001..Our findings provide evidence that the deletion of RT residue 69 selectively confers high-level NVP resistance...
- Impact of HIV type 1 protease, reverse transcriptase, cleavage site, and p6 mutations on the virological response to quadruple therapy with saquinavir, ritonavir, and two nucleoside analogsG R Kaufmann
National Centre in HIV Epidemiology and Clinical Research, Sydney NSW 2010, Australia
AIDS Res Hum Retroviruses 17:487-97. 2001..The relationship between mutations of cleavage sites or C-terminal p6* residues and protease mutations suggests that these alterations may serve a compensatory role, increasing viral fitness...
- Primary HIV-1 infection: a review of clinical manifestations, immunologic and virologic changesG R Kaufmann
Centre for Immunology, St Vincent s Hospital, Sydney, Australia
AIDS Patient Care STDS 12:759-67. 1998..Cytokines have been shown to play a role in primary HIV-1 infection, and the therapy of primary infection has gained more interest due to the introduction of potent triple combinations, including protease inhibitors...
- Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort studyA Carr
HIV Medicine Unit and Centre for Immunology, St Vincent s Hospital, Sydney, NSW, Australia
Lancet 353:2093-9. 1999..We studied the natural course of the syndrome to develop diagnostic criteria and identifying markers that predict its severity...