Research Topics
Genomes and GenesSpecies | Barry IacopettaSummaryAffiliation: University of Western Australia Country: Australia Publications
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Publications
Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort studyFeng Zhu
Department of Medicine, National University of Singapore, Singapore, Singapore
BMC Gastroenterol 9:76. 2009..A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC...- Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular featuresPei Woon Ang
Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
BMC Cancer 10:227. 2010..In the present study we performed comprehensive DNA methylation profiling of CRC with the aim of characterizing CIMP subgroups... 
Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosaBarry Iacopetta
School of Surgery and Pathology, WA Institute for Medical Research, University of Western Australia, 35 Stirling Highway, Nedlands 6009, Australia
Cancer Sci 98:1454-60. 2007..Further investigation of genomic and CpG island methylation in normal colonic mucosa and the possible influences of environmental and genetic factors may provide new insights into the development of CIMP+ colorectal cancer...
Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup?Barry Iacopetta
School of Surgery M507, University of Western Australia, Nedlands, 6009, Australia
Int J Clin Oncol 13:498-503. 2008..Further studies on tumors from randomized clinical trials are required to confirm the value of CIMP+ and associated molecular features for the prediction of clinical outcome to 5-FU-based chemotherapy...- Microsatellite instability in colorectal cancerBarry Iacopetta
School of Surgery, University of Western Australia Anatomical Pathology, PathWest, Nedlands, Western Australia, Australia
Asia Pac J Clin Oncol 6:260-9. 2010..Finally, the MSI status of CRC is an extremely useful marker for population-based screening programs that aim to identify individuals and families with the hereditary cancer condition known as Lynch syndrome... - APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancerBarry Iacopetta
School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
Int J Cancer 119:2272-8. 2006..003) and with lower concentrations of methyl group carriers (p < 0.05). These findings highlight the importance of gene selection in studies that aim to characterize the biological features and clinical behaviour of CIMP+ tumours... - The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancerBarry Iacopetta
School of Surgery, University of Western Australia, Nedlands, Australia
Int J Cancer 125:84-90. 2009..02). Epidemiological studies on dietary and genetic risk factors for CRC should take into account these may confer different risks for right- and left-sided tumors... - Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancerShao Ying Li
School of Surgery and Pathology, University of Western Australia, Nedlands
Oncol Rep 15:221-5. 2006..Our results show that polymorphisms in two genes involved in methyl group metabolism are associated with hormone receptor content and DNA methylation frequency in breast cancer, however these observations are unlikely to be linked... - Tumor-infiltrating lymphocytes and perforation in colon cancer predict positive response to 5-fluorouracil chemotherapyMelinda Morris
School of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia, Australia
Clin Cancer Res 14:1413-7. 2008..The aim of the present study was to investigate the prognostic significance of TILs and other routinely reported pathologic features in colon cancer, particularly in relation to the use of adjuvant chemotherapy... - Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancerPaul Salama
School of Surgery and Biostatistics Unit, Cancer Trials, Western Australian Institute for Medical Research, University of Western Australia, Australia
J Clin Oncol 27:186-92. 2009..To determine the prognostic significance of FOXP3(+) lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8(+) and CD45RO(+) lymphocyte densities... - BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability statusWei Qi Li
School of Surgery and Pathology, University of Western Australia, Nedlands, WA 6009, Australia
Mol Cancer 5:2. 2006..The aim of the present study was to evaluate the clinical, pathological and molecular phenotype of colorectal tumors with BRAF mutations... - CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancerMarius van Rijnsoever
Departments of Surgery, University of Western Australia, Nedlands 6907, Australia
Clin Cancer Res 9:2898-903. 2003..This molecular marker should be incorporated into prospective clinical trials of fluorouracil-based therapies to confirm its clinical value... - Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial testLyn Schofield
School of Surgery, University of Western Australia, Nedlands, Australia
Int J Cancer 124:1097-102. 2009..We recommend MSI as the initial test for population-based screening of Lynch syndrome in younger CRC patients, regardless of family history... - BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patientsPei Woon Ang
School of Surgery M507, University of Western Australia, 35 Stirling Hwy, Nedlands 6009, Australia
Cancer Lett 273:221-4. 2009..02). BRAF mutation and CIMP+ are therefore likely to be involved in an alternate, albeit rare, pathway to APC inactivation during the development of CRC in younger patients... - Screening for defective DNA mismatch repair in stage II and III colorectal cancer patientsSiaw Ming Chai
School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
Clin Gastroenterol Hepatol 2:1017-25. 2004..5%) showed loss of hMSH2. CONCLUSIONS: Routine immunohistochemical screening for MMR loss in younger colorectal cancer patients may provide a useful, first-step screening tool for the population-based detection of HNPCC... - Heterogeneous staining for mismatch repair proteins during population-based prescreening for hereditary nonpolyposis colorectal cancerNatasha Watson
School of Surgery and Pathology M507, University of Western Australia, Nedlands 6009, Australia
J Mol Diagn 9:472-8. 2007..Because of possible misinterpretation of heterogeneous immunohistochemistry staining for MMR protein loss, MSI testing is recommended as the initial screen for population-based detection of hereditary nonpolyposis colorectal cancer... - Comparing survival outcomes for patients with colorectal cancer treated in public and private hospitalsMelinda Morris
School of Surgery and Pathology, University of Western Australia, Perth, WA
Med J Aust 186:296-300. 2007..To determine whether treatment in a private versus public hospital was an independent predictor of survival outcomes in patients with colorectal cancer... - Survival rates for stage II colon cancer patients treated with or without chemotherapy in a population-based settingMelinda Morris
School of Surgery and Pathology M507, University of Western Australia, Nedlands, Australia
Int J Colorectal Dis 22:887-95. 2007..The aim of the present study is to compare the survival rate of stage II colon cancer patients treated by surgery alone with that of patients also treated by chemotherapy... - Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasionPaul Salama
School of Surgery, University of Western Australia, Nedlands, Australia
Histopathology 59:207-15. 2011..Because there is evidence that some tumour-infiltrating CD8+ T cells may be inactive, the present study aimed to investigate the prognostic significance of Granzyme B, one of the major effector molecules of T cells... - Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancersFabienne Grieu
Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands 6009, Australia
Anticancer Res 23:4257-9. 2003..The aim of this case-control study was to investigate whether the common G870A polymorphism in the Cyclin D1 gene (CCND1) is a risk factor for breast and colorectal cancers in an Australian population... - PIK3CA mutations in breast cancer are associated with poor outcomeShao Ying Li
School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
Breast Cancer Res Treat 96:91-5. 2006..002). PIK3CA mutation was an independent factor for worse survival in breast cancer patients with non-amplified erbB2 (RR = 2.6, 95%CI [1.2-5.5], p = 0.016)... - Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotypeFabienne Grieu
Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands 6009, Australia
Anticancer Res 24:3215-9. 2004..Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate metabolism... - A population-based study of age-related variation in clinicopathological features, molecular. Markers and outcome from colorectal cancerMelinda Morris
School of Surgery and Pathology, University of Western Australia, Nedlands 6009, Western Australia
Anticancer Res 27:2833-8. 2007..To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population-based series of CRC... - Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studiesFabienne Grieu
Department of Radiation Oncology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands 6009, Australia
Oncol Rep 11:501-4. 2004..The low start-up and running costs make this method particularly well suited for SNP genotyping studies that involve up to 1,000 DNA samples... - Incidence of BRAF p.Val600Glu and p.Val600Lys mutations in a consecutive series of 183 metastatic melanoma patients from a high incidence regionBenhur Amanuel
Anatomical Pathology, PathWest, Sir Charles Gairdner Hospital, Nedlands, Australia
Pathology 44:357-9. 2012..Val600Glu (V600E) hotspot mutation in exon 15. The aim of the present study was to investigate the frequency of the less common p.Val600Lys (V600K) mutation in metastatic melanoma from a high incidence region... - FOXP3+ cell density in lymphoid follicles from histologically normal mucosa is a strong prognostic factor in early stage colon cancerPaul Salama
School of Surgery M507, University of Western Australia, 35 Stirling Hwy, Nedlands 6009, Australia
Cancer Immunol Immunother 61:1183-90. 2012..The density of FOXP3+ cells within lymphoid follicles and the frequency of these structures in normal colonic mucosa represent novel and independent prognostic factors... - Methyl-group metabolism and the response of colorectal cancer to 5-fluorouracilBarry Iacopetta
School of Surgery and Pathology, University of Western Australia, Nedlands
Crit Rev Oncog 12:115-26. 2006..This is particularly important for early-stage disease where conclusive demonstration of a survival benefit from 5FU in the overall CRC group has thus far proven difficult... - DNA hypermethylation in breast cancer and its association with clinicopathological featuresShaoying Li
School of Surgery and Pathology, M507, University of Western Australia, Nedlands 6009, Australia
Cancer Lett 237:272-80. 2006..Our data suggests that gene methylation may be linked to various pathological features of breast cancer, however, this requires confirmation in larger studies... - Prognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancerCathy Wang
School of Surgery and Pathology, University of Western Australia, Nedlands 6907, Australia
Oncology 64:259-65. 2003..Further prospective and/or cohort studies are required to determine whether these molecular changes have predictive value for survival benefit from 5-fluorouracil-based adjuvant chemotherapy... - Selected dietary micronutrients and the risk of right- and left-sided colorectal cancers: a case-control study in Western AustraliaLinde van Lee
Western Australian Institute for Medical Research, University of Western Australia, Nedlands 6009, Australia
Ann Epidemiol 21:170-7. 2011..Contradictory results about the role of dietary factors in the causation of colorectal cancer (CRC) may partly be due to failure to discriminate between left- and right-sided CRC... - Challenges in the diagnosis and management of Lynch Syndrome in an Indigenous family living in a remote West Australian communityLyn Schofield
Genetic Services of Western Australia, Familial Cancer Program, Perth, Western Australia, Australia
Rural Remote Health 11:1836. 2011..This approach has now become routine practice in Western Australia and has led to the identification of more than 20 new LS families, including the Indigenous family described in this report... - An improved quality control for bisulfite-PCR-based DNA methylation analysis: cycle threshold valuePei Woon Ang
School of Surgery, University of Western Australia, Nedlands, Australia
Clin Chem Lab Med 46:1117-21. 2008..Here, we tested whether cycle threshold (Ct) values from real-time quantitative PCR correlate better with the reliability of bisulfite-PCR methylation analyses than spectrophotometric concentrations... - Associations between common polymorphisms in TP53 and p21WAF1/Cip1 and phenotypic features of breast cancerBrenda L Powell
Department of Surgery, University of Western Australia, Nedlands 6907, Australia
Carcinogenesis 23:311-5. 2002..These results add to the growing body of evidence that genetic variants can influence not only the risk of breast cancer but also the disease phenotype... - 3D radiotherapy can be safely combined with sandwich systemic gemcitabine chemotherapy in the management of pancreatic cancer: factors influencing outcomeNigel Spry
Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
Int J Radiat Oncol Biol Phys 70:1438-46. 2008.... - Aberrant DNA methylation: have we entered the era of more than one type of colorectal cancer?Barry Iacopetta
School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
Am J Pathol 162:1043-5. 2003 - TP53 mutation in colorectal cancerBarry Iacopetta
Department of Surgery, University of Western Australia, Nedlands, Australia
Hum Mutat 21:271-6. 2003.... - Are there two sides to colorectal cancer?Barry Iacopetta
Department of Surgery, University of Western Australia, Nedlands, Australia
Int J Cancer 101:403-8. 2002....