Paul Jackson

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Relationship between expression of KAI1 metastasis suppressor gene, mRNA levels and p53 in human bladder and prostate cancer cell lines
    Paul Jackson
    Oncology Research Centre, Prince of Wales Hospital, School of Medicine, University of New South Wales, Barker Street, Randwick, NSW 2031, Australia
    Urol Oncol 7:99-104. 2002
  2. ncbi request reprint Downregulation of KAI1 mRNA in localised prostate cancer and its bony metastases does not correlate with p53 overexpression
    P Jackson
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW, Australia
    Prostate Cancer Prostatic Dis 6:174-81. 2003
  3. ncbi request reprint Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo
    L A Perryman
    Oncology Research Centre, Prince of Wales Hospital, Barker St, Randwick, NSW 2031, Australia
    Biochem Biophys Res Commun 345:1207-14. 2006
  4. ncbi request reprint Distinct distal and proximal p53-binding sites in the MCK promoter govern the transcriptional response to p53
    P Jackson
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW, Australia
    FEBS Lett 406:271-4. 1997
  5. ncbi request reprint KAI1 tetraspanin and metastasis suppressor
    Paul Jackson
    Oncology Research Centre, Level 2 Clinical Sciences Building, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia
    Int J Biochem Cell Biol 37:530-4. 2005
  6. ncbi request reprint Inverse correlation between KAI1 mRNA levels and invasive behaviour in bladder cancer cell lines
    P Jackson
    Oncology Research Centre, Level 2, Old Theatre Block, Prince of Wales Hospital, New South Wales 2031, Randwick, Australia
    Cancer Lett 156:9-17. 2000
  7. ncbi request reprint Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines
    P Jackson
    Oncology Research Centre, Level 2 Old Theatre Block, Prince of Wales Hospital, New South Wales 2031, Randwick, Australia
    Cancer Lett 157:169-76. 2000
  8. ncbi request reprint KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells
    Alexandra Marreiros
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW, Australia
    Oncogene 24:637-49. 2005
  9. ncbi request reprint Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines
    Sheri Nixdorf
    Oncology Research Centre, Prince of Wales Hospital, Level 2 Clinical Sciences Building, Barker Street, Randwick, NSW 2031, Australia
    Cancer Lett 215:209-20. 2004
  10. ncbi request reprint Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival
    Ross D Farhadieh
    Department of Otolaryngology Surgery, Prince of Wales Hospital, UNSW, Randwick 2031, Sydney NSW, Australia
    Cancer Lett 213:91-8. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Relationship between expression of KAI1 metastasis suppressor gene, mRNA levels and p53 in human bladder and prostate cancer cell lines
    Paul Jackson
    Oncology Research Centre, Prince of Wales Hospital, School of Medicine, University of New South Wales, Barker Street, Randwick, NSW 2031, Australia
    Urol Oncol 7:99-104. 2002
    ..Our data suggest that p53 is not a major factor regulating levels of KAI1 mRNA in bladder and prostate cancer cell lines...
  2. ncbi request reprint Downregulation of KAI1 mRNA in localised prostate cancer and its bony metastases does not correlate with p53 overexpression
    P Jackson
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW, Australia
    Prostate Cancer Prostatic Dis 6:174-81. 2003
    ..Our data suggest that mutation of p53 is independent of the loss of KAI1 mRNA, and do not support a role for p53 in regulating the expression of KAI1...
  3. ncbi request reprint Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo
    L A Perryman
    Oncology Research Centre, Prince of Wales Hospital, Barker St, Randwick, NSW 2031, Australia
    Biochem Biophys Res Commun 345:1207-14. 2006
    ..Our results support the possibility that decreased angiogenesis might account for reduced growth rate of tumor cells expressing the F134L p53 mutation...
  4. ncbi request reprint Distinct distal and proximal p53-binding sites in the MCK promoter govern the transcriptional response to p53
    P Jackson
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW, Australia
    FEBS Lett 406:271-4. 1997
    ..These studies imply that distinct D- and P-p53-binding sites in the MCK promoter may dictate the promoter response to p53...
  5. ncbi request reprint KAI1 tetraspanin and metastasis suppressor
    Paul Jackson
    Oncology Research Centre, Level 2 Clinical Sciences Building, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia
    Int J Biochem Cell Biol 37:530-4. 2005
    ..The recent identification of signalling pathways downstream of KAI1, and proteins that specifically interact with KAI1, are beginning to elucidate the biological pathways involving KAI1...
  6. ncbi request reprint Inverse correlation between KAI1 mRNA levels and invasive behaviour in bladder cancer cell lines
    P Jackson
    Oncology Research Centre, Level 2, Old Theatre Block, Prince of Wales Hospital, New South Wales 2031, Randwick, Australia
    Cancer Lett 156:9-17. 2000
    ..These data support the idea that loss of KAI1 expression is an important factor in tumour cell invasive behaviour...
  7. ncbi request reprint Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines
    P Jackson
    Oncology Research Centre, Level 2 Old Theatre Block, Prince of Wales Hospital, New South Wales 2031, Randwick, Australia
    Cancer Lett 157:169-76. 2000
    ..We found no evidence for hypermethylation of the CpG island and suggest that mechanisms other than promoter hypermethylation are responsible for reduced KAI1 expression in invasive bladder tumours and tumour cell lines...
  8. ncbi request reprint KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells
    Alexandra Marreiros
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW, Australia
    Oncogene 24:637-49. 2005
    ..A loss of p53 function and/or expression of junB, combined with reduced expression of specific AP2 proteins may underly downregulated KAI1 expression in tumour cells...
  9. ncbi request reprint Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines
    Sheri Nixdorf
    Oncology Research Centre, Prince of Wales Hospital, Level 2 Clinical Sciences Building, Barker Street, Randwick, NSW 2031, Australia
    Cancer Lett 215:209-20. 2004
    ..Our data also suggest that in those cell lines with reduced levels of MIM and MIM-B mRNA, down-regulation is unlikely to be due to promoter hypermethylation or loss of p53 function...
  10. ncbi request reprint Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival
    Ross D Farhadieh
    Department of Otolaryngology Surgery, Prince of Wales Hospital, UNSW, Randwick 2031, Sydney NSW, Australia
    Cancer Lett 213:91-8. 2004
    ..Univariate and multivariate Cox proportional hazard models showed a correlation between KAI1/CD82 expression with disease free survival (P = 0.01, P = 0.009) and overall survival (P = 0.04, P = 0.053) respectively...
  11. ncbi request reprint An alternatively spliced KAI1 mRNA is expressed at low levels in human bladder cancers and bladder cancer cell lines and is not associated with invasive behaviour
    Paul Jackson
    Oncology Research Centre, Prince of Wales Hospital, Randwick, New South Wales, Faculty of Medicine, University of New South Wales, New South Wales, Australia
    Oncol Rep 18:1357-63. 2007
    ..Low levels of an alternatively spliced form of KAI1 mRNA are present in most bladder cancer tumours and tumour cell lines, but are not associated with invasive behaviour...
  12. ncbi request reprint Expression of the KAI1 metastasis suppressor gene in non-metastatic versus metastatic human colorectal cancer
    Jia Lin Yang
    Department of Surgery, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    Anticancer Res 22:3337-42. 2002
    ..The importance of KAI1 to colorectal cancer (CRC) progression is unclear, with conflicting data regarding changes in KAI1 expression during tumour progression...
  13. pmc Phorbol ester enhances KAI1 transcription by recruiting Tip60/Pontin complexes
    Alexandra Rowe
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW, Australia
    Neoplasia 10:1421-32, following 1432. 2008
    ..These changes were not associated with differences in overall levels of Tip60, Pontin, beta-catenin, or Reptin protein expression but with PMA-induced nuclear translocation of Tip60...
  14. ncbi request reprint Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53
    Alexandra Marreiros
    Oncology Research Centre, Level 2 Clinical Sciences Building, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia
    Gene 302:155-64. 2003
    ..Our data suggested that a loss of KAI1 mRNA was not simply due to absence of AP2, AP1 or p53 expression...
  15. doi request reprint An inverse relationship between KAI1 expression, invasive ability, and MMP-2 expression and activity in bladder cancer cell lines
    Jingjing You
    Oncology Research Centre, Prince of Wales Hospital, Randwick, Australia
    Urol Oncol 30:502-8. 2012
    ..To investigate the relationship between the expression of the cancer metastasis suppressor gene KAI1 and MMP-2 and MMP-9 in human bladder cancer cell lines that express variable levels of KAI1...
  16. ncbi request reprint Elevated levels of prostate-specific antigen (PSA) in prostate cancer cells expressing mutant p53 is associated with tumor metastasis
    Sean Downing
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW, Australia
    Mol Carcinog 38:130-40. 2003
    ..These data provide in vitro and in vivo support for the notion that p53 mutations directly contribute to increased levels of serum PSA, and are associated with more aggressive tumors...
  17. ncbi request reprint No differences in p53 mutation frequencies between BRCA1-associated and sporadic ovarian cancers
    Morteza Aghmesheh
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    Gynecol Oncol 95:430-6. 2004
    ..This study aimed to clarify the role of p53 mutation in BRCA1-associated and sporadic ovarian cancer by comparing two, large, matched cohorts from two different populations who developed BRCA1-linked or sporadic ovarian cancers...
  18. ncbi request reprint Alterations of p53 are common in early stage prostate cancer
    Sean R Downing
    Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW, 2031, Australia
    Can J Urol 10:1924-33. 2003
    ..The alteration of genes involved in p53 regulation are also examined, as well as animal models that support an early role for p53 in the initiation and development of prostate cancer...
  19. ncbi request reprint Expression of KITENIN, a KAI1/CD82 binding protein and metastasis enhancer, in bladder cancer cell lines: relationship to KAI1/CD82 levels and invasive behaviour
    Alexandra Rowe
    Oncology Research Centre, Prince of Wales Hospital, Randwick, 2031 NSW, Australia
    Oncol Rep 16:1267-72. 2006
    ..Our data suggest that the relationship between KITENIN and KAI1/CD82 may be an important determinant of tumour cell behaviour...
  20. ncbi request reprint Regulation and deregulation of G2 checkpoint proteins with cisplatin
    M Links
    Oncology Research Centre, Prince of Wales Hospital, University of New South Wales, Randwick, Australia
    Anticancer Res 18:4057-66. 1998
    ..G2 arrest following DNA damage is associated with inactivation of the protein kinase cyclin B-cdc2. The role of changes in protein expression in enzyme inhibition is controversial...
  21. ncbi request reprint Androgen decreases osteoprotegerin expression in prostate cancer cells
    K Vandyke
    Oncology Research Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia
    Prostate Cancer Prostatic Dis 10:160-6. 2007
    ..These data suggest that androgen may modulate OPG protein levels in CaP cell lines in vitro using a post-transcriptional mechanism...
  22. pmc Uroplakin Ib gene transcription in urothelial tumor cells is regulated by CpG methylation
    Prue Cowled
    Department of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Neoplasia 7:1091-103. 2005
    ..Our data suggest that the methylation of specific CpG sites can silence the uroplakin Ib promoter, at least in part, by blocking the binding of Sp1 and NFkappaB, although other factors may be involved...
  23. pmc Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma
    Andrea E Varga
    Department of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Neoplasia 6:128-35. 2004
    ..The data are consistent with the hypothesis that methylation of specific sites within the uroplakin Ib promoter may be an important factor in the loss of uroplakin Ib expression in TCCs...
  24. ncbi request reprint Differential expression analysis of MIM (MTSS1) splice variants and a functional role of MIM in prostate cancer cell biology
    Robert D Loberg
    Department of Urology, University of Michigan Urology Center, 7431 CCGC, Ann Arbor, MI 48109 0946, USA
    Int J Oncol 26:1699-705. 2005
    ..These data suggest that the reduction of MIM-A gene expression in prostate cancer and other cancers may contribute to tumor growth and development, as well as metastasis...
  25. ncbi request reprint Timing of repeat colonoscopy: disparity between guidelines and endoscopists' recommendation
    Alex H Krist
    Department of Family Medicine, Virginia Commonwealth University, Richmond, USA
    Am J Prev Med 33:471-8. 2007
    ..The study objective was to examine whether endoscopists' recommendations for repeat colonoscopy, as communicated to primary care clinicians after the procedure, adhered to published guidelines...
  26. ncbi request reprint The p53 story: layers of complexity
    Antony W Braithwaite
    Department of Pathology, School of Medicine, University of Otago, Dunedin, New Zealand
    Carcinogenesis 26:1161-9. 2005
    ..The Convenor of the organizing committee was Antony Braithwaite, University of Otago, Dunedin. Janice Royds and Paul Jackson were also members of the organizing committee. There were 61 oral presentations and 101 posters.