Barry Iacopetta

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc Failure to complete adjuvant chemotherapy is associated with adverse survival in stage III colon cancer patients
    M Morris
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Br J Cancer 96:701-7. 2007
  2. pmc Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
    Feng Zhu
    Department of Medicine, National University of Singapore, Singapore, Singapore
    BMC Gastroenterol 9:76. 2009
  3. pmc Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features
    Pei Woon Ang
    Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
    BMC Cancer 10:227. 2010
  4. ncbi request reprint Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa
    Barry Iacopetta
    School of Surgery and Pathology, WA Institute for Medical Research, University of Western Australia, 35 Stirling Highway, Nedlands 6009, Australia
    Cancer Sci 98:1454-60. 2007
  5. doi request reprint Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup?
    Barry Iacopetta
    School of Surgery M507, University of Western Australia, Nedlands, 6009, Australia
    Int J Clin Oncol 13:498-503. 2008
  6. doi request reprint The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer
    Barry Iacopetta
    School of Surgery, University of Western Australia, Nedlands, Australia
    Int J Cancer 125:84-90. 2009
  7. ncbi request reprint APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Int J Cancer 119:2272-8. 2006
  8. doi request reprint Microsatellite instability in colorectal cancer
    Barry Iacopetta
    School of Surgery, University of Western Australia Anatomical Pathology, PathWest, Nedlands, Western Australia, Australia
    Asia Pac J Clin Oncol 6:260-9. 2010
  9. ncbi request reprint Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer
    Shao Ying Li
    School of Surgery and Pathology, University of Western Australia, Nedlands
    Oncol Rep 15:221-5. 2006
  10. doi request reprint Tumor-infiltrating lymphocytes and perforation in colon cancer predict positive response to 5-fluorouracil chemotherapy
    Melinda Morris
    School of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia, Australia
    Clin Cancer Res 14:1413-7. 2008

Collaborators

Detail Information

Publications39

  1. pmc Failure to complete adjuvant chemotherapy is associated with adverse survival in stage III colon cancer patients
    M Morris
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Br J Cancer 96:701-7. 2007
    ..Further prospective studies are required to identify better the physiological and socioeconomic factors responsible for failure to complete chemotherapy so that appropriate improvements in health service delivery can be made...
  2. pmc Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
    Feng Zhu
    Department of Medicine, National University of Singapore, Singapore, Singapore
    BMC Gastroenterol 9:76. 2009
    ..A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC...
  3. pmc Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features
    Pei Woon Ang
    Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
    BMC Cancer 10:227. 2010
    ..In the present study we performed comprehensive DNA methylation profiling of CRC with the aim of characterizing CIMP subgroups...
  4. ncbi request reprint Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa
    Barry Iacopetta
    School of Surgery and Pathology, WA Institute for Medical Research, University of Western Australia, 35 Stirling Highway, Nedlands 6009, Australia
    Cancer Sci 98:1454-60. 2007
    ..Further investigation of genomic and CpG island methylation in normal colonic mucosa and the possible influences of environmental and genetic factors may provide new insights into the development of CIMP+ colorectal cancer...
  5. doi request reprint Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup?
    Barry Iacopetta
    School of Surgery M507, University of Western Australia, Nedlands, 6009, Australia
    Int J Clin Oncol 13:498-503. 2008
    ..Further studies on tumors from randomized clinical trials are required to confirm the value of CIMP+ and associated molecular features for the prediction of clinical outcome to 5-FU-based chemotherapy...
  6. doi request reprint The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer
    Barry Iacopetta
    School of Surgery, University of Western Australia, Nedlands, Australia
    Int J Cancer 125:84-90. 2009
    ..02). Epidemiological studies on dietary and genetic risk factors for CRC should take into account these may confer different risks for right- and left-sided tumors...
  7. ncbi request reprint APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Int J Cancer 119:2272-8. 2006
    ..003) and with lower concentrations of methyl group carriers (p < 0.05). These findings highlight the importance of gene selection in studies that aim to characterize the biological features and clinical behaviour of CIMP+ tumours...
  8. doi request reprint Microsatellite instability in colorectal cancer
    Barry Iacopetta
    School of Surgery, University of Western Australia Anatomical Pathology, PathWest, Nedlands, Western Australia, Australia
    Asia Pac J Clin Oncol 6:260-9. 2010
    ..Finally, the MSI status of CRC is an extremely useful marker for population-based screening programs that aim to identify individuals and families with the hereditary cancer condition known as Lynch syndrome...
  9. ncbi request reprint Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer
    Shao Ying Li
    School of Surgery and Pathology, University of Western Australia, Nedlands
    Oncol Rep 15:221-5. 2006
    ..Our results show that polymorphisms in two genes involved in methyl group metabolism are associated with hormone receptor content and DNA methylation frequency in breast cancer, however these observations are unlikely to be linked...
  10. doi request reprint Tumor-infiltrating lymphocytes and perforation in colon cancer predict positive response to 5-fluorouracil chemotherapy
    Melinda Morris
    School of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia, Australia
    Clin Cancer Res 14:1413-7. 2008
    ..The aim of the present study was to investigate the prognostic significance of TILs and other routinely reported pathologic features in colon cancer, particularly in relation to the use of adjuvant chemotherapy...
  11. doi request reprint Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
    Paul Salama
    School of Surgery and Biostatistics Unit, Cancer Trials, Western Australian Institute for Medical Research, University of Western Australia, Australia
    J Clin Oncol 27:186-92. 2009
    ..To determine the prognostic significance of FOXP3(+) lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8(+) and CD45RO(+) lymphocyte densities...
  12. doi request reprint Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test
    Lyn Schofield
    School of Surgery, University of Western Australia, Nedlands, Australia
    Int J Cancer 124:1097-102. 2009
    ..We recommend MSI as the initial test for population-based screening of Lynch syndrome in younger CRC patients, regardless of family history...
  13. ncbi request reprint CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer
    Marius van Rijnsoever
    Departments of Surgery, University of Western Australia, Nedlands 6907, Australia
    Clin Cancer Res 9:2898-903. 2003
    ..The two cohorts were randomly pair-matched for age, sex, and tumor site, and the median length of follow-up time was 39 months...
  14. pmc BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status
    Wei Qi Li
    School of Surgery and Pathology, University of Western Australia, Nedlands, WA 6009, Australia
    Mol Cancer 5:2. 2006
    ..The aim of the present study was to evaluate the clinical, pathological and molecular phenotype of colorectal tumors with BRAF mutations...
  15. doi request reprint BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients
    Pei Woon Ang
    School of Surgery M507, University of Western Australia, 35 Stirling Hwy, Nedlands 6009, Australia
    Cancer Lett 273:221-4. 2009
    ..02). BRAF mutation and CIMP+ are therefore likely to be involved in an alternate, albeit rare, pathway to APC inactivation during the development of CRC in younger patients...
  16. pmc Heterogeneous staining for mismatch repair proteins during population-based prescreening for hereditary nonpolyposis colorectal cancer
    Natasha Watson
    School of Surgery and Pathology M507, University of Western Australia, Nedlands 6009, Australia
    J Mol Diagn 9:472-8. 2007
    ..Because of possible misinterpretation of heterogeneous immunohistochemistry staining for MMR protein loss, MSI testing is recommended as the initial screen for population-based detection of hereditary nonpolyposis colorectal cancer...
  17. ncbi request reprint Screening for defective DNA mismatch repair in stage II and III colorectal cancer patients
    Siaw Ming Chai
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Clin Gastroenterol Hepatol 2:1017-25. 2004
    ..About 12% of sporadic colorectal cancers also show MMR loss and MSI. The aims of this study were to evaluate MMR loss and MSI in relation to patient age, sex, tumor stage, and site in the large bowel...
  18. ncbi request reprint PIK3CA mutations in breast cancer are associated with poor outcome
    Shao Ying Li
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Breast Cancer Res Treat 96:91-5. 2006
    ..002). PIK3CA mutation was an independent factor for worse survival in breast cancer patients with non-amplified erbB2 (RR = 2.6, 95%CI [1.2-5.5], p = 0.016)...
  19. ncbi request reprint Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype
    Fabienne Grieu
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands 6009, Australia
    Anticancer Res 24:3215-9. 2004
    ..Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate metabolism...
  20. ncbi request reprint Survival rates for stage II colon cancer patients treated with or without chemotherapy in a population-based setting
    Melinda Morris
    School of Surgery and Pathology M507, University of Western Australia, Nedlands, Australia
    Int J Colorectal Dis 22:887-95. 2007
    ..The aim of the present study is to compare the survival rate of stage II colon cancer patients treated by surgery alone with that of patients also treated by chemotherapy...
  21. ncbi request reprint Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers
    Fabienne Grieu
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands 6009, Australia
    Anticancer Res 23:4257-9. 2003
    ..The aim of this case-control study was to investigate whether the common G870A polymorphism in the Cyclin D1 gene (CCND1) is a risk factor for breast and colorectal cancers in an Australian population...
  22. ncbi request reprint Comparing survival outcomes for patients with colorectal cancer treated in public and private hospitals
    Melinda Morris
    School of Surgery and Pathology, University of Western Australia, Perth, WA
    Med J Aust 186:296-300. 2007
    ..To determine whether treatment in a private versus public hospital was an independent predictor of survival outcomes in patients with colorectal cancer...
  23. doi request reprint Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasion
    Paul Salama
    School of Surgery, University of Western Australia, Nedlands, Australia
    Histopathology 59:207-15. 2011
    ..Because there is evidence that some tumour-infiltrating CD8+ T cells may be inactive, the present study aimed to investigate the prognostic significance of Granzyme B, one of the major effector molecules of T cells...
  24. ncbi request reprint A population-based study of age-related variation in clinicopathological features, molecular. Markers and outcome from colorectal cancer
    Melinda Morris
    School of Surgery and Pathology, University of Western Australia, Nedlands 6009, Western Australia
    Anticancer Res 27:2833-8. 2007
    ..To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population-based series of CRC...
  25. ncbi request reprint Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studies
    Fabienne Grieu
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands 6009, Australia
    Oncol Rep 11:501-4. 2004
    ..The low start-up and running costs make this method particularly well suited for SNP genotyping studies that involve up to 1,000 DNA samples...
  26. doi request reprint Incidence of BRAF p.Val600Glu and p.Val600Lys mutations in a consecutive series of 183 metastatic melanoma patients from a high incidence region
    Benhur Amanuel
    Anatomical Pathology, PathWest, Sir Charles Gairdner Hospital, Nedlands, Australia
    Pathology 44:357-9. 2012
    ..Val600Glu (V600E) hotspot mutation in exon 15. The aim of the present study was to investigate the frequency of the less common p.Val600Lys (V600K) mutation in metastatic melanoma from a high incidence region...
  27. doi request reprint FOXP3+ cell density in lymphoid follicles from histologically normal mucosa is a strong prognostic factor in early stage colon cancer
    Paul Salama
    School of Surgery M507, University of Western Australia, 35 Stirling Hwy, Nedlands 6009, Australia
    Cancer Immunol Immunother 61:1183-90. 2012
    ..The density of FOXP3+ cells within lymphoid follicles and the frequency of these structures in normal colonic mucosa represent novel and independent prognostic factors...
  28. ncbi request reprint Methyl-group metabolism and the response of colorectal cancer to 5-fluorouracil
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands
    Crit Rev Oncog 12:115-26. 2006
    ..This is particularly important for early-stage disease where conclusive demonstration of a survival benefit from 5FU in the overall CRC group has thus far proven difficult...
  29. pmc A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma
    Anna Richter
    School of Surgery, University of Western Australia, Nedlands, Australia
    Sci Rep 3:1659. 2013
    ..CAST-PCR was useful for samples with low tumour purity and may also be a cost-effective and robust method for routine diagnostics...
  30. ncbi request reprint Prognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancer
    Cathy Wang
    School of Surgery and Pathology, University of Western Australia, Nedlands 6907, Australia
    Oncology 64:259-65. 2003
    ..In the present study we investigated the prognostic significance of two major genetic alterations in CRC: microsatellite instability (MSI+) and the type of Ki-RAS mutation...
  31. ncbi request reprint DNA hypermethylation in breast cancer and its association with clinicopathological features
    Shaoying Li
    School of Surgery and Pathology, M507, University of Western Australia, Nedlands 6009, Australia
    Cancer Lett 237:272-80. 2006
    ..Our data suggests that gene methylation may be linked to various pathological features of breast cancer, however, this requires confirmation in larger studies...
  32. doi request reprint Selected dietary micronutrients and the risk of right- and left-sided colorectal cancers: a case-control study in Western Australia
    Linde van Lee
    Western Australian Institute for Medical Research, University of Western Australia, Nedlands 6009, Australia
    Ann Epidemiol 21:170-7. 2011
    ..Contradictory results about the role of dietary factors in the causation of colorectal cancer (CRC) may partly be due to failure to discriminate between left- and right-sided CRC...
  33. ncbi request reprint Challenges in the diagnosis and management of Lynch Syndrome in an Indigenous family living in a remote West Australian community
    Lyn Schofield
    Genetic Services of Western Australia, Familial Cancer Program, Perth, Western Australia, Australia
    Rural Remote Health 11:1836. 2011
    ..This approach has now become routine practice in Western Australia and has led to the identification of more than 20 new LS families, including the Indigenous family described in this report...
  34. doi request reprint An improved quality control for bisulfite-PCR-based DNA methylation analysis: cycle threshold value
    Pei Woon Ang
    School of Surgery, University of Western Australia, Nedlands, Australia
    Clin Chem Lab Med 46:1117-21. 2008
    ..Here, we tested whether cycle threshold (Ct) values from real-time quantitative PCR correlate better with the reliability of bisulfite-PCR methylation analyses than spectrophotometric concentrations...
  35. ncbi request reprint Associations between common polymorphisms in TP53 and p21WAF1/Cip1 and phenotypic features of breast cancer
    Brenda L Powell
    Department of Surgery, University of Western Australia, Nedlands 6907, Australia
    Carcinogenesis 23:311-5. 2002
    ..These results add to the growing body of evidence that genetic variants can influence not only the risk of breast cancer but also the disease phenotype...
  36. pmc Aberrant DNA methylation: have we entered the era of more than one type of colorectal cancer?
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Am J Pathol 162:1043-5. 2003
  37. doi request reprint 3D radiotherapy can be safely combined with sandwich systemic gemcitabine chemotherapy in the management of pancreatic cancer: factors influencing outcome
    Nigel Spry
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Int J Radiat Oncol Biol Phys 70:1438-46. 2008
    ....
  38. ncbi request reprint TP53 mutation in colorectal cancer
    Barry Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Hum Mutat 21:271-6. 2003
    ....
  39. ncbi request reprint Are there two sides to colorectal cancer?
    Barry Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Int J Cancer 101:403-8. 2002
    ....