Amos C Hung
Affiliation: University of Tasmania
- p53 mediates nitric oxide-induced apoptosis in murine neural progenitor cellsAmos C Hung
Cell Death and Human Disease Group, Division of Cancer and Developmental Cell Biology, Institute of Molecular and Cell Biology, Singapore
Neurosci Lett 467:241-6. 2009..Our current results suggest a central role of p53 in the NO-induced apoptotic pathway in NPCs, which may hence provide new insights into the regulation of cell death in NPCs that respond to overproduction of NO in injured brain...
- The role of Abeta-induced calcium dysregulation in the pathogenesis of Alzheimer's diseaseDavid H Small
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
J Alzheimers Dis 16:225-33. 2009..It is likely that elucidation of the mechanism by which Abeta and presenilin cause Ca(2+) dysregulation in neurons will help to identify new drug targets for the treatment of AD...
- PKCdelta mediates Nrf2-dependent protection of neuronal cells from NO-induced apoptosisJindan Zhang
Cell Death and Human Disease Group, Division of Cancer and Developmental Cell Biology, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
Biochem Biophys Res Commun 386:750-6. 2009..Hence, PKCdelta is an important positive modulator of NO-induced Nrf2/ARE-dependent signaling that counteracts NO-mediated apoptosis in neuronal cells...