Research Topics
Genomes and GenesSpecies | Keith T JonesSummaryAffiliation: University of Newcastle Country: Australia Publications
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Publications
Chromosomal, metabolic, environmental, and hormonal origins of aneuploidy in mammalian oocytesKeith T Jones
Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
Exp Cell Res 318:1394-9. 2012..Environmental insults and hormonal changes could also affect the fidelity of this process. Here we review how all these factors converge on the meiotic spindle during MI to cause mis-segregation errors...- Anaphase-promoting complex control in female mouse meiosisKeith T Jones
University of Newcastle, 2308 Newcastle, NSW, Australia
Results Probl Cell Differ 53:343-63. 2011.... - Cohesin and Cdk1: an anaphase barricadeKeith T Jones
School of Biomedical Sciences, Faculty of Health, University of Newcastle, NSW 2308, Australia
Nat Cell Biol 12:106-8. 2010..Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated... 
APC(FZR1) prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timingJanet E Holt
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Mol Biol Cell 23:3970-81. 2012..This study implicates FZR1 as a major regulator of prometaphase whose activity helps to prevent chromosome nondisjunction...- Reduced chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young miceJulie A Merriman
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Biol Reprod 88:31. 2013..Based on these results, we propose that individual oocytes undergo loss in chromosomal cohesion at different rates and that the greater this loss, the greater the risk for becoming aneuploid... - Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 monthsJulie A Merriman
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Biol Reprod 86:49. 2012..We conclude that in aging CD1 mice, a reduction in the ovulated egg number precedes a rise in aneuploidy and, furthermore, except at very advanced ages, increased interkinetochore distance is associated with aneuploidy... - The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytesJanet E Holt
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Development 138:905-13. 2011..Thus, APC/C(FZR1) activity is required to repress cyclin B1 levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption... - Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tensionSimon I R Lane
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
Development 139:1947-55. 2012..We conclude that, in oocytes, a few erroneous attachments of bivalent kinetochores to microtubules do not generate a sufficient SAC 'wait anaphase' signal to inhibit the APC/C... - Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking micePhoebe C Jennings
School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, Australia
Hum Reprod 26:878-84. 2011.... - Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytesJanet E Holt
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Development 137:1297-304. 2010..We propose a simple spatial model of G2 arrest in which nuclear APC(Cdh1)-proteasomal activity guards against any cyclin B1 accumulation mediated by nuclear import... - Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720Heng Yu Chang
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, 2308, Australia
J Biol Chem 286:14705-12. 2011..Therefore, in conclusion, we used okadaic acid, dn-PP2Ac-L199P, and FTY720 on mouse eggs to demonstrate that PP2A is needed to for both continued metaphase arrest and successful exit from meiosis... - Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis I in mouse oocytesJanet E Holt
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia
Methods Mol Biol 957:91-106. 2013..Here we describe the process of microinjecting cRNA to proteins of interest that have been coupled to a fluorescent protein using cyclin B1 as an example... - The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpointSimon I R Lane
School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
Reproduction 140:521-30. 2010..We hypothesize that Aurora kinase activity controls the SAC in meiosis I, despite differences to the mitotic cell cycle division in spindle architecture brought about by the meiotic mono-orientation of sister kinetochores... - DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytesWai Shan Yuen
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
PLoS ONE 7:e43875. 2012..The ability of oocytes to tolerate severe ICL damage and yet complete meiosis, means that this type of DNA lesion goes unrepaired in oocytes but impacts on subsequent embryo quality... - The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo developmentMichelle K Y Seah
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
J Cell Sci 125:6030-7. 2012.... - Meiosis: mouse eggs do their anaphase topsy-turvyKeith T Jones
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan NSW 2308, Australia
Curr Biol 22:R153-5. 2012..Having Anaphase B precede Anaphase A may be the mechanism by which mammalian eggs can generate a haploid chromosome number but without the loss of too much cytoplasm... 
Degradation of APCcdc20 and APCcdh1 substrates during the second meiotic division in mouse eggsHeng Yu Chang
Cell and Developmental Physiology Research Group, Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle, NE2 4HH, UK
J Cell Sci 117:6289-96. 2004..Interestingly, therefore, we propose that mammalian eggs undergo meiosis II with both APCcdc20 and APCcdh1, whereas eggs of other species so far described have APCcdc20 activity only...- The control of meiotic maturation in mammalian oocytesJanet E Holt
Center for Reproductive Sciences and School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
Curr Top Dev Biol 102:207-26. 2013..This is achieved by APC(CDC20), whose activity is critically regulated by the spindle assembly checkpoint, and which induces both a loss in CDK1 activity as well as the cohesive ties holding chromosomes together... - Control of homologous chromosome division in the mammalian oocyteJanet E Holt
University of Newcastle, Callaghan, NSW, Australia
Mol Hum Reprod 15:139-47. 2009..In particular, we examine the role played by the spindle assembly checkpoint in controlling the APC/C activity, and in so doing ensuring accurate disjunction of homologs... - Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggsIbtissem Nabti
Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle, NE2 4HH, UK
Dev Biol 321:379-86. 2008..In contrast, securin morpholino knockdown specifically induced loss of sister attachment, that could be restored by securin cRNA rescue. During metII arrest separase appears primarily regulated by securin binding, not CDK1/cyclin B1... - Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with ageKeith T Jones
Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle, NE2 4HH, UK
Hum Reprod Update 14:143-58. 2008.... - Mammalian egg activation: from Ca2+ spiking to cell cycle progressionKeith T Jones
Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle, NE2 4HH, UK
Reproduction 130:813-23. 2005..APC/C activation leads to securin and cyclin B1 degradation and in so doing allows sister chromatids to be segregated and to decondense... - Calmodulin-dependent protein kinase gamma 3 (CamKIIgamma3) mediates the cell cycle resumption of metaphase II eggs in mouseHeng Yu Chang
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Development 136:4077-81. 2009..Therefore, CamKIIgamma3 plays a necessary and sufficient role in transducing the oscillatory Ca(2+) signal into cell cycle resumption, but not into cortical granule release... - Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggsSuzanne Madgwick
Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle, NE2 4HH, UK
J Cell Sci 118:3849-59. 2005..These data, combined with the knowledge that CamKII activity increase at fertilization, suggest that mouse eggs undergo cell-cycle resumption through stimulation of CamKII...