Mark A Jenkins

..3, 95% CI = 8.56 to 42.9), and breast cancer (SIR = 2.51, 95% CI = 1.17 to 4.14). Conclusions Women with Lynch syndrome who are diagnosed with endometrial cancer have increased risks of several cancers, including breast cancer...

..However, the abundance of associations around 128 Mb on chromosome 8 could mask the appearance of a weaker, but important, association elsewhere on 8q24...

..These may be overestimates, due to analytic problems, and not generalizable. We estimated average cancer risks for mutations identified in population-based early onset colorectal cancer cases (probands) unselected for family history...

..There is evidence for a role of yet to be identified genes associated with a high recessively-inherited risk of colorectal cancer...

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..Our aim was to identify pathology and other features that independently predict high MSI (MSI-H)...

..To determine whether cancer risks for carriers and noncarriers from families with a mismatch repair (MMR) gene mutation are increased above the risks of the general population...

..We estimated the risks of primary cancers other than colorectal cancer following a diagnosis of colorectal cancer in mutation carriers...

..Monoallelic MUTYH mutation carriers with a family history of CRC, such as those identified from screening multiple-case CRC families, are at increased risk of colorectal, gastric, endometrial and possibly liver cancers...

..To investigate the association of body mass index (BMI) in early adulthood and endometrial cancer risk for carriers of a germline mutation in a DNA mismatch repair gene...

..To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39 years...

..Germline mutations in MSH6 account for 10%-20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because there have been only a few studies of mutation carriers, their cancer risks are uncertain...

..Larger studies would be required to determine if this variant is associated with a smaller risk of breast cancer...

..We wanted to examine which microsatellite markers currently used to detect MSI best predict early-onset colorectal cancer caused by germ-line mutations in MMR genes...

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..The atopic march hypothesis proposes that eczema precedes the development of asthma and allergic rhinitis...

..We attempted to replicate the findings of studies assessing such interactions with the -34T-->C polymorphism...

..If confirmed by larger studies, these results will have important implications for the etiology of CRC and for the clinical management of MMR gene mutation carriers...

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..Our findings should provide reassurance that in terms of life time risk of asthma and atopic disease, childhood immunization is safe...

..Sunbed use is associated with increased risk of early-onset melanoma, with risk increasing with greater use, an earlier age at first use and for earlier onset disease...

..To examine asthma remission from childhood to middle age...

..We conducted a population-based study to estimate CRC screening practices existing outside the current program...

..The aim of this study was to estimate the risks of CRC and extracolonic cancers for relatives of patients with serrated polyposis...

..Clinicians should be aware that women diagnosed with breast cancer within a few years following childbirth may have a worse outcome than that suggested solely by the standard histopathological prognostic factors of their cancer...

..CDKN2A mutations confer a substantial risk of cutaneous melanoma; however, the magnitude of risk is uncertain...

..The association between allergic rhinitis and asthma is well documented, but the temporal sequence of this association has not been closely examined...

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..Incomplete penetrance and differences in risk by subcategories are consistent with the existence of genetic and/or environmental risk -modifiers. Data from large cohorts of carriers are required to study such modifiers with precision...

..The aim of this study was to assess whether a history of asthma or the use of asthma medications is associated with prostate cancer risk...

..3%; SE 0.9%) than for controls (1.4%; SE 0.3%) (P = 0.02). Monoallelic MUTYH mutation carriers are at increased risk of CRC but the average increase is small...

..Guidelines for CRC screening are not being implemented in the population. More research is needed to identify the reasons so as to enable development of strategies to improve participation in screening...

..To assess misclassification in adults reporting childhood asthma...

..The role of somatic K-ras mutations in early-onset colorectal cancer carcinogenesis appears to be minor, in contrast to its significant role in colorectal cancer of later age of onset...

..Our estimates of CRC and EC cumulative risks for MLH1 and MSH2 mutation carriers are the most precise currently available...

..We conclude that there is no model that sufficiently covers the known risk factors for colorectal cancer that is suitable for assessment of people from across the full range of risk and that a new comprehensive model is needed...

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..There is ongoing conjecture over whether childhood immunisation leads to an increased risk of developing atopic diseases...

..Women from BRCA mutation-positive families who do not carry the family-specific mutation are generally at average cancer risk and therefore do not require intensive risk management...

..The authors discuss methodological and analytical issues related to the study design and conduct, as well as the potentially novel insights the study can deliver...

..The issue of the pathogenicity of specific variants may be addressed analytically providing there are one or more suitably informative families with that mutation...

..In this study, we investigated the potential for interaction of genetic and epigenetic variation in DNMT genes, in the aetiology of HPS...

..To describe the associations between sociodemographic, lifestyle, and medical risk factors and visual impairment in a Southeast Asian population...

..These data suggest that common variants may play important roles in the risk of CRC...

..The relationships between mismatch repair (MMR) protein expression, microsatellite instability (MSI), family history, and germline MMR gene mutation status have not been studied on a population basis...

..Rarely, there is selective loss of PMS2 expression. We sought to describe the frequency and clinical correlates of selective loss of expression of PMS2 with the MSI-H tumor phenotype...

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..We examined these two ATM mutations in a population-based, case-control series of breast cancer families and multiple-case breast cancer families...

..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice...

..While the sample size was not sufficient to detect the linkage, there was a clear signal at the MLH1 location indicating that relatively small sample sizes would have been adequate to detect linkage to this gene...

..Information about the clinical significance of PMS2 mutations is crucial for appropriate counseling. Here, we report the clinical characteristics of a large series of PMS2 mutation carriers...

..This study indicates that there is a significant prevalence of ATM mutations in breast and ovarian cancer families and adds to a growing body of evidence that ATM mutations confer increased susceptibility to breast cancer...

..Here, we discuss their role in the development of other familial colorectal cancers (CRC). We studied non-FAP, non-HNPCC CRC families characterized by tumors that varied in their level of MSI between individual members...

..By resisting medial secondary redisplacement, this technique adds to stable fixation for acetabular fractures involving medial displacement, particularly of the quadrilateral plate...