Research Topics
| Geoffrey K IsbisterSummaryAffiliation: University of Newcastle Country: Australia Publications
| Collaborators
|
Detail Information
Publications
Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13)Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW
Med J Aust 197:173-7. 2012..To describe the clinical syndrome associated with definite tiger snake (Notechis spp) envenoming and to examine the ability of tiger snake antivenom (TSAV) to bind free venom in vivo...
Snakebite doesn't cause disseminated intravascular coagulation: coagulopathy and thrombotic microangiopathy in snake envenomingGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, and Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah NSW, Australia
Semin Thromb Hemost 36:444-51. 2010..The existence of the overlapping clinical syndromes of VICC and thrombotic microangiopathy in snake envenoming is the likely reason for the mistaken idea that snakebite causes DIC...- Aspiration pneumonitis in an overdose population: frequency, predictors, and outcomesGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Australia
Crit Care Med 32:88-93. 2004..Patients with aspiration pneumonitis have a significantly increased mortality and length of stay in the hospital... - Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdoseGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
J Toxicol Clin Toxicol 42:277-85. 2004..Objective: To determine the effect of SSRIs in overdose, as a group, and the relative toxicity of five different SSRIs... - Amisulpride overdose is frequently associated with QT prolongation and torsades de pointesGeoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia
J Clin Psychopharmacol 30:391-5. 2010..Amisulpride overdose commonly causes QT prolongation, bradycardia, and hypotension. Torsades de pointes occurred commonly enough to suggest that amisulpride is highly cardiotoxic in overdose... - Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenomGeoffrey K Isbister
Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
Toxicon 56:75-85. 2010..ETP is a useful assay to investigate mechanisms of other procoagulant venoms and is a robust method of assessing antivenom efficacy... - Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: in vivo and in vitro studiesGeoffrey K Isbister
Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NSW, Australia
Toxicon 49:57-67. 2007..One vial of antivenom appears to be sufficient to bind and neutralise all venom in patients with severe brown snake envenoming... - Antivenom efficacy or effectiveness: the Australian experienceGeoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
Toxicology 268:148-54. 2010.... 
The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency departmentLeonie A Calver
Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
BMC Emerg Med 10:14. 2010..Acute behavioural disturbance (ABD) is an increasing problem in emergency departments. This study aimed to determine the impact of a structured intramuscular (IM) sedation protocol on the duration of ABD in the emergency department...- Latrodectism: a prospective cohort study of bites by formally identified redback spidersGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298
Med J Aust 179:88-91. 2003..To determine the spectrum of severity and early diagnostic predictors of redback spider bites (Latrodectus hasselti), and to examine the effect of intramuscular redback antivenom... - Spider biteGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
Lancet 378:2039-47. 2011..Antivenoms are an important treatment for spider envenomation but have been less successful than have those for snake envenomation, with concerns about their effectiveness for both latrodectism and loxoscelism... - Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM studyGeoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
Ann Emerg Med 56:392-401.e1. 2010..We determine whether droperidol, midazolam, or the combination is more effective for intramuscular sedation in violent and acute behavioral disturbance in the emergency department (ED)... - An examination of the activity of expired and mistreated commercial Australian antivenomsMargaret A O'Leary
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
Trans R Soc Trop Med Hyg 103:937-42. 2009..CSL antivenoms are more robust than indicated on their label and maintain useful activity long past their nominated expiry dates... - Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?Margaret A O'Leary
Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle, NSW, Australia
Toxicon 50:206-13. 2007..Single-polyvalent antivenom for brown snake and tiger snake may be feasible in the future... - Effects of envenoming by comb-footed spiders of the genera Steatoda and Achaearanea (family Theridiidae: Araneae) in AustraliaGeoffrey K Isbister
University of Newcastle, Newcastle, Australia
J Toxicol Clin Toxicol 41:809-19. 2003..The family Theridiidae (comb-footed spiders) contains the well-known and medically important widow spider group (Latrodectus spp.). Little is known about the effects of envenoming by other common members of this family... - Sedation assessment tool to score acute behavioural disturbance in the emergency departmentLeonie A Calver
Discipline of Clinical Pharmacology, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
Emerg Med Australas 23:732-40. 2011..The objective of the study was to evaluate the effectiveness of the sedation assessment tool (SAT) in assessing patient response to treatment for acute behavioural disturbance (ABD)... - Cross-neutralisation of Australian brown snake, taipan and death adder venoms by monovalent antibodiesGeoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
Vaccine 28:798-802. 2010..However, they did cross-neutralise the procoagulant effects of both procoagulant venoms. This supports the idea of developing antivenoms against groups of snake toxins rather than individual snake venoms... - Digital Holter measurement of QT prolongation in ziprasidone overdoseIngrid Berling
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, Australia
Clin Toxicol (Phila) 49:694-6. 2011..We report a case of ziprasidone overdose with QT prolongation, demonstrating different methods of measuring the QT interval... - Risperidone overdose causes extrapyramidal effects but not cardiac toxicityColin B Page
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
J Clin Psychopharmacol 30:387-90. 2010..The aim of this study was to describe the clinical and electrocardiographic features of risperidone overdose, including the frequency of dystonic reactions... - Arsenic trioxide poisoning: a description of two acute overdosesGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
Hum Exp Toxicol 23:359-64. 2004..Arsenic quantification in blood, urine and faeces suggested that enhanced gastrointestinal decontamination was minimally effective for decontamination and that DMSA for at least two weeks was required... - Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: detecting venom, antivenom and venom-antivenom complexesGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Waratah NSW, Australia
Toxicon 48:4-11. 2006..Quantification of venom and antivenom will help to determine the dose of antivenom required to bind venom and to establish appropriate end points for antivenom treatment... - Bupropion overdose: QTc prolongation and its clinical significanceGeoffrey K Isbister
University of Newcastle, Waratah, Australia
Ann Pharmacother 37:999-1002. 2003..To investigate the cardiotoxicity of bupropion hydrochloride in deliberate self-poisoning... - A prospective study of definite bites by spiders of the family Sparassidae (huntsmen spiders) with identification to species levelGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Clinical Toxicologist and Emergency Physician, Newcastle Mater Misericordiae Hospital, Level 5, Clinical Sciences Building Edith St, Waratah, NSW 2298, Australia
Toxicon 42:163-71. 2003..The mechanism of effects appeared to be trauma rather than envenoming. There were no major differences between genera, and Neosparassus spp. did not cause major effects... - Clinical consequences of spider bites: recent advances in our understandingGeoffrey K Isbister
Emergency Department, Newcastle Mater Misericordiae Hospital and the University of Newcastle, Newcastle, NSW 2298, Australia
Toxicon 43:477-92. 2004..Most spiders only cause minor effects, including a large number of groups that have been implicated in necrotic arachnidism... - Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicityGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
Br J Clin Pharmacol 56:441-50. 2003..To investigate the spectrum of toxicity of moclobemide overdose, the occurrence of serotonin toxicity, and to estimate toxicokinetic parameters... - A turbidimetric assay for the measurement of clotting times of procoagulant venoms in plasmaMargaret A O'Leary
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
J Pharmacol Toxicol Methods 61:27-31. 2010..Assessment of the procoagulant effect of snake venoms is important for understanding their effects. The aim of this study was to develop a simple automated method to measure clotting times to assess procoagulant venoms... - Indications for single-dose activated charcoal administration in acute overdoseGeoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
Curr Opin Crit Care 17:351-7. 2011..There has been a significant decrease in the use of single-dose activated charcoal (SDAC) in recent years based on little new evidence and possibly because the overall mortality in overdose patients is low... - Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoalGeoffrey K Isbister
aDepartment of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, Australia
Int Clin Psychopharmacol 24:174-80. 2009..SDAC seems to have only modest effects on outcomes but may be considered within 2 h for large ingestions. Electrocardiogram monitoring is unlikely to be necessary... - Australian scorpion stings: a prospective study of definite stingsGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Clinical Sciences Building, Level 5 Edith Street, Waratah, NSW 2298, Australia
Toxicon 41:877-83. 2003..This differs from other parts of the world, where severe envenoming is reported. The major clinical effect is severe pain, consistent with other scorpion stings. Most stings occurred indoors and at night... - White-tail spider bite: a prospective study of 130 definite bites by Lampona speciesGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Australia
Med J Aust 179:199-202. 2003..To investigate the circumstances and clinical effects of bites by white-tail spiders, including the two species Lampona cylindrata and L. murina commonly encountered by humans, and the incidence of necrotic lesions... - Alprazolam is relatively more toxic than other benzodiazepines in overdoseGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
Br J Clin Pharmacol 58:88-95. 2004..To describe alprazolam poisoning and the relative toxicity of alprazolam compared with other benzodiazepines... - Dexmedetomidine in the emergency department: assessing safety and effectiveness in difficult-to-sedate acute behavioural disturbanceLeonie Calver
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
Emerg Med J 29:915-8. 2012..To investigate the safety and effectiveness of dexmedetomidine for sedating patients in whom previous attempts at sedation in the emergency department have failed... - Bites by spiders of the family Theraphosidae in humans and caninesGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Waratah, NSW 2298, Australia
Toxicon 41:519-24. 2003..Bites by these spiders are unlikely to cause major problems in humans. The study also demonstrates that the venom is far more toxic to canines... - The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case reportColin Page
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
J Med Toxicol 5:139-43. 2009..Although the metoprolol concentrations measured in plasma were approximately 100-200 times therapeutic concentrations, the pharmacokinetics appeared to be similar to therapeutic metoprolol dosing... - Australian wolf spider bites (Lycosidae): clinical effects and influence of species on bite circumstancesGeoffrey K Isbister
Discipline of Clinical Pharmacology, Newcastle Mater Misericordiae Hospital, University of Newcastle, Waratah, New South Wales, Australia
J Toxicol Clin Toxicol 42:153-61. 2004..Necrotic arachnidism continues to be attributed to wolf spider bites. This study investigates the clinical effects of bites by wolf spiders in Australia (family Lycosidae)... - Necrotic arachnidism: the mythology of a modern plagueGeoffrey K Isbister
Clinical Envenoming Research Group, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah NSW 2298, Australia
Lancet 364:549-53. 2004 - Developing a decision tree algorithm for the diagnosis of suspected spider bitesGeoffrey K Isbister
Emergency Department, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
Emerg Med Australas 16:161-6. 2004.... - Spotted black snake (Pseudechis guttatus) envenomingMelanie Jansen
School of Medical Practice and Population Health, University of Newcastle, Newcastle, NSW, Australia
Med J Aust 186:41-2. 2007..Neither patient developed significant coagulopathy, myolysis or neuromuscular paralysis. Bites by this species appear to cause effects similar to those of the more common red-bellied black snake (P. porphyriacus)... - Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiologyGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
Emerg Med (Fremantle) 15:376-82. 2003..To investigate the pattern and epidemiology of anticholinergic plant poisoning, and to characterize its time course and clinical features... - Emergency department performance indicators that encompass the patient journeyDavid Sibbritt
School of Medical Practice and Population Health, University of Newcastle, New South Wales, Australia
Qual Manag Health Care 15:27-38. 2006..The study aimed to provide a recommended list of performance indicators from routinely collected data that measure most aspects of the patient journey through the emergency department (ED)... - Antivenom treatment in arachnidismGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, NSW, Australia
J Toxicol Clin Toxicol 41:291-300. 2003..Although envenomation from arthropods is common, no antivenoms exist for these, excepting Lonomia caterpillars in South America, and Ixodes paralysis ticks in Australia... - Intentional warfarin overdoseGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
Ther Drug Monit 25:715-22. 2003..Titrating intravenous vitamin K with doses of 0.5 to 2.0 mg when INR > 5 is appropriate to reduce INR without causing warfarin resistance. The high-risk group must be kept anticoagulated, and warfarin resistance avoided... - Commercial monovalent antivenoms in Australia are polyvalentMargaret A O'Leary
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
Toxicon 54:192-5. 2009..However, it would be possible for the manufacturer to reduce the number of types of snake antivenoms available in Australia to two polyvalent antivenoms which would simplify treatment of snakebite... - A randomised controlled trial of hot water (45 degrees C) immersion versus ice packs for pain relief in bluebottle stingsConrad Loten
Hunter New England Area Health Service, Newcastle, NSW
Med J Aust 184:329-33. 2006..039). Systemic effects were uncommon in both groups. CONCLUSIONS: Immersion in water at 45 degrees C for 20 minutes is an effective and practical treatment for pain from bluebottle stings... - A randomised controlled trial of two infusion rates to decrease reactions to antivenomGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
PLoS ONE 7:e38739. 2012..This study aimed to investigate whether the rate of infusion of antivenom reduced the frequency of severe systemic hypersensitivity reactions... - Suspected snakebite: one year prospective study of emergency department presentationsGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
Emerg Med (Fremantle) 15:160-9. 2003..Snakebite is an uncommon, but potentially life-threatening condition. The more common clinical scenario is suspected snake-bite. Our aim was to characterise the epidemiology, diagnosis and management of patients with suspected snakebites... - Nefazodone poisoning: toxicokinetics and toxicodynamics using continuous data collectionGeoffrey K Isbister
University of Newcastle, Newcastle, Australia
J Toxicol Clin Toxicol 41:167-73. 2003..Bradycardia, hypotension, and drowsiness are the most significant effects and are maximal in the first 12 hours when parent and metabolite concentrations are high... - Acute conjunctival inflammation following contact with squashed spider contentsGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, and Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
Am J Ophthalmol 136:563-4. 2003..To report the effects to the eye following contact with spider contents... - The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatmentGeoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital and University of Newcastle, NSW, Australia
Clin Neuropharmacol 28:205-14. 2005..However, the mainstay of treatment of severe cases is good supportive care and early intubation and paralysis in life-threatening serotonin toxicity... - The dark side of the moonLeonie A Calver
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
Med J Aust 191:692-4. 2009..We investigated the possibility that there is an association between only extreme behavioural disturbance and the full moon... - Investigating the relationship between emergency departments and complementary and alternative medicine use in AustraliaGeoffrey K Isbister
Emergency Department, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
Emerg Med Australas 16:378-81. 2004 - Reviewing deaths in the emergency department: deaths in the department or deaths within 48 hSally Clunas
Emergency Department, John Hunter Hospital, Newcastle, NSW, Australia
Emerg Med Australas 21:117-23. 2009..To investigate an ED death audit process that included deaths occurring within 48 h of admission in addition to deaths in the ED... - Valproate overdose: a comparative cohort study of self poisoningsGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Newcastle, Australia
Br J Clin Pharmacol 55:398-404. 2003..Based on individual case reports of massive overdoses, valproate is often regarded as having significant toxicity. This study aimed to describe the epidemiology of valproate poisoning and the spectrum of its clinical effects... - How do we use drug concentration data to improve the treatment of overdose patients?Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, University of Newcastle, New South Wales, Australia
Ther Drug Monit 32:300-4. 2010..Using such an approach means that the use of drug concentration data in research will improve the risk assessment in overdose patients, without requiring these assays to be rapidly available in the acute health setting... - Failure of intramuscular antivenom in Red-back spider envenomingGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Hospital, Edith St, Waratah NSW 2298, Australia
Emerg Med (Fremantle) 14:436-9. 2002..Controlled studies should be undertaken to establish the effectiveness of intravenous and intramuscular Red-back antivenom... - Two cases of bites by the black-bellied swamp snake (Hemiaspis signata)Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Locked Bag 7, Hunter Region Main Centre, Newcastle, NSW 2310, Australia
Toxicon 40:317-9. 2002..These cases indicate the potential for coagulopathy and local symptoms following bites by large specimens of H. signata in young children... - Individual patient assessment of methadone-induced QT prolongation with digital holter recordingLeonie Calver
Department of Clinical Toxicology, Calvary Mater Newcastle Hospital, Edith St, Waratah New South Wales 2298, Australia
J Addict Med 6:92-3. 2012..For each 24-hour period QT-HR pairs were plotted on the QT nomogram showing QT prolongation on methadone but not when it was ceased. This provides a highly accurate method for evaluating drug-induced QT prolongation... - Intravenous paracetamol toxicity in a malnourished childIngrid Berling
Discipline of Clinical Pharmacology, Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, Australia
Clin Toxicol (Phila) 50:74-6. 2012....