M R Hutchinson

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. pmc Why is neuroimmunopharmacology crucial for the future of addiction research?
    Mark R Hutchinson
    Discipline of Physiology, School of Medical Sciences, University of Adelaide, Level 5, Medical School South, Frome Rd, Adelaide, South Australia 5005, Australia Electronic address
    Neuropharmacology 76:218-27. 2014
  2. pmc Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
    Mark R Hutchinson
    Discipline of Pharmacology, School of Medical Science, University of Adelaide, South Australia, Australia, 5005
    Pharmacol Rev 63:772-810. 2011
  3. pmc Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences
    M R Hutchinson
    Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Neuroscience 167:880-93. 2010
  4. ncbi request reprint Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, The University of Adelaide, Level 5, Medical School North, Frome Road, Adelaide, South Australia 5005, Australia
    Eur J Pharmacol 453:27-32. 2002
  5. ncbi request reprint (S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Level 5, Medical School North, Frome Road, 5005, Adelaide, Australia
    Int Immunopharmacol 4:1525-30. 2004
  6. ncbi request reprint In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, Level 5, Medical School North, University of Adelaide, Frome Rd, Adelaide, SA 5005, Australia
    Pain 110:751-5. 2004
  7. ncbi request reprint Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, Level 5, Medical School North, University of Adelaide, Frome Road, Adelaide 5005, South Australia, Australia
    Eur J Pharmacol 494:251-62. 2004
  8. pmc CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia, 5005
    Br J Clin Pharmacol 57:287-97. 2004
  9. pmc Opioid activation of toll-like receptor 4 contributes to drug reinforcement
    M R Hutchinson
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309, USA
    J Neurosci 32:11187-200. 2012
  10. pmc Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta
    S S Lewis
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Neuroscience 165:569-83. 2010

Detail Information

Publications31

  1. pmc Why is neuroimmunopharmacology crucial for the future of addiction research?
    Mark R Hutchinson
    Discipline of Physiology, School of Medical Sciences, University of Adelaide, Level 5, Medical School South, Frome Rd, Adelaide, South Australia 5005, Australia Electronic address
    Neuropharmacology 76:218-27. 2014
    ..Such discoveries will point us in the direction such that one day soon we might successfully intervene to successfully treat drug addiction. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  2. pmc Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
    Mark R Hutchinson
    Discipline of Pharmacology, School of Medical Science, University of Adelaide, South Australia, Australia, 5005
    Pharmacol Rev 63:772-810. 2011
    ..Novel pharmacological targets for future drug development are discussed in the hope that disease-modifying chronic pain treatments arising from the appreciation of opioid-induced central immune signaling may become practical...
  3. pmc Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences
    M R Hutchinson
    Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Neuroscience 167:880-93. 2010
    ..Collectively, these data provide the first evidence of the pro-nociceptive consequences of small molecule xenobiotic activation of spinal TLR4 signaling independent of classical opioid receptor involvement...
  4. ncbi request reprint Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, The University of Adelaide, Level 5, Medical School North, Frome Road, Adelaide, South Australia 5005, Australia
    Eur J Pharmacol 453:27-32. 2002
    ..The study highlights the limitations of conclusions made in previous studies which have not recognised diacetylmorphine instability...
  5. ncbi request reprint (S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Level 5, Medical School North, Frome Road, 5005, Adelaide, Australia
    Int Immunopharmacol 4:1525-30. 2004
    ..Moreover, the dose at which immune suppression occurred could be achieved clinically...
  6. ncbi request reprint In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, Level 5, Medical School North, University of Adelaide, Frome Rd, Adelaide, SA 5005, Australia
    Pain 110:751-5. 2004
    ..92, P < 0.0001). These pilot data provide evidence of a novel objective biological marker of pain tolerance in humans, which also links the immune and opioid systems with basal pain tolerance...
  7. ncbi request reprint Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, Level 5, Medical School North, University of Adelaide, Frome Road, Adelaide 5005, South Australia, Australia
    Eur J Pharmacol 494:251-62. 2004
    ..A structure-effect relationship was developed and significant evidence for non-classical opioid receptor function on immune cells was concluded...
  8. pmc CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia, 5005
    Br J Clin Pharmacol 57:287-97. 2004
    ....
  9. pmc Opioid activation of toll-like receptor 4 contributes to drug reinforcement
    M R Hutchinson
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309, USA
    J Neurosci 32:11187-200. 2012
    ....
  10. pmc Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta
    S S Lewis
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Neuroscience 165:569-83. 2010
    ..These data provide the first evidence for a TLR4 and IL-1 mediated component to M3G-induced effects, likely of at least microglial origin...
  11. pmc Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity
    M R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Neuroscience 168:551-63. 2010
    ....
  12. pmc Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats
    M R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Neuroscience 164:1821-32. 2009
    ..Rather, the data suggest that TLR4-dependent pain phenomena may require contributions by multiple components of the TLR4 receptor complex...
  13. pmc Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1178-89. 2008
    ..These data implicate multiple opioid-induced spinal proinflammatory cytokines in opposing both acute and chronic opioid analgesia, and provide a novel mechanism for the opposition of acute opioid analgesia...
  14. pmc Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:240-50. 2009
    ..Hence, suppression of glial proinflammatory responses can significantly reduce opioid withdrawal, while improving analgesia...
  15. pmc The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release
    Sondra T Bland
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:492-7. 2009
    ..These results indicate that glial activation contributes to the effects of morphine on NAc DA, which is associated with somatic signs of precipitated withdrawal...
  16. ncbi request reprint Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, Level 5, Medical School North, University of Adelaide, Adelaide, South Australia, 5005, Australia
    Int Immunopharmacol 5:1713-22. 2005
    ..These data support the non-classical opioid nature of direct opioid modulation of splenocyte proliferation...
  17. pmc Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 28:20-9. 2008
    ..Thus, these data suggest that (+)-opioid antagonists such as (+)-naloxone may be useful clinically to suppress glial activation, yet (-)-opioid agonists suppress pain...
  18. doi request reprint A novel animal model of graded neuropathic pain: utility to investigate mechanisms of population heterogeneity
    Peter M Grace
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, Australia
    J Neurosci Methods 193:47-53. 2010
    ..05, r(2)>0.9). DLF glial activation may represent a contributor to contralateral pain. Our novel graded model has a dynamic range, allowing sensitive detection of interactions and subtle influences on neuropathic pain processing...
  19. doi request reprint Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain
    Peter M Grace
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide 5005, Australia
    Brain Behav Immun 25:503-13. 2011
    ..001), confirming that infiltrating immune cells are not passive bystanders, but actively contribute to nociceptive hypersensitivity in the lumbar spinal cord...
  20. ncbi request reprint Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection
    Andrew Menelaou
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 785:81-8. 2003
    ..These methods provide good precision, accuracy and sensitivity for use in in vitro kinetic studies investigating the oxidative metabolism of hydrocodone and oxycodone in human liver microsomes...
  21. pmc Evidence that opioids may have toll-like receptor 4 and MD-2 effects
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:83-95. 2010
    ..These data provide evidence that select opioids may non-stereoselectively influence TLR4 signaling and have behavioral consequences resulting, in part, via TLR4 signaling...
  22. pmc Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia
    Mark R Hutchinson
    Department of Psychology, The Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1248-56. 2008
    ....
  23. pmc The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia
    Linda R Watkins
    Department of Psychology and Neuroscience and The Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado USA
    Trends Pharmacol Sci 30:581-91. 2009
    ..Excitingly, with newly-established clinical trials of two glial modulators for treating neuropathic pain and improving the utility of opioids, translation from rats-to-humans now begins with the promise of improved clinical pain control...
  24. ncbi request reprint Glia: novel counter-regulators of opioid analgesia
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Trends Neurosci 28:661-9. 2005
    ..New data suggest that glia also release neuroexcitatory substances in response to morphine, thereby opposing its effects. Controlling glial activation could therefore increase the clinical utility of analgesic drugs...
  25. pmc Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, Muenzinger D 244, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:131-46. 2007
    ....
  26. ncbi request reprint The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats
    Andre Der-Avakian
    Department of Psychology and Center for Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309 0345, USA
    Psychopharmacology (Berl) 191:909-17. 2007
    ..However, this persistent, trans-situational enhancement did not occur to amphetamine CPP...
  27. pmc "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids
    Linda R Watkins
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Res Rev 56:148-69. 2007
    ..Such changes in neuronal function would be expected to occur wherever immune-derived substances come in close contact with neurons...
  28. ncbi request reprint Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    ScientificWorldJournal 7:98-111. 2007
    ....
  29. pmc Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain
    Lisa C Loram
    Department of Psychology and Center for Neurosciences, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    J Neurosci 29:14015-25. 2009
    ..Activation of A(2A)Rs after intrathecal administration may be a novel, therapeutic approach for the treatment of neuropathic pain by increasing IL-10 in the immunocompetent cells of the CNS...
  30. pmc The cortical innate immune response increases local neuronal excitability leading to seizures
    Krista M Rodgers
    Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309, USA
    Brain 132:2478-86. 2009
    ....
  31. ncbi request reprint Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes
    Annemarie Ledeboer
    Avigen, Inc, Department of Preclinical Development, Alameda, CA 94502, USA
    Expert Opin Investig Drugs 16:935-50. 2007
    ..Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain, with a novel mechanism of action...