P R Johnson

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi Airway smooth muscle and fibroblasts in the pathogenesis of asthma
    Peter R A Johnson
    Department of Pharmacology, The University of Sydney, NSW Australia 2006
    Curr Allergy Asthma Rep 4:102-8. 2004
  2. ncbi Airway smooth muscle cell proliferation is increased in asthma
    P R Johnson
    Department of Pharmacology, University of Sydney, Sydney, Australia
    Am J Respir Crit Care Med 164:474-7. 2001
  3. ncbi Role of human airway smooth muscle in altered extracellular matrix production in asthma
    P R Johnson
    Department of Pharmacology, University of Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 28:233-6. 2001
  4. ncbi Potentiation of contraction of rabbit airway smooth muscle by some cyclooxygenase products
    C L Armour
    Department of Pharmacology, University of Sydney, N S W, Australia
    Prostaglandins 35:959-68. 1988
  5. ncbi Parasympathetic neurotransmission in rabbit isolated bronchus is modulated at prejunctional sites via endothelinB receptor stimulation
    K O McKay
    Department of Pharmacology, The University of Sydney, New South Wales, Australia
    Respirology 5:343-53. 2000
  6. ncbi Extracellular calcium and human isolated airway muscle: ionophore A23187 induced contraction
    R Marthan
    Department of Pharmacology, University of Sydney, N S W, Australia
    Respir Physiol 71:157-68. 1988
  7. ncbi Characterization of contractile prostanoid receptors on human airway smooth muscle
    C L Armour
    Department of Pharmacology, University of Sydney, Australia
    Eur J Pharmacol 165:215-22. 1989
  8. ncbi Factors controlling transduction signaling and proliferation of airway smooth muscle
    J L Black
    Department of Pharmacology, University of Sydney, NSW 2006, Sydney, Australia
    Curr Allergy Asthma Rep 1:116-21. 2001
  9. ncbi Mechanisms of airway remodeling. Airway smooth muscle
    J L Black
    Department of Pharmacology, and Institute of Respiratory Medicine, University of Sydney, Sydney, Australia
    Am J Respir Crit Care Med 164:S63-6. 2001
  10. ncbi Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle
    L S Chambers
    Department of Pharmacology, University of Sydney, New South Wales 2006, Australia
    Am J Physiol Lung Cell Mol Physiol 281:L1369-78. 2001

Collaborators

Detail Information

Publications17

  1. ncbi Airway smooth muscle and fibroblasts in the pathogenesis of asthma
    Peter R A Johnson
    Department of Pharmacology, The University of Sydney, NSW Australia 2006
    Curr Allergy Asthma Rep 4:102-8. 2004
    ..Current asthma therapies lack the ability to completely prevent or reverse the remodeling of the airways, therefore indicating the need for new therapeutic strategies to counter this important aspect of asthma...
  2. ncbi Airway smooth muscle cell proliferation is increased in asthma
    P R Johnson
    Department of Pharmacology, University of Sydney, Sydney, Australia
    Am J Respir Crit Care Med 164:474-7. 2001
    ..Keywords: asthma; human airway smooth muscle; cell culture; cell proliferation; hyperplasia..
  3. ncbi Role of human airway smooth muscle in altered extracellular matrix production in asthma
    P R Johnson
    Department of Pharmacology, University of Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 28:233-6. 2001
    ..Further studies are needed to fully understand the role of the ASM in the production of ECM proteins, MMP and TIMP andtheir potential influence in the mechanisms underlying asthma...
  4. ncbi Potentiation of contraction of rabbit airway smooth muscle by some cyclooxygenase products
    C L Armour
    Department of Pharmacology, University of Sydney, N S W, Australia
    Prostaglandins 35:959-68. 1988
    ..The fact that we could alter smooth muscle sensitivity in vitro with PGF2 alpha and a thromboxane analogue suggests that these mediators may be involved in the airway hyperresponsiveness observed in asthma...
  5. ncbi Parasympathetic neurotransmission in rabbit isolated bronchus is modulated at prejunctional sites via endothelinB receptor stimulation
    K O McKay
    Department of Pharmacology, The University of Sydney, New South Wales, Australia
    Respirology 5:343-53. 2000
    ..The aim of this study was to investigate the mechanism involved in endothelin-induced potentiation of the response to parasympathetic nerve stimulation...
  6. ncbi Extracellular calcium and human isolated airway muscle: ionophore A23187 induced contraction
    R Marthan
    Department of Pharmacology, University of Sydney, N S W, Australia
    Respir Physiol 71:157-68. 1988
    ..ii) Extracellular calcium mobilization through different pathways has a cumulative effect on human airway contraction...
  7. ncbi Characterization of contractile prostanoid receptors on human airway smooth muscle
    C L Armour
    Department of Pharmacology, University of Sydney, Australia
    Eur J Pharmacol 165:215-22. 1989
    ..GR32191 10(-7) M inhibited the contractile portion of the response curve in 8 of 11 tissues. Based on these results we conclude that U46619, PGF2 alpha and PGE2 all contract human airways by stimulation of the TxA2 (TP) receptor...
  8. ncbi Factors controlling transduction signaling and proliferation of airway smooth muscle
    J L Black
    Department of Pharmacology, University of Sydney, NSW 2006, Sydney, Australia
    Curr Allergy Asthma Rep 1:116-21. 2001
    ..These properties may contribute to the increase in the amount of airway smooth muscle that characterizes the asthmatic airway wall and the remodeling that underlies the structural changes that lead to persistent asthma...
  9. ncbi Mechanisms of airway remodeling. Airway smooth muscle
    J L Black
    Department of Pharmacology, and Institute of Respiratory Medicine, University of Sydney, Sydney, Australia
    Am J Respir Crit Care Med 164:S63-6. 2001
    ..Once the relationships between allergy and inflammation of the smooth muscle and its extracellular matrix are better defined, opportunities to prevent or reverse airway remodeling will become available...
  10. ncbi Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle
    L S Chambers
    Department of Pharmacology, University of Sydney, New South Wales 2006, Australia
    Am J Physiol Lung Cell Mol Physiol 281:L1369-78. 2001
    ..In conclusion, activation of PAR-2 can induce contractions of human airways, potentiate contractions to histamine, and induce proliferation and therefore may contribute to airway diseases such as asthma...
  11. ncbi An epithelial-derived factor inhibits contraction in canine perfused bronchial segments
    B E McParland
    Department of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 402:151-9. 2000
    ....
  12. ncbi Airway smooth muscle in asthma
    J L Black
    Department of Pharmacology, University of Sydney, NSW, Australia
    Respirology 1:153-8. 1996
    ..Passive sensitization of non-asthmatic airways in vitro provides a good model for the study of the mechanisms underlying airway hyperresponsiveness, and will be the subject of more intensive study in the future...
  13. ncbi GM-CSF production from human airway smooth muscle cells is potentiated by human serum
    M B Sukkar
    Department of Pharmacy, University of Sydney, NSW, Australia
    Mediators Inflamm 9:161-8. 2000
    ....
  14. ncbi Human eosinophil-airway smooth muscle cell interactions
    J M Hughes
    Respiratory Research Group, Faculty of Pharmacy, University of Sydney, NSW, Australia
    Mediators Inflamm 9:93-9. 2000
    ..These results provide evidence that eosinophil interactions with ASMC involve VCAM-1 and ICAM-1 and are modulated by TNF-alpha...
  15. ncbi Tumour necrosis factor-alpha potentiates contraction of human bronchus in vitro
    M B Sukkar
    Respiratory Research Group, Faculty of Pharmacy and Department of Pharmacology, University of Sydney, New South Wales, Australia
    Respirology 6:199-203. 2001
    ..CONCLUSIONS: The relative concentrations of IL-1beta/TNF-alpha in the vicinity of ASM may ultimately determine their effects on ASM contraction in asthma...
  16. ncbi ERK activation and mitogenesis in human airway smooth muscle cells
    J H Lee
    Department of Pharmacology, University of Sydney, New South Wales 2006, Australia
    Am J Physiol Lung Cell Mol Physiol 280:L1019-29. 2001
    ..These results indicate that ERK is required for human airway smooth muscle cell proliferation. Thus targeting the control of ERK activation may provide a new therapeutic approach for hyperplasia seen in asthma...
  17. ncbi Tachykinin receptors in rabbit airways--characterization by functional, autoradiographic and binding studies
    J L Black
    Department of Pharmacology, University of Sydney, NSW, Australia
    Br J Pharmacol 107:429-36. 1992
    ..These receptors have unusual characteristics in that the NK, antagonist, CP-96,345 and the NK2 antagonist, MDL 29,913 respectively exhibited only weak potency...