Keith T Jones

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. doi request reprint Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension
    Simon I R Lane
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 139:1947-55. 2012
  2. doi request reprint Chromosomal, metabolic, environmental, and hormonal origins of aneuploidy in mammalian oocytes
    Keith T Jones
    Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
    Exp Cell Res 318:1394-9. 2012
  3. doi request reprint Anaphase-promoting complex control in female mouse meiosis
    Keith T Jones
    University of Newcastle, 2308 Newcastle, NSW, Australia
    Results Probl Cell Differ 53:343-63. 2011
  4. doi request reprint Cohesin and Cdk1: an anaphase barricade
    Keith T Jones
    School of Biomedical Sciences, Faculty of Health, University of Newcastle, NSW 2308, Australia
    Nat Cell Biol 12:106-8. 2010
  5. doi request reprint Reduced chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young mice
    Julie A Merriman
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 88:31. 2013
  6. pmc APC(FZR1) prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Biol Cell 23:3970-81. 2012
  7. doi request reprint Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months
    Julie A Merriman
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 86:49. 2012
  8. doi request reprint The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 138:905-13. 2011
  9. pmc Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720
    Heng Yu Chang
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, 2308, Australia
    J Biol Chem 286:14705-12. 2011
  10. doi request reprint Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking mice
    Phoebe C Jennings
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, Australia
    Hum Reprod 26:878-84. 2011

Collaborators

  • Janet E Holt
  • Brett Nixon
  • Moira K O'Bryan
  • Olaf Stemmann
  • Suzanne Madgwick
  • Julie A Merriman
  • Simon I R Lane
  • Phoebe C Jennings
  • Heng Yu Chang
  • Yan Yun
  • Tessa Lord
  • Irene Garcia-Higuera
  • Sergio Moreno
  • Eileen A McLaughlin
  • Wai Shan Yuen
  • Michelle K Y Seah
  • Ibtissem Nabti
  • Mark Levasseur
  • R John Aitken
  • Emma L Beckett
  • Nicole M Verrills
  • Philip M Hansbro
  • Jessica Stewart
  • Kyra Minahan
  • Alexandra Reis

Detail Information

Publications26

  1. doi request reprint Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension
    Simon I R Lane
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 139:1947-55. 2012
    ..We conclude that, in oocytes, a few erroneous attachments of bivalent kinetochores to microtubules do not generate a sufficient SAC 'wait anaphase' signal to inhibit the APC/C...
  2. doi request reprint Chromosomal, metabolic, environmental, and hormonal origins of aneuploidy in mammalian oocytes
    Keith T Jones
    Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
    Exp Cell Res 318:1394-9. 2012
    ..Environmental insults and hormonal changes could also affect the fidelity of this process. Here we review how all these factors converge on the meiotic spindle during MI to cause mis-segregation errors...
  3. doi request reprint Anaphase-promoting complex control in female mouse meiosis
    Keith T Jones
    University of Newcastle, 2308 Newcastle, NSW, Australia
    Results Probl Cell Differ 53:343-63. 2011
    ....
  4. doi request reprint Cohesin and Cdk1: an anaphase barricade
    Keith T Jones
    School of Biomedical Sciences, Faculty of Health, University of Newcastle, NSW 2308, Australia
    Nat Cell Biol 12:106-8. 2010
    ..Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated...
  5. doi request reprint Reduced chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young mice
    Julie A Merriman
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 88:31. 2013
    ..Based on these results, we propose that individual oocytes undergo loss in chromosomal cohesion at different rates and that the greater this loss, the greater the risk for becoming aneuploid...
  6. pmc APC(FZR1) prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Biol Cell 23:3970-81. 2012
    ..This study implicates FZR1 as a major regulator of prometaphase whose activity helps to prevent chromosome nondisjunction...
  7. doi request reprint Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months
    Julie A Merriman
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 86:49. 2012
    ..We conclude that in aging CD1 mice, a reduction in the ovulated egg number precedes a rise in aneuploidy and, furthermore, except at very advanced ages, increased interkinetochore distance is associated with aneuploidy...
  8. doi request reprint The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 138:905-13. 2011
    ..Thus, APC/C(FZR1) activity is required to repress cyclin B1 levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption...
  9. pmc Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720
    Heng Yu Chang
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, 2308, Australia
    J Biol Chem 286:14705-12. 2011
    ..Therefore, in conclusion, we used okadaic acid, dn-PP2Ac-L199P, and FTY720 on mouse eggs to demonstrate that PP2A is needed to for both continued metaphase arrest and successful exit from meiosis...
  10. doi request reprint Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking mice
    Phoebe C Jennings
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, Australia
    Hum Reprod 26:878-84. 2011
    ....
  11. doi request reprint Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 137:1297-304. 2010
    ..We propose a simple spatial model of G2 arrest in which nuclear APC(Cdh1)-proteasomal activity guards against any cyclin B1 accumulation mediated by nuclear import...
  12. doi request reprint The control of meiotic maturation in mammalian oocytes
    Janet E Holt
    Center for Reproductive Sciences and School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Curr Top Dev Biol 102:207-26. 2013
    ..This is achieved by APC(CDC20), whose activity is critically regulated by the spindle assembly checkpoint, and which induces both a loss in CDK1 activity as well as the cohesive ties holding chromosomes together...
  13. doi request reprint Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis I in mouse oocytes
    Janet E Holt
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia
    Methods Mol Biol 957:91-106. 2013
    ..Here we describe the process of microinjecting cRNA to proteins of interest that have been coupled to a fluorescent protein using cyclin B1 as an example...
  14. doi request reprint The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint
    Simon I R Lane
    School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Reproduction 140:521-30. 2010
    ..We hypothesize that Aurora kinase activity controls the SAC in meiosis I, despite differences to the mitotic cell cycle division in spindle architecture brought about by the meiotic mono-orientation of sister kinetochores...
  15. pmc DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes
    Wai Shan Yuen
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 7:e43875. 2012
    ..The ability of oocytes to tolerate severe ICL damage and yet complete meiosis, means that this type of DNA lesion goes unrepaired in oocytes but impacts on subsequent embryo quality...
  16. doi request reprint The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development
    Michelle K Y Seah
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    J Cell Sci 125:6030-7. 2012
    ....
  17. doi request reprint Meiosis: mouse eggs do their anaphase topsy-turvy
    Keith T Jones
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan NSW 2308, Australia
    Curr Biol 22:R153-5. 2012
    ..Having Anaphase B precede Anaphase A may be the mechanism by which mammalian eggs can generate a haploid chromosome number but without the loss of too much cytoplasm...
  18. ncbi request reprint Degradation of APCcdc20 and APCcdh1 substrates during the second meiotic division in mouse eggs
    Heng Yu Chang
    Cell and Developmental Physiology Research Group, Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle, NE2 4HH, UK
    J Cell Sci 117:6289-96. 2004
    ..Interestingly, therefore, we propose that mammalian eggs undergo meiosis II with both APCcdc20 and APCcdh1, whereas eggs of other species so far described have APCcdc20 activity only...
  19. doi request reprint Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes
    Yan Yun
    Centre for Reproductive Science, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 141:199-208. 2014
    ..These data show that although considerable cohesion loss occurs during MI, its consequences are observed during meiosis II, when centromeric cohesion is needed to maintain dyad integrity. ..
  20. doi request reprint Control of homologous chromosome division in the mammalian oocyte
    Janet E Holt
    University of Newcastle, Callaghan, NSW, Australia
    Mol Hum Reprod 15:139-47. 2009
    ..In particular, we examine the role played by the spindle assembly checkpoint in controlling the APC/C activity, and in so doing ensuring accurate disjunction of homologs...
  21. doi request reprint Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs
    Ibtissem Nabti
    Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle, NE2 4HH, UK
    Dev Biol 321:379-86. 2008
    ..In contrast, securin morpholino knockdown specifically induced loss of sister attachment, that could be restored by securin cRNA rescue. During metII arrest separase appears primarily regulated by securin binding, not CDK1/cyclin B1...
  22. ncbi request reprint Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age
    Keith T Jones
    Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle, NE2 4HH, UK
    Hum Reprod Update 14:143-58. 2008
    ....
  23. ncbi request reprint Mammalian egg activation: from Ca2+ spiking to cell cycle progression
    Keith T Jones
    Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle, NE2 4HH, UK
    Reproduction 130:813-23. 2005
    ..APC/C activation leads to securin and cyclin B1 degradation and in so doing allows sister chromatids to be segregated and to decondense...
  24. doi request reprint Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro
    Tessa Lord
    Priority Research Centre for Reproductive Biology, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 88:67. 2013
    ..01). We conclude that melatonin may be a useful tool in a clinical setting to prevent the time-dependent deterioration of oocyte quality following prolonged culture in vitro...
  25. doi request reprint Calmodulin-dependent protein kinase gamma 3 (CamKIIgamma3) mediates the cell cycle resumption of metaphase II eggs in mouse
    Heng Yu Chang
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 136:4077-81. 2009
    ..Therefore, CamKIIgamma3 plays a necessary and sufficient role in transducing the oscillatory Ca(2+) signal into cell cycle resumption, but not into cortical granule release...
  26. ncbi request reprint Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggs
    Suzanne Madgwick
    Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle, NE2 4HH, UK
    J Cell Sci 118:3849-59. 2005
    ..These data, combined with the knowledge that CamKII activity increase at fertilization, suggest that mouse eggs undergo cell-cycle resumption through stimulation of CamKII...