G P Jeffrey

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Hepatitis C virus eradication in intravenous drug users maintained with subcutaneous naltrexone implants
    Gary P Jeffrey
    School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia
    Hepatology 45:111-7. 2007
  2. ncbi request reprint Pitfalls in the genetic diagnosis of hereditary hemochromatosis
    G P Jeffrey
    Faculty of Medicine and Dentistry, University of Western Australia, and Sir Charles Gairdner Hospital, Nedlands, Perth
    Genet Test 4:143-6. 2000
  3. ncbi request reprint Liver transplantation in Jehovah's Witness patients in Australasia
    Gary P Jeffrey
    Western Australian Liver Transplantation Service, Sir Charles Gairdner Hospital, Perth, WA, Australia
    Med J Aust 187:188-9. 2007
  4. ncbi request reprint Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infection
    Gerry C MacQuillan
    Department of Medicine, The University of Western Australia, Western Australia
    J Med Virol 70:219-27. 2003
  5. doi request reprint Malignant fibrous histiocytoma complicating nephrogenic systemic fibrosis post liver transplantation
    K So
    Western Australian Liver Transplantation Service, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Intern Med J 39:613-7. 2009
  6. ncbi request reprint Hepatic iron loading in patients with compound heterozygous HFE mutations
    Ee Mun Lim
    Department of Clinical Biochemistry, PathCentre Western Australian Centre for Pathology and Medical Research, Nedlands, WA, Australia
    Liver Int 24:631-6. 2004
  7. doi request reprint Levetiracetam as a possible cause of fulminant liver failure
    T C H Tan
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6008 Australia
    Neurology 71:685-6. 2008
  8. ncbi request reprint Genotyping as a diagnostic aid in genetic haemochromatosis
    E Rossi
    Biochemistry Section, PathCentre, QE II Medical Centre, Nedlands, Western Australia, Australia
    J Gastroenterol Hepatol 14:427-30. 1999
  9. doi request reprint Hepatic epithelioid haemangioendothelioma: challenges in diagnosis and management
    L W Y Thin
    WA Liver Transplant Service, PathWest Laboratory Medicine and Radiology Department, Sir Charles Gairdner Hospital, and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    Intern Med J 40:710-5. 2010
  10. ncbi request reprint Adult-to-adult living donor liver transplantation for fulminant hepatic failure
    A K House
    Liver Transplant Service of Western Australia, Sir Charles Gairdner Hospital, Perth
    Med J Aust 175:202-4. 2001

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Hepatitis C virus eradication in intravenous drug users maintained with subcutaneous naltrexone implants
    Gary P Jeffrey
    School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia
    Hepatology 45:111-7. 2007
    ..This result is comparable to that reported in hospital-based clinics in non-IDU patients. The side effect profile and compliance was also similar. HCV antiviral therapy should be offered to this large and currently under treated group...
  2. ncbi request reprint Pitfalls in the genetic diagnosis of hereditary hemochromatosis
    G P Jeffrey
    Faculty of Medicine and Dentistry, University of Western Australia, and Sir Charles Gairdner Hospital, Nedlands, Perth
    Genet Test 4:143-6. 2000
    ....
  3. ncbi request reprint Liver transplantation in Jehovah's Witness patients in Australasia
    Gary P Jeffrey
    Western Australian Liver Transplantation Service, Sir Charles Gairdner Hospital, Perth, WA, Australia
    Med J Aust 187:188-9. 2007
    ..To our knowledge, these are the first such cases in Australasia. The techniques used to minimise blood loss and transfusion requirements could potentially benefit all patients undergoing major surgery...
  4. ncbi request reprint Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infection
    Gerry C MacQuillan
    Department of Medicine, The University of Western Australia, Western Australia
    J Med Virol 70:219-27. 2003
    ....
  5. doi request reprint Malignant fibrous histiocytoma complicating nephrogenic systemic fibrosis post liver transplantation
    K So
    Western Australian Liver Transplantation Service, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Intern Med J 39:613-7. 2009
    ..We present this case highlighting the occurrence of two rare conditions in the same patient following liver transplantation. We believe this is the first case of its kind to be reported...
  6. ncbi request reprint Hepatic iron loading in patients with compound heterozygous HFE mutations
    Ee Mun Lim
    Department of Clinical Biochemistry, PathCentre Western Australian Centre for Pathology and Medical Research, Nedlands, WA, Australia
    Liver Int 24:631-6. 2004
    ..To assess the severity of hepatic iron loading in patients with a compound heterozygous C282Y/H63D HFE genotype...
  7. doi request reprint Levetiracetam as a possible cause of fulminant liver failure
    T C H Tan
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6008 Australia
    Neurology 71:685-6. 2008
  8. ncbi request reprint Genotyping as a diagnostic aid in genetic haemochromatosis
    E Rossi
    Biochemistry Section, PathCentre, QE II Medical Centre, Nedlands, Western Australia, Australia
    J Gastroenterol Hepatol 14:427-30. 1999
    ..Two mutations in a newly described gene, HFE, have been proposed as genetic markers for the inherited iron overload disease, genetic haemochromatosis...
  9. doi request reprint Hepatic epithelioid haemangioendothelioma: challenges in diagnosis and management
    L W Y Thin
    WA Liver Transplant Service, PathWest Laboratory Medicine and Radiology Department, Sir Charles Gairdner Hospital, and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    Intern Med J 40:710-5. 2010
    ..We review five HEH cases from our centre with the aim of identifying clinical predictors of outcome and various therapeutic options...
  10. ncbi request reprint Adult-to-adult living donor liver transplantation for fulminant hepatic failure
    A K House
    Liver Transplant Service of Western Australia, Sir Charles Gairdner Hospital, Perth
    Med J Aust 175:202-4. 2001
    ..The donor's recovery was uneventful, allowing hospital discharge on Day 6. Two months after transplantation the recipient developed a biliary stricture requiring surgery. One year after transplantation, her liver function was normal...
  11. ncbi request reprint Immunological markers predicting outcome in patients with hepatitis C treated with interferon-alpha and ribavirin
    Silvia Lee
    Department of Pathology, University of Western Australia, Australia
    Immunol Cell Biol 80:391-7. 2002
    ..High baseline sCD30 levels predicted an early (P = 0.008) and sustained (P = 0.03) virological response to therapy, suggesting treatment may be more effective in patients with a predominant T2 profile...
  12. ncbi request reprint Does sequencing the PKRBD of hepatitis C virus NS5A predict therapeutic response to combination therapy in an Australian population?
    Gerry C MacQuillan
    Department of Medicine, University of Western Australia, Crawley, Western Australia, Australia
    J Gastroenterol Hepatol 19:551-7. 2004
    ..Patients infected with a HCV genotype 1 prototype sequence should be counseled before receiving combination IFN-alpha and ribavirin therapy as they have a poor response to treatment...
  13. ncbi request reprint Liver transplantation in Western Australia: improved services to an isolated population
    D G Ormonde
    Western Australian Liver Transplantation Service, Sir Charles Gairdner Hospital
    Med J Aust 167:354-7. 1997
    ..To assess performance of the Western Australian Liver Transplantation Service in the light of debate about whether small transplant centres can produce optimal outcomes...
  14. doi request reprint Iron and oxidative stress in cold-initiated necrotic death of rat hepatocyte
    X Niu
    School of Medicine and Pharmacology University of Western Australia, Crawley, Western Australia
    Transplant Proc 42:1563-8. 2010
    ..Deferoxamine was more effective in preventing cell death when added prior to hypothermia, indicating cell death processes were likely initiated during hypothermia...
  15. pmc Prevalence, characteristics, and prognostic significance of HFE gene mutations in type 2 diabetes: the Fremantle Diabetes Study
    Timothy M E Davis
    School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, Fremantle, Australia
    Diabetes Care 31:1795-801. 2008
    ..To examine the relationship between iron status, hereditary hemochromatosis (HFE) gene mutations, and clinical features and outcomes of type 2 diabetes in a well-characterized representative sample of community-based patients...
  16. ncbi request reprint Intrahepatic MxA and PKR protein expression in chronic hepatitis C virus infection
    Gerry C MacQuillan
    Department of Medicine, The University of Western Australia, Australia
    J Med Virol 68:197-205. 2002
    ..63-53.2). This effect was independent of HCV genotype and viral load. It is concluded that pretreatment hepatocellular MxA expression may become a useful predictor of response to combination treatment with IFN-alpha and ribavirin...
  17. doi request reprint The inaccuracy of cystatin C and creatinine-based equations in predicting GFR in orthotopic liver transplant recipients
    Neil Boudville
    University of Western Australia, Australia
    Nephrol Dial Transplant 24:2926-30. 2009
    ..The aim of this study was to assess the accuracy of creatinine- and cystatin C-based equations to estimate kidney function in long-term OLT recipients...
  18. doi request reprint Hepatocellular MxA protein expression supports the differentiation of recurrent hepatitis C disease from acute cellular rejection after liver transplantation
    Gerry C MacQuillan
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Clin Transplant 24:252-8. 2010
    ..In conclusion, analysis of intrahepatic MxA levels has the potential to reduce the inappropriate use with high-dose pulsing of steroids post-operatively...
  19. ncbi request reprint Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
    Timothy G St Pierre
    School of Physics, University of Western Australia, Perth, Australia
    Blood 105:855-61. 2005
    ..Measurements of proton transverse relaxivity of aqueous MnCl2 phantoms on 13 different magnetic resonance imaging units using the method yielded a coefficient of variation of 2.1%...
  20. ncbi request reprint Urgent liver transplantation for acute liver failure due to parvovirus B19 infection complicated by primary Epstein-Barr virus and cytomegalovirus infections and aplastic anaemia
    K So
    Western Australian Liver Transplantation Service, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Intern Med J 37:192-5. 2007
    ..We present this case to emphasize parvovirus as a rare cause of hepatic failure and of aplastic anaemia as a complication of the virus...
  21. ncbi request reprint Outcome, tolerability and compliance of compassionate use interferon and ribavirin for hepatitis C infection in a shared care hospital clinic
    N Kontorinis
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Intern Med J 33:500-4. 2003
    ..To determine response rate, side-effects and compliance in patients with chronic hepatitis C virus (HCV) infection following treatment with interferon-alpha-2b and ribavirin in a 'shared care' hospital clinic...
  22. ncbi request reprint Aciclovir or ganciclovir universal prophylaxis of cytomegalovirus infection in liver transplantation: an economic analysis
    R W L Leong
    Western Australian Liver Transplantation Service, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Intern Med J 34:410-5. 2004
    ..Prophylaxis with oral aciclovir (ACV) or ganciclovir (GCV) for all transplant recipients (universal prophylaxis) may be beneficial, but which agent is more cost-effective is unknown...
  23. doi request reprint Ultra-structural localisation of hepatocellular PKR protein using immuno-gold labelling in chronic hepatitis C virus disease
    Gerry C MacQuillan
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    J Mol Histol 40:171-6. 2009
    ..This represented an increase, though not statistically significant, in nuclear and cytoplasmic labelling for PKR protein in HCV biopsies relative to normal liver tissue...
  24. doi request reprint Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy
    Silvana Gaudieri
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Australia
    Hepatology 49:1069-82. 2009
    ..Furthermore, we identified areas in HCV protease and polymerase that are under both potential HLA-driven pressure and therapy selection and identified six HLA-associated polymorphisms (P <or= 0.05) at known drug resistance sites...
  25. ncbi request reprint Expression of the HFE hemochromatosis gene in a community-based population of elderly women
    Enrico Rossi
    Department of Clinical Biochemistry, PathCentre Western Australian Centre for Pathology and Medical Research, Nedlands, Western Australia, Australia
    J Gastroenterol Hepatol 19:1150-4. 2004
    ..Recent studies suggest that the clinical penetrance of associated hereditary hemochromatosis, defined as either the C282Y homozygote or compound heterozygote HFE genotype status, is much lower than previously thought...
  26. ncbi request reprint Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection
    Leon A Adams
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia
    Clin Chem 51:1867-73. 2005
    ..We sought to create an algorithm of serum markers that accurately and reliably predict liver fibrosis stage among hepatitis C patients...
  27. ncbi request reprint Clinical expression of C282Y homozygous HFE haemochromatosis at 14 years of age
    Enrico Rossi
    Department of Clinical Biochemistry, PathWest Nedlands, Western Australia, Australia
    Ann Clin Biochem 43:233-6. 2006
    ..Although no mutations were found, the most likely cause for the early expression is the presence of novel mutations or gene(s)...
  28. ncbi request reprint Iron excretion in iron-overloaded rats following the change from an iron-loaded to an iron-deficient diet
    P S Oates
    Department of Physiology, University of Western Australia, Nedlands, Australia
    J Gastroenterol Hepatol 15:665-74. 2000
    ..We report the existence of an iron excretory process that results in the loss of significant amounts of liver iron...
  29. ncbi request reprint Disease recurrence after liver transplantation in Western Australia
    Ian F Yusoff
    The Western Australian Liver Transplant Service, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    J Gastroenterol Hepatol 17:203-7. 2002
    ..Our aim was to document the rate of disease recurrence after liver transplantation for conditions other than hepatitis C, in patients followed up by the Western Australian Liver Transplant Service (WALTS)...
  30. ncbi request reprint Oxidative stress causes a decline in lysosomal integrity during hypothermic incubation of rat hepatocytes
    Peter G Arthur
    School of Biochemical and Chemical Sciences, University of Western Australia, Crawley, WA 6009, Australia
    Free Radic Biol Med 44:24-33. 2008
    ..The progressive loss of lysosomal integrity during hypothermic incubation has the potential to affect liver function after transplantation...
  31. ncbi request reprint Lamivudine plus low-dose hepatitis B immunoglobulin to prevent recurrent hepatitis B following liver transplantation
    Edward J Gane
    Auckland City Hospital, Auckland, New Zealand
    Gastroenterology 132:931-7. 2007
    ..We report on long-term safety and efficacy of an alternative strategy of very low doses (400-800 IU/month) of intramuscular (IM) HBIG plus lamivudine...
  32. ncbi request reprint Patient and graft survival after liver transplantation for hereditary hemochromatosis: Implications for pathogenesis
    Darrell H G Crawford
    Queensland Liver Transplant Service and The University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Hepatology 39:1655-62. 2004
    ..Our data suggest that iron excess in HH does not wholly depend on intestinal iron absorption but is also influenced by liver factors that moderate iron metabolism...
  33. ncbi request reprint Octreotide in the treatment of refractory ascites of cirrhosis
    Rupert W L Leong
    Scand J Gastroenterol 41:763; author reply 764. 2006