Graham A R Johnston

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Medicinal chemistry and molecular pharmacology of GABA(C) receptors
    Graham A R Johnston
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, Sydney, NSW, 2006, Australia
    Curr Top Med Chem 2:903-13. 2002
  2. ncbi request reprint GABA(C) receptors as drug targets
    Graham A R Johnston
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, NSW 2006, Australia
    Curr Drug Targets CNS Neurol Disord 2:260-8. 2003
  3. ncbi request reprint GABA(A) receptor channel pharmacology
    Graham A R Johnston
    The Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, NSW 2006, Australia
    Curr Pharm Des 11:1867-85. 2005
  4. doi request reprint Neurochemicals for the investigation of GABA(C) receptors
    Graham A R Johnston
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology D06, The University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 35:1970-7. 2010
  5. doi request reprint Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice
    Sebastian P Fernandez
    Department of Pharmacology, Faculty of Medicine, The University of Sydney, NSW 2006, Australia
    Neuropharmacology 55:900-7. 2008
  6. ncbi request reprint Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors
    Shelley H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 494:131-8. 2004
  7. ncbi request reprint Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors
    Belinda J Hall
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 491:1-8. 2004
  8. ncbi request reprint 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes
    Belinda J Hall
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 512:97-104. 2005
  9. pmc Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory
    Mary Chebib
    Faculty of Pharmacy A15, The University of Sydney, Sydney, NSW 2006, Australia
    J Pharmacol Exp Ther 328:448-57. 2009
  10. pmc Differentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ρ(1) receptors
    Izumi Yamamoto
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
    ACS Chem Neurosci 3:665-73. 2012

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Medicinal chemistry and molecular pharmacology of GABA(C) receptors
    Graham A R Johnston
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, Sydney, NSW, 2006, Australia
    Curr Top Med Chem 2:903-13. 2002
    ..The most useful currently available ligands that show some GABA(C) receptor subtype selectivity are TPMPA, P4PMA, imidazole-4-acetic acid, 2-methyl-TACA and (+/-)-TAMP...
  2. ncbi request reprint GABA(C) receptors as drug targets
    Graham A R Johnston
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, NSW 2006, Australia
    Curr Drug Targets CNS Neurol Disord 2:260-8. 2003
    ..TPMPA and related compounds such as P4MPA, PPA and SEPI are also important leads for the development of systemically active selective GABA(C) receptor antagonists...
  3. ncbi request reprint GABA(A) receptor channel pharmacology
    Graham A R Johnston
    The Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, NSW 2006, Australia
    Curr Pharm Des 11:1867-85. 2005
    ..Many herbal medicines are used to promote sleep and many of their active ingredients include flavonoids and terpenoids known to modulate GABA(A) receptor function...
  4. doi request reprint Neurochemicals for the investigation of GABA(C) receptors
    Graham A R Johnston
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology D06, The University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 35:1970-7. 2010
    ..Given their less widespread distribution, lower abundance and relative structural simplicity compared to GABA(A) and GABA(B) receptors, GABA(C) receptors are attractive drug targets...
  5. doi request reprint Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice
    Sebastian P Fernandez
    Department of Pharmacology, Faculty of Medicine, The University of Sydney, NSW 2006, Australia
    Neuropharmacology 55:900-7. 2008
    ..Finally, flavan derivatives highlight the potential of targeting non-benzodiazepine allosteric sites in the search for new anxioselective drugs...
  6. ncbi request reprint Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors
    Shelley H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 494:131-8. 2004
    ..Antagonism by these ginkgolides at alpha(1)beta(2)gamma(2L) GABA(A) receptors appears to be noncompetitive as indicated by the nonparallel right shift and reduced maximal GABA response in their GABA concentration-effect curves...
  7. ncbi request reprint Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors
    Belinda J Hall
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 491:1-8. 2004
    ..6-Methylflavone acts as a positive modulator of recombinant GABAA receptors at sites independent of flumazenil-sensitive benzodiazepine sites...
  8. ncbi request reprint 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes
    Belinda J Hall
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 512:97-104. 2005
    ....
  9. pmc Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory
    Mary Chebib
    Faculty of Pharmacy A15, The University of Sydney, Sydney, NSW 2006, Australia
    J Pharmacol Exp Ther 328:448-57. 2009
    ..05; n = 10). As the physiological effects of cis- and trans-3-ACPBPA are similar to those reported for CGP36742, the memory and refractive effects of CGP36742 may be due in part to its GABA(C) activity...
  10. pmc Differentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ρ(1) receptors
    Izumi Yamamoto
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
    ACS Chem Neurosci 3:665-73. 2012
    ..This suggests that T244 is not critical for antagonist binding. Receptor gating is dynamic, and this study highlights the role of loop C in agonist-evoked receptor activation, coupling agonist binding to channel gating...
  11. ncbi request reprint (3-Aminocyclopentyl)methylphosphinic acids: novel GABA(C) receptor antagonists
    Mary Chebib
    Faculty of Pharmacy, Pharmacy Building A15, The University of Sydney, NSW 2006, Australia
    Neuropharmacology 52:779-87. 2007
    ..cis- and (+/-)-trans-3-ACPMPA are novel lead compounds for developing into more potent and selective GABA(C) receptor antagonists with increased lipophilicity for in vivo studies...
  12. ncbi request reprint Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity
    Jane E Carland
    Faculty of Pharmacy, A15, The University of Sydney, NSW 2006, Australia
    Eur J Pharmacol 580:27-35. 2008
    ....
  13. doi request reprint 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes
    Nasiara Karim
    University of Sydney, Sydney NSW, 2006, Australia
    Biochem Pharmacol 82:1971-83. 2011
    ....
  14. ncbi request reprint Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites
    Kelly J Skilbeck
    Department of Pharmacology, Blackburn D06, The University of Sydney, NSW 2006, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 32:492-8. 2008
    ..These findings confirm that the subset of GABA(A) receptors sensitive to benzodiazepines are regulated differently from other GABA(A) receptor subtypes following antipsychotic drug administration, in a time- and region-dependent manner...
  15. pmc Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ρ1 receptor
    Izumi Yamamoto
    Faculty of Pharmacy and Department of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    ACS Chem Neurosci 3:293-301. 2012
    ..This study contributes to our understanding of the mechanism of inverse agonism. This is important, as such agents are emerging as potential therapeutics...
  16. ncbi request reprint Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors
    Tina Hinton
    The Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, NSW 2006, Australia
    Bioorg Med Chem Lett 18:402-4. 2008
    ..These studies highlight the different stereochemical requirements for the hydroxy group in these analogues at GABA(A), GABA(B) and GABA(C) receptors...
  17. doi request reprint Guanidino acids act as rho1 GABA(C) receptor antagonists
    Mary Chebib
    Faculty of Pharmacy A15, The University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 34:1704-11. 2009
    ..The results of this study contribute to the structure-activity-relationship profile required in developing novel therapeutic agents...
  18. doi request reprint Medicinal chemistry of ρ GABAC receptors
    Clarissa K L Ng
    Faculty of Pharmacy A15, The University of Sydney, NSW, Australia
    Future Med Chem 3:197-209. 2011
    ..Of particular interest is the development of selective phosphinic acid analogs of GABA and their potential use in sleep disorders, inhibiting the development of myopia, and in improving learning and memory...
  19. doi request reprint Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review
    Nasiara Karim
    Faculty of Pharmacy A15, University of Sydney, Sydney, NSW, 2006, Australia
    Amino Acids 44:1139-49. 2013
    ..At α4β2δ, GABA had low micromolar activity...
  20. doi request reprint Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors
    Nasiara Karim
    Faculty of Pharmacy, Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    Biochem Pharmacol 84:549-57. 2012
    ..Taken together, GABA may have different binding modes for extrasynaptic δ-containing GABA(A) receptors compared to their synaptic counterparts...
  21. doi request reprint A molecular basis for agonist and antagonist actions at GABA(C) receptors
    Heba Abdel-Halim
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
    Chem Biol Drug Des 71:306-27. 2008
    ..Agonists elicit loop C closure, while a more open loop C was observed upon antagonist binding. The model differentiates the role for key residues known to be involved in either binding and/or gating...
  22. ncbi request reprint The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined
    Kelly J Skilbeck
    Department of Pharmacology, The University of Sydney, NSW 2006, Australia
    Schizophr Res 90:76-80. 2007
    ..These changes in the properties of GABA(A) receptor binding following antipsychotic drug administration are not consistent with those observed in schizophrenia and suggest a 'reshuffling' in GABA(A) receptor subtypes over time...
  23. doi request reprint Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships
    Rohan J Kumar
    Faculty of Pharmacy, University of Sydney, NSW, Australia
    J Med Chem 51:3825-40. 2008
    ..97 microM) were obtained. The data obtained was analyzed along with the known set of GABA C rho 1 receptor-ligands, leading to the development of a pharmacophore model for this receptor, which can be used for in silico screening...
  24. ncbi request reprint Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors
    Jane R Hanrahan
    Faculty of Pharmacy, University of Sydney, 2006, Sydney, NSW, Australia
    Bioorg Med Chem Lett 13:2281-4. 2003
    ....
  25. pmc Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q
    Tin T Yow
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia
    Br J Pharmacol 163:1017-33. 2011
    ..Flavonoids have been shown to have significant health benefits and are a diverse source of compounds for identifying agents with novel mechanisms of action...
  26. doi request reprint Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors
    Kenneth N Mewett
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, The University of Sydney, NSW 2006, Australia
    Bioorg Med Chem 17:7156-73. 2009
    ..A trans configuration and a 3-acetoxy moiety are essential for activity. Substitution of the B ring appears to be well tolerated, with substituents on the A ring playing a major role in determining activity...
  27. ncbi request reprint Convulsant actions of calycanthine
    Mary Chebib
    Faculty of Pharmacy, The University of Sydney, New South Wales, 2006, Australia
    Toxicol Appl Pharmacol 190:58-64. 2003
    ....
  28. ncbi request reprint Modulation of ionotropic GABA receptors by natural products of plant origin
    Graham A R Johnston
    Department of Pharmacology, The University of Sydney, NSW, 2006, Australia
    Adv Pharmacol 54:285-316. 2006
  29. doi request reprint GABA analogues derived from 4-aminocyclopent-1-enecarboxylic acid
    Katherine E S Locock
    The Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 34:1698-703. 2009
    ..This study has shown that GABA analogues derived by thiol addition to 4-aminocyclopent-1-enecarboxylic acid display interesting antagonist activity at the alpha(1)beta(2)gamma(2L) GABA(A) receptor...
  30. ncbi request reprint Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors
    Deborah L Crittenden
    School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
    Bioorg Med Chem 14:447-55. 2006
    ..On the basis of these expanded biological activity data and the solution-phase molecular structures obtained at the MP2/6-31+G* level of ab initio theory, a rationale is proposed for the genesis of this stereoselectivity effect...
  31. ncbi request reprint The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors
    Erica L Campbell
    Department of Pharmacology, The University of Sydney, Sydney 2006, NSW, Australia
    Biochem Pharmacol 68:1631-8. 2004
    ..This was not found with genistein, nor was it observed with enhancement by allopregnanolone or pentobarbitone...
  32. ncbi request reprint Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA
    Jane R Hanrahan
    The Faculty of Pharmacy, University of Sydney, NSW, Australia
    Org Biomol Chem 4:2642-9. 2006
    ..Both diastereoisomers are obtained in 5 steps from the key (+/-)-(3-hydroxycyclopent-1-ene)alkylphosphinate esters which are prepared via a palladium catalysed C-P bond forming reaction...
  33. ncbi request reprint Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors
    Shelley H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, University of Sydney, NSW 2006, Sydney, Australia
    Eur J Pharmacol 464:1-8. 2003
    ..While bilobalide and picrotoxinin were clearly noncompetitive antagonists, the potency of bilobalide decreased at high GABA concentrations suggesting a component of competitive antagonism...
  34. ncbi request reprint Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses
    Jane E Carland
    Faculty of Pharmacy, A15, University of Sydney, Sydney, NSW 2006, Australia
    Neuropharmacology 46:770-81. 2004
    ....
  35. pmc Flavonoid modulation of GABA(A) receptors
    Jane R Hanrahan
    Faculty of Pharmacy Department of Pharmacology, The University of Sydney, NSW, Australia
    Br J Pharmacol 163:234-45. 2011
    ..Like steroids, flavonoids have wide-ranging effects on numerous biological targets. The challenge is to understand the structural determinants of flavonoid effects on particular targets and to develop agents specific for these targets...
  36. doi request reprint Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors
    Izumi Yamamoto
    Faculty of Pharmacy, University of Sydney, NSW, 2006, Australia
    Chem Commun (Camb) 47:7956-8. 2011
    ..This result is consistent with a folded binding mode for GABA, a conclusion which suggests a different binding mode to that found in the related but pharmacologically distinct GABA(A) receptors...
  37. doi request reprint γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates
    Katherine E S Locock
    Adrien Albert Laboratory of Medicinal Chemistry, Pharmacology, University of Sydney, NSW, Australia
    J Med Chem 56:5626-30. 2013
    ..This provides evidence that a zwitterionic structure is not essential for GABAC antagonists, rather the emphasis lies in appropriate heteroatoms to participate in hydrogen bonding. ..
  38. doi request reprint Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531)
    Navnath Gavande
    Faculty of Pharmacy The University of Sydney, Sydney, NSW, Australia
    Org Biomol Chem 8:4131-6. 2010
    ..The total synthesis of gabazine (SR-95531) has been achieved using a versatile strategy in four steps and 73% overall yield...
  39. doi request reprint The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice
    Sebastian P Fernandez
    Faculty of Medicine, Department of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 34:1867-75. 2009
    ..Hence, naringin (30 mg/kg) and gossypin (30 mg/kg) induce both anxiolytic and sedative effects. These results suggest that flavonoid glycosides have the potential to exert a range of CNS-mediated biological activities...
  40. pmc trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors
    Jimmy Vien
    Department of Pharmacology, University of Sydney, NSW 2006, Australia
    Br J Pharmacol 135:883-90. 2002
    ..Thus, 2-MeTACA and (+/-)-TAMP could be important pharmacological tools because they may functionally differentiate between rho1, rho2 and rho3 GABA(C) receptors in vitro...
  41. ncbi request reprint (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors
    Renee E Granger
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW 2006, Australia
    Biochem Pharmacol 69:1101-11. 2005
    ..The relatively rigid cage structure of these bicyclic monoterpenes and their high efficacy may aid in a greater understanding of molecular aspects of positive modulation of the activation of GABA(A) receptors...
  42. doi request reprint Stress and GABA receptors
    Kelly J Skilbeck
    Department of Pharmacology, University of Sydney, Sydney, New South Wales, Australia
    J Neurochem 112:1115-30. 2010
    ..The short- and long-term stress sensitivity of the GABAergic system implicates GABA(A) receptors in the non-genetic etiology of psychiatric illnesses such as depression and schizophrenia in which stress may be an important factor...
  43. ncbi request reprint Novel oral drug administration in an animal model of neuroleptic therapy
    Sonja B Schleimer
    Department of Pharmacology, School of Medical Sciences, Institute for Biomedical Research and Neuroscience Institute of Schizophrenia and Allied Disorders, Blackburn Bldg DO6, The University of Sydney, NSW 2006, Australia
    J Neurosci Methods 146:159-64. 2005
    ..Additionally, the combination of tests used provided an efficient discrimination between the behavioural effects of clozapine, haloperidol and diazepam in rodents...
  44. ncbi request reprint GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex in schizophrenia
    Sonja B Schleimer
    Department of Pharmacology and Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
    Neuropsychobiology 50:226-30. 2004
    ..The observed elevation of GAT-3 levels could be due to a compensatory effect for any functional loss of GABA re-uptake by the decreased GAT-1 levels...
  45. ncbi request reprint Aza-THIP and related analogues of THIP as GABA C antagonists
    Dorte Krehan
    Centre for Drug Design and Transport, Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, DK 2100 Copenhagen, Denmark
    Bioorg Med Chem 11:4891-6. 2003
    ....
  46. ncbi request reprint Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists
    Dorte Krehan
    Centre for Drug Design and Transport, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Neurochem Int 42:561-5. 2003
    ....
  47. ncbi request reprint Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability
    Jane E Carland
    Faculty of Pharmacy, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 279:54153-60. 2004
    ..Hill coefficients of both mutants were decreased, but competitive antagonist studies indicated that their binding sites were not significantly affected...
  48. ncbi request reprint Central nervous system depressant action of flavonoid glycosides
    Sebastian P Fernandez
    Instituto de Quimica y Fisicoquimica Biologicas, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina
    Eur J Pharmacol 539:168-76. 2006
    ..The pharmacological properties of the flavonoid glycosides studied here, in addition to our previous results with hesperidin and linarin, opens a promising new avenue of research in the field...