B J Iacopetta

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi Methyl-group metabolism and the response of colorectal cancer to 5-fluorouracil
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands
    Crit Rev Oncog 12:115-26. 2006
  2. ncbi BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status
    Wei Qi Li
    School of Surgery and Pathology, University of Western Australia, Nedlands, WA 6009, Australia
    Mol Cancer 5:2. 2006
  3. ncbi Aberrant DNA methylation: have we entered the era of more than one type of colorectal cancer?
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Am J Pathol 162:1043-5. 2003
  4. ncbi TP53 mutation in colorectal cancer
    Barry Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Hum Mutat 21:271-6. 2003
  5. ncbi Routine detection of the replication error phenotype in clinical tumor specimens using fluorescence-SSCP
    B Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Biotechniques 28:566-8, 570. 2000
  6. ncbi Routine analysis of p53 mutation in clinical breast tumor specimens using fluorescence-based polymerase chain reaction and single strand conformation polymorphism
    B Iacopetta
    Department of Surgery, University of Western Australia, Nedlands
    Diagn Mol Pathol 9:20-5. 2000
  7. ncbi Gastric carcinomas with microsatellite instability: clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and BAX genes
    B J Iacopetta
    Department of Surgery, University of Western Australia, Nedlands 6907, Australia
    J Pathol 187:428-32. 1999
  8. ncbi Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations
    B J Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    J Pathol 184:390-5. 1998
  9. ncbi Are there two sides to colorectal cancer?
    Barry Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Int J Cancer 101:403-8. 2002
  10. ncbi Analysis of p53 gene mutation by polymerase chain reaction-single strand conformation polymorphism provides independent prognostic information in node-negative breast cancer
    B Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Clin Cancer Res 4:1597-602. 1998

Collaborators

Detail Information

Publications52

  1. ncbi Methyl-group metabolism and the response of colorectal cancer to 5-fluorouracil
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands
    Crit Rev Oncog 12:115-26. 2006
    ..This is particularly important for early-stage disease where conclusive demonstration of a survival benefit from 5FU in the overall CRC group has thus far proven difficult...
  2. ncbi BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status
    Wei Qi Li
    School of Surgery and Pathology, University of Western Australia, Nedlands, WA 6009, Australia
    Mol Cancer 5:2. 2006
    ..The aim of the present study was to evaluate the clinical, pathological and molecular phenotype of colorectal tumors with BRAF mutations...
  3. ncbi Aberrant DNA methylation: have we entered the era of more than one type of colorectal cancer?
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Am J Pathol 162:1043-5. 2003
  4. ncbi TP53 mutation in colorectal cancer
    Barry Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Hum Mutat 21:271-6. 2003
    ....
  5. ncbi Routine detection of the replication error phenotype in clinical tumor specimens using fluorescence-SSCP
    B Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Biotechniques 28:566-8, 570. 2000
    ..This technique provides a sensitive, rapid, reproducible and inexpensive assay suitable for the routine identification of RER+ status in clinical tumor specimens...
  6. ncbi Routine analysis of p53 mutation in clinical breast tumor specimens using fluorescence-based polymerase chain reaction and single strand conformation polymorphism
    B Iacopetta
    Department of Surgery, University of Western Australia, Nedlands
    Diagn Mol Pathol 9:20-5. 2000
    ..The authors propose that the prognostic and predictive values of p53 mutation in breast cancer should be further evaluated in prospective, randomized studies using this standardized technique...
  7. ncbi Gastric carcinomas with microsatellite instability: clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and BAX genes
    B J Iacopetta
    Department of Surgery, University of Western Australia, Nedlands 6907, Australia
    J Pathol 187:428-32. 1999
    ....
  8. ncbi Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations
    B J Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    J Pathol 184:390-5. 1998
    ..These results indicate that right-sided colorectal tumours containing RII mutations resemble those with the RER+ phenotype in terms of their clinicopathological features and genetic alterations...
  9. ncbi Are there two sides to colorectal cancer?
    Barry Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Int J Cancer 101:403-8. 2002
    ....
  10. ncbi Analysis of p53 gene mutation by polymerase chain reaction-single strand conformation polymorphism provides independent prognostic information in node-negative breast cancer
    B Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Clin Cancer Res 4:1597-602. 1998
    ..We conclude that a relatively simple and rapid single strand conformation polymorphism method of determining p53 mutation status in node-negative breast cancers can provide independent prognostic information...
  11. ncbi Rapid and nonisotopic SSCP-based analysis of the BAT-26 mononucleotide repeat for identification of the replication error phenotype in human cancers
    B Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Hum Mutat 12:355-60. 1998
    ..Our results demonstrate that nonisotopic PCR-SSCP of the poly(A) BAT-26 tract is a specific, sensitive and rapid method for determining the RER status of human tumors...
  12. ncbi Overexpression of p53 protein is an independent prognostic indicator in human endometrial carcinoma
    R Soong
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Br J Cancer 74:562-7. 1996
    ..98), P = 0.047] were independent prognostic factors. Immunohistochemical assessment of p53 overexpression in the nucleus and cytoplasm could provide useful prognostic information for the management of patients with endometrial cancer...
  13. ncbi Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features
    B A Shannon
    Department of Surgery, University of Western Australia, WA 6009, Nedlands, Australia
    Cancer Lett 167:91-7. 2001
    ..001). There were trends for associations between methylation at one or more of these loci and proximal tumor location, advanced Dukes' stage and the presence of wild-type p53 (P=0.06 for each)...
  14. ncbi Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer
    Shao Ying Li
    School of Surgery and Pathology, University of Western Australia, Nedlands
    Oncol Rep 15:221-5. 2006
    ..Our results show that polymorphisms in two genes involved in methyl group metabolism are associated with hormone receptor content and DNA methylation frequency in breast cancer, however these observations are unlikely to be linked...
  15. ncbi BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients
    Pei Woon Ang
    School of Surgery M507, University of Western Australia, 35 Stirling Hwy, Nedlands 6009, Australia
    Cancer Lett 273:221-4. 2009
    ..02). BRAF mutation and CIMP+ are therefore likely to be involved in an alternate, albeit rare, pathway to APC inactivation during the development of CRC in younger patients...
  16. ncbi Tumor-infiltrating lymphocytes and perforation in colon cancer predict positive response to 5-fluorouracil chemotherapy
    Melinda Morris
    School of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia, Australia
    Clin Cancer Res 14:1413-7. 2008
    ..The aim of the present study was to investigate the prognostic significance of TILs and other routinely reported pathologic features in colon cancer, particularly in relation to the use of adjuvant chemotherapy...
  17. ncbi CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer
    Marius van Rijnsoever
    Departments of Surgery, University of Western Australia, Nedlands 6907, Australia
    Clin Cancer Res 9:2898-903. 2003
    ..This molecular marker should be incorporated into prospective clinical trials of fluorouracil-based therapies to confirm its clinical value...
  18. ncbi Sarcomatoid renal cell carcinoma of papillary origin. A case report and cytogenic evaluation
    R J Cohen
    Urological Research Centre, Department of Surgery, University of Western Australia, Nedlands, Western Australia
    Arch Pathol Lab Med 124:1830-2. 2000
    ..The patient is well and without evidence of tumor progression 1 year after surgery, and the sinister outlook of SRCC in association with clear cell carcinoma may not apply in SRCC of non-clear cell origin...
  19. ncbi APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Int J Cancer 119:2272-8. 2006
    ..003) and with lower concentrations of methyl group carriers (p < 0.05). These findings highlight the importance of gene selection in studies that aim to characterize the biological features and clinical behaviour of CIMP+ tumours...
  20. ncbi Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa
    Barry Iacopetta
    School of Surgery and Pathology, WA Institute for Medical Research, University of Western Australia, 35 Stirling Highway, Nedlands 6009, Australia
    Cancer Sci 98:1454-60. 2007
    ..Further investigation of genomic and CpG island methylation in normal colonic mucosa and the possible influences of environmental and genetic factors may provide new insights into the development of CIMP+ colorectal cancer...
  21. ncbi Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup?
    Barry Iacopetta
    School of Surgery M507, University of Western Australia, Nedlands, 6009, Australia
    Int J Clin Oncol 13:498-503. 2008
    ..Further studies on tumors from randomized clinical trials are required to confirm the value of CIMP+ and associated molecular features for the prediction of clinical outcome to 5-FU-based chemotherapy...
  22. ncbi The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer
    Barry Iacopetta
    School of Surgery, University of Western Australia, Nedlands, Australia
    Int J Cancer 125:84-90. 2009
    ..02). Epidemiological studies on dietary and genetic risk factors for CRC should take into account these may confer different risks for right- and left-sided tumors...
  23. ncbi Screening for defective DNA mismatch repair in stage II and III colorectal cancer patients
    Siaw Ming Chai
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Clin Gastroenterol Hepatol 2:1017-25. 2004
    ..5%) showed loss of hMSH2. CONCLUSIONS: Routine immunohistochemical screening for MMR loss in younger colorectal cancer patients may provide a useful, first-step screening tool for the population-based detection of HNPCC...
  24. ncbi Survival rates for stage II colon cancer patients treated with or without chemotherapy in a population-based setting
    Melinda Morris
    School of Surgery and Pathology M507, University of Western Australia, Nedlands, Australia
    Int J Colorectal Dis 22:887-95. 2007
    ..The aim of the present study is to compare the survival rate of stage II colon cancer patients treated by surgery alone with that of patients also treated by chemotherapy...
  25. ncbi Associations between common polymorphisms in TP53 and p21WAF1/Cip1 and phenotypic features of breast cancer
    Brenda L Powell
    Department of Surgery, University of Western Australia, Nedlands 6907, Australia
    Carcinogenesis 23:311-5. 2002
    ..These results add to the growing body of evidence that genetic variants can influence not only the risk of breast cancer but also the disease phenotype...
  26. ncbi Prognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancer
    Cathy Wang
    School of Surgery and Pathology, University of Western Australia, Nedlands 6907, Australia
    Oncology 64:259-65. 2003
    ..Further prospective and/or cohort studies are required to determine whether these molecular changes have predictive value for survival benefit from 5-fluorouracil-based adjuvant chemotherapy...
  27. ncbi Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset
    B L Powell
    Department of Surgery, University of Western Australia, Nedlands 6907, Australia
    J Clin Endocrinol Metab 88:1653-7. 2003
    ..Our findings suggest that the LHR18insLQ gene polymorphism determines an earlier age of disease onset and is prognostic for poor outcome of breast cancer...
  28. ncbi Meat consumption and cooking practices and the risk of colorectal cancer
    S M Tabatabaei
    School of Population Health, University of Western Australia, Nedlands, Australia
    Eur J Clin Nutr 65:668-75. 2011
    ..One of the difficulties in determining this association has been measurement of different attributes of meat consumption, including cooking methods and level of doneness...
  29. ncbi 3D radiotherapy can be safely combined with sandwich systemic gemcitabine chemotherapy in the management of pancreatic cancer: factors influencing outcome
    Nigel Spry
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Int J Radiat Oncol Biol Phys 70:1438-46. 2008
    ....
  30. ncbi Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
    Paul Salama
    School of Surgery and Biostatistics Unit, Cancer Trials, Western Australian Institute for Medical Research, University of Western Australia, Australia
    J Clin Oncol 27:186-92. 2009
    ..To determine the prognostic significance of FOXP3(+) lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8(+) and CD45RO(+) lymphocyte densities...
  31. ncbi Comparing survival outcomes for patients with colorectal cancer treated in public and private hospitals
    Melinda Morris
    School of Surgery and Pathology, University of Western Australia, Perth, WA
    Med J Aust 186:296-300. 2007
    ..To determine whether treatment in a private versus public hospital was an independent predictor of survival outcomes in patients with colorectal cancer...
  32. ncbi A population-based study of age-related variation in clinicopathological features, molecular. Markers and outcome from colorectal cancer
    Melinda Morris
    School of Surgery and Pathology, University of Western Australia, Nedlands 6009, Western Australia
    Anticancer Res 27:2833-8. 2007
    ..To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population-based series of CRC...
  33. ncbi PIK3CA mutations in breast cancer are associated with poor outcome
    Shao Ying Li
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Breast Cancer Res Treat 96:91-5. 2006
    ..002). PIK3CA mutation was an independent factor for worse survival in breast cancer patients with non-amplified erbB2 (RR = 2.6, 95%CI [1.2-5.5], p = 0.016)...
  34. ncbi An improved quality control for bisulfite-PCR-based DNA methylation analysis: cycle threshold value
    Pei Woon Ang
    School of Surgery, University of Western Australia, Nedlands, Australia
    Clin Chem Lab Med 46:1117-21. 2008
    ..Here, we tested whether cycle threshold (Ct) values from real-time quantitative PCR correlate better with the reliability of bisulfite-PCR methylation analyses than spectrophotometric concentrations...
  35. ncbi DNA hypermethylation in breast cancer and its association with clinicopathological features
    Shaoying Li
    School of Surgery and Pathology, M507, University of Western Australia, Nedlands 6009, Australia
    Cancer Lett 237:272-80. 2006
    ..Our data suggests that gene methylation may be linked to various pathological features of breast cancer, however, this requires confirmation in larger studies...
  36. ncbi Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studies
    Fabienne Grieu
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands 6009, Australia
    Oncol Rep 11:501-4. 2004
    ..The low start-up and running costs make this method particularly well suited for SNP genotyping studies that involve up to 1,000 DNA samples...
  37. ncbi Extent of nodal involvement in Stage III colorectal carcinoma: relationship to clinicopathologic variables and genetic alterations
    Hany Elsaleh
    Department of Radiation Oncology, UCLA School of Medicine and Jonsson Comprehensive Cancer Center, USA
    Dis Colon Rectum 45:1218-22. 2002
    ..These results indicate that differences in metastatic nodal burden cannot explain previously observed site, gender, and mutation differences in the response to chemotherapy...
  38. ncbi The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase
    Kazuyuki Kawakami
    Department of Surgery, Kanazawa University School of Medicine, Kanazawa, Japan
    Clin Cancer Res 9:5860-5. 2003
    ..FIs could serve as biochemical markers for the risk of developing this disease, as well as for the prediction of toxicity and efficacy of fluorouracil-based treatments...
  39. ncbi The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment
    Antonio Russo
    Universita di Palermo, Department of Oncology, Italy
    J Clin Oncol 23:7518-28. 2005
    ....
  40. ncbi Re: Pooled analysis of fluorouracil-based adjuvant therapy of stage II and III colon cancer: who benefits and by how much?
    Hany Elsaleh
    J Clin Oncol 23:653-4; author reply 654-5. 2005
  41. ncbi Expression of sFRP-4 and beta-catenin in human colorectal carcinoma
    Qian Feng Han
    Department of Gastroenterological Surgery and Institute of Digestive System Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Cancer Lett 231:129-37. 2006
    ..In contrast to other sFRP family members, sFRP-4 expression appears to be upregulated in colorectal carcinoma...
  42. ncbi Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype
    Fabienne Grieu
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands 6009, Australia
    Anticancer Res 24:3215-9. 2004
    ..Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate metabolism...
  43. ncbi Microsatellite instability in colorectal cancer: prognostic, predictive or both?
    Marius van Rijnsoever
    Am J Pathol 160:384-5; author reply 385-6. 2002
  44. ncbi Target gene mutation profile differs between gastrointestinal and endometrial tumors with mismatch repair deficiency
    Alex Duval
    INSERM U434-CEPH, 75010 Paris, France
    Cancer Res 62:1609-12. 2002
    ..Our results show that the profile of target gene mutations in MSI-H tumors is tissue specific, with both qualitative and quantitative differences between gastrointestinal and endometrial MSI-H cancers...
  45. ncbi Microsatellite instability in colon cancer
    Barry Iacopetta
    N Engl J Med 349:1774-6; author reply 1774-6. 2003
  46. ncbi Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR
    Nirosha Suraweera
    INSERM U434, Centre d'Etudes du Polymorphisme Humain, Paris, France
    Gastroenterology 123:1804-11. 2002
    ..This assay is simpler to use than those involving dinucleotides and is more specific than using BAT-26 alone...
  47. ncbi Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer phenotype
    Fabienne Grieu
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands
    Breast Cancer Res Treat 88:197-204. 2004
    ..06). These findings suggest that breast cancer phenotype and outcome can be influenced by common functional polymorphisms in MMP genes...
  48. ncbi Denaturing high performance liquid chromatography for the detection of microsatellite instability using bethesda and pentaplex marker panels
    Richie Soong
    Oncology Research Institute, National University of Singapore, 117456 Singapore
    Diagn Mol Pathol 17:127-33. 2008
    ..In conclusion, DHPLC provides a sensitive and specific alternative for routine MSI analysis that is free of the stutter peaks observed with CE and which can be used with either the Bethesda or pentaplex mononucleotide marker panels...
  49. ncbi Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers
    Fabienne Grieu
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands 6009, Australia
    Anticancer Res 23:4257-9. 2003
    ..The aim of this case-control study was to investigate whether the common G870A polymorphism in the Cyclin D1 gene (CCND1) is a risk factor for breast and colorectal cancers in an Australian population...
  50. ncbi Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers
    Honor Hugo
    Peter MacCallum Cancer Center, East Melbourne and Department of Pathology, The University of Melbourne, Australia
    Genes Chromosomes Cancer 45:1143-54. 2006
    ..In CRC, these mutations may contribute to MYB overexpression, highlighting the importance of noncoding sequences in the regulation of key cancer genes...
  51. ncbi Gastrointestinal stromal tumours (GISTs): a clinicopathological and molecular study of 66 cases
    M H Eleanor Koay
    Department of Anatomical Pathology, PathCentre, Western Australia
    Pathology 37:22-31. 2005
    ..PCR-SSCP analysis is a fast, sensitive and relatively inexpensive method of analysing c-kit mutations, which may be important prognostically and also of therapeutic relevance in the assessment of new tyrosine kinase inhibitor therapies...
  52. ncbi Detection of BRAF V600E mutation by pyrosequencing
    Yi Hui Tan
    Oncology Research Institute, National University of Singapore, Singapore
    Pathology 40:295-8. 2008
    ..Here we describe a method for detecting this mutation based upon pyrosequencing technology...