A R Jex

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. Jex A, Gasser R. Analysis of the genetic diversity within Cryptosporidium hominis and Cryptosporidium parvum from imported and autochtonous cases of human cryptosporidiosis by mutation scanning. Electrophoresis. 2008;29:4119-29 pubmed publisher
    ..hominis and C. parvum and emphasizes the need to undertake investigations of human and animal populations in countries for which there is no information on the genetic make-up of Cryptosporidium infecting humans. ..
  2. Jex A, Young N, Sripa J, Hall R, Scheerlinck J, Laha T, et al. Molecular changes in Opisthorchis viverrini (Southeast Asian liver fluke) during the transition from the juvenile to the adult stage. PLoS Negl Trop Dis. 2012;6:e1916 pubmed publisher
    ..Furthermore, these data indicate that major lineages of cysteine peptidases of socioeconomically important trematodes have evolved through a process of gene loss rather than independent radiation, contrasting previous proposals. ..
  3. Alvarez Rojas C, Ansell B, Hall R, Gasser R, Young N, Jex A, et al. Transcriptional analysis identifies key genes involved in metabolism, fibrosis/tissue repair and the immune response against Fasciola hepatica in sheep liver. Parasit Vectors. 2015;8:124 pubmed publisher
    ..It defines the involvement of specific genes associated with the host's metabolism, immune response and tissue repair/regeneration, and highlights an apparent overlapping function of many genes involved in these processes. ..
  4. Jex A, Smith H, Monis P, Campbell B, Gasser R. Cryptosporidium--biotechnological advances in the detection, diagnosis and analysis of genetic variation. Biotechnol Adv. 2008;26:304-17 pubmed publisher
    ..These advances represent a significant step toward an improved understanding of the epidemiology as well as the prevention and control of cryptosporidiosis. ..
  5. Jex A, Stanley K, Lo W, Littman R, Verweij J, Campbell B, et al. Detection of diarrhoeal pathogens in human faeces using an automated, robotic platform. Mol Cell Probes. 2012;26:11-5 pubmed publisher
    ..This platform requires little molecular biological expertise and is well suited to various diagnostic facilities and settings. ..
  6. Jex A, Littlewood D, Gasser R. Sequencing and annotation of mitochondrial genomes from individual parasitic helminths. Methods Mol Biol. 2015;1201:51-63 pubmed publisher
    ..In addition, these methods have broader utility and might be readily adapted to a range of other medium-sized molecular regions (i.e., 10-100 kb), including large genomic operons, and other organellar (e.g., plastid) and viral genomes. ..
  7. Cantacessi C, Campbell B, Young N, Jex A, Hall R, Presidente P, et al. Differences in transcription between free-living and CO2-activated third-stage larvae of Haemonchus contortus. BMC Genomics. 2010;11:266 pubmed publisher
    ..Such advances should lead to a significantly improved understanding of the molecular biology of H. contortus and, from an applied perspective, to novel methods of intervention. ..
  8. Jabbar A, Beveridge I, Mohandas N, Chilton N, Littlewood D, Jex A, et al. Analyses of mitochondrial amino acid sequence datasets support the proposal that specimens of Hypodontus macropi from three species of macropodid hosts represent distinct species. BMC Evol Biol. 2013;13:259 pubmed publisher
    ..The present analyses of inferred mt protein sequence datasets clearly supported the hypothesis that H. macropi from M. robustus robustus, M. bicolor and T. billardierii represent distinct species. ..
  9. Jex A, Hu M, Littlewood D, Waeschenbach A, Gasser R. Using 454 technology for long-PCR based sequencing of the complete mitochondrial genome from single Haemonchus contortus (Nematoda). BMC Genomics. 2008;9:11 pubmed publisher
    ..This approach provides a novel platform for high-throughput sequencing of mt genomes from nematodes and other organisms...

More Information

Publications15

  1. Jex A, Waeschenbach A, Littlewood D, Hu M, Gasser R. The mitochondrial genome of Toxocara canis. PLoS Negl Trop Dis. 2008;2:e273 pubmed publisher
    ..Such markers can now be used in prospecting for cryptic species and for exploring host specificity and zoonotic potential, thus underpinning the prevention and control of toxocariasis in humans and other hosts. ..
  2. Jex A, Hall R, Littlewood D, Gasser R. An integrated pipeline for next-generation sequencing and annotation of mitochondrial genomes. Nucleic Acids Res. 2010;38:522-33 pubmed publisher
    ..These mt genomic data provide a rich source of markers for studies of the systematics and population genetics of a group of socioeconomically important pathogens of humans and other animals...
  3. Jex A, Littlewood D, Gasser R. Toward next-generation sequencing of mitochondrial genomes--focus on parasitic worms of animals and biotechnological implications. Biotechnol Adv. 2010;28:151-9 pubmed publisher
  4. Jex A, Waeschenbach A, Hu M, van Wyk J, Beveridge I, Littlewood D, et al. The mitochondrial genomes of Ancylostoma caninum and Bunostomum phlebotomum--two hookworms of animal health and zoonotic importance. BMC Genomics. 2009;10:79 pubmed publisher
  5. Jex A, Liu S, Li B, Young N, Hall R, Li Y, et al. Ascaris suum draft genome. Nature. 2011;479:529-33 pubmed publisher
    ..This genome provides a comprehensive resource to the scientific community and underpins the development of new and urgently needed interventions (drugs, vaccines and diagnostic tests) against ascariasis and other nematodiases. ..
  6. Koehler A, Haydon S, Jex A, Gasser R. Is Cryptosporidium from the common wombat (Vombatus ursinus) a new species and distinct from Cryptosporidium ubiquitum?. Infect Genet Evol. 2016;44:28-33 pubmed publisher
    ..Phylogenetic analysis suggests that subtypes of C. ubiquitum can be divided into generalist and specialist groups, which is important when considering the zoonotic potential of C. ubiquitum in the context of drinking water safety. ..