Amy S Jordan

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Adult obstructive sleep apnoea
    Amy S Jordan
    University of Melbourne, Melbourne, Vic, Australia Institute for Breathing and Sleep, Melbourne, Vic, Australia Electronic address
    Lancet 383:736-47. 2014
  2. pmc Termination of respiratory events with and without cortical arousal in obstructive sleep apnea
    Amy S Jordan
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 184:1183-91. 2011
  3. pmc The effect of increased genioglossus activity and end-expiratory lung volume on pharyngeal collapse
    Amy S Jordan
    Sleep Laboratory, Psychological Sciences, Univ of Melbourne, Grattan St, Parkville, Victoria 3010, Australia
    J Appl Physiol (1985) 109:469-75. 2010
  4. pmc A method for measuring and modeling the physiological traits causing obstructive sleep apnea
    Andrew Wellman
    221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
    J Appl Physiol (1985) 110:1627-37. 2011
  5. pmc Discharge patterns of human genioglossus motor units during arousal from sleep
    Vanessa Wilkinson
    Department of Psychology, University of Melbourne, Parkville, Australia
    Sleep 33:379-87. 2010
  6. pmc Discharge patterns of human tensor palatini motor units during sleep onset
    Christian L Nicholas
    School of Psychological Science, University of Melbourne, Parkville, Australia
    Sleep 35:699-707. 2012
  7. pmc The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility
    Robert L Owens
    Sleep Disorders Research Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:445-51. 2010
  8. pmc Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea
    Amy S Jordan
    Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    Sleep 32:361-8. 2009
  9. pmc The influence of aging on pharyngeal collapsibility during sleep
    Matthias Eikermann
    Department of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Chest 131:1702-9. 2007
  10. pmc Recruitment and rate-coding strategies of the human genioglossus muscle
    Julian P Saboisky
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 109:1939-49. 2010

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Adult obstructive sleep apnoea
    Amy S Jordan
    University of Melbourne, Melbourne, Vic, Australia Institute for Breathing and Sleep, Melbourne, Vic, Australia Electronic address
    Lancet 383:736-47. 2014
    ..Bi-level positive airway pressure or adaptive servo-ventilation can be used for patients who are intolerant to continuous positive airway pressure. Other treatments include dental devices, surgery, and weight loss. ..
  2. pmc Termination of respiratory events with and without cortical arousal in obstructive sleep apnea
    Amy S Jordan
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 184:1183-91. 2011
    ..Arousals are thought to predispose to further events by promoting hyperventilation, hypocapnia, and upper-airway dilator muscle hypotonia. Therefore, events terminated without arousal may promote stable breathing...
  3. pmc The effect of increased genioglossus activity and end-expiratory lung volume on pharyngeal collapse
    Amy S Jordan
    Sleep Laboratory, Psychological Sciences, Univ of Melbourne, Grattan St, Parkville, Victoria 3010, Australia
    J Appl Physiol (1985) 109:469-75. 2010
    ..001). These findings indicate that while both increased GG and EELV improve airway collapsibility, the combination of both variables has little additional effect over increasing EELV alone...
  4. pmc A method for measuring and modeling the physiological traits causing obstructive sleep apnea
    Andrew Wellman
    221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
    J Appl Physiol (1985) 110:1627-37. 2011
    ..This technique could conceivably be used clinically to define a patient's physiology and guide therapy based on the traits...
  5. pmc Discharge patterns of human genioglossus motor units during arousal from sleep
    Vanessa Wilkinson
    Department of Psychology, University of Melbourne, Parkville, Australia
    Sleep 33:379-87. 2010
    ..The aim of the present study was to determine the effect of arousal from sleep on the activity of individual motor units as a function of their particular discharge pattern...
  6. pmc Discharge patterns of human tensor palatini motor units during sleep onset
    Christian L Nicholas
    School of Psychological Science, University of Melbourne, Parkville, Australia
    Sleep 35:699-707. 2012
    ..However, unlike GG, TP shows minimal respiratory modulation and presumably has few inspiratory modulated motor units and minimal input from the RPG. Thus, we investigated the mechanism by which TP reduces activity at sleep onset...
  7. pmc The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility
    Robert L Owens
    Sleep Disorders Research Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:445-51. 2010
    ..Changes in lung volume alter Pcrit substantially. This work supports a role for lung volume in the pathogenesis of OSA, and lung volume changes should be a consideration during assessment of pharyngeal mechanics...
  8. pmc Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea
    Amy S Jordan
    Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    Sleep 32:361-8. 2009
    ....
  9. pmc The influence of aging on pharyngeal collapsibility during sleep
    Matthias Eikermann
    Department of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Chest 131:1702-9. 2007
    ..We tested the hypotheses that upper airway closing pressure (PCLOSE) and the increase in pharyngeal resistance during sleep (primary outcomes) as well as measures of arousal threshold (secondary outcomes) increase with age...
  10. pmc Recruitment and rate-coding strategies of the human genioglossus muscle
    Julian P Saboisky
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 109:1939-49. 2010
    ..Understanding upper airway muscle recruitment/derecruitment may yield therapeutic targets for maintenance of pharyngeal patency...
  11. doi request reprint Effect of oxygen in obstructive sleep apnea: role of loop gain
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Respir Physiol Neurobiol 162:144-51. 2008
    ..These data suggest that ventilatory instability is an important mechanism causing obstructive sleep apnea in some patients (those with a relatively high LG), since lowering LG with oxygen in these patients significantly reduces AHI...
  12. pmc Motor unit recruitment in human genioglossus muscle in response to hypercapnia
    Christian L Nicholas
    School of Psychological Science, University of Melbourne, Parkville, Australia
    Sleep 33:1529-38. 2010
    ..In this study, we investigated the effect of hypercapnia on GG motor unit activity in humans during wakefulness...
  13. pmc Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans
    Amy S Jordan
    Sleep Disorders Program BIDMC, 75 Francis St, Boston, Massachusetts 02115, USA
    Thorax 62:861-7. 2007
    ..The aims of this study were to compare the ability to recover ventilation and the mechanisms of compensation following a sudden reduction of continuous positive airway pressure (CPAP) in subjects with and without OSA...
  14. pmc A mechanism for upper airway stability during slow wave sleep
    David G McSharry
    Sleep Disorders Research Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Sleep 36:555-63. 2013
    ..Therefore, we hypothesized that genioglossus SMUs would increase their activity during SWS in comparison with Stage N2 sleep...
  15. pmc Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats
    Matthias Eikermann
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114 2696, USA
    Anesthesiology 110:1327-34. 2009
    ..The authors assessed the effects of pentobarbital on upper airway dilator and respiratory pump muscle function in rats and compared these results with the effects of normal sleep...
  16. pmc Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea
    Danny J Eckert
    Brigham and Women s Hospital, Div of Sleep Medicine, Sleep Disorders Program, Boston, MA 02115, USA
    J Appl Physiol (1985) 111:1644-53. 2011
    ..However, OSA patients may be vulnerable to fatigue of upper-airway dilator muscles, which could contribute to disease progression...
  17. pmc Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea
    Amy S Jordan
    Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, Sleep Disorders Research Program, Boston, MA 02115, USA
    J Appl Physiol (1985) 99:2020-7. 2005
    ..38 +/- 0.02 vs. 0.33 +/- 0.03; P = 0.14). These results suggest that women may be protected from developing OSA by having a less collapsible upper airway for any given degree of obesity...
  18. pmc The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program, 221 Longwood Avenue, Boston, MA 02115, USA
    Chest 135:957-64. 2009
    ....
  19. pmc Neurogenic changes in the upper airway of patients with obstructive sleep apnea
    Julian P Saboisky
    Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 185:322-9. 2012
    ..Controversy persists regarding the presence and importance of hypoglossal nerve dysfunction in obstructive sleep apnea (OSA)...
  20. pmc Ventilatory control and airway anatomy in obstructive sleep apnea
    Andrew Wellman
    Sleep Disorders Program at BI, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1225-32. 2004
    ..88, p = 0.0016). We conclude that loop gain has a substantial impact on apnea severity in certain patients with sleep apnea, particularly those with a pharyngeal closing pressure near atmospheric...
  21. doi request reprint Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing
    Matthias Eikermann
    Department of Anesthesia, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 108:897-906. 2008
    ..The authors sought to understand which anesthetics increase or decrease upper airway dilator muscle activity and to study the mechanisms mediating the effect...
  22. pmc Obstructive sleep apnea and aging effects on macrovascular and microcirculatory function
    Susie Yim-Yeh
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Sleep 33:1177-83. 2010
    ..We hypothesize that OSA, independent of obesity, contributes to abnormal vascular function...
  23. doi request reprint Inspiratory-resistive loading increases the ventilatory response to arousal but does not reduce genioglossus muscle activity on the return to sleep
    Jennifer M Cori
    Department of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia
    J Appl Physiol (1985) 113:909-16. 2012
    ..Whether similar findings occur following obstructive events in patients remains to be determined...
  24. pmc Discharge patterns of human genioglossus motor units during sleep onset
    Vanessa Wilkinson
    Department of Psychology, University of Melbourne, Parkville, Australia
    Sleep 31:525-33. 2008
    ..The aim of the present study was to determine the effect of sleep onset on the activity of individual motor units as a function of their particular discharge pattern...
  25. pmc Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function
    Matthias Eikermann
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 107:621-9. 2007
    ..The authors hypothesized that cholinesterase inhibition when given the in absence of neuromuscular blockade (NB) would decrease upper airway dilatory muscle activity and consequently upper airway volume...
  26. pmc Effect of expiratory positive airway pressure on sleep disordered breathing
    Raphael Heinzer
    Sleep Medicine Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Sleep 31:429-32. 2008
    ..We sought to determine the effect of expiratory positive airway pressure on end expiratory lung volume (EELV) and sleep disordered breathing in obstructive sleep apnea patients...
  27. pmc Influence of wakefulness on pharyngeal airway muscle activity
    Yu Lun Lo
    Brigham and Women s Hospital, Sleep Disorders Research Program, 75 Francis Street, Boston, Massachusetts 02115, USA
    Thorax 62:799-805. 2007
    ..A study was therefore undertaken to assess the isolated impact of sleep on upper airway muscle activity after minimising respiratory/mechanical inputs...
  28. pmc Chemical control stability in the elderly
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 581:291-8. 2007
    ..26). We conclude that the chemical control of breathing does not become unstable with ageing and is thus an unlikely cause of central (and possibly obstructive) apnoeas in this population...
  29. pmc Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets
    Danny J Eckert
    1 Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Am J Respir Crit Care Med 188:996-1004. 2013
    ..The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among patients but have not been well characterized...
  30. pmc Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea
    Raphael C Heinzer
    Division of Sleep Medicine, Sleep Disorders Program BI, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:114-7. 2005
    ..These results demonstrate that relatively small changes in lung volume have an important effect on the upper airway in subjects with sleep apnea during non-REM sleep...
  31. pmc Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program, Harvard Medical School, Boston, MA 02115, USA
    J Clin Sleep Med 3:570-3. 2007
    ..Thus, future studies should carefully explore the functional consequences of UAM abnormalities and define which patients, if any, are susceptible to these potentially detrimental effects...
  32. pmc The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans
    Amy S Jordan
    Brigham and Women s Hospital, Sleep Disorders Research Program BIDMC, 75 Francis Street, Boston, MA 02115, USA
    J Physiol 558:993-1004. 2004
    ..These results demonstrate that the ventilatory response to arousal is influenced by pre-arousal airway resistance and gender. Whether this contributes to the perpetuation of respiratory events and the pathogenesis of OSA is unclear...
  33. pmc Pharyngeal motor control and the pathogenesis of obstructive sleep apnea
    Amy S Jordan
    Brigham and Women s Hospital, Boston, MA 02115, United States
    Respir Physiol Neurobiol 160:1-7. 2008
    ..This review briefly describes the currently proposed sleep and respiratory neural pathways and how these circuits interact with the upper airway dilator muscle motorneurones, including recent evidence from animal studies...
  34. pmc Mechanisms of apnea
    Danny J Eckert
    Division of Sleep Medicine, Brigham and Women s Hospital, Sleep Disorders Program and Harvard Medical School, Boston, MA, USA
    Prog Cardiovasc Dis 51:313-23. 2009
    ....
  35. pmc Aging and sleep: physiology and pathophysiology
    Bradley A Edwards
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Semin Respir Crit Care Med 31:618-33. 2010
    ....
  36. pmc A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure
    Danny J Eckert
    Sleep Disorders Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:1619-24. 2010
    ..These differential responses support the hypothesis that GG reflex suppression may be mediated via inhibition of respiratory-related premotor input...
  37. ncbi request reprint Gender differences in sleep apnea: epidemiology, clinical presentation and pathogenic mechanisms
    Amy S Jordan
    Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital, 221 Longwood Av, RFB 486, Boston, MA, 02115, USA
    Sleep Med Rev 7:377-89. 2003
    ....
  38. pmc Central sleep apnea: Pathophysiology and treatment
    Danny J Eckert
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 131:595-607. 2007
    ..The clinical implications of improved CSA pathophysiology knowledge and the potential for novel therapeutic treatment approaches are also discussed...
  39. doi request reprint Sleep and cardiovascular regulation
    John Trinder
    School of Psychological Sciences, University of Melbourne, Gratton St, Melbourne, Vic, 3010, Australia
    Pflugers Arch 463:161-8. 2012
    ....
  40. ncbi request reprint Recent advances in understanding the pathogenesis of obstructive sleep apnea
    Amy S Jordan
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 9:459-64. 2003
    ..With the reduction in muscle tone at sleep onset, the airway collapses and causes apnea. While this appears to be the case for many patients with OSA, other patients show no major airway anatomic defects or minimal obesity...