K F Ilett

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint 1998 International Meeting on the Arylamine N-Acetyltransferases: synopsis of the workshop on nomenclature, biochemistry, molecular biology, interspecies comparisons, and role in human disease risk
    K F Ilett
    Department of Pharmacology, University of Western Australia, Perth, Australia
    Drug Metab Dispos 27:957-9. 1999
  2. ncbi request reprint Use of nicotine patches in breast-feeding mothers: transfer of nicotine and cotinine into human milk
    Kenneth F Ilett
    Pharmacology Unit, M510, School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Western Australia, Australia
    Clin Pharmacol Ther 74:516-24. 2003
  3. ncbi request reprint Transfer of risperidone and 9-hydroxyrisperidone into human milk
    Kenneth F Ilett
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Ann Pharmacother 38:273-6. 2004
  4. ncbi request reprint Drug use and breastfeeding
    Kenneth F Ilett
    University of Western Australia, School of Medicine and Pharmacology, Crawley, 6009, Australia
    Expert Opin Drug Saf 4:745-68. 2005
  5. pmc The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria
    Kenneth F Ilett
    Department of Pharmacology, University of Western Australia, Nedlands 6009 Western Australia
    Br J Clin Pharmacol 53:23-30. 2002
  6. pmc Distribution of venlafaxine and its O-desmethyl metabolite in human milk and their effects in breastfed infants
    Kenneth F Ilett
    Department of Pharmacology, University of Western Australia, Nedlands 6009 Western Australia
    Br J Clin Pharmacol 53:17-22. 2002
  7. pmc Modification of general practitioner prescribing of antibiotics by use of a therapeutics adviser (academic detailer)
    K F Ilett
    Department of Pharmacology, University of Western Australia, Nedlands, Perth, Australia
    Br J Clin Pharmacol 49:168-73. 2000
  8. ncbi request reprint Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid
    N J Butcher
    Department of Pharmacology, University of Western Australia, Western Australia 6907, Nedlands, Australia
    Biochem Pharmacol 60:1829-36. 2000
  9. pmc Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria
    T M Davis
    Department of Medicine, University of Western Australia, Fremantle Hospital, Fremantle, Australia
    Antimicrob Agents Chemother 45:181-6. 2001
  10. pmc The excretion of dothiepin and its primary metabolites in breast milk
    K F Ilett
    Combined Unit in Clinical Pharmacology and Toxicology, University of Western Australia, Nedlands
    Br J Clin Pharmacol 33:635-9. 1992

Collaborators

Detail Information

Publications74

  1. ncbi request reprint 1998 International Meeting on the Arylamine N-Acetyltransferases: synopsis of the workshop on nomenclature, biochemistry, molecular biology, interspecies comparisons, and role in human disease risk
    K F Ilett
    Department of Pharmacology, University of Western Australia, Perth, Australia
    Drug Metab Dispos 27:957-9. 1999
    ..The full text of all meeting abstracts can be viewed at...
  2. ncbi request reprint Use of nicotine patches in breast-feeding mothers: transfer of nicotine and cotinine into human milk
    Kenneth F Ilett
    Pharmacology Unit, M510, School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Western Australia, Australia
    Clin Pharmacol Ther 74:516-24. 2003
    ..Our objective was to assess the extent of exposure to nicotine and cotinine in breast-fed infants during maternal smoking and later during maternal use of the nicotine transdermal patch to achieve smoking cessation...
  3. ncbi request reprint Transfer of risperidone and 9-hydroxyrisperidone into human milk
    Kenneth F Ilett
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Ann Pharmacother 38:273-6. 2004
    ..3%, 2.8%, and 4.7% (as risperidone equivalents) of the maternal weight-adjusted doses. Risperidone and 9-hydroxyrisperidone were not detected in the plasma of the 2 breast-fed infants studied, and no adverse effects were noted...
  4. ncbi request reprint Drug use and breastfeeding
    Kenneth F Ilett
    University of Western Australia, School of Medicine and Pharmacology, Crawley, 6009, Australia
    Expert Opin Drug Saf 4:745-68. 2005
    ....
  5. pmc The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria
    Kenneth F Ilett
    Department of Pharmacology, University of Western Australia, Nedlands 6009 Western Australia
    Br J Clin Pharmacol 53:23-30. 2002
    ..To obtain pharmacokinetic data for artesunate (ARTS) and its active metabolite dihydroartemisinin (DHA) following i.m. ARTS and rectal DHA administration...
  6. pmc Distribution of venlafaxine and its O-desmethyl metabolite in human milk and their effects in breastfed infants
    Kenneth F Ilett
    Department of Pharmacology, University of Western Australia, Nedlands 6009 Western Australia
    Br J Clin Pharmacol 53:17-22. 2002
    ....
  7. pmc Modification of general practitioner prescribing of antibiotics by use of a therapeutics adviser (academic detailer)
    K F Ilett
    Department of Pharmacology, University of Western Australia, Nedlands, Perth, Australia
    Br J Clin Pharmacol 49:168-73. 2000
    ..This was a pilot study of the use of a clinical pharmacist as a therapeutics adviser (academic detailer) to modify antibiotic prescribing by general practitioners...
  8. ncbi request reprint Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid
    N J Butcher
    Department of Pharmacology, University of Western Australia, Western Australia 6907, Nedlands, Australia
    Biochem Pharmacol 60:1829-36. 2000
    ..This is in contrast to our findings for PABA, which appears to reduce NAT1 activity by down-regulating the enzyme, leading to a decrease in NAT1 protein content...
  9. pmc Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria
    T M Davis
    Department of Medicine, University of Western Australia, Fremantle Hospital, Fremantle, Australia
    Antimicrob Agents Chemother 45:181-6. 2001
    ..Conventional doses of artesunate are safe and effective when given to patients with complications of falciparum malaria...
  10. pmc The excretion of dothiepin and its primary metabolites in breast milk
    K F Ilett
    Combined Unit in Clinical Pharmacology and Toxicology, University of Western Australia, Nedlands
    Br J Clin Pharmacol 33:635-9. 1992
    ..No adverse effects were found in any of the eight infants. 5. Use of dothiepin by depressed mothers is unlikely to be a significant hazard to their breast-feeding infants...
  11. ncbi request reprint Cyclosporin immunosuppression of sheep: pharmacokinetics and allograft survival
    A H Rose
    Department of Medicine, University of Western Australia and Fremantle Hospital, Freemantle, WA 6160, Australia
    Vet Immunol Immunopathol 81:23-36. 2001
    ..Provided that the trough concentration of blood CsA was maintained between 1500-2500 mg/l, long-term healthy skin allografts were maintained on the sheep without significant adverse effects on haematological or biochemical parameters...
  12. ncbi request reprint Severe falciparum malaria with hyperparasitaemia treated with intravenous artesunate
    T M Davis
    Fremantle Hospital, WA
    Med J Aust 166:416-8. 1997
    ..This case illustrates the potential for malaria to be fatal despite appropriate treatment and is one of the first reports of the use of artesunate in a hospital in a developed country...
  13. ncbi request reprint Disposition of dothiepin after overdose: effects of repeated-dose activated charcoal
    K F Ilett
    Department of Pharmacology, University of Western Australia, Nedlands
    Ther Drug Monit 13:485-9. 1991
    ..We suggest that repeated-dose activated charcoal treatment may decrease the dothiepin half-life after overdose...
  14. pmc Pharmacokinetics and pharmacodynamics of gliclazide in Caucasians and Australian Aborigines with type 2 diabetes
    T M Davis
    University of Western Australia, Department of Medicine, Fremantle Hospital, Fremantle, Western Australia, Australia
    Br J Clin Pharmacol 49:223-30. 2000
    ..Gliclazide pharmacokinetics and pharmacodynamics were assessed in 9 Caucasians and 10 Australian Aborigines with uncomplicated type 2 diabetes...
  15. pmc Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam
    L J Dusci
    Combined Unit in Clinical Pharmacology and Toxicology, State Health Laboratory Services, Perth, Western Australia
    Br J Clin Pharmacol 29:123-6. 1990
    ..5 and 9.6 micrograms l-1) were present. The infant showed no overt physical or mental symptoms of benzodiazepine intoxication...
  16. ncbi request reprint Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations
    N J Butcher
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    Pharmacogenetics 8:67-72. 1998
    ..Because NAT1 can bioactivate several carcinogens, this polymorphism may have implications for cancer risk in individual subjects...
  17. ncbi request reprint Quantification of naltrexone and 6,beta-naltrexol in plasma and milk using gas chromatography-mass spectrometry. Application to studies in the lactating sheep
    C F Chan
    Department of Pharmacology, The University of Western Australia, Crawley, Australia
    J Chromatogr B Biomed Sci Appl 761:85-92. 2001
    ..Analysis of the plasma and milk from the lactating sheep showed mean milk-to-plasma ratios of 55 for naltrexone and 3 for 6,beta-naltrexol...
  18. ncbi request reprint Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain
    Kirsten Auret
    Palliative Care Unit Hollywood Private Hospital, Nedlands, Australia
    Ther Drug Monit 28:359-66. 2006
    ..Best practice for methadone use in this patient group should include monitoring of both pain and methadone concentration...
  19. ncbi request reprint Transfer of reboxetine into breastmilk, its plasma concentrations and lack of adverse effects in the breastfed infant
    L Peter Hackett
    Clinical Pharmacology and Toxicology Laboratory, PathWest Laboratory Medicine, Nedlands, Australia
    Eur J Clin Pharmacol 62:633-8. 2006
    ..To investigate the transfer of reboxetine into milk, the absolute and relative infant doses via milk and to assess plasma concentrations and adverse unwanted effects in the breastfed infant...
  20. ncbi request reprint Transfer of probenecid and cephalexin into breast milk
    Kenneth F Ilett
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Ann Pharmacother 40:986-9. 2006
    ..To report a case of the transfer of probenecid and cephalexin into human milk...
  21. pmc In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs
    Timothy M E Davis
    University of Western Australia, School of Medicine and Pharmacology, Crawley, Western Australia 6959, Australia
    Antimicrob Agents Chemother 50:2883-5. 2006
    ..Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines...
  22. pmc Artesunate suppositories versus intramuscular artemether for treatment of severe malaria in children in Papua New Guinea
    Harin A Karunajeewa
    Medicine Unit Fremantle, School of Medicine and Pharmacology, University of Western Australia, Crawley
    Antimicrob Agents Chemother 50:968-74. 2006
    ..In severely ill children with malaria in PNG, artesunate suppositories were at least as effective as i.m. artemether and may, therefore, be useful in settings where parenteral therapy cannot be given...
  23. pmc Effects of a high-fat meal on the relative oral bioavailability of piperaquine
    Ing Kye Sim
    Medicine Unit Fremantle, M510, School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia
    Antimicrob Agents Chemother 49:2407-11. 2005
    ..020). The side effects, postural blood pressure changes, electrocardiographic corrected QT interval, serum glucose, and other biochemical and hematological indices were similar in the fasting and fed states over 28 days of follow-up...
  24. ncbi request reprint Artemisinin-based combination therapies for uncomplicated malaria
    Timothy M E Davis
    Medicine Unit, School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, Fremantle, WA
    Med J Aust 182:181-5. 2005
    ..The goal of potent, safe, easy-to-administer and inexpensive ACTs may see trioxolanes in place of artemisinin derivatives, as well as novel partner drugs such as pyronaridine or naphthoquine, in the future...
  25. ncbi request reprint Piperaquine: a resurgent antimalarial drug
    Timothy M E Davis
    Medicine Unit Fremantle and Pharmacology Unit Nedlands, School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Drugs 65:75-87. 2005
    ..The tolerability, efficacy, pharmacokinetic profile and low cost of piperaquine make it a promising partner drug for use as part of an ACT...
  26. pmc Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria
    Harin A Karunajeewa
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Antimicrob Agents Chemother 48:2966-72. 2004
    ..An ARTS suppositories dose of 10 of 20 mg/kg is appropriate for use in children with uncomplicated malaria...
  27. pmc Transfer of escitalopram and its metabolite demethylescitalopram into breastmilk
    Jonathan Rampono
    Department of Psychological Medicine, Women s and Children s Health Service, Subiaco, Australia
    Br J Clin Pharmacol 62:316-22. 2006
    ..To investigate the transfer of escitalopram and its demethyl metabolite into milk, the absolute and relative infant doses via milk and to assess any unwanted effects in the breastfed infant...
  28. pmc Transfer of the antidepressant mirtazapine into breast milk
    J H Kristensen
    Pharmacy Department, Women s and Children s Health Service, Subiaco, Australia
    Br J Clin Pharmacol 63:322-7. 2007
    ..To investigate the transfer of mirtazapine and desmethylmirtazapine into milk and to calculate dose to the infant via milk...
  29. ncbi request reprint Gabapentin and breastfeeding: a case report
    Judith H Kristensen
    Department of Pharmacy at the Women s and Children s Health Service, Subiaco, Western Australia
    J Hum Lact 22:426-8. 2006
    ..In combination with a previously published report, these limited data support the prescription of gabapentin to a breastfeeding mother after a careful individual risk-benefit analysis...
  30. ncbi request reprint Pharmacokinetics of dihydroartemisinin in a murine malaria model
    Kevin T Batty
    School of Pharmacy, Curtin University of Technology, Bentley, Western Australia
    Am J Trop Med Hyg 78:641-2. 2008
    ..3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic-pharmacodynamic evaluations of DHA in murine models...
  31. pmc Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk
    Kenneth F Ilett
    Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Br J Clin Pharmacol 65:661-6. 2008
    ..There are presently no published data on tramadol transfer into breast milk or on its effects in the breastfed infant...
  32. pmc Transfer of chloroquine and desethylchloroquine across the placenta and into milk in Melanesian mothers
    Irwin Law
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Br J Clin Pharmacol 65:674-9. 2008
    ..The literature on placental and milk transfer of chloroquine and its major bioactive metabolite desethylchloroquine is sparse and incomplete...
  33. doi request reprint Disposition and clinical outcome after intraperitoneal meperidine and ropivacaine administration during laparoscopic surgery
    Michael J Paech
    Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia
    Anesth Analg 106:278-86, table of contents. 2008
    ..The null hypothesis was that there was no significant difference among groups for dynamic pain in the first 24 h after major abdominal laparoscopic surgery...
  34. pmc Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model
    Brioni R Moore
    School of Pharmacy, Curtin University of Technology, Bentley, Western Australia, Australia
    Antimicrob Agents Chemother 52:306-11. 2008
    ..berghei infection. PQ has a potent antimalarial effect after single-dose treatment, and its efficacy was enhanced by combination with DHA...
  35. pmc Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria
    Harin A Karunajeewa
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Antimicrob Agents Chemother 52:237-43. 2008
    ..Although PQ has a longer t 1/2 beta than CQ, its prompt distribution and lack of active metabolite may limit its posttreatment malaria-suppressive properties...
  36. ncbi request reprint Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin
    Peter L Gibbons
    School of Pharmacy, Curtin University of Technology, Bentley, GPO Box U1987, Perth, WA 6845, Australia
    Int J Parasitol 37:1569-76. 2007
    ..This study demonstrates that a murine malaria pharmacodynamic model is a valuable tool for understanding how single drugs and their dosing schedules alter the time course and level of infection...
  37. ncbi request reprint Rectal administration of artemisinin derivatives for the treatment of malaria
    Harin A Karunajeewa
    Medicine Unit, School of Medicine and Pharmacology, University of Western Australia, Fremantle, Australia
    JAMA 297:2381-90. 2007
    ..Many different preparations are marketed in tropical countries, but their pharmacokinetic disposition and clinical efficacy may vary...
  38. pmc Transfer of dexamphetamine into breast milk during treatment for attention deficit hyperactivity disorder
    Kenneth F Ilett
    Pharmacology Unit M510, School of Medicine and Pharmacology, University of Western Australia, 35 Stirling Hwy, Crawley, 6009 Australia
    Br J Clin Pharmacol 63:371-5. 2007
    ..To investigate dexamphetamine transfer into milk, infant doses and effects in the breast-fed infant...
  39. ncbi request reprint Quetiapine and breast feeding
    Jonathan Rampono
    Department of Psychological Medicine, King Edward Memorial Hospital for Women, Subiaco, Western Australia
    Ann Pharmacother 41:711-4. 2007
    ..To quantify the relative infant dose of quetiapine during breast feeding, describe the milk:plasma (M:P) ratio, and determine the well-being of the exposed infant...
  40. pmc Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers
    Timothy M E Davis
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, P O Box 480, Fremantle, Western Australia 6959, Australia
    Antimicrob Agents Chemother 51:1099-101. 2007
    ..The areas under the concentration-time curve from 0 h to infinity for dihydroartemisinin, the active metabolite of artesunate, were similar on day 3 of the two dosing periods (P = 0.12), implying no interaction...
  41. doi request reprint Toxicology and pharmacokinetics of piperaquine in mice
    Kevin T Batty
    School of Pharmacy, Curtin University of Technology, Bentley, Western Australia, Australia
    Toxicology 249:55-61. 2008
    ..Significant effects in humans will likely be infrequent and dose-related...
  42. ncbi request reprint The selective pulmonary vasodilatory effect of inhaled DETA/NO, a novel nitric oxide donor, in ARDS-a pilot human trial
    Chen Fuh Lam
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    J Crit Care 19:48-53. 2004
    ..To examine the effects of inhaled NONOates in patients with acute respiratory distress syndrome (ARDS)...
  43. ncbi request reprint The safety of aerosolized diethylenetriamine nitric oxide adduct after single-dose administration to anesthetized piglets and multiple-dose administration to conscious rats
    Chen Fuh Lam
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia
    Toxicol Appl Pharmacol 190:65-71. 2003
    ..This study shows no evidence of pulmonary or hematological toxicity following single or repeated doses of DETA/NO in animals...
  44. ncbi request reprint Measurement of piperaquine in plasma by liquid chromatography with ultraviolet absorbance detection
    Te Yu Hung
    School of Medicine and Pharmacology, The University of Western Australia, Crawley 6009, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 791:93-101. 2003
    ..56 g of PQ phosphate orally with dihydroartemisinin as four doses over 32 h found an apparent steady-state volume of distribution of 447 l/kg, an apparent oral clearance 0.93 l/h/kg and a terminal half-life of 17.3 days...
  45. ncbi request reprint Toxicity related to chloroquine treatment of resistant vivax malaria
    Timothy M E Davis
    School of Medicine and Pharmacology, Fremantle Hospital, Fremantle, Western Australia, Australia
    Ann Pharmacother 37:526-9. 2003
    ..To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax...
  46. ncbi request reprint Safety and therapeutic efficacy of artesunate suppositories for treatment of malaria in children in Papua New Guinea
    Harin A Karunajeewa
    University of Western Australia, School of Medicine and Pharmacology, Perth, Australia
    Pediatr Infect Dis J 22:251-6. 2003
    ..Although suppositories of artemisinin derivatives may be a valuable option for treatment of malaria in children when circumstances prevent oral and parenteral therapy, few confirmatory data have been published...
  47. ncbi request reprint Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension
    Chen F Lam
    Department of Pharmacology, University of Western Australia, Crawley, Australia
    Chest 123:869-74. 2003
    ..To determine the selective vasodilatory effects of two inhaled "NONOate" aerosols in a closed chest pig model of acute pulmonary hypertension (APH)...
  48. pmc Penetration of dihydroartemisinin into cerebrospinal fluid after administration of intravenous artesunate in severe falciparum malaria
    Timothy M E Davis
    Tropical Diseases Research Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam
    Antimicrob Agents Chemother 47:368-70. 2003
    ..No artesunate was detectable in CSF. In both studies, DHA levels in CSF increased with time while dihydroartemisinin levels in plasma fell. Dihydroartemisinin might accumulate in CSF during frequent artesunate dosing...
  49. ncbi request reprint The ratio of polymorphonuclear leucocytes (PMN) to non-PMN cells--a novel method of assessing acute lung inflammation
    Chen Fuh Lam
    Pharmacology Department, University of Western Australia, Crawley, Australia
    Exp Toxicol Pathol 54:187-91. 2002
    ..It is suitable for use in research of lung inflammation, and as an accessory diagnostic tool and an objective descriptor for clinical histopathology...
  50. ncbi request reprint Cyclosporin monitoring in Australasia: 2002 update of consensus guidelines
    Raymond G Morris
    Department of Cardiology and Clinical Pharmacology, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Ther Drug Monit 24:677-88. 2002
    ..The revision was prepared following a recent survey of all Australasian CsA-monitoring laboratories where discordant practices were evident...
  51. ncbi request reprint Studying drugs in human milk: time to unify the approach
    Evan J Begg
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    J Hum Lact 18:323-32. 2002
    ....
  52. ncbi request reprint Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases
    Kenneth F Ilett
    Department of Pharmacology, University of Western Australia, Crawley, Western Australia
    Drug Metab Dispos 30:1005-12. 2002
    ..There was no significant metabolism of DHA by cytochrome-P450 oxidation or by cytosolic sulfotransferases. We conclude that alpha-DHA-G is an important metabolite of DHA in humans and that its formation is catalyzed by UGT1A9 and UGT2B7...
  53. ncbi request reprint Inhaled diazeniumdiolates (NONOates) as selective pulmonary vasodilators
    Chen Fuh Lam
    Department of Pharmacology, University of Western Australia, Crawley, WA 6009, Australia
    Expert Opin Investig Drugs 11:897-909. 2002
    ..This review focuses on the therapeutic potential of inhaled NONOates in pulmonary hypertension, other lung conditions associated with right ventricular dysfunction and in asthma. The potential toxicity of NONOates is also discussed...
  54. ncbi request reprint The amount of fluvoxamine in milk is unlikely to be a cause of adverse effects in breastfed infants
    Judith H Kristensen
    Department of Pharmacy, King Edward Memorial and Princess Margaret Hospitals, Bagot Road, Subiaco 6008, Western Australia
    J Hum Lact 18:139-43. 2002
    ..These limited data support the prescription of fluvoxamine to breastfeeding mothers after a careful, individual risk/benefit analysis is undertaken...
  55. pmc Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk
    Khalidah Aljazaf
    Department of Medical Imaging, Curtin University of Technology, Bentley, Western Australia
    Br J Clin Pharmacol 56:18-24. 2003
    ..To assess the effects of pseudoephedrine on breast blood flow, temperature and milk production, and to estimate the likely infant dose during breastfeeding...
  56. pmc Population pharmacokinetics of piperaquine in adults and children with uncomplicated falciparum or vivax malaria
    Te Yu Hung
    Medicine Unit Fremantle Hospital and Pharmacology Unit Queen Elizabeth 2 Medical Centre, School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Br J Clin Pharmacol 57:253-62. 2004
    ..To study the population pharmacokinetics of piperaquine after co-administration with dihydroartemisinin in uncomplicated malaria...
  57. ncbi request reprint Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene
    James L Maggs
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, UK
    Chem Biol Interact 147:173-84. 2004
    ..Cellular glutathione was depleted under these conditions. Therefore arteflene was acutely cytotoxic, though only at relatively high concentrations, when it was metabolized via a pathway which generates carbon-centered radicals...
  58. pmc Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria
    Harin Karunajeewa
    Medicine Unit Fremantle Hospital, School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia
    Br J Clin Pharmacol 57:93-9. 2004
    ..To assess the haemodynamic, electrocardiographic and glycaemic effects of piperaquine-dihydroartemisinin (Artekin) fixed combination therapy in uncomplicated malaria...
  59. ncbi request reprint Measurement of nicotine and cotinine in human milk by high-performance liquid chromatography with ultraviolet absorbance detection
    Madhu Page-Sharp
    Pharmacology Unit, School of Medicine and Pharmacology, The University of Western Australia, M510, 35 Stirling Highway, Crawley 6009, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 796:173-80. 2003
    ..We found that this method was sensitive and reliable in measuring nicotine and cotinine concentrations in milk from a nursing mother who participated in a trial of the nicotine patch for smoking cessation...
  60. ncbi request reprint Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurh Hospital, New Zealand
    Am J Psychiatry 160:1428-31. 2003
    ..This study characterized infant drug doses and breast-milk-to-plasma area-under-the-curve ratios for olanzapine and determined plasma concentrations and effects of this drug on breast-feeding infants...
  61. pmc Protein binding and alpha : beta anomer ratio of dihydroartemisinin in vivo
    Kevin T Batty
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Br J Clin Pharmacol 57:529-33. 2004
    ..To determine the ratio of alpha : beta anomers and the protein binding of dihydroartemisinin (DHA) in vivo...
  62. ncbi request reprint Transfer of naltrexone and its metabolite 6,beta-naltrexol into human milk
    Carol F Chan
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia
    J Hum Lact 20:322-6. 2004
    ..Only 6,beta-naltrexol was detected in infant plasma and at a very low concentration of 1.1 micro g/L. Use of naltrexone during breastfeeding should be undertaken only after an individual risk benefit analysis...
  63. ncbi request reprint Determination of olanzapine in plasma by high-performance liquid chromatography using ultraviolet absorbance detection
    Leon J Dusci
    Clinical Pharmacology and Toxicology Laboratory, The Western Australian Centre for Pathology and Medical Research, Locked Bag 2009, Nedlands 6009, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 773:191-7. 2002
    ..The method has been used to measure olanzapine concentrations in patients treated with various doses of the drug varying from 5 to 40 mg/day...
  64. pmc Comparison of gentamicin dose estimates derived from manual calculations, the Australian 'Therapeutic Guidelines: Antibiotic' nomogram and the SeBA-GEN and DoseCalc software programs
    Mitali Mohan
    School of Pharmacy, Curtin University of Technology, Bentley, Western Australia, Australia
    Br J Clin Pharmacol 58:521-7. 2004
    ..To compare gentamicin dose estimates from four predictive methods...
  65. ncbi request reprint A pilot study of newer antidepressant concentrations in cord and maternal serum and possible effects in the neonate
    Jonathan Rampono
    Department of Psychological Medicine, Womens and Childrens Health Service Subiaco, WA, Australia
    Int J Neuropsychopharmacol 7:329-34. 2004
    ..Our data show substantial placental transfer of antidepressants, but only fluoxetine persisted in the infants serum. Neonatal toxicity may be associated with serotonin uptake blockade, and also be influenced by neonatal clearance...
  66. ncbi request reprint Olanzapine excretion in human breast milk: estimation of infant exposure
    Simon Croke
    Department of Psychiatry, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Int J Neuropsychopharmacol 5:243-7. 2002
    ..As with other antipsychotic drugs this study demonstrates that olanzapine passes into breast milk. The long-term effects of exposure in infants exposed to olanzapine requires further investigation...
  67. pmc Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk
    Elise W X Wan
    Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Br J Clin Pharmacol 66:283-9. 2008
    ..To investigate the possibility of a dose-response relationship for the use of domperidone in treating insufficient milk supply in mothers of preterm infants, and to quantify the exposure of the breastfed infant to domperidone...
  68. pmc Role of P glycoprotein in absorption of novel antimalarial drugs
    Andrew Crowe
    Curtin University of Technology, School of Pharmacy, Perth, Western Australia, Australia
    Antimicrob Agents Chemother 50:3504-6. 2006
    ..With 20 microM naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system...
  69. ncbi request reprint Prediction of milk/plasma concentration ratio of drugs
    Kenneth F Ilett
    Ann Pharmacother 38:175-6; author's reply 176. 2004
  70. ncbi request reprint Blood concentrations of enflurane before, during, and after hypothermic cardiopulmonary bypass
    C Roger Goucke
    Department of Anaesthesia, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    J Cardiothorac Vasc Anesth 21:218-23. 2007
    ....
  71. ncbi request reprint Diethylenetriamine nitric oxide adduct relaxes precontracted mouse tracheal smooth muscle
    Chen Fuh Lam
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Clin Exp Pharmacol Physiol 30:709-11. 2003
    ..4. We conclude that DETA/NO induces a concentration-dependent relaxation of mouse carbachol-contracted isolated tracheal smooth muscle that is mediated by NO released from DETA/NO via the activation of sGC...
  72. ncbi request reprint Transfer of lamotrigine into breast milk
    Madhu Page-Sharp
    Ann Pharmacother 40:1470-1. 2006
  73. ncbi request reprint Methylphenidate and breast-feeding
    L Peter Hackett
    Ann Pharmacother 40:1890-1. 2006
  74. doi request reprint Evaluation of a deuterium-labeled internal standard for the measurement of sirolimus by high-throughput HPLC electrospray ionization tandem mass spectrometry
    Sean O'Halloran
    Clinical Pharmacology and Toxicology, PathWest Laboratory Medicine, Nedlands, Australia
    Clin Chem 54:1386-9. 2008
    ..A stable isotope-labeled IS can be used to minimize analytical interpatient variation...