Jonathan Karnon

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi request reprint Alternative decision modelling techniques for the evaluation of health care technologies: Markov processes versus discrete event simulation
    Jonathan Karnon
    Health Economics Research Group, Brunel University, UK
    Health Econ 12:837-48. 2003
  2. doi request reprint Model-based cost-effectiveness analysis of interventions aimed at preventing medication error at hospital admission (medicines reconciliation)
    Jonathan Karnon
    School of Health and Related Research, University of Sheffield, Sheffield, UK
    J Eval Clin Pract 15:299-306. 2009
  3. ncbi request reprint When to Use Discrete Event Simulation (DES) for the Economic Evaluation of Health Technologies? A Review and Critique of the Costs and Benefits of DES
    Jonathan Karnon
    School of Population Health, University of Adelaide, Adelaide, Australia
    Pharmacoeconomics 32:547-58. 2014
  4. doi request reprint Applying risk adjusted cost-effectiveness (RAC-E) analysis to hospitals: estimating the costs and consequences of variation in clinical practice
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, Australia
    Health Econ 22:631-42. 2013
  5. doi request reprint A risk adjusted cost-effectiveness analysis of alternative models of nurse involvement in obesity management in primary care
    J Karnon
    Discipline of Public Health, School of Population Health, University of Adelaide, SA 5005, Australia
    Obesity (Silver Spring) 21:472-9. 2013
  6. doi request reprint Lifetime cost-utility analyses of deferasirox in beta-thalassaemia patients with chronic iron overload: a UK perspective
    Jonathan Karnon
    University of Adelaide, Adelaide, Australia
    Clin Drug Investig 32:805-15. 2012
  7. ncbi request reprint Modeling using discrete event simulation: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-4
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, South Australia
    Med Decis Making 32:701-11. 2012
  8. doi request reprint Modeling using discrete event simulation: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force--4
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, SA, Australia
    Value Health 15:821-7. 2012
  9. pmc Is different better?: models of teaching and their influence on the net financial outcome for general practice teaching posts
    Caroline O Laurence
    Adelaide to Outback GP Training Program, South Australia
    BMC Med Educ 11:45. 2011
  10. doi request reprint A cost-utility analysis of clopidogrel in patients with ST elevation acute coronary syndromes in the UK
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, Australia
    Int J Cardiol 140:315-22. 2010

Detail Information

Publications43

  1. ncbi request reprint Alternative decision modelling techniques for the evaluation of health care technologies: Markov processes versus discrete event simulation
    Jonathan Karnon
    Health Economics Research Group, Brunel University, UK
    Health Econ 12:837-48. 2003
    ..These results indicate that the use of DES may be beneficial only when the available data demonstrates particular characteristics...
  2. doi request reprint Model-based cost-effectiveness analysis of interventions aimed at preventing medication error at hospital admission (medicines reconciliation)
    Jonathan Karnon
    School of Health and Related Research, University of Sheffield, Sheffield, UK
    J Eval Clin Pract 15:299-306. 2009
    ..The aim of this study is to assess the incremental costs and effects [measured as quality adjusted life years (QALYs)] of a range of such interventions for which evidence of effectiveness exists...
  3. ncbi request reprint When to Use Discrete Event Simulation (DES) for the Economic Evaluation of Health Technologies? A Review and Critique of the Costs and Benefits of DES
    Jonathan Karnon
    School of Population Health, University of Adelaide, Adelaide, Australia
    Pharmacoeconomics 32:547-58. 2014
    ..More generally, further direct, empirical comparisons of complex models with simpler models would better inform the benefits of DES to implement more complex models, and the circumstances in which such benefits are most likely. ..
  4. doi request reprint Applying risk adjusted cost-effectiveness (RAC-E) analysis to hospitals: estimating the costs and consequences of variation in clinical practice
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, Australia
    Health Econ 22:631-42. 2013
    ....
  5. doi request reprint A risk adjusted cost-effectiveness analysis of alternative models of nurse involvement in obesity management in primary care
    J Karnon
    Discipline of Public Health, School of Population Health, University of Adelaide, SA 5005, Australia
    Obesity (Silver Spring) 21:472-9. 2013
    ..Models were based on the reported level of involvement of practice nurses (registered or enrolled nurses working in general practice) in the provision of clinical-based activities...
  6. doi request reprint Lifetime cost-utility analyses of deferasirox in beta-thalassaemia patients with chronic iron overload: a UK perspective
    Jonathan Karnon
    University of Adelaide, Adelaide, Australia
    Clin Drug Investig 32:805-15. 2012
    ....
  7. ncbi request reprint Modeling using discrete event simulation: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-4
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, South Australia
    Med Decis Making 32:701-11. 2012
    ..Each section contains a number of best practice recommendations that were iterated among the authors, as well as the wider modeling task force...
  8. doi request reprint Modeling using discrete event simulation: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force--4
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, SA, Australia
    Value Health 15:821-7. 2012
    ..Each section contains a number of best practice recommendations that were iterated among the authors, as well as among the wider modeling task force...
  9. pmc Is different better?: models of teaching and their influence on the net financial outcome for general practice teaching posts
    Caroline O Laurence
    Adelaide to Outback GP Training Program, South Australia
    BMC Med Educ 11:45. 2011
    ..A question that arises in posing such an option is whether different models of teaching change the costs for a teaching practice. The aim of this study is to determine the net financial outcome of teaching models in private GP...
  10. doi request reprint A cost-utility analysis of clopidogrel in patients with ST elevation acute coronary syndromes in the UK
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, Australia
    Int J Cardiol 140:315-22. 2010
    ....
  11. doi request reprint Informing disinvestment through cost-effectiveness modelling: is lack of data a surmountable barrier?
    Jonathan Karnon
    University of Sheffield, Sheffield, UK
    Appl Health Econ Health Policy 7:1-9. 2009
    ....
  12. doi request reprint Calibrating models in economic evaluation: a comparison of alternative measures of goodness of fit, parameter search strategies and convergence criteria
    Jonathan Karnon
    University of Adelaide, Adelaide, South Australia, Australia
    Pharmacoeconomics 29:51-62. 2011
    ..Model calibration involves the identification of input parameter values that produce model output parameters that best predict observed data...
  13. doi request reprint Cost-utility analysis of screening high-risk groups for anal cancer
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, SA 5005, Australia
    J Public Health (Oxf) 30:293-304. 2008
    ..Cost-utility analysis of screening for anal cancer in high-risk groups from a UK perspective...
  14. ncbi request reprint Cost utility analysis of early adjuvant letrozole or anastrozole versus tamoxifen in postmenopausal women with early invasive breast cancer: the UK perspective
    Jonathan Karnon
    School of Health and Related Research, University of Sheffield, Regent Street, Sheffield, S1 4DA, UK
    Eur J Health Econ 9:171-83. 2008
    ..Though the respective confidence intervals show significant overlap, letrozole has a 95% probability of being more cost-effective than tamoxifen at a 20,000pounds QALY value, whilst anastrozole has an 85% probability...
  15. pmc Evaluating the effects of variation in clinical practice: a risk adjusted cost-effectiveness (RAC-E) analysis of acute stroke services
    Clarabelle Pham
    Discipline of Public Health, The University of Adelaide, South Australia, Australia
    BMC Health Serv Res 12:266. 2012
    ....
  16. doi request reprint A hybrid cohort individual sampling natural history model of age-related macular degeneration: assessing the cost-effectiveness of screening using probabilistic calibration
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, Australia
    Med Decis Making 29:304-16. 2009
    ..The aim of this study was to develop a natural history model of AMD to estimate the cost-effectiveness of screening...
  17. doi request reprint Practice nurse involvement in primary care depression management: an observational cost-effectiveness analysis
    Jodi Gray
    Discipline of Public Health, The University of Adelaide, Adelaide, South Australia
    BMC Fam Pract 15:10. 2014
    ..Previous analyses have demonstrated the value of high level practice nurse involvement in the management of diabetes and obesity. This paper reports on their value in the management of depression...
  18. doi request reprint Model performance evaluation (validation and calibration) in model-based studies of therapeutic interventions for cardiovascular diseases : a review and suggested reporting framework
    Hossein Haji Ali Afzali
    Discipline of Public Health, School of Population Health, University of Adelaide, Level 7, 178 North Terrace, Adelaide, SA, 5005, Australia
    Appl Health Econ Health Policy 11:85-93. 2013
    ..Recognising the fundamental role of decision analytic models in informing public funding decisions, the proposed framework should usefully inform guidelines for preparing submissions to reimbursement bodies...
  19. pmc Home videophones improve direct observation in tuberculosis treatment: a mixed methods evaluation
    Victoria A Wade
    Discipline of Public Health, The University of Adelaide, Adelaide, Australia
    PLoS ONE 7:e50155. 2012
    ..This study aimed to evaluate the clinical and cost-effectiveness of a telehealth service delivering direct observation, compared to an in-person drive-around service...
  20. ncbi request reprint Cost effectiveness of extended adjuvant letrozole in postmenopausal women after adjuvant tamoxifen therapy: the UK perspective
    Jonathan Karnon
    School of Health and Related Research, University of Sheffield, Sheffield, UK
    Pharmacoeconomics 24:237-50. 2006
    ..The objective of this evaluation was to extrapolate the findings from the MA17 trial to estimate the lifetime cost effectiveness of letrozole in this setting...
  21. doi request reprint A proposed model for economic evaluations of major depressive disorder
    Hossein Haji Ali Afzali
    Discipline of Public Health, The University of Adelaide, Level 3, 122 Frome Street, Mail Drop 207, Adelaide, SA 5005, Australia
    Eur J Health Econ 13:501-10. 2012
    ..We argue that the proposed model can be used as a reference model in model-based studies of depression improving the quality and comparability of studies...
  22. doi request reprint Medication errors--what is the best way to reduce their impact on patients' health?
    Jonathan Karnon
    School of Population Health and Clinical Practice, University of Adelaide, Australia
    J Health Serv Res Policy 15:60-3. 2010
    ....
  23. ncbi request reprint A critique and impact analysis of decision modeling assumptions
    Jonathan Karnon
    School of Health and Related Research, University of Sheffield, Sheffield, UK
    Med Decis Making 27:491-9. 2007
    ..A case study model is analyzed to illustrate the quantitative impact of 3 of the issues...
  24. doi request reprint A critical review of model-based economic studies of depression: modelling techniques, model structure and data sources
    Hossein Haji Ali Afzali
    Discipline of Public Health, The University of Adelaide, Adelaide, SA, Australia
    Pharmacoeconomics 30:461-82. 2012
    ..We argue that the above issues can potentially bias results and reduce the comparability of economic evaluations...
  25. doi request reprint The efficient price: an opportunity for funding reform
    Jonathan Karnon
    Discipline of Public Health, University of Adelaide, Adelaide, SA 5005, Australia
    Aust Health Rev 35:501-6. 2011
    ..This paper describes a potential approach to setting the efficient price using risk adjusted cost-effectiveness (RAC-E) analysis...
  26. pmc The LINKIN Health Census process: design and implementation
    Catherine Elizabeth Hoon-Leahy
    School of Population Health, University of Adelaide, Adelaide, Australia
    BMC Health Serv Res 12:321. 2012
    ..Response was greater when face-to-face contact was made at delivery compared to when questionnaires were left in the letterbox (89% vs 64%), falling to 26% when no face-to-face contact was made at either delivery or collection...
  27. doi request reprint A model-based economic evaluation of improved primary care management of patients with type 2 diabetes in Australia
    Hossein Haji Ali Afzali
    Discipline of Public Health, School of Population Health, University of Adelaide, Level 7, 178 North Terrace, Adelaide, SA, 5005, Australia
    Appl Health Econ Health Policy 11:661-70. 2013
    ..This is particularly important in Australia, where the government needs evidence to inform decisions on whether to maintain or redirect current financial incentives that encourage practices to recruit practice nurses...
  28. pmc A systematic review of economic analyses of telehealth services using real time video communication
    Victoria A Wade
    Discipline of Public Health, The University of Adelaide, North Tce, Adelaide 5005, Australia
    BMC Health Serv Res 10:233. 2010
    ....
  29. doi request reprint Modelling the expected net benefits of interventions to reduce the burden of medication errors
    Jonathan Karnon
    Department of Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK
    J Health Serv Res Policy 13:85-91. 2008
    ....
  30. ncbi request reprint Monitoring progress in the management of hip fractures in South Australia, Australia
    Jason Gordon
    Discipline of Public Health, University of Adelaide, Adelaide, SA 5005, Australia
    Arch Osteoporos 7:267-73. 2012
    ..Hip fracture admissions increased over the study period. Men fared worst in terms of higher absolute mortality. Refracture rates and male health outcomes require further attention...
  31. ncbi request reprint Systematic review of reducing population meat consumption to reduce greenhouse gas emissions and obtain health benefits: effectiveness and models assessments
    Cynthia Sau Chun Yip
    The University of Adelaide, Adelaide, SA, Australia
    Int J Public Health 58:683-93. 2013
    ..This review evaluates existing co-benefit models for emission and health outcomes of counterfactual scenarios of reduced meat consumption at a population level...
  32. doi request reprint Improving the accuracy and comparability of model-based economic evaluations of health technologies for reimbursement decisions: a methodological framework for the development of reference models
    Hossein Haji Ali Afzali
    University of Adelaide, Adelaide, Australia
    Med Decis Making 33:325-32. 2013
    ..We contend that the use of reference models will improve the accuracy and comparability of public funding decisions. This can lead to the more efficient allocation of public funds...
  33. doi request reprint A model-based evaluation of collaborative care in management of patients with type 2 diabetes in Australia: an initial report
    Hossein Haji Ali Afzali
    Discipline of Public Health, School of Population Health and Clinical Practice, The University of Adelaide, Australia
    Aust Health Rev 36:258-63. 2012
    ..The models of care reflect differential uptake of primary care-based incentive programs, including reminder systems and involvement of practice nurses in management. This paper describes our study protocol and its progress...
  34. pmc The effect of testosterone and a nutritional supplement on hospital admissions in under-nourished, older people
    Cynthia Piantadosi
    The Health Observatory, University of Adelaide, Department of Medicine, Adelaide SA 5005, Australia
    BMC Geriatr 11:66. 2011
    ..We propose a larger, multicentre study to explore and hopefully confirm this exciting, potentially important finding (NHMRC project grant number 627178)...
  35. ncbi request reprint Identifying existing health care services that do not provide value for money
    Adam G Elshaug
    Adelaide Health Technology Assessment, Discipline of Public Health, University of Adelaide, Adelaide, SA, Australia
    Med J Aust 190:269-73. 2009
    ..The process could be jointly funded by all relevant stakeholders but centrally administered, with HTA groups resourced to undertake identification and assessment and to liaise with clinicians, consumers and funding stakeholders...
  36. ncbi request reprint A qualitative study of sustainability and vulnerability in Australian telehealth services
    Victoria Wade
    Discipline of Public Health, The University of Adelaide, Adelaide, South Australia, Australia
    Stud Health Technol Inform 161:190-201. 2010
    ....
  37. ncbi request reprint Aromatase inhibitors in breast cancer: a review of cost considerations and cost effectiveness
    Jonathan Karnon
    School of Health and Related Research, University of Sheffield, Sheffield, England
    Pharmacoeconomics 24:215-32. 2006
    ..No direct comparisons of alternative AIs in the adjuvant setting are reported, although indirect comparisons may be feasible. Future evaluations of treatment strategies over the entire course of the disease may also be needed...
  38. ncbi request reprint To teach or not to teach? A cost-benefit analysis of teaching in private general practice
    Caroline O Laurence
    Adelaide to Outback GP Training Program, Adelaide, SA, Australia
    Med J Aust 193:608-13. 2010
    ..To identify the financial costs and benefits associated with teaching in private general practice...
  39. ncbi request reprint Developing a relativities approach to valuing the prevention of non-fatal work-related accidents and ill health
    Jonathan Karnon
    School of Health and Related Research, University of Sheffield, UK
    Health Econ 14:1103-15. 2005
    ..Potential amendments are suggested, but the general relativities approach warrants further investigation for the valuation of non-fatal work-related accidents and ill health...
  40. ncbi request reprint Cost-effectiveness of extended adjuvant letrozole therapy after 5 years of adjuvant tamoxifen therapy in postmenopausal women with early-stage breast cancer
    Thomas E Delea
    Policy Analysis Inc, 4 Davis Court, Brookline, MA 02245, USA
    Am J Manag Care 12:374-86. 2006
    ..To estimate the cost-effectiveness of extended adjuvant letrozole in postmenopausal women with early breast cancer and estrogen or progesterone receptor-positive tumors who had completed 5 years of adjuvant tamoxifen...
  41. ncbi request reprint Cost-effectiveness of letrozole versus tamoxifen as initial adjuvant therapy in postmenopausal women with hormone-receptor positive early breast cancer from a Canadian perspective
    Thomas E Delea
    Policy Analysis Inc PAI, Brookline, MA 02445, USA
    Breast Cancer Res Treat 108:375-87. 2008
    ....
  42. ncbi request reprint Planning the efficient allocation of research funds: an adapted application of a non-parametric Bayesian value of information analysis
    Jonathan Karnon
    Health and Safety Laboratory, Broad Lane, Sheffield S3 7HQ, UK
    Health Policy 61:329-47. 2002
    ....
  43. ncbi request reprint Tamoxifen plus chemotherapy versus tamoxifen alone as adjuvant therapies for node-positive postmenopausal women with early breast cancer: a stochastic economic evaluation
    Jonathan Karnon
    Health Economics Research Group, Brunel University, Uxbridge, Middlesex, United Kingdom
    Pharmacoeconomics 20:119-37. 2002
    ..There remains uncertainty around the appropriate choice of adjuvant therapies to offer postmenopausal women with node-positive early breast cancer...