Les Irwig

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint A randomized crossover trial of PAPNET for primary cervical screening
    Les Irwig
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Edward Ford Building A27, NSW 2006, Sydney, Australia
    J Clin Epidemiol 57:75-81. 2004
  2. pmc Designing studies to ensure that estimates of test accuracy are transferable
    Les Irwig
    Screening and Test Evaluation Program, Department of Public Health and Community Medicine, University of Sydney, NSW 2006, Australia
    BMJ 324:669-71. 2002
  3. pmc 'This added to my multiple myopia'
    Les Irwig
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 326:1336. 2003
  4. ncbi request reprint New methods give better estimates of changes in diagnostic accuracy when prior information is provided
    Les Irwig
    Screening and Test Evaluation Program, School of Public Health, Building A 27, University of Sydney, New South Wales 2006, Australia
    J Clin Epidemiol 59:299-307. 2006
  5. pmc Informed choice for screening: implications for evaluation
    Les Irwig
    Screening and Test Evaluation Program, School of Public Health, Edward Ford Building, A27, University of Sydney, NSW 2006, Australia
    BMJ 332:1148-50. 2006
  6. pmc New technologies in screening for breast cancer: a systematic review of their accuracy
    L Irwig
    Screening and Test Evaluation Program STEP, School of Public Health, A27, University of Sydney, NSW 2006, Australia
    Br J Cancer 90:2118-22. 2004
  7. doi request reprint Magnetic resonance imaging screening of the contralateral breast in women with newly diagnosed breast cancer: systematic review and meta-analysis of incremental cancer detection and impact on surgical management
    Meagan Elizabeth Brennan
    Screening and Test Evaluation Program, School of Public Health, Faculty of Medicine, and National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia
    J Clin Oncol 27:5640-9. 2009
  8. doi request reprint HPV testing versus repeat Pap testing for the management of a minor abnormal Pap smear: evaluation of a decision aid to support informed choice
    Kirsten J McCaffery
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    Patient Educ Couns 73:473-9, 481. 2008
  9. doi request reprint Effects of additional blood pressure and lipid measurements on the prediction of cardiovascular risk
    Katy Bell
    Screening and Test Evaluation Program STEP, School of Public Health, University of Sydney, NSW 2006, Australia
    Eur J Prev Cardiol 19:1474-85. 2012
  10. doi request reprint Estimates of overdiagnosis of invasive breast cancer associated with screening mammography
    Stephen Morrell
    School of Public Health, University of Sydney, Sydney, NSW, Australia
    Cancer Causes Control 21:275-82. 2010

Detail Information

Publications90

  1. ncbi request reprint A randomized crossover trial of PAPNET for primary cervical screening
    Les Irwig
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Edward Ford Building A27, NSW 2006, Sydney, Australia
    J Clin Epidemiol 57:75-81. 2004
    ..To develop and demonstrate efficient methods to estimate the relative true positive and false positive rates of two cervical screening tests (conventional cytology and PAPNET)...
  2. pmc Designing studies to ensure that estimates of test accuracy are transferable
    Les Irwig
    Screening and Test Evaluation Program, Department of Public Health and Community Medicine, University of Sydney, NSW 2006, Australia
    BMJ 324:669-71. 2002
  3. pmc 'This added to my multiple myopia'
    Les Irwig
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 326:1336. 2003
  4. ncbi request reprint New methods give better estimates of changes in diagnostic accuracy when prior information is provided
    Les Irwig
    Screening and Test Evaluation Program, School of Public Health, Building A 27, University of Sydney, New South Wales 2006, Australia
    J Clin Epidemiol 59:299-307. 2006
    ..We propose comparing the combined accuracy of prior information and a test read (i) with or (ii) without knowledge of prior information. Analysis methods include simple decision rules and logistic regression...
  5. pmc Informed choice for screening: implications for evaluation
    Les Irwig
    Screening and Test Evaluation Program, School of Public Health, Edward Ford Building, A27, University of Sydney, NSW 2006, Australia
    BMJ 332:1148-50. 2006
  6. pmc New technologies in screening for breast cancer: a systematic review of their accuracy
    L Irwig
    Screening and Test Evaluation Program STEP, School of Public Health, A27, University of Sydney, NSW 2006, Australia
    Br J Cancer 90:2118-22. 2004
    ..The evidence is currently insufficient to support the use of any of these new technologies in population screening, but would support further evaluation...
  7. doi request reprint Magnetic resonance imaging screening of the contralateral breast in women with newly diagnosed breast cancer: systematic review and meta-analysis of incremental cancer detection and impact on surgical management
    Meagan Elizabeth Brennan
    Screening and Test Evaluation Program, School of Public Health, Faculty of Medicine, and National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia
    J Clin Oncol 27:5640-9. 2009
    ..This article is a review and meta-analysis of studies reporting contralateral MRI in women with newly diagnosed invasive breast cancer...
  8. doi request reprint HPV testing versus repeat Pap testing for the management of a minor abnormal Pap smear: evaluation of a decision aid to support informed choice
    Kirsten J McCaffery
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    Patient Educ Couns 73:473-9, 481. 2008
    ..To examine women's informed preference for the management of a mildly abnormal Pap smear and the impact of a decision aid...
  9. doi request reprint Effects of additional blood pressure and lipid measurements on the prediction of cardiovascular risk
    Katy Bell
    Screening and Test Evaluation Program STEP, School of Public Health, University of Sydney, NSW 2006, Australia
    Eur J Prev Cardiol 19:1474-85. 2012
    ..We aimed to assess whether two measurements of blood pressure and lipids improves the prediction of cardiovascular risk compared to one measurement...
  10. doi request reprint Estimates of overdiagnosis of invasive breast cancer associated with screening mammography
    Stephen Morrell
    School of Public Health, University of Sydney, Sydney, NSW, Australia
    Cancer Causes Control 21:275-82. 2010
    ..To estimate the extent of overdiagnosis of invasive breast cancer associated with screening in New South Wales, Australia, a population with a well-established mammography screening program which has achieved full geographic coverage...
  11. ncbi request reprint The influence of knowledge of mammography findings on the accuracy of breast ultrasound in symptomatic women
    Nehmat Houssami
    Screening and Test Evaluation Program STEP, School of Public Health, University of Sydney, NSW 2006, Australia
    Breast J 11:167-72. 2005
    ..Our study indicates that knowledge of the findings of mammography improves the interpretation of breast ultrasound in symptomatic women...
  12. doi request reprint Follow-up of early stage melanoma: specialist clinician perspectives on the functions of follow-up and implications for extending follow-up intervals
    Lucie Rychetnik
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    J Surg Oncol 107:463-8. 2013
    ..There is limited evidence on the relative effectiveness of different follow-up schedules for patients with AJCC stage I or II melanoma, but less frequent follow-up than is currently recommended has been proposed...
  13. doi request reprint Meta-analysis of magnetic resonance imaging in detecting residual breast cancer after neoadjuvant therapy
    Michael L Marinovich
    Screening and Test Evaluation Program, Sydney School of Public Health, A27, Edward Ford Building, University of Sydney, NSW 2006, Australia
    J Natl Cancer Inst 105:321-33. 2013
    ..This meta-analysis examines MRI accuracy in detecting residual tumor, investigates variables potentially affecting MRI performance, and compares MRI with other tests...
  14. pmc The value of age and medical history for predicting colorectal cancer and adenomas in people referred for colonoscopy
    Barbara Ann Adelstein
    Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia
    BMC Gastroenterol 11:97. 2011
    ..The aim of this study is to assess a model that identifies people with colorectal cancer, advanced, large and small adenomas...
  15. ncbi request reprint Cervical cytology reading times: a comparison between ThinPrep Imager and conventional methods
    Elizabeth Davey
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    Diagn Cytopathol 35:550-4. 2007
    ..The TPI significantly reduced reading times compared with CC. This reduction was greater amongst slower readers, and was unrelated to experience...
  16. ncbi request reprint Effects of study methods and biases on estimates of invasive breast cancer overdetection with mammography screening: a systematic review
    Corné Biesheuvel
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, NSW, Australia
    Lancet Oncol 8:1129-38. 2007
    ..New studies are urgently needed to quantify the true extent of overdetection in current mammography screening programmes. These studies should be designed to avoid the multiple sources of bias identified in this review...
  17. pmc Psychosocial outcomes of three triage methods for the management of borderline abnormal cervical smears: an open randomised trial
    Kirsten J McCaffery
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 340:b4491. 2010
    ..To assess which of three triage strategies for women with borderline abnormal cervical smear results in the best psychosocial outcomes...
  18. doi request reprint Psychosocial aspects of post-treatment follow-up for stage I/II melanoma: a systematic review of the literature
    Lucie Rychetnik
    Screening and Test Evaluation Program, School of Public Health, The University of Sydney, Camperdown, Australia
    Psychooncology 22:721-36. 2013
    ..This systematic review summarised patient and clinician preferences, experiences and adherence with recommended follow-up of stage I/II melanoma...
  19. doi request reprint How do we achieve informed choice for women considering breast screening?
    Jolyn Hersch
    Screening and Test Evaluation Program, Sydney School of Public Health, Edward Ford Bldg A27, University of Sydney, NSW 2006, Australia
    Prev Med 53:144-6. 2011
    ..This paper discusses the issues around informed choice for women considering breast screening...
  20. doi request reprint Determining the impact of informed choice: separating treatment effects from the effects of choice and selection in randomized trials
    Kirsten J McCaffery
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    Med Decis Making 31:229-36. 2011
    ..The Rucker 2-stage randomized trial (RCT) design and method allows treatment, preference, and selection effects to be estimated separately in clinical trials...
  21. pmc Risk factors for second screen-detected or interval breast cancers in women with a personal history of breast cancer participating in mammography screening
    Nehmat Houssami
    Screening and Test Evaluation Program, School of Public Health A27, Sydney Medical School, University of Sydney, NSW 2006, Australia
    Cancer Epidemiol Biomarkers Prev 22:946-61. 2013
    ..We aimed to identify risk factors for second (ipsilateral or contralateral) screen-detected or interval breast cancer within 1 year of screening in PHBC women...
  22. pmc Patients who take their symptoms less seriously are more likely to have colorectal cancer
    Barbara Ann Adelstein
    Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia
    BMC Gastroenterol 12:130. 2012
    ..To do this we assessed whether the likelihood of detecting colorectal cancer is higher in patients who report that they take symptoms less seriously than other people do...
  23. pmc Women's views on overdiagnosis in breast cancer screening: a qualitative study
    Jolyn Hersch
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 346:f158. 2013
    ....
  24. doi request reprint Monitoring initial response to Angiotensin-converting enzyme inhibitor-based regimens: an individual patient data meta-analysis from randomized, placebo-controlled trials
    Katy J L Bell
    Screening and Test Evaluation Program, School of Public Health, Edward Ford Building A27, University of Sydney, NSW 2006, Australia
    Hypertension 56:533-9. 2010
    ..Instead of monitoring an individual's blood pressure response, a better approach may be to simply assume the mean treatment effect...
  25. doi request reprint Accuracy and surgical impact of magnetic resonance imaging in breast cancer staging: systematic review and meta-analysis in detection of multifocal and multicentric cancer
    Nehmat Houssami
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    J Clin Oncol 26:3248-58. 2008
    ..Randomized trials are needed to determine the clinical value of detecting additional disease which changes surgical treatment in women with apparently localized breast cancer...
  26. pmc Long term monitoring in patients receiving treatment to lower blood pressure: analysis of data from placebo controlled randomised controlled trial
    Katherine Keenan
    Screening and Test Evaluation Program STEP, School of Public Health, Building A27, University of Sydney, New South Wales 2006, Australia
    BMJ 338:b1492. 2009
    ..To determine the value of monitoring blood pressure by quantifying the probability that observed changes in blood pressure reflect true changes...
  27. pmc Meta-analysis: retinal vessel caliber and risk for coronary heart disease
    Kevin McGeechan
    School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    Ann Intern Med 151:404-13. 2009
    ..Retinal vessel caliber may be a novel marker of coronary heart disease (CHD) risk. However, the sex-specific effect, magnitude of association, and effect independent of traditional CHD disease risk factors remain unclear...
  28. doi request reprint Appropriate statistical methods are required to assess diagnostic tests for replacement, add-on, and triage
    Andrew Hayen
    Screening and Test Evaluation Program, Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    J Clin Epidemiol 63:883-91. 2010
    ..To explain which measures of accuracy and which statistical methods should be used in studies to assess the value of a new binary test as a replacement test, an add-on test, or a triage test...
  29. pmc Shared care in the follow-up of early-stage melanoma: a qualitative study of Australian melanoma clinicians' perspectives and models of care
    Lucie Rychetnik
    Screening and Test Evaluation Program, School of Public Health, The University of Sydney, Sydney, Australia
    BMC Health Serv Res 12:468. 2012
    ..Shared care between melanoma specialists and general practitioners is an increasingly important approach to meeting the needs of a growing population of melanoma survivors...
  30. doi request reprint Optimizing the frequency of follow-up visits for patients treated for localized primary cutaneous melanoma
    Robin M Turner
    School of Public Health, The University of Sydney, New South Wales, Australia
    J Clin Oncol 29:4641-6. 2011
    ..To develop more evidence-based guidelines for the frequency of patient follow-up after treatment of localized (American Joint Committee on Cancer [AJCC] stage I or II) melanoma...
  31. doi request reprint Lax sphygmomanometer standard causes overdetection and underdetection of hypertension: a computer simulation study
    Martin J Turner
    Department of Anaesthetics, School of Public Health, University of Sydney, Sydney, Australia
    Blood Press Monit 13:91-9. 2008
    ..To quantify overdetection and underdetection of hypertension caused by systematic sphygmomanometer errors permitted by the current European standard (EN 1060 'noninvasive sphygmomanometers')...
  32. ncbi request reprint HPV triage testing or repeat Pap smear for the management of atypical squamous cells (ASCUS) on Pap smear: is there evidence of process utility?
    Kirsten Howard
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, NSW, Australia
    Health Econ 17:593-605. 2008
    ..A modelled application of trial-based data will allow characterisation of the true population costs, benefits, risks and harms of alternative triage strategies and subsequent policy implications thereof...
  33. doi request reprint Monitoring adherence to medication by measuring change in blood pressure
    Andrew Hayen
    Sydney School of Public Health A27, University of Sydney, Sydney, NSW 2006, Australia
    Hypertension 56:612-6. 2010
    ..67). Monitoring blood pressure is poor at detecting nonadherence to blood pressure-lowering treatment. Further research should look at other methods of assessing adherence...
  34. pmc Most bowel cancer symptoms do not indicate colorectal cancer and polyps: a systematic review
    Barbara Ann Adelstein
    Prince of Wales Clinical School, Faculty of Medicine, University of NSW, Sydney, Australia
    BMC Gastroenterol 11:65. 2011
    ..However, the evidence for this practice is unclear. The objective of this study is to systematically review the evidence about the association between bowel symptoms and colorectal cancer or polyps...
  35. doi request reprint Should response rules be used to decide continued subsidy of very expensive drugs? A checklist for decision makers
    Katy J L Bell
    Screening and Test Evaluation Program, School of Public Health, The University of Sydney, Edward Ford Building A27, NSW 2006, Australia
    Pharmacoepidemiol Drug Saf 19:99-105. 2010
    ..Careful assessment is needed before decision makers adopt a response rule as a way of increasing the cost effectiveness of therapy...
  36. pmc Communicating cardiovascular disease risk: an interview study of General Practitioners' use of absolute risk within tailored communication strategies
    Carissa Bonner
    Screening and Test Evaluation Program STEP, Sydney School of Public Health, Edward Ford Building A27, The University of Sydney, Sydney, NSW 2006, Australia
    BMC Fam Pract 15:106. 2014
    ..This study aimed to explore GPs' descriptions of their CVD risk communication strategies, including the role of absolute risk...
  37. pmc I don't believe it, but i'd better do something about it: patient experiences of online heart age risk calculators
    Carissa Bonner
    Screening and Test Evaluation Program STEP, Sydney School of Public Health, The University of Sydney, Sydney, Australia
    J Med Internet Res 16:e120. 2014
    ..Previous studies have not investigated patient understanding of heart age compared to 5-year percentage risk, or the best way to present heart age...
  38. ncbi request reprint General practitioners' use of different cardiovascular risk assessment strategies: a qualitative study
    Carissa Bonner
    Screening and Test Evaluation Program, Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia
    Med J Aust 199:485-9. 2013
    ..To identify factors that influence the extent to which general practitioners use absolute risk (AR) assessment in cardiovascular disease (CVD) risk assessment...
  39. doi request reprint Monitoring adherence to drug treatment by using change in cholesterol concentration: secondary analysis of trial data
    Katy J L Bell
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 342:d12. 2011
    ..To estimate the accuracy of monitoring cholesterol concentration for detecting non-adherence to lipid lowering treatment...
  40. pmc Accuracy and outcomes of screening mammography in women with a personal history of early-stage breast cancer
    Nehmat Houssami
    Screening and Test Evaluation Program, School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia
    JAMA 305:790-9. 2011
    ..Women with a personal history of breast cancer (PHBC) are at risk of developing another breast cancer and are recommended for screening mammography. Few high-quality data exist on screening performance in PHBC women...
  41. ncbi request reprint The influence of clinical information on the accuracy of diagnostic mammography
    Nehmat Houssami
    Screening and Test Evaluation Program STEP, School of Public Health, A27, University of Sydney, New South Wales, Australia
    Breast Cancer Res Treat 85:223-8. 2004
    ..This study examined the influence of knowledge of clinical information on the accuracy of mammography in women referred for investigation of breast symptoms...
  42. pmc Model of outcomes of screening mammography: information to support informed choices
    Alexandra Barratt
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 330:936. 2005
    ..To provide easy to use estimates of the benefits and harms of biennial screening mammography for women aged 40, 50, 60, and 70 years...
  43. ncbi request reprint High participation rates are not necessary for cost-effective colorectal cancer screening
    Kirsten Howard
    Health Economics, Screening and Test Evaluation Program STEP, School of Public Health, Edward Ford Building A27, University of Sydney, Australia
    J Med Screen 12:96-102. 2005
    ....
  44. ncbi request reprint Reply to braillon and nicot
    Jolyn Hersch
    Screening and Test Evaluation Program, Sydney School of Public Health, Edward Ford Bldg A27, University of Sydney, NSW 2006, Australia Centre for Medical Psychology and Evidence based Decision making, Transient Bldg F12, University of Sydney, NSW 2006, Australia
    Prev Med 53:438. 2011
  45. pmc Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study
    Elizabeth Davey
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 335:31. 2007
    ..To compare the accuracy of liquid based cytology using the computerised ThinPrep Imager with that of manually read conventional cytology...
  46. pmc The reliability of a quality appraisal tool for studies of diagnostic reliability (QAREL)
    Nicholas Lucas
    Screening and Test Evaluation Program, Sydney School of Public Health, University of Sydney, Sydney, Australia
    BMC Med Res Methodol 13:111. 2013
    ..The reliability of physical examination is a challenging area to study given the complex testing procedures, the range of tests, and lack of procedural standardisation...
  47. pmc Red flags to screen for malignancy and fracture in patients with low back pain: systematic review
    Aron Downie
    George Institute For Global Health, University of Sydney, Sydney, NSW, 2050, Australia
    BMJ 347:f7095. 2013
    ..To review the evidence on diagnostic accuracy of red flag signs and symptoms to screen for fracture or malignancy in patients presenting with low back pain to primary, secondary, or tertiary care...
  48. doi request reprint The potential value of monitoring bone turnover markers among women on alendronate
    Katy J L Bell
    School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    J Bone Miner Res 27:195-201. 2012
    ..In summary, although bone turnover markers appear promising for monitoring between-person differences in response to treatment, their use in clinical practice is currently limited by large random within-person variation...
  49. ncbi request reprint Expanding the evidence on cancer screening: the value of scientific, social and ethical perspectives
    Lucie Rychetnik
    University of Sydney, Sydney, NSW, Australia
    Med J Aust 198:536-9. 2013
    ..An expanded approach will offer essential information to better support well reasoned judgements, and develop more accountable and less contested cancer screening policies...
  50. pmc Using patient management as a surrogate for patient health outcomes in diagnostic test evaluation
    Lukas P Staub
    NHMRC Clinical Trials Centre, The University of Sydney, Sydney, Australia
    BMC Med Res Methodol 12:12. 2012
    ..There is a lack of guidance on the interpretation of this evidence, and patient management studies often neglect a discussion of the limitations of measuring patient management as a surrogate for health outcomes...
  51. ncbi request reprint Does providing previous results change the accuracy of cervical cytology?
    Elizabeth Davey
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    Acta Cytol 53:644-52. 2009
    ..To determine whether providing previous cytology and histology findings alters the accuracy of conventional cervical cytology reading or changes reading times...
  52. doi request reprint The development of a quality appraisal tool for studies of diagnostic reliability (QAREL)
    Nicholas P Lucas
    School of Biomedical and Health Sciences, University of Western Sydney, Narellan Road, Campbelltown, Sydney, Australia
    J Clin Epidemiol 63:854-61. 2010
    ..In systematic reviews of the reliability of diagnostic tests, no quality assessment tool has been used consistently. The aim of this study was to develop a specific quality appraisal tool for studies of diagnostic reliability...
  53. ncbi request reprint Australian women's needs and preferences for information about human papillomavirus in cervical screening
    Kirsten McCaffery
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    J Med Screen 12:134-41. 2005
    ..The role of human papillomavirus (HPV) in cervical cancer and developments in medical technology to prevent cervical cancer has changed information needs for women participating in cervical screening...
  54. ncbi request reprint The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed
    Jonathan J Deeks
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, New South Wales 2006, Australia
    J Clin Epidemiol 58:882-93. 2005
    ..We investigate limitations of standard funnel plots and tests when applied to meta-analyses of test accuracy and look for improved methods...
  55. ncbi request reprint Radiological surveillance of interval breast cancers in screening programmes
    Nehmat Houssami
    Screening and Test Evaluation Program STEP, School of Public Health, University of Sydney, New South Wales, Australia
    Lancet Oncol 7:259-65. 2006
    ..Standardised radiological surveillance of interval cancers might allow within-programme comparisons and has the potential to guide practice and improve quality...
  56. doi request reprint Criteria for monitoring tests were described: validity, responsiveness, detectability of long-term change, and practicality
    Katy J L Bell
    Centre for Research in Evidence Based Practice CREBP, Bond University, Gold Coast, QLD 4229, Australia Screening and Diagnostic Test Evaluation Program STEP, School of Public Health, Building A27, University of Sydney, Sydney, NSW 2006, Australia Electronic address
    J Clin Epidemiol 67:152-9. 2014
    ..To describe how evidence from trials and cohort studies may be used to guide choice of test for monitoring patients with chronic disease...
  57. ncbi request reprint Observed differences in diagnostic test accuracy between patient subgroups: is it real or due to reference standard misclassification?
    Corné Biesheuvel
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    Clin Chem 53:1725-9. 2007
    ..Such misclassification may be ascertained by examining how the apparent sensitivity and specificity change with the prevalence of the target condition in the subgroups...
  58. doi request reprint Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy
    Nehmat Houssami
    School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia
    Eur J Cancer 46:3219-32. 2010
    ..There is no consensus on what constitutes adequate negative margins in breast-conserving therapy (BCT). We review the evidence on surgical margins in BCT for early-stage invasive breast cancer...
  59. ncbi request reprint Three methods to construct predictive models using logistic regression and likelihood ratios to facilitate adjustment for pretest probability give similar results
    Siew Foong Chan
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    J Clin Epidemiol 61:52-63. 2008
    ..To compare three predictive models based on logistic regression to estimate adjusted likelihood ratios allowing for interdependency between diagnostic variables (tests)...
  60. ncbi request reprint Assessing the gain in diagnostic performance when combining two diagnostic tests
    Petra Macaskill
    Screening and Test Evaluation Program STEP, Department of Public Health and Community Medicine, University of Sydney, Sydney, NSW, Australia, 2006
    Stat Med 21:2527-46. 2002
    ..These methods are illustrated with an example that considers the combined use of Pap and HPV testing...
  61. pmc The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses
    Jonathan C Craig
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    BMJ 340:c1594. 2010
    ..Design Two year prospective cohort study. Setting The emergency department of The Children's Hospital at Westmead, Westmead, Australia...
  62. doi request reprint Mixed models showed no need for initial response monitoring after starting antihypertensive therapy
    Katy J L Bell
    School of Public Health, The University of Sydney, New South Wales, Australia
    J Clin Epidemiol 62:650-9. 2009
    ..To demonstrate how mixed models may be used to estimate treatment effects, and inform decisions on the need for monitoring initial response...
  63. pmc Value of routine monitoring of bone mineral density after starting bisphosphonate treatment: secondary analysis of trial data
    Katy J L Bell
    Screening and Test Evaluation Program, School of Public Health, Edward Ford Building A27, University of Sydney, NSW 2006, Australia
    BMJ 338:b2266. 2009
    ..To assess the value of monitoring response to bisphosphonate treatment by means of measuring bone mineral density...
  64. ncbi request reprint Combining carbohydrate-deficient transferrin and gamma-glutamyltransferase to increase diagnostic accuracy for problem drinking
    Jack Chen
    School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    Alcohol Alcohol 38:574-82. 2003
    ..To examine methods for combining quantitative results for serum carbohydrate deficient transferrin (CDT), gamma-glutamyltransferase (GGT) and/or aspartate aminotransferase (AST), and refining these by inclusion of patient characteristics...
  65. ncbi request reprint Randomized trial of a self-administered decision aid for colorectal cancer screening
    Lyndal J Trevena
    University of Sydney NSW 2006, Australia
    J Med Screen 15:76-82. 2008
    ....
  66. ncbi request reprint Oxygen-saturation targets and outcomes in extremely preterm infants
    Lisa Maree Askie
    Centre for Perinatal Health Services Research, University of Sydney, NSW, Australia
    N Engl J Med 349:959-67. 2003
    ..Anecdotal reports and uncontrolled observational studies have suggested that a higher oxygen-saturation range may be beneficial in terms of growth and development...
  67. ncbi request reprint GPs want tailored, user friendly evidence summaries--a cross sectional study in New South Wales
    Lyndal J Trevena
    School of Public Health, The University of Sydney, New South Wales
    Aust Fam Physician 36:1065-9. 2007
    ....
  68. pmc A self administered reliable questionnaire to assess lower bowel symptoms
    Barbara Ann Adelstein
    Screening and Test Evaluation Program STEP, School of Public Health, University of Sydney, Australia
    BMC Gastroenterol 8:8. 2008
    ..Our aim was to develop a self administered questionnaire for eliciting the presence, nature and severity of lower bowel symptoms potentially related to colorectal cancer, and assess its reliability...
  69. ncbi request reprint Patient decision aids to support clinical decision making: evaluating the decision or the outcomes of the decision
    Kirsten McCaffery
    School of Public Health, University of Sydney, Sydney, Australia
    Med Decis Making 27:619-25. 2007
    ..Health and quality of life measured over the long term are presented as the primary outcomes. The authors propose that this design will allow the proper assessment of different modes of decision making...
  70. doi request reprint Control charts demonstrated limited utility for the monitoring of lung function in asthma
    Robin M Turner
    Screening and Test Evaluation Program, Sydney School of Public Health, University of Sydney, Edward Ford Building A27, Camperdown, NSW 2006, Australia
    J Clin Epidemiol 65:53-61. 2012
    ..Statistical process control charts have been advocated for use in monitoring of lung function in asthma. We aimed to evaluate their application in asthma using existing data from a randomized trial...
  71. ncbi request reprint Effect of study design and quality on unsatisfactory rates, cytology classifications, and accuracy in liquid-based versus conventional cervical cytology: a systematic review
    Elizabeth Davey
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Australia
    Lancet 367:122-32. 2006
    ..We reviewed the published work to assess the performance of liquid-based cytology relative to conventional cytology in primary studies assessed to be of low, medium, or high methodological quality...
  72. pmc Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study)
    Kevin McGeechan
    School of Public Health, University of Sydney, Sydney, Australia
    Am J Cardiol 102:58-63. 2008
    ..In conclusion, although retinal vascular caliber independently predicted CHD risk in women, the incremental predictive ability over that of the Framingham model was modest and unlikely to translate meaningfully into clinical practice...
  73. pmc Use of randomised trials to decide when to monitor response to new treatment
    Katy J L Bell
    Screening and Test Evaluation Program, School of Public Health, Edward Ford Building A27, The University of Sydney, NSW 2006, Australia
    BMJ 336:361-5. 2008
  74. doi request reprint Using the principles of randomized controlled trial design to guide test evaluation
    Sarah J Lord
    National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW 2050, Australia
    Med Decis Making 29:E1-E12. 2009
    ..Long-term RCTs will not be necessary if it is valid to use other sources of evidence to address these questions. Validity will depend on issues such as the spectrum of patients identified by the old and new test strategies...
  75. ncbi request reprint Lack of sphygmomanometer calibration causes over- and under-detection of hypertension: a computer simulation study
    Martin J Turner
    Department of Anaesthetics, University of Sydney, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    J Hypertens 24:1931-8. 2006
    ..To estimate the contribution of inadequate sphygmomanometer calibration to over- and under-detection of hypertension...
  76. ncbi request reprint When is measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do we need randomized trials?
    Sarah J Lord
    National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, Camperdown, NSW, Australia
    Ann Intern Med 144:850-5. 2006
    ....
  77. ncbi request reprint Adjustment for baseline measurement error in randomized controlled trials induces bias
    Siew F Chan
    Screening and Test Evaluation Program STEP, School of Public Health, The University of Sydney, Edward Ford Building, A27, Sydney, NSW 2006, Australia
    Control Clin Trials 25:408-16. 2004
    ..It is underestimated when the control group has a smaller baseline mean...
  78. ncbi request reprint Accuracy of diagnostic tests read with and without clinical information: a systematic review
    Clement T Loy
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    JAMA 292:1602-9. 2004
    ..Although it is common practice to read tests with clinical information, whether this improves or decreases the accuracy of test reading is uncertain...
  79. ncbi request reprint Analytic methods for comparing two dichotomous screening or diagnostic tests applied to two populations of differing disease prevalence when individuals negative on both tests are unverified
    Geoffrey Berry
    Department of Public Health and Community Medicine, Edward Ford Building A27, University of Sydney, New South Wales 2006, Australia
    Stat Med 21:853-62. 2002
    ..The methods are based on the assumption that the sensitivities and specificities of the two tests, and the dependencies between the tests, are independent of prevalence. A test of goodness of fit provides a test of this...
  80. doi request reprint Expanding the evidence base in transplantation: more and better randomized trials, and extending the value of observational data
    Jonathan C Craig
    Screening and Diagnostic Test Evaluation Program, School of Public Health, University of Sydney, Sydney, NSW, Australia
    Transplantation 86:32-5. 2008
    ....
  81. ncbi request reprint Intraocular lens power in bilateral cataract surgery: whether adjusting for error of predicted refraction in the first eye improves prediction in the second eye
    James Jabbour
    University of New South Wales at the Prince of Wales Hospital and the School of Public Health, University of Sydney, Sydney, Australia
    J Cataract Refract Surg 32:2091-7. 2006
    ..To assess whether the retrospectively calculated intraocular lens (IOL) position value in the first eye reduces the error of predicted refraction in the second...
  82. doi request reprint Communicating about screening
    Vikki A Entwistle
    Social Dimensions of Health Institute, University of Dundee, UK
    BMJ 337:a1591. 2008
  83. ncbi request reprint Sydney Breast Imaging Accuracy Study: Comparative sensitivity and specificity of mammography and sonography in young women with symptoms
    Nehmat Houssami
    The Sydney Square Breast Clinic, Medical Benefits Fund of Australia, and School of Public Health, Faculty of Medicine, The University of Sydney, New South Wales, Australia
    AJR Am J Roentgenol 180:935-40. 2003
    ....
  84. ncbi request reprint Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (hemoccult): an update
    Paul Hewitson
    Department of Primary Health Care, University of Oxford, Oxford, United Kingdom
    Am J Gastroenterol 103:1541-9. 2008
    ....
  85. pmc Comparative accuracy: assessing new tests against existing diagnostic pathways
    Patrick M Bossuyt
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, Amsterdam 1100 DE, Netherlands
    BMJ 332:1089-92. 2006
  86. ncbi request reprint The number needed to treat (NNT) can be adjusted for bias when the outcome is measured with error
    Ian C Marschner
    Asia Biometrics Centre, Pfizer Global Pharmaceuticals, 38 Wharf Road, West Ryde, 2114 New South Wales, Australia
    J Clin Epidemiol 57:1244-52. 2004
    ..If the response is measured with error, the resulting NNT is biased. We consider methods to reduce this bias...
  87. pmc Monitoring in chronic disease: a rational approach
    Paul Glasziou
    University of Oxford, Department of Primary Health Care, Oxford OX3 7LF, UK
    BMJ 330:644-8. 2005
  88. ncbi request reprint Review of complex breast cysts: implications for cancer detection and clinical practice
    Nehmat Houssami
    New South Wales Breast Cancer Institute, Westmead Hospital, New South Wales, Australia
    ANZ J Surg 75:1080-5. 2005
    ..Provided adequate information is given to the patient, complex breast cysts with a very low risk of malignancy do not always require image-guided biopsy...
  89. pmc Evaluating new screening tests for breast cancer
    Les Irwig
    BMJ 332:678-9. 2006
  90. ncbi request reprint Re: In response to the correspondence arising from Twisk and Proper: evaluation of the results of a randomized controlled trial: how to define changes between baseline and follow-up
    Siew F Chan
    J Clin Epidemiol 59:323; author reply 323-4. 2006