George Jerums

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Integrating albuminuria and GFR in the assessment of diabetic nephropathy
    George Jerums
    Endocrine Center, Austin Health, Victoria, Australia
    Nat Rev Nephrol 5:397-406. 2009
  2. ncbi New and old markers of progression of diabetic nephropathy
    G Jerums
    Endocrine Centre of Excellence, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Level 2 Centaur Building, 300 Waterdale Road, Heidelberg West 3081, Victoria, Australia
    Diabetes Res Clin Pract 82:S30-7. 2008
  3. ncbi New approaches for the evaluation of renal vascular function in diabetes
    G Jerums
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg West, PO Box 5444, VIC 3081, Australia
    Diabetologia 54:2223-5. 2011
  4. ncbi The clinical significance of hyperfiltration in diabetes
    G Jerums
    Endocrine Centre, Austin Health, Heidelberg Repatriation Hospital, Level 2, Centaur Building, 300 Waterdale Road, PO Box 5444, Heidelberg West, Victoria 3081, Australia
    Diabetologia 53:2093-104. 2010
  5. ncbi Study Protocol--accurate assessment of kidney function in Indigenous Australians: aims and methods of the eGFR study
    Louise J Maple-Brown
    Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, Australia
    BMC Public Health 10:80. 2010
  6. ncbi The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes
    Sheila K Patel
    Department of Medicine, Austin Health, University of Melbourne, Level 7, Lance Townsend Building, 145 Studley Road, Melbourne, VIC 3084, Australia
    Cardiovasc Diabetol 11:42. 2012
  7. ncbi Nonalbuminuric renal impairment in type 2 diabetic patients and in the general population (national evaluation of the frequency of renal impairment cO-existing with NIDDM [NEFRON] 11)
    Merlin C Thomas
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes Care 32:1497-502. 2009
  8. ncbi Low testosterone and anaemia in men with type 2 diabetes
    Mathis Grossmann
    Department of Endocrinology and Medicine, University of Melbourne, Austin Health, Australia
    Clin Endocrinol (Oxf) 70:547-53. 2009
  9. ncbi Additive effects of hypertension and diabetes on renal cortical expression of PKC-alpha and -epsilon and alpha-tubulin but not PKC-beta 1 and -beta 2
    Tanya M Osicka
    Endocrine Unit, Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    J Hypertens 21:2399-407. 2003
  10. ncbi Prevalence and predictors of cardiac hypertrophy and dysfunction in patients with Type 2 diabetes
    Piyush M Srivastava
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia
    Clin Sci (Lond) 114:313-20. 2008

Collaborators

Detail Information

Publications50

  1. ncbi Integrating albuminuria and GFR in the assessment of diabetic nephropathy
    George Jerums
    Endocrine Center, Austin Health, Victoria, Australia
    Nat Rev Nephrol 5:397-406. 2009
    ..The successful integration of AER categories with the recently defined stages of GFR represents a new challenge in the management of diabetic nephropathy...
  2. ncbi New and old markers of progression of diabetic nephropathy
    G Jerums
    Endocrine Centre of Excellence, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Level 2 Centaur Building, 300 Waterdale Road, Heidelberg West 3081, Victoria, Australia
    Diabetes Res Clin Pract 82:S30-7. 2008
    ..However, improved formulas for estimating GFR based on using creatinine or other markers are still required, because this may still provide the most cost effective approach applicable to existing clinical practice...
  3. ncbi New approaches for the evaluation of renal vascular function in diabetes
    G Jerums
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg West, PO Box 5444, VIC 3081, Australia
    Diabetologia 54:2223-5. 2011
    ....
  4. ncbi The clinical significance of hyperfiltration in diabetes
    G Jerums
    Endocrine Centre, Austin Health, Heidelberg Repatriation Hospital, Level 2, Centaur Building, 300 Waterdale Road, PO Box 5444, Heidelberg West, Victoria 3081, Australia
    Diabetologia 53:2093-104. 2010
    ..Future studies will therefore need to address the independent role of hyperfiltration, not only in the evolution of albuminuria, but also in the subsequent decline of GFR...
  5. ncbi Study Protocol--accurate assessment of kidney function in Indigenous Australians: aims and methods of the eGFR study
    Louise J Maple-Brown
    Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, Australia
    BMC Public Health 10:80. 2010
    ....
  6. ncbi The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes
    Sheila K Patel
    Department of Medicine, Austin Health, University of Melbourne, Level 7, Lance Townsend Building, 145 Studley Road, Melbourne, VIC 3084, Australia
    Cardiovasc Diabetol 11:42. 2012
    ..This study investigated the association of the CTGF -945 G/C promoter variant with cardiac complications (left ventricular (LV) hypertrophy (LVH), diastolic and systolic dysfunction) and chronic kidney disease (CKD) in type 2 diabetes...
  7. ncbi Nonalbuminuric renal impairment in type 2 diabetic patients and in the general population (national evaluation of the frequency of renal impairment cO-existing with NIDDM [NEFRON] 11)
    Merlin C Thomas
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes Care 32:1497-502. 2009
    ..However, its impact may be more significant. New studies are required to address the pathogenesis, prevention, and treatment of nonalbuminuric renal disease...
  8. ncbi Low testosterone and anaemia in men with type 2 diabetes
    Mathis Grossmann
    Department of Endocrinology and Medicine, University of Melbourne, Austin Health, Australia
    Clin Endocrinol (Oxf) 70:547-53. 2009
    ..Low testosterone levels are also common in men with type 2 diabetes. We hypothesized that low testosterone levels are also associated with anaemia in men with type 2 diabetes, over the effects of chronic kidney disease...
  9. ncbi Additive effects of hypertension and diabetes on renal cortical expression of PKC-alpha and -epsilon and alpha-tubulin but not PKC-beta 1 and -beta 2
    Tanya M Osicka
    Endocrine Unit, Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    J Hypertens 21:2399-407. 2003
    ..Corresponding changes in renal microtubules were also assessed...
  10. ncbi Prevalence and predictors of cardiac hypertrophy and dysfunction in patients with Type 2 diabetes
    Piyush M Srivastava
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia
    Clin Sci (Lond) 114:313-20. 2008
    ....
  11. ncbi Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes
    Richard J MacIsaac
    Endocrine Centre, Austin Health and University of Melbourne, Melbourne, Australia
    Cardiovasc Diabetol 7:15. 2008
    ....
  12. ncbi Low-molecular-weight AGEs are associated with GFR and anemia in patients with type 2 diabetes
    Merlin C Thomas
    Danielle Alberti Memorial Centre for Diabetic Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Kidney Int 66:1167-72. 2004
    ..We examined the predictors of low-molecular-weight (LMW) AGEs in a cross-sectional survey of 604 patients with type 2 diabetes in a single clinic...
  13. ncbi The effect of ramipril on albumin excretion in diabetes and hypertension: the role of increased lysosomal activity and decreased transforming growth factor-beta expression
    Leileata M Russo
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Hypertens 21:419-28. 2003
    ..Ramipril treatment reduced total albumin excretion in the WKY-d + RAM group (P < 0.001). CONCLUSIONS: Ramipril prevents increases in both intact albumin and total albumin excretion in hypertensive and diabetic states, respectively...
  14. ncbi Effects of salt supplementation on the albuminuric response to telmisartan with or without hydrochlorothiazide therapy in hypertensive patients with type 2 diabetes are modulated by habitual dietary salt intake
    Elif I Ekinci
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg West, Victoria, Australia
    Diabetes Care 32:1398-403. 2009
    ..By contrast, when there is already a suppressed renin angiotensin aldosterone system under habitual high dietary salt intake, the additional NaCl does not alter the AER response...
  15. ncbi Increased tubular organic ion clearance following chronic ACE inhibition in patients with type 1 diabetes
    Merlin C Thomas
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Kidney Int 67:2494-9. 2005
    ..This study examines the effect and implications of chronic ACE inhibition on renal organic ion excretion in patients with type 1 diabetes...
  16. ncbi Is nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease?
    Richard J MacIsaac
    Endocrine Centre and Department of Medicine, Austin Health, Heidelberg Repatriation Hospital, Waterdale Road, Heidelberg West, Victoria 3081, Australia
    Diabetes Care 29:1560-6. 2006
    ..To investigate the role of intrarenal vascular disease in the pathogenesis of nonalbuminuric renal insufficiency in type 2 diabetes...
  17. ncbi Lowering of proteinuria in response to antihypertensive therapy predicts improved renal function in late but not in early diabetic nephropathy: a pooled analysis
    George Jerums
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg, Vic, Australia
    Am J Nephrol 28:614-27. 2008
    ..It follows that assessment of renoprotection during antihypertensive therapy in early nephropathy should be based not only on albuminuria but also on the GFR response...
  18. ncbi Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy
    Josephine M Forbes
    Address correspondence to Dr Josephine Forbes, Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, P O Box 6492, St Kilda Road, Melbourne, Victoria, 8008, Australia
    J Am Soc Nephrol 16:2363-72. 2005
    ..It is postulated that ACE inhibition reduces the accumulation of AGE in diabetes partly by increasing the production and secretion of sRAGE into plasma...
  19. ncbi Earlier detection of microalbuminuria in diabetic patients using a new urinary albumin assay
    Wayne D Comper
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Kidney Int 65:1850-5. 2004
    ....
  20. ncbi Ramipril prevents microtubular changes in proximal tubules from streptozotocin diabetic rats
    Tanya M Osicka
    Endocrine Unit, Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Nephrology (Carlton) 8:205-11. 2003
    ..These results raise the possibility that diabetes-induced changes in microtubules in the renal proximal tubules may contribute, in part, to the increase in albuminuria observed in diabetes...
  21. ncbi Association of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in Caucasians with type 2 diabetes
    Sheila K Patel
    Department of Medicine, University of Melbourne, Austin Health, Victoria, Australia
    Am J Hypertens 25:216-22. 2012
    ..Angiotensin-converting enzyme (ACE)2 is a recently described member of the RAS, and this study investigated whether ACE2 polymorphisms are associated with hypertension, left ventricular (LV) mass, and cardiac function in type 2 diabetes...
  22. ncbi Serial measurements of cystatin C are more accurate than creatinine-based methods in detecting declining renal function in type 1 diabetes
    Erosha Premaratne
    Endocrine Centre, Austin Health, University of Melbourne, Melbourne, Australia
    Diabetes Care 31:971-3. 2008
    ..Cystatin C-and creatinine-based methods were compared with (99m)-technetium-diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) plasma clearance (isotopic glomerular filtration rate [iGFR]) for detecting declining renal function...
  23. ncbi Low-molecular weight advanced glycation end products: markers of tissue AGE accumulation and more?
    Merlin C Thomas
    The Baker Heart Research Institute, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria, Australia
    Ann N Y Acad Sci 1043:644-54. 2005
    ..These findings provide clinical support for the association between AGEs and progressive renal injury in diabetes...
  24. ncbi Treatment of microalbuminuria in patients with type 2 diabetes mellitus
    George Jerums
    Endocrinology Unit, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Treat Endocrinol 1:163-73. 2002
    ..Antihypertensive therapy in patients with microalbuminuria and type 2 diabetes mellitus should be initiated with angiotensin converting enzyme (ACE) inhibitors or angiotensin-II type 1 receptor antagonists...
  25. ncbi Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease
    George Jerums
    Endocrine Unit, Austin Health, University of Melbourne, Studley Road, 3084 Heidelberg, Australia
    Arch Biochem Biophys 419:55-62. 2003
    ..There is also evidence to suggest that AGE-dependent pathways may play a role in the development of tubulointerstitial fibrosis in the diabetic kidney. This effect is mediated through RAGE and is TGF-beta and CTGF-dependent...
  26. ncbi Diastolic dysfunction is associated with anaemia in patients with Type II diabetes
    Piyush M Srivastava
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria 3084, Australia
    Clin Sci (Lond) 110:109-16. 2006
    ..Notably, the predictive utility of these markers was eliminated after adjusting for Hb. Consequently, the inexpensive measurement of Hb may be a useful tool to identify diabetic patients at increased risk of cardiac dysfunction...
  27. ncbi Nonalbuminuric renal insufficiency in type 2 diabetes
    Richard J MacIsaac
    Endocrinology Unit, Austin Health, Heidelberg, Victoria, Australia
    Diabetes Care 27:195-200. 2004
    ..To determine the prevalence and characteristics of patients with type 2 diabetes who have impaired renal function, defined as a glomerular filtration rate (GFR) <60 ml. min(-1). 1.73 m(-2), and normoalbuminuria...
  28. ncbi Low testosterone levels are common and associated with insulin resistance in men with diabetes
    Mathis Grossmann
    Department of Endocrinology and Medicine, University of Melbourne, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia
    J Clin Endocrinol Metab 93:1834-40. 2008
    ..Low testosterone levels are common in men with type 2 diabetes and may be associated with insulin resistance...
  29. ncbi Reduced tubular cation transport in diabetes: prevented by ACE inhibition
    Merlin C Thomas
    Division of Diabetic Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Kidney Int 63:2152-61. 2003
    ..Alterations of cation transport may occur in diabetes, although the role of the OCTs has not been previously assessed...
  30. ncbi The burden of anaemia in type 2 diabetes and the role of nephropathy: a cross-sectional audit
    Merlin C Thomas
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Nephrol Dial Transplant 19:1792-7. 2004
    ..This study examines the prevalence and predictors of anaemia in long-term outpatients with type 2 diabetes from three large clinical centres...
  31. ncbi Effects and clinical potential of very-low-calorie diets (VLCDs) in type 2 diabetes
    Scott Baker
    Department of Medicine, Austin Health, University of Melbourne, Heidelberg Repatriation Hospital, 300 Waterdale Road, West Heidelberg, VIC 3081, Australia
    Diabetes Res Clin Pract 85:235-42. 2009
    ..The present review analyses the evidence from available trials on the effects of VLCDs on body weight, glycaemic control and complications, and their potential for clinical use in diabetes management...
  32. ncbi Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy
    Sally A Penfold
    Division of Diabetes Complications, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Kidney Int 78:287-95. 2010
    ..These data show that ligands that activate RAGE present in the circulation of patients with type 2 diabetes and nephropathy are predominantly of high molecular weight...
  33. ncbi Unrecognized anemia in patients with diabetes: a cross-sectional survey
    Merlin C Thomas
    Department of Medicine, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia
    Diabetes Care 26:1164-9. 2003
    ..This study aims to establish the prevalence and independent predictors of anemia in a cross-sectional survey of 820 patients with diabetes in long-term follow-up in a single clinic...
  34. ncbi Renal processing of serum proteins in an albumin-deficient environment: an in vivo study of glomerulonephritis in the Nagase analbuminaemic rat
    Tanya M Osicka
    Endocrine Unit, Austin and Repatriation Medical Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
    Nephrol Dial Transplant 19:320-8. 2004
    ..These studies also demonstrate that albumin is not a critical factor in governing glomerular permselectivity or proteinuria...
  35. ncbi Less fat reduction per unit weight loss in type 2 diabetic compared with nondiabetic obese individuals completing a very-low-calorie diet program
    Scott T Baker
    Endocrine Centre, Austin Health, Heidelberg Repatriation Hospital Campus, Heidelberg West, Victoria 3081, Australia
    Metabolism 61:873-82. 2012
    ..Hyperinsulinemia may have inhibited lipolysis in the diabetic group; however, further investigation into other factors is needed...
  36. ncbi Outcomes for general medical inpatients with diabetes mellitus and new hyperglycaemia
    Scott T Baker
    Austin Health and University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 188:340-3. 2008
    ..To investigate the relationship between admission glycaemic status and inpatient mortality in patients with and without pre-existing diabetes...
  37. ncbi Albumin to creatinine ratio: a screening test with limitations
    Christine A Houlihan
    Endocrine Unit and Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Am J Kidney Dis 39:1183-9. 2002
    ..The increase in spot ACR relative to 24-hour AER with age supports the use of sex- and age-adjusted ACR cutoff values...
  38. ncbi Diabetic kidney disease with and without albuminuria
    Richard J MacIsaac
    Endocrine Centre, Austin Health and University of Melbourne, Heidelberg West, Victoria, Australia
    Curr Opin Nephrol Hypertens 20:246-57. 2011
    ..We review recent findings that suggest that in some people with diabetic CKD there is an uncoupling of progressive increases in AER and declining GFR...
  39. ncbi 3: Preventing complications of diabetes
    Katherine L Bate
    Endocrinology Unit, Austin Health, Studley Road, Heidelberg, VIC 3084, Australia
    Med J Aust 179:498-503. 2003
    ..Regular annual screening for diabetes complications allows treatable disease to be identified. Aggressive management of hyperglycaemia and other risk factors can prevent many complications..
  40. ncbi Chronic type 1 diabetes in spontaneously hypertensive rats leads to exacerbated cardiac fibrosis
    Mary Jane Black
    Department of Anatomy and Developmental Biology, Monash University, Victoria, Australia
    Cardiovasc Pathol 19:361-70. 2010
    ..Diabetes in human subjects is often associated with hypertension. The aim of this study was to examine the development of cardiac fibrosis following induction of type 1 diabetes in genetically hypertensive rats...
  41. ncbi Elevated iron indices in patients with diabetes
    M C Thomas
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia
    Diabet Med 21:798-802. 2004
    ....
  42. ncbi High prevalence of immuno-unreactive intact albumin in urine of diabetic patients
    Wayne D Comper
    Department of Biochemistry and Molecular Biology, Monash University, Clayton; and the Endocrine Unit, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia
    Am J Kidney Dis 41:336-42. 2003
    ..Conclusion: These studies show that to determine microalbuminuria accurately, there is a need to assess urinary total intact albumin, rather than simply immunoreactive albumin. Am J Kidney Dis 41:336-342...
  43. ncbi Dietary salt intake and mortality in patients with type 2 diabetes
    Elif I Ekinci
    Endocrine Centre, Austin Health and the University of Melbourne, Victoria, Australia
    Diabetes Care 34:703-9. 2011
    ..However, the precise relationship between dietary salt intake and mortality in patients with type 2 diabetes has not been previously explored...
  44. ncbi New insights into the significance of microalbuminuria
    Richard J MacIsaac
    Endocrinology Unit, Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
    Curr Opin Nephrol Hypertens 13:83-91. 2004
    ..This review summarizes recent work that has explored the association between microalbuminuria and adverse clinical outcomes in the presence and absence of diabetes...
  45. ncbi Urinary transforming growth factor-beta excretion in patients with hypertension, type 2 diabetes, and elevated albumin excretion rate: effects of angiotensin receptor blockade and sodium restriction
    Christine A Houlihan
    University of Melbourne, Department of Medicine at Austin, Victoria, Australia
    Diabetes Care 25:1072-7. 2002
    ..These data suggest that the renoprotective effects of losartan in patients with type 2 diabetes and nephropathy may include a reduction in renal TGF-beta production...
  46. ncbi Albuminuria in hypertension is linked to altered lysosomal activity and TGF-beta1 expression
    Leileata M Russo
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Hypertension 39:281-6. 2002
    ..These changes may be correlated with increased renal transforming growth factor-beta(1) expression...
  47. ncbi Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies
    Darren J Kelly
    University of Melbourne Department of Medicine at St Vincent s Hospital, Fitzroy, Victoria, Australia
    Nephrol Dial Transplant 17:1327-32. 2002
    ..In addition, the study also sought to examine nephrin expression in animals treated with different anti-proteinuric therapies...
  48. ncbi Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1
    Justine A Ellis
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    J Hum Genet 50:534-7. 2005
    ..These results suggest that functional genetic variants might exist in or around SRD5A1 that affect the activity of the 5alpha-reductase enzyme type 1 and influence androgen levels...
  49. ncbi Hypocalcemia induced by raloxifene
    Thuy D T Vu
    Endocrinology Department, Austin Health, Victoria, Australia
    Curr Drug Saf 7:176-8. 2012
    ..Since vitamin D deficiency is widely prevalent in the community, screening for vitamin D deficiency and its correction is advisable before the initiation of anti-resorptive therapy...
  50. ncbi Failure of functional imaging with gallium-68-DOTA-D-Phe1-Tyr3-octreotide positron emission tomography to localize the site of ectopic adrenocorticotropic hormone secretion: a case report
    Linsey U Gani
    Endocrine Centre and Department of Medicine, Austin Health and University of Melbourne, PO Box 5444, Heidelberg West 3081, Victoria, Australia
    J Med Case Reports 5:405. 2011
    ..abstract:..