Jereny R Jass

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients
    Coral V A Wynter
    Conjoint Gastroenterology Laboratory, Clinical Research Centre, Queensland Institute of Medical Research, Brisbane, Queensland Australia
    Int J Cancer 118:907-15. 2006
  2. pmc Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways
    J R Jass
    Department of Pathology, University of Queensland Medical School, Herston, Australia
    J Clin Pathol 52:455-60. 1999
  3. ncbi request reprint Altered mucin expression in the gastrointestinal tract: a review
    J R Jass
    Department of Pathology, University of Queensland School of Medicine, Herston Road, Queensland 4006, Australia
    J Cell Mol Med 5:327-51. 2001
  4. ncbi request reprint Evolution of colorectal cancer: change of pace and change of direction
    Jereny R Jass
    Department of Pathology, School of Medicine, University of Queensland, Herston, Australia
    J Gastroenterol Hepatol 17:17-26. 2002
  5. ncbi request reprint Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability
    J R Jass
    Department of Pathology, University of Queensland, Herston, Queensland 4006, Australia
    Eur J Cancer 38:858-66. 2002
  6. ncbi request reprint Familial colorectal cancer: pathology and molecular characteristics
    J R Jass
    Department of Pathology, University of Queensland, Mayne Medical School, Herston, Australia
    Lancet Oncol 1:220-6. 2000
  7. ncbi request reprint Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum
    J R Jass
    Department of Pathology, The University of Queensland, and Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital, Queensland, Australia
    Histopathology 37:295-301. 2000
  8. ncbi request reprint Pathology of hereditary nonpolyposis colorectal cancer
    J R Jass
    Department of Pathology, University of Queensland Mayne Medical School, Australia
    Ann N Y Acad Sci 910:62-73; discussion 73-4. 2000
  9. ncbi request reprint Broadsheet number 52: Molecular genetics of colorectal cancer
    J R Jass
    Department of Pathology, University of Queensland Medical School, Brisbane, Australia
    Pathology 31:354-64. 1999
  10. ncbi request reprint Towards a molecular classification of colorectal cancer
    J R Jass
    Department of Pathology, University of Queensland, Australia
    Int J Colorectal Dis 14:194-200. 1999

Research Grants

  1. AUSTRALASIAN C0L0RECTAL CANCER FAMILY STUDY
    Jeremy Jass; Fiscal Year: 2002

Collaborators

Detail Information

Publications71

  1. ncbi request reprint DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients
    Coral V A Wynter
    Conjoint Gastroenterology Laboratory, Clinical Research Centre, Queensland Institute of Medical Research, Brisbane, Queensland Australia
    Int J Cancer 118:907-15. 2006
    ..Genetic profiling of adenomas supports the concept that adenomas belonging to familial syndromes pursue a different pathway to tumorigenesis than their sporadic counterpar/ts from their earliest formation...
  2. pmc Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways
    J R Jass
    Department of Pathology, University of Queensland Medical School, Herston, Australia
    J Clin Pathol 52:455-60. 1999
    ....
  3. ncbi request reprint Altered mucin expression in the gastrointestinal tract: a review
    J R Jass
    Department of Pathology, University of Queensland School of Medicine, Herston Road, Queensland 4006, Australia
    J Cell Mol Med 5:327-51. 2001
    ..As such they may serve as markers to explain pathogenesis and provide novel diagnostic and prognostic information...
  4. ncbi request reprint Evolution of colorectal cancer: change of pace and change of direction
    Jereny R Jass
    Department of Pathology, School of Medicine, University of Queensland, Herston, Australia
    J Gastroenterol Hepatol 17:17-26. 2002
    ..Cancers in hereditary non-polyposis colorectal cancer show features of both classical (adenoma and APC mutation) and alternative pathways (rapid evolution, MSI-H and lack of chromosomal instability)...
  5. ncbi request reprint Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability
    J R Jass
    Department of Pathology, University of Queensland, Herston, Queensland 4006, Australia
    Eur J Cancer 38:858-66. 2002
    ....
  6. ncbi request reprint Familial colorectal cancer: pathology and molecular characteristics
    J R Jass
    Department of Pathology, University of Queensland, Mayne Medical School, Herston, Australia
    Lancet Oncol 1:220-6. 2000
    ..Some of these, notably hyperplastic polyposis and mixed polyposis, may closely mimic FAP or HNPCC...
  7. ncbi request reprint Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum
    J R Jass
    Department of Pathology, The University of Queensland, and Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital, Queensland, Australia
    Histopathology 37:295-301. 2000
    ..These mechanisms fit with clinical observations relating to sporadic MSI-H colorectal cancer, specifically proximal location, multiplicity, higher frequency among females and rapid evolution of early cancer...
  8. ncbi request reprint Pathology of hereditary nonpolyposis colorectal cancer
    J R Jass
    Department of Pathology, University of Queensland Mayne Medical School, Australia
    Ann N Y Acad Sci 910:62-73; discussion 73-4. 2000
    ..Immunohistochemical staining for hMLH1 and hMSH2 identifies the underlying mutation in a proportion of cases. The colorectal adenoma is the usual precursor lesion in HNPCC, though serrated polyps are implicated in a small subset...
  9. ncbi request reprint Broadsheet number 52: Molecular genetics of colorectal cancer
    J R Jass
    Department of Pathology, University of Queensland Medical School, Brisbane, Australia
    Pathology 31:354-64. 1999
    ..It is shown how the fundamental principle of genetic instability cuts across applied research, tissue diagnosis and clinical management with respect to both sporadic and inherited forms of colorectal cancer...
  10. ncbi request reprint Towards a molecular classification of colorectal cancer
    J R Jass
    Department of Pathology, University of Queensland, Australia
    Int J Colorectal Dis 14:194-200. 1999
    ..It is likely that testing for DNA mismatch repair will be adopted as a routine for colorectal cancer as more is learned of the distinctive pathobiology and behaviour of MSS, MSI-L and MSI-H cancers...
  11. ncbi request reprint Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue
    J R Jass
    Departments of Pathology, University of Queensland, Royal Brisbane Hospital, Queensland, Australia
    Histopathology 36:116-20. 2000
    ..An early adenocarcinoma of the ascending colon was confined to a mass of gut-associated lymphoid tissue (GALT). The first description of an adenocarcinoma of colon differentiating as dome epithelium is presented...
  12. pmc Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum
    J R Jass
    Department of Pathology, University of Queensland, Mayne Medical School, Herston, Australia
    Gut 47:43-9. 2000
    ....
  13. ncbi request reprint Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation
    Takeshi Nagasaka
    Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Clin Oncol 22:4584-94. 2004
    ..The aim of this study was to further investigate the link between genetic alterations in the RAS/RAF/ERK pathway and an underlying epigenetic disorder...
  14. ncbi request reprint Role of the pathologist in the diagnosis of hereditary non-polyposis colorectal cancer
    Jeremy R Jass
    McGill University, Montreal, Quebec, Canada
    Dis Markers 20:215-24. 2004
    ..Immunohistochemistry to demonstrate loss of expression of DNA mismatch repair genes serves as a highly reliable test of mismatch repair deficiency if antibodies to hMLH1, hMSH2, hMSH6 and hPMS2 are employed...
  15. pmc Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer
    Graham Casey
    Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    JAMA 293:799-809. 2005
    ..Current data suggest that mismatch repair mutations are highly heterogeneous and that many mutations are not detected when conventional DNA sequencing alone is used...
  16. ncbi request reprint Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer
    Joanne Young
    Conjoint Gastroenterology Laboratory, Queensland Institute of Medical Research, Herston, Australia
    Clin Gastroenterol Hepatol 3:254-63. 2005
    ..Here, we discuss their role in the development of other familial colorectal cancers (CRC). We studied non-FAP, non-HNPCC CRC families characterized by tumors that varied in their level of MSI between individual members...
  17. ncbi request reprint Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer
    Melissa C Southey
    Genetic Epidemiology Laboratory, Department of Pathology, Australia
    J Clin Oncol 23:6524-32. 2005
    ..The relationships between mismatch repair (MMR) protein expression, microsatellite instability (MSI), family history, and germline MMR gene mutation status have not been studied on a population basis...
  18. ncbi request reprint Serrated adenoma of the colorectum and the DNA-methylator phenotype
    Jeremy R Jass
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec H3A 2B4, Canada
    Nat Clin Pract Oncol 2:398-405. 2005
    ..The current lack of guidelines for managing serrated polyps may explain the static incidence of proximal CRC, despite the falling incidence rates for left-sided CRC during the same time period...
  19. ncbi request reprint Re: Ward et al. Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified. J Pathol 2005;207:377-384
    Jeremy R Jass
    J Pathol 208:590-1. 2006
  20. ncbi request reprint Cancer risks for mismatch repair gene mutation carriers: a population-based early onset case-family study
    Mark A Jenkins
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Victoria, Australia
    Clin Gastroenterol Hepatol 4:489-98. 2006
    ..These may be overestimates, due to analytic problems, and not generalizable. We estimated average cancer risks for mutations identified in population-based early onset colorectal cancer cases (probands) unselected for family history...
  21. ncbi request reprint Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer
    Eiji Shinto
    Department of Pathology, McGill University, Montreal, Canada
    Dis Colon Rectum 49:1193-202. 2006
    ..It is hypothesized that tumor budding in this subset may lack biologic aggressiveness because it is not associated with aberrant expression of the independent prognostic factor, laminin-5 gamma 2...
  22. ncbi request reprint Hereditary Non-Polyposis Colorectal Cancer: the rise and fall of a confusing term
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec H3A 2B4, Canada
    World J Gastroenterol 12:4943-50. 2006
    ..The first step in characterizing these cancer families is to distinguish them from Lynch syndrome. The term HNPCC no longer serves any useful purpose and should be phased out...
  23. ncbi request reprint The case for a genetic predisposition to serrated neoplasia in the colorectum: hypothesis and review of the literature
    Joanne Young
    Molecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia
    Cancer Epidemiol Biomarkers Prev 15:1778-84. 2006
    ..The tendency for these lesions to be multiple, associated with smoking, and to show frequent BRAF mutation and CIMP points to a defect that may result from interactions between the environment and a weakly penetrant genetic alteration...
  24. ncbi request reprint Stability of BAT26 in Lynch syndrome colorectal tumours
    Lesley Jaskowski
    Eur J Hum Genet 15:139-41; author reply 141-2. 2007
  25. doi request reprint Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development
    Kim Loh
    Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation Clinical Research Centre and Queensland Institute of Medical Research, Brisbane 4029, Australia
    Genes Chromosomes Cancer 47:449-60. 2008
    ..This study provides molecular and functional data supporting the importance of BMP3 silencing as an early and frequent event in colorectal tumors progressing via the serrated and traditional pathways...
  26. ncbi request reprint Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer
    Inti Zlobec
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Canada H3A 2B4
    Eur J Cancer 43:1101-7. 2007
    ..001). No methylation was found in the selected region of APAF-1. APAF-1 is a marker of tumour progression in MMR-proficient CRC and an independent adverse prognostic factor in MLH1-negative CRC...
  27. ncbi request reprint Colorectal cancer: a multipathway disease
    Jeremy R Jass
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec H3A 2B4, Canada
    Crit Rev Oncog 12:273-87. 2006
    ..CRC comprises subgroups with particular clinical, pathological, and molecular features...
  28. ncbi request reprint Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer
    Parham Minoo
    Department of Pathology, McGill University, Montreal, Canada
    Am J Clin Pathol 127:820-7. 2007
    ..Methylation analysis of 28 cases showed that loss of RKIP expression is unlikely to be due to promoter methylation.Loss of RKIP expression is a marker of tumor progression and distant metastasis in MMR-proficient and MMR-deficient CRCs...
  29. ncbi request reprint Limitations of the adenoma-carcinoma sequence in colorectum
    Jeremy R Jass
    Clin Cancer Res 10:5969-70; author reply 5970. 2004
  30. ncbi request reprint HNPCC and sporadic MSI-H colorectal cancer: a review of the morphological similarities and differences
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Fam Cancer 3:93-100. 2004
    ..Morphological features can assist is distinguishing such families from bona fide HNPCC families which they closely mimic...
  31. ncbi request reprint Clinical significance of early-onset "sporadic" colorectal cancer with microsatellite instability
    Jeremy R Jass
    Dis Colon Rectum 46:1305-9. 2003
  32. ncbi request reprint Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer
    Vicki L J Whitehall
    Conjoint Gastroenterology Laboratory, Clinical Research Centre, Royal Brisbane Hospital Research Foundation, Queensland 4029, Australia
    Cancer Res 62:6011-4. 2002
    ..004) and lower frequency of hMLH1 methylation (P < 0.001) in the latter. These data demonstrate that the separation of CRC into two nonoverlapping groups (MSI-H versus MSS/MSI-L) is a misleading oversimplification...
  33. ncbi request reprint Emerging concepts in colorectal neoplasia
    Jeremy R Jass
    Department of Molecular and Cellular Pathology, University of Queensland Medical School, Australia
    Gastroenterology 123:862-76. 2002
    ..If colorectal cancer is a heterogeneous disease comprising discrete subsets that evolve through different pathways, it is evident that these subsets will need to be studied individually in the future...
  34. ncbi request reprint Pathogenesis of colorectal cancer
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada, H3A2B4
    Surg Clin North Am 82:891-904. 2002
    ..Specifically, modern genomics will allow polyps and cancers to be grouped within pathogenic pathways on the basis of shared gene expression profiles. The era of molecular medicine has dawned for colorectal cancer...
  35. ncbi request reprint Re: Tomlinson et al. Does MSI-low exist. J Pathol 2002; 197: 6-13
    Jeremy R Jass
    J Pathol 199:267-9; author reply 269-70. 2003
  36. ncbi request reprint Emerging pathways in colorectal-cancer development
    Andrew M M Haydon
    Department of Epidemiology and Preventive Medicine, Monash Medical School, Alfred Hospital, Prahran, Victoria, Australia
    Lancet Oncol 3:83-8. 2002
    ..Tumours may have high or low type C (cancer-related) CpG-island methylation. When methylation affects hMLH1 (mismatch repair gene), the resultant cancer has high MSI...
  37. ncbi request reprint Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors
    Noralane M Lindor
    Department of Medical Genetics, Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 20:1043-8. 2002
    ..To compare microsatellite instability (MSI) testing with immunohistochemical (IHC) detection of hMLH1 and hMSH2 in colorectal cancer...
  38. ncbi request reprint Mutation searching in colorectal cancer studies: experience with a denaturing high-pressure liquid chromatography system for exon-by-exon scanning of tumour suppressor genes
    Joanne Young
    Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital Foundation Clinical Research Centre, Bancroft Centre, Herston, Queensland, Australia
    Pathology 34:529-33. 2002
    ..Here we report our progress using denaturing gradient high-pressure liquid chromatography (DHPLC) in the screening of the mismatch repair genes MLH1 and MSH2 and in screening the APC and HPP1 tumour suppressor genes for mutations...
  39. pmc Serrated adenoma of the colorectum: a lesion with teeth
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Am J Pathol 162:705-8. 2003
  40. ncbi request reprint Role of inherited defects of MYH in the development of sporadic colorectal cancer
    Takeshi Kambara
    Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation and Queensland Institute of Medical Research, Brisbane, Australia
    Genes Chromosomes Cancer 40:1-9. 2004
    ..02). These results suggest that single germ-line variants of MYH may influence genetic pathways in CRC...
  41. ncbi request reprint Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer
    Takeshi Kambara
    Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Clin Cancer Res 10:1758-63. 2004
    ..Our aim in the present study was to determine whether allelic losses on 1p were likely to be of much value in predicting the prognosis of CRC cases...
  42. ncbi request reprint Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases
    Takeshi Nagasaka
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Clin Cancer Res 9:5306-12. 2003
    ....
  43. ncbi request reprint Molecular heterogeneity of colorectal cancer: Implications for cancer control
    Jeremy R Jass
    Department of Cellular Pathology, St Mark s Hospital, Watford Road, Harrow, Middx HA1 3UJ, UK
    Surg Oncol 16:S7-9. 2007
    ..In particular, new strategies for detecting and managing sessile serrated polyps will need to be developed and evaluated...
  44. ncbi request reprint Silencing of O6-methylguanine DNA methyltransferase in the absence of promoter hypermethylation in hepatocellular carcinomas from Australia and South Africa
    Nirmitha I Herath
    Leukaemia Foundation of Queensland, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Oncol Rep 17:817-22. 2007
    ..This suggests that epigenetic silencing of MGMT and microsatellite instability does not play an important role in this series of HCCs derived from different populations...
  45. ncbi request reprint Recommendations for the reporting of surgically resected specimens of colorectal carcinoma
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Hum Pathol 38:537-545. 2007
    ....
  46. ncbi request reprint The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas
    Michael D Walsh
    Molecular Cancer Epidemiology Laboratory, Bancroft Centre, Queensland Institute of Medical Research, Herston, QLD, Australia
    Hum Pathol 38:883-92. 2007
    ..In summary, MUC13 was expressed abundantly by all colorectal cancers, with the highest expression in more poorly differentiated tumors...
  47. doi request reprint Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients
    Michael D Walsh
    Familial Cancer Laboratory and Molecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research, Herston, Australia
    Clin Cancer Res 14:1692-700. 2008
    ..The aim of this study was to determine the incidence of Lynch syndrome in a series of young-onset EC, and to identify molecular, clinical, and pathologic features that may alert clinicians to the presence of this disorder...
  48. doi request reprint Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression
    Inti Zlobec
    Institute of Pathology, University Hospital of Basel, Basel, Switzerland
    Clin Cancer Res 14:143-8. 2008
    ....
  49. ncbi request reprint Recommendations for the reporting of surgically resected specimens of colorectal carcinoma: Association of Directors of Anatomic and Surgical Pathology
    Jeremy R Jass
    Department of Cellular Pathology, St Mark s Hospital, Harrow, England
    Am J Clin Pathol 129:13-23. 2008
  50. ncbi request reprint Value of staining intensity in the interpretation of immunohistochemistry for tumor markers in colorectal cancer
    Inti Zlobec
    Institute of Pathology, University Hospital of Basel, Schonbeinstrasse 40, Basel 4031, Switzerland
    Virchows Arch 451:763-9. 2007
    ....
  51. ncbi request reprint Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update
    David T Rubin
    University of Chicago Medical Center, Chicago, IL 60637, USA
    Inflamm Bowel Dis 14:265-74. 2008
    ..This article provides a comprehensive overview of the issues discussed and should act as a guide to shaping the design of future studies in this area...
  52. ncbi request reprint Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer
    Inti Zlobec
    Institute of Pathology, University Hospital of Basel, Basel, Switzerland
    Cancer 112:495-502. 2008
    ..The objective of this study was to define a multimarker prognostic model of 5-year survival in patients with lymph node-negative, mismatch repair (MMR)-proficient colorectal cancer (CRC)...
  53. ncbi request reprint The "Fas counterattack" is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability
    Aileen M Houston
    Department of Medicine, National University of Ireland Cork, Clinical Science Building, Cork University Hospital, Wilton, Cork, Ireland
    Hum Pathol 39:243-50. 2008
    ..059). Together, these findings suggest that the abundance of TILs found in MSI-H tumors may be due to the failure of these tumor cells to up-regulate FasL and may explain, in part, the improved prognosis associated with these tumors...
  54. ncbi request reprint Gastrointestinal polyposes: clinical, pathological and molecular features
    Jeremy R Jass
    Department of Cellular Pathology, St Mark s Hospital and Imperial College, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gastroenterol Clin North Am 36:927-46, viii. 2007
    ..One of the most important, but often neglected, of these is hyperplastic polyposis...
  55. ncbi request reprint Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer
    Parham Minoo
    Department of Pathology, McGill University, Montreal, QC, Canada
    Mod Pathol 20:331-8. 2007
    ..These results are suggestive of a tumor suppressor role for Mst1 in human colorectal cancer...
  56. ncbi request reprint Correspondence re: P. Laiho et al., Low-level microsatellite instability in most colorectal carcinomas. Cancer Res., 62: 1166-1170, 2002
    Jeremy R Jass
    Cancer Res 62:5988-9; author reply 5989-90. 2002
  57. ncbi request reprint Sporadic versus hereditary forms of colorectal cancer with the DNA microsatellite instability phenotype: to 'lump' or 'split'?
    Jeremy R Jass
    Fam Cancer 3:83. 2004
  58. ncbi request reprint Fas ligand and tumour counter-attack in colorectal cancer stratified according to microsatellite instability status
    Julie M Michael-Robinson
    Inflammatory Bowel Disease Laboratory, Royal Brisbane Hospital Foundation Clinical Research Centre, Brisbane, Australia
    J Pathol 201:46-54. 2003
    ..004; p = 0.046 respectively). This study therefore suggests that MSS colorectal cancers are killing incoming TILs in an effective tumour counter-attack, but apparently not via membrane-bound FasL...
  59. ncbi request reprint The impact of microsatellite instability on the molecular phenotype of colorectal tumors
    Yuriko Mori
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Cancer Res 63:4577-82. 2003
    ..Thus, both components 3 and 10 reflected different aspects of MSI and helped to establish principal components analysis as a useful tool to identify and characterize distinct biological features of human malignancy...
  60. ncbi request reprint Isolated loss of PMS2 expression in colorectal cancers: frequency, patient age, and familial aggregation
    Sharlene Gill
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 11:6466-71. 2005
    ..Rarely, there is selective loss of PMS2 expression. We sought to describe the frequency and clinical correlates of selective loss of expression of PMS2 with the MSI-H tumor phenotype...
  61. ncbi request reprint Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept
    Dale C Snover
    Department of Pathology, Fairview Southdale Hospital, Edina, MN 55435, USA, and McGill University, Montreal, Canada
    Am J Clin Pathol 124:380-91. 2005
    ....
  62. ncbi request reprint What's new in hereditary colorectal cancer?
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Arch Pathol Lab Med 129:1380-4. 2005
    ..The remainder of the editorial discusses the role of the revised Bethesda guidelines in the diagnosis of hereditary nonpolyposis colorectal cancer and concludes with the recently identified serrated pathway syndrome...
  63. ncbi request reprint Hyperplastic-like polyps as precursors of microsatellite-unstable colorectal cancer
    Jeremy R Jass
    Am J Clin Pathol 119:773-5. 2003
  64. ncbi request reprint Overexpression of the receptor for hyaluronic acid mediated motility is an independent adverse prognostic factor in colorectal cancer
    Alessandro Lugli
    Department of Pathology, McGill University, Duff Medical Building, Montreal, QC, Canada
    Mod Pathol 19:1302-9. 2006
    ..012) and with complete RHAMM expression in presumed HNPCC (P=0.03). Increasing and complete RHAMM expressions are independent adverse prognostic factors in MMR-proficient CRC and presumed Lynch syndrome...
  65. ncbi request reprint Differential prognostic significance of morphologic invasive markers in colorectal cancer: tumor budding and cytoplasmic podia
    Eiji Shinto
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Dis Colon Rectum 49:1422-30. 2006
    ..In this study, we have investigated the prognostic significance of cytoplasmic podia...
  66. ncbi request reprint Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in colorectal cancer-a tissue microarray-based approach
    Alessandro Lugli
    Department of Pathology, McGill University, Montreal, Canada H3A 2B4
    Hum Pathol 37:1022-31. 2006
    ....
  67. ncbi request reprint Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis
    Kazuhide Ozaki
    Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Int J Cancer 119:2513-9. 2006
    ..Expression of the MMR proteins was not lost in any of the lesions examined. Microsatellite alterations rather seem to be related to the initiation than to the progression of colitic cancer...
  68. pmc SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
    June A Chia
    The Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Foundation Clinical Research Centre and the Queensland Institute of Medical Research, Brisbane, 4029, Australia
    BMC Cancer 6:252. 2006
    ..SnoN is an important regulator of the transforming growth factor beta (TGFbeta) signalling pathway and has been shown to exhibit both tumour promotion and suppression activity...
  69. ncbi request reprint High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy
    Kevin J Spring
    Conjoint Gastroenterology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Gastroenterology 131:1400-7. 2006
    ..This prospective study examined the prevalence of sessile serrated adenomas and determined the incidence of BRAF and K-ras mutations in different types of polyps...
  70. pmc Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer
    Inti Zlobec
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    J Clin Pathol 60:1112-6. 2007
    ..Cut-off scores for determining positivity of biomarkers detected by immunohistochemistry are often set arbitrarily and vary between reports...
  71. ncbi request reprint Hyperplastic polyps and colorectal cancer: is there a link?
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Clin Gastroenterol Hepatol 2:1-8. 2004
    ..Screening can then be targeted more selectively toward patients who are at significantly increased risk of malignant transformation of hyperplastic polyps...

Research Grants1

  1. AUSTRALASIAN C0L0RECTAL CANCER FAMILY STUDY
    Jeremy Jass; Fiscal Year: 2002
    ..These characteristics include manageable yet sufficient size, ethnically diverse, highly localised, stable, and with families that are intact and large. ..