Research Topics
| M J JamesSummaryAffiliation: University of Adelaide Country: Australia Publications
| Collaborators
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Detail Information
Publications
Marine oils for antiinflammatory effect -- time to take stockLeslie G Cleland
J Rheumatol 33:207-9. 2006- Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acidsMichael J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
Am J Clin Nutr 77:1140-5. 2003.... 
Applying a research ethics committee approach to a medical practice controversy: the case of the selective COX-2 inhibitor rofecoxibM J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, SA, Australia
J Med Ethics 30:182-4. 2004..A consideration of the legal tests for disclosure of information suggests that therapeutic medical practice should mirror that within the research environment, in this case...- Eicosanoid production by human monocytes: does COX-2 contribute to a self-limiting inflammatory response?M J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, SA, Australia
Inflamm Res 50:249-53. 2001..The findings have implications for the use of NSAIDs and selective COX-2 inhibitors whose actions can increase the monocyte TXA2/PGE2 ratio... - Differential regulation of prostaglandin E2 and thromboxane A2 production in human monocytes: implications for the use of cyclooxygenase inhibitorsP S Penglis
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
J Immunol 165:1605-11. 2000.... - Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2G E Caughey
Rheumatology Unit, Royal Adelaide Hospital, and Division of Human Immunology, Hanson Centre for Cancer Research, Adelaide, South Australia, Australia
J Immunol 167:2831-8. 2001..These findings have particular importance with regard to the potential for cardiovascular consequences of COX-2 inhibition... - A biomarker of n-3 compliance in patients taking fish oil for rheumatoid arthritisLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
Lipids 38:419-24. 2003..It may also provide a guide to the effectiveness of therapeutic and preventive messages designed to increase n-3 PUFA intake... - Cyclooxygenase inhibitors: any reservations?P S Penglis
Rheumatology Unit, Royal Adelaide Hospital, South Australia
Intern Med J 31:37-41. 2001..Thus, despite the relatively safe gastrointestinal profile, vigilant post-marketing surveillance for other adverse effects is required... - COX-2 inhibition and thrombotic tendency: a need for surveillanceL G Cleland
Rheumatology Unit, Royal Adelaide Hospital, SA
Med J Aust 175:214-7. 2001..It is important to canvass the possibility that use of these agents could be associated with thrombotic events... - A practical approach to increasing intakes of n-3 polyunsaturated fatty acids: use of novel foods enriched with n-3 fatsR G Metcalf
Department of Rheumatology, Royal Adelaide Hospital, North Tce, Adelaide, SA 5000, Australia
Eur J Clin Nutr 57:1605-12. 2003..To assess the effects of providing a wide range of foodstuffs containing n-3 polyunsaturated fatty acids (PUFA), occurring naturally or from fortification, on intake and blood and tissue proportions of n-3 PUFA... - Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinaseM Pouliot
Rheumatology Unit, Royal Adelaide Hospital, South Australia
J Immunol 158:4930-7. 1997..These results indicate a new and potentially important anti-inflammatory property of SK&F 86002, namely the specific suppression of PGHS-2 induction... - Effect of dietary oils on the production of n-3 and n-6 metabolites of leukocyte 5-lipoxygenase in five rat strainsL G Cleland
Morialta Trust Bone and Joint Research Laboratory, Royal Adelaide Hospital, Australia
Biochim Biophys Acta 1043:253-8. 1990.... - Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: role of interleukin 17 and tumor necrosis factor-alphaLisa K Stamp
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
J Rheumatol 31:1246-54. 2004..These data provide additional evidence for the contribution of T cells in rheumatoid inflammation and highlight the potential of IL-17 as a therapeutic target... - Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritisLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, Australia
J Rheumatol 33:1973-9. 2006..Fish oil has been shown to reduce symptoms in RA and to reduce CV risk. We assessed the effect of an antiinflammatory dose of fish oil on CV risk factors within a program of combination chemotherapy for patients with early RA... - Omega-6/omega-3 fatty acids and arthritisLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, S.A, Australia
World Rev Nutr Diet 92:152-68. 2003 
Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expressionW C Tu
Foodplus Research Centre, School of Agriculture, Food and Wine, Waite Campus, University of Adelaide, Adelaide, South Australia, Australia
Prostaglandins Leukot Essent Fatty Acids 83:61-8. 2010....- Up-regulation of endothelial cyclooxygenase-2 and prostanoid synthesis by platelets. Role of thromboxane A2G E Caughey
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
J Biol Chem 276:37839-45. 2001..These observations are of particular importance given the recent observations regarding selective COX-2 inhibitors and the suppression of PGI2 synthesis... - Effects of fish-oil supplementation on myocardial fatty acids in humansRobert G Metcalf
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
Am J Clin Nutr 85:1222-8. 2007..This benefit putatively arises from the incorporation of the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into cardiomyocyte phospholipids... - Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesisMaryanne Demasi
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
J Biol Chem 278:38607-16. 2003.... - Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heartLeslie G Cleland
Hanson Institute and Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
Lipids 40:995-8. 2005..e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Delta6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation... - Effects of hypoxia on the expression and activity of cyclooxygenase 2 in fibroblast-like synoviocytes: interactions with monocyte-derived soluble mediatorsMaryanne Demasi
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Arthritis Rheum 50:2441-9. 2004..Therefore, this study was designed to assess the effect of hypoxia on FLS responses to the monokine interleukin-1beta (IL-1beta) and to monocyte conditioned medium... - Treatment-induced stable, moderate reduction in blood cell counts correlate to disease control in early rheumatoid arthritisS E Lester
Arthritis Research Laboratory, Hanson Research Institute, Adelaide, South Australia, Australia
Intern Med J 39:296-303. 2009..The objective was to analyse cell counts obtained as routine surveillance for adverse effects to assess the effect of intensive treatment and treatment dosage and to examine correlations to disease activity scores... - Selective COX-2 inhibitors, eicosanoid synthesis and clinical outcomes: a case study of system failureM J James
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, 5000, Australia
Lipids 42:779-85. 2007..The commercial success of rofecoxib provides a case-study of failure of the medical journal literature to guide drug usage. Attention to ethical issues may have provided a more useful guide for prescribers... - Paracrine upregulation of monocyte cyclooxygenase-2 by mediators produced by T lymphocytes: role of interleukin 17 and interferon-gammaLisa K Stamp
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
J Rheumatol 31:1255-64. 2004..In rheumatoid joints, previously observed high concentrations of IL-17 and low concentrations of IFN-g could contribute to T cell-driven upregulation of monocyte COX-2... - Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophilsMireille St-Onge
Centre de Recherche en Rhumatologie et Immunologie du CHUQ CHUL, Sainte Foy, and Department of Anatomy Physiology, Faculty of Medicine, Laval University, Quebec, Canada, and Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
Biochim Biophys Acta 1771:1235-45. 2007..These results highlight key differences in regulatory processes of the 5-LO and COX pathways, and enhance our knowledge at several levels in the PGE2 biosynthesis in neutrophils... - Dietary n-3 fats as adjunctive therapy in a prototypic inflammatory disease: issues and obstacles for use in rheumatoid arthritisM J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, North Terrace, SA 5000, Adelaide, Australia
Prostaglandins Leukot Essent Fatty Acids 68:399-405. 2003..The implementation of these findings will require among other things, a range of n-3 fat enriched foods, as well as physician awareness of the possibilities for dietary n-3 fat increases to be used as adjunctive therapy in RA... - Low density lipoprotein of synovial fluid in inflammatory joint disease is mildly oxidizedM J James
Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
Lipids 33:1115-21. 1998..Thus, extensive LDL oxidation is not a necessary correlate of location in a chronic inflammatory site, even though it is characteristic of atherosclerotic lesions... - The role of fish oils in the treatment of rheumatoid arthritisLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Drugs 63:845-53. 2003..Collectively, these issues highlight the challenges in advancing the use of fish oil amid the complexities of modern management of RA, with its emphasis on combination chemotherapy applied early... - The role of fats in the lifecycle stages. Adulthood--prevention: rheumatoid arthritisLes G Cleland
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
Med J Aust 176:S119-20. 2002.... - Dietary omega-3 fats for treatment of inflammatory joint disease: efficacy and utilitySusanna M Proudman
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
Rheum Dis Clin North Am 34:469-79. 2008..This is an important aspect of fish oil use, given the increased cardiovascular risk in rheumatoid arthritis. Perceived barriers to clinical use are readily addressed... 
Fish oil: what the prescriber needs to knowLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, Australia
Arthritis Res Ther 8:202. 2006..This review provides an evidence-based resource for doctors and patients who may choose to prescribe or take fish oil...- Endothelial cell COX-2 expression and activity in hypoxiaRebecca J Cook-Johnson
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
Biochim Biophys Acta 1761:1443-9. 2006..The endothelial cell response to hypoxia involves increased production of the anti-thrombotic eicosanoid, PGI(2), which is dependent on COX-2 upregulation by a HIF-mediated process... - Response-driven combination therapy with conventional disease-modifying antirheumatic drugs can achieve high response rates in early rheumatoid arthritis with minimal glucocorticoid and nonsteroidal anti-inflammatory drug useSusanna M Proudman
Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia
Semin Arthritis Rheum 37:99-111. 2007..To assess the safety and efficacy of combination therapy in recent-onset rheumatoid arthritis (RA), with dose adjustments determined by response, in a clinic setting over 3 years... - Effect of dietary n-3 polyunsaturated fatty acids on the inducibility of ventricular tachycardia in patients with ischemic cardiomyopathyRobert G Metcalf
The Cardiovascular Research Centre, Department of Rheumatology, Royal Adelaide Hospital, Adelaide, Australia
Am J Cardiol 101:758-61. 2008..In conclusion, dietary n-3 fatty acid supplementation decreased the inducibility of VT in patients at risk of SCD. These findings suggest that dietary fish oil can have an antiarrhythmic effect... - Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis?Lisa K Stamp
Rheumatology Unit, Eleanor Harrald Building, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Immunol Cell Biol 82:1-9. 2004..As such, IL-17 warrants consideration for its potential as a therapeutic target in rheumatoid arthritis... - Effect of red clover isoflavones on cox-2 activity in murine and human monocyte/macrophage cellsAnna N C Lam
Faculty of Veterinary Science, University of Sydney, NSW, Australia
Nutr Cancer 49:89-93. 2004..001 to P < 0.05), indicating COX inhibition. Thus, it is possible that the lower rates of some cancers in populations with a high intake of dietary isoflavones is linked to their inhibition of COX activity... - COX-2 selectivity varies across classLeslie G Cleland
Med J Aust 182:197-8; author reply 199. 2005 - Cyclooxygenase-2 inhibitors: what went wrong?Michael J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Curr Opin Clin Nutr Metab Care 9:89-94. 2006.... - Diet and rheumatoid arthritis: a review of the literatureLisa K Stamp
Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand
Semin Arthritis Rheum 35:77-94. 2005..A large number of patients seek alternative or complementary therapies of which diet is an important component. This article reviews the evidence for diet in rheumatoid arthritis along with the associated concept of oral tolerization...