A J Hulbert

Summary

Affiliation: University of Wollongong
Country: Australia

Publications

  1. ncbi Membrane fatty acid composition of tissues is related to body mass of mammals
    P Couture
    Department of Biological Sciences, University of Wollongong, Australia
    J Membr Biol 148:27-39. 1995
  2. ncbi Membranes as possible pacemakers of metabolism
    A J Hulbert
    Departments of Biological and, University of Wollongong, NSW 2522, Australia
    J Theor Biol 199:257-74. 1999
  3. ncbi Polyunsaturated fatty acids, membrane function and metabolic diseases such as diabetes and obesity
    L H Storlien
    Department of Biomedical, University of Wollongong, Australia
    Curr Opin Clin Nutr Metab Care 1:559-63. 1998
  4. ncbi Life, death and membrane bilayers
    A J Hulbert
    Metabolic Research Centre and Department of Biological Science, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 206:2303-11. 2003
  5. ncbi On the importance of fatty acid composition of membranes for aging
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    J Theor Biol 234:277-88. 2005
  6. ncbi The exceptional longevity of an egg-laying mammal, the short-beaked echidna (Tachyglossus aculeatus) is associated with peroxidation-resistant membrane composition
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
    Exp Gerontol 43:729-33. 2008
  7. ncbi Life and death: metabolic rate, membrane composition, and life span of animals
    A J Hulbert
    Metabolic Research Centre, Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia
    Physiol Rev 87:1175-213. 2007
  8. ncbi Membrane fatty acids as pacemakers of animal metabolism
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia
    Lipids 42:811-9. 2007
  9. ncbi Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Exp Gerontol 39:1137-43. 2004
  10. ncbi The links between membrane composition, metabolic rate and lifespan
    A J Hulbert
    Metabolic Research Centre, School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Comp Biochem Physiol A Mol Integr Physiol 150:196-203. 2008

Detail Information

Publications56

  1. ncbi Membrane fatty acid composition of tissues is related to body mass of mammals
    P Couture
    Department of Biological Sciences, University of Wollongong, Australia
    J Membr Biol 148:27-39. 1995
    ..It is proposed that the elevated degree of polyunsaturation in the membranes of several tissues from small mammals is related to their higher metabolic activity...
  2. ncbi Membranes as possible pacemakers of metabolism
    A J Hulbert
    Departments of Biological and, University of Wollongong, NSW 2522, Australia
    J Theor Biol 199:257-74. 1999
    ..The proposed pacemaker role of differences in membrane bilayer composition is briefly discussed with respect to the brain (and sensory cells), evolution of mammalian endothermic metabolism, and its clinical implications for humans...
  3. ncbi Polyunsaturated fatty acids, membrane function and metabolic diseases such as diabetes and obesity
    L H Storlien
    Department of Biomedical, University of Wollongong, Australia
    Curr Opin Clin Nutr Metab Care 1:559-63. 1998
    ..New data are extending our understanding of how lipid subclasses influence carbohydrate and lipid metabolism at multiple control points: from the modulation of membrane proteins to the regulation of gene transcription...
  4. ncbi Life, death and membrane bilayers
    A J Hulbert
    Metabolic Research Centre and Department of Biological Science, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 206:2303-11. 2003
    ..The membrane pacemaker theory of metabolism has given birth to the membrane pacemaker hypothesis of aging, which will require further investigation...
  5. ncbi On the importance of fatty acid composition of membranes for aging
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    J Theor Biol 234:277-88. 2005
    ..It is suggested that lifespan extension by reduced insulin/IGF signalling may also be mediated by changes in membrane fatty acid composition...
  6. ncbi The exceptional longevity of an egg-laying mammal, the short-beaked echidna (Tachyglossus aculeatus) is associated with peroxidation-resistant membrane composition
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
    Exp Gerontol 43:729-33. 2008
    ..These findings support the membrane pacemaker theory of aging and emphasise the potential importance of membrane fatty acid composition in aging and in the determination of maximum longevity...
  7. ncbi Life and death: metabolic rate, membrane composition, and life span of animals
    A J Hulbert
    Metabolic Research Centre, Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia
    Physiol Rev 87:1175-213. 2007
    ..The more limited information for ectothermic animals and treatments that extend life span (e.g., caloric restriction) are also reviewed...
  8. ncbi Membrane fatty acids as pacemakers of animal metabolism
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia
    Lipids 42:811-9. 2007
    ....
  9. ncbi Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Exp Gerontol 39:1137-43. 2004
    ..Thus, individual variation in lifespan in wild-type flies, and life extension by dietary-restriction and reduced insulin/IGF-1 signalling is not attributable to differences in metabolic rate...
  10. ncbi The links between membrane composition, metabolic rate and lifespan
    A J Hulbert
    Metabolic Research Centre, School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Comp Biochem Physiol A Mol Integr Physiol 150:196-203. 2008
    ..It is suggested that these chemical properties of highly polyunsaturated membrane acyl chains have important implications for understanding aging and the determination of longevity...
  11. ncbi Food consumption and individual lifespan of adults of the blowfly, Calliphora stygia: a test of the 'rate of living' theory of aging
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    Exp Gerontol 39:1485-90. 2004
    ....
  12. ncbi Basal metabolic rate: history, composition, regulation, and usefulness
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Physiol Biochem Zool 77:869-76. 2004
    ..It is suggested that in different-sized mammals, the secretion/production of thyroid hormones is a result of BMR differences rather than their cause. BMR is a useful concept in some situations but not in others...
  13. ncbi Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    Mech Ageing Dev 127:653-7. 2006
    ..It is suggested that peroxidation-resistant membranes may be an important component of extended longevity...
  14. ncbi How might you compare mitochondria from different tissues and different species?
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia
    J Comp Physiol B 176:93-105. 2006
    ..The molecular activity of mitochondrial cytochromes was found to be significantly positively correlated with the relative polyunsaturation of mitochondrial membrane lipids...
  15. ncbi Membranes and the setting of energy demand
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 208:1593-9. 2005
    ..These differences in membrane composition may also represent a link between metabolism and aging. They probably explain the lifespan-body size relationship in mammals and birds and also the mammal-bird difference in lifespan...
  16. ncbi Explaining longevity of different animals: is membrane fatty acid composition the missing link?
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia
    Age (Dordr) 30:89-97. 2008
    ..Membrane fatty acid composition is a little appreciated but important correlate of the rate of aging of animals and the determination of their longevity...
  17. ncbi Thyroid hormones and their effects: a new perspective
    A J Hulbert
    Metabolic Research Centre and Department of Biological Sciences, University of Wollongong, NSW, Australia
    Biol Rev Camb Philos Soc 75:519-631. 2000
    ..Findings from receptor 'knockout' mice supports an important role for receptors in the development of the thyroid axis. These iodothyronines may be better thought of as 'vitamone'-like molecules than traditional hormonal messengers...
  18. ncbi Mechanisms underlying the cost of living in animals
    A J Hulbert
    Department of Biological Science, University of Wollongong, NSW, Australia
    Annu Rev Physiol 62:207-35. 2000
    ..The potential importance of membrane acyl composition in metabolic depression, hormonal control of metabolism, the evolution of endothermy, as well as its implications for lifespan and human health, are briefly discussed...
  19. ncbi Metabolism and longevity: is there a role for membrane fatty acids?
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Integr Comp Biol 50:808-17. 2010
    ..The exceptional longevity of Homo sapiens combined with the limited knowledge of the fatty acid composition of human tissues support the potential importance of mitochondrial membranes in determination of longevity...
  20. ncbi The acyl composition of mammalian phospholipids: an allometric analysis
    A J Hulbert
    Metabolic Research Centre, Department of Biological Science, University of Wollongong, NSW 2522, Wollongong, Australia
    Comp Biochem Physiol B Biochem Mol Biol 132:515-27. 2002
    ..These trends are discussed in light of the hypothesis that the relative content of polyunsaturated acyl chains in membranes, and especially docosahexaenoate (22:6 n-3), can act as a membrane pacemaker for metabolic activity...
  21. ncbi Proton leak in hepatocytes and liver mitochondria from archosaurs (crocodiles) and allometric relationships for ectotherms
    A J Hulbert
    Metabolic Research Centre and Department of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    J Comp Physiol B 172:387-97. 2002
    ..2, similar to the exponent in mammalian hepatocytes. However, unlike mammals, liver mitochondrial proton conductance in ectotherms showed no allometric relationship with body size...
  22. ncbi Acyl composition of muscle membranes varies with body size in birds
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 205:3561-9. 2002
    ..This allometric variation in phospholipid acyl composition is discussed with respect to both the metabolic intensity and lifespan of different sized bird species...
  23. ncbi Metabolic rate and membrane fatty acid composition in birds: a comparison between long-living parrots and short-living fowl
    Magdalene K Montgomery
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia
    J Comp Physiol B 182:127-37. 2012
    ....
  24. ncbi Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts
    Nigel Turner
    Department of Biomedical Science, Metabolic Research Centre, University of Wollongong, New South Wales, Australia
    Physiol Biochem Zool 79:522-33. 2006
    ....
  25. ncbi Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidney
    Nigel Turner
    Metabolic Research Centre, Department of Biomedical Science, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Am J Physiol Regul Integr Comp Physiol 288:R301-10. 2005
    ..These relationships are discussed with respect to the metabolic intensity of different-sized animals...
  26. ncbi Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): a comparative study using shotgun lipidomics
    Todd W Mitchell
    Metabolic Research Centre, University of Wollongong, NSW, Australia
    Exp Gerontol 42:1053-62. 2007
    ..Both characteristics possibly contribute to the exceptional longevity of naked mole-rats and may indicate a special role for peroxisomes in this extended longevity...
  27. ncbi Does the oxidative stress theory of aging explain longevity differences in birds? I. Mitochondrial ROS production
    Magdalene K Montgomery
    School of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Exp Gerontol 47:203-10. 2012
    ..These findings cast doubt on the robustness of the oxidative stress theory of aging...
  28. ncbi Does the oxidative stress theory of aging explain longevity differences in birds? II. Antioxidant systems and oxidative damage
    Magdalene K Montgomery
    School of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Exp Gerontol 47:211-22. 2012
    ..Despite indications of higher protection against some aspects of oxidative stress in the parrots, the pronounced longevity of parrots appears to be independent of their antioxidant mechanisms and their accumulation of oxidative damage...
  29. ncbi Phospholipid composition of the rat lens is independent of diet
    Jessica R Nealon
    School of Chemistry, University of Wollongong, Wollongong, 2522 NSW, Australia
    Exp Eye Res 87:502-14. 2008
    ..As phospholipids determine membrane fluidity and influence the activity and function of integral membrane proteins, regulation of their composition may be important for the function of the lens...
  30. ncbi Molecular activity of Na(+)/K(+)-ATPase from different sources is related to the packing of membrane lipids
    B J Wu
    Metabolic Research Centre, Department of Biomedical Science, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 204:4271-80. 2001
    ....
  31. ncbi Membrane fatty acid composition of rat skeletal muscle is most responsive to the balance of dietary n-3 and n-6 PUFA
    Sarah K Abbott
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    Br J Nutr 103:522-9. 2010
    ..Diet PUFA balance dramatically affects muscle 20 : 4n-6 and 22 : 6n-3. This may have significant implications for some disease states in human subjects...
  32. ncbi Dietary fats and membrane function: implications for metabolism and disease
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW, Australia
    Biol Rev Camb Philos Soc 80:155-69. 2005
    ..The understanding of dietary lipid profile and its influence on membrane function in relation to metabolic dysregulation has exciting potential for the prevention and treatment of a range of prevalent disease states...
  33. ncbi An allometric comparison of microsomal membrane lipid composition and sodium pump molecular activity in the brain of mammals and birds
    Nigel Turner
    Metabolic Research Centre, Department of Biomedical Science, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 208:371-81. 2005
    ..Bird membranes also contained a relatively large percentage of 22:5 (n-6) as well as high levels of cholesterol. These results are discussed in relation to neurological function and the emerging field of membrane lipid rafts...
  34. ncbi Membrane lipids and sodium pumps of cattle and crocodiles: an experimental test of the membrane pacemaker theory of metabolism
    B J Wu
    Department of Biomedical Science, University of Wollongong, Wollongong, NSW Australia 2522
    Am J Physiol Regul Integr Comp Physiol 287:R633-41. 2004
    ..43%). The results support the membrane pacemaker theory of metabolism and suggest membrane lipids and their polyunsaturates play a significant role in determining the molecular activity of the sodium pump...
  35. ncbi Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism
    Nigel Turner
    Metabolic Research Centre, University of Wollongong, 2522, Wollongong, NSW, Australia
    Naturwissenschaften 90:521-3. 2003
    ....
  36. ncbi Dietary fatty acid profile affects endurance in rats
    K J Ayre
    Department of Biological Sciences, University of Wollongong, N S W, Australia
    Lipids 32:1265-70. 1997
    ..005). Although n-3 fats are considered beneficial for cardiovascular health, they appear to reduce endurance times, and their side effects need to be further investigated...
  37. ncbi Exercise alters the profile of phospholipid molecular species in rat skeletal muscle
    Todd W Mitchell
    Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales 2522
    J Appl Physiol 97:1823-9. 2004
    ..Even though little is known about the physiological or pathophysiological role of specific phospholipid molecular species in skeletal muscle, it is likely that this remodeling will have an impact on a range of cellular functions...
  38. ncbi The long life of birds: the rat-pigeon comparison revisited
    Magdalene K Montgomery
    School of Biological Sciences, University of Wollongong, Wollongong, corrected New South Wales, Australia
    PLoS ONE 6:e24138. 2011
    ..Had mitochondria been harvested from other tissues or other relevant mitochondrial metabolic substrates been used, then very different conclusions regarding differences in oxidative stress would have been reached...
  39. ncbi Calorie restriction in mice: effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition
    Sally C Faulks
    School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    J Gerontol A Biol Sci Med Sci 61:781-94. 2006
    ..Changes in the fatty acid composition of phospholipids from liver, kidneys, heart, brain, and skeletal muscle were observed following 1 month of CR...
  40. ncbi Respiration rate of hepatocytes varies with body mass in birds
    Paul L Else
    Department of Biomedical Science, Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 207:2305-11. 2004
    ..These results are discussed in the context of competing theories to explain the metabolism-body size allometry, and are found to support the 'allometric cascade' model...
  41. ncbi Fowl play and the price of petrel: long-living Procellariiformes have peroxidation-resistant membrane composition compared with short-living Galliformes
    William A Buttemer
    School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
    Biol Lett 4:351-4. 2008
    ..Peroxidation-resistant membrane composition may be an important physiological trait for longevous species...
  42. ncbi Sodium pump molecular activity and membrane lipid composition in two disparate ectotherms, and comparison with endotherms
    Nigel Turner
    Department of Biomedical Science, Metabolic Research Centre, University of Wollongong, Wollongong, NSW, 2522, Australia
    J Comp Physiol B 175:77-85. 2005
    ..003) correlation was observed between sodium pump molecular activity and the content of 22:6 (n-3) in the surrounding membrane. These results are discussed in relation to recent work which shows a similar relationship in endotherms...
  43. ncbi The evolution of endothermy: role for membranes and molecular activity
    Paul L Else
    Department of Biomedical Science, Metabolic Research Centre, University of Wollongong, New South Wales 2522, Australia
    Physiol Biochem Zool 77:950-8. 2004
    ..Such changes (from monounsaturated to polyunsaturated membranes) would allow membranes to set the pace of metabolism in the evolution of endothermy...
  44. ncbi Extended longevity of queen honey bees compared to workers is associated with peroxidation-resistant membranes
    Laura Saade Haddad
    Metabolic Research Centre, and School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
    Exp Gerontol 42:601-9. 2007
    ....
  45. ncbi Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle
    Nigel Turner
    Metabolic Research Centre, Department of Biomedical Sciences, University of Wollongong, New South Wales, Australia
    J Appl Physiol 96:974-80. 2004
    ....
  46. ncbi Molecular activity of sodium pumps in the kidney of mammals and birds
    Nigel Turner
    Metabolic Research Centre, University of Wollongong, New South Wales, Australia 2522
    Ann N Y Acad Sci 986:606-7. 2003
  47. ncbi Experimental studies of blowfly (Calliphora stygia) longevity: A little dietary fat is beneficial but too much is detrimental
    Beata Ujvari
    Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Comp Biochem Physiol A Mol Integr Physiol 154:383-8. 2009
    ..Our results highlight the need for further studies to understand how dietary fats are metabolised and utilised in the golden-haired blowfly...
  48. ncbi The ω-3 and ω-6 fats in meals: a proposal for a simple new label
    Nigel Turner
    Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia
    Nutrition 27:719-26. 2011
    ..Our goal in this study was to analyze the PUFA content of whole meals and produce a simple measurement to estimate the intake of these fatty acids...
  49. ncbi Fatty acid composition of membrane bilayers: importance of diet polyunsaturated fat balance
    Sarah K Abbott
    Metabolic Research Centre, University of Wollongong, NSW 2522, Australia
    Biochim Biophys Acta 1818:1309-17. 2012
    ..95), while diet PUFA balance>10% had little influence (average slope 0.19). The modern human diet has an average PUFA balance ~10% and this will likely have significant health implications...
  50. ncbi Molecular activity of Na+,K+-ATPase relates to the packing of membrane lipids
    Paul L Else
    Metabolic Research Centre, University of Wollongong, NSW 2522 Australia
    Ann N Y Acad Sci 986:525-6. 2003
  51. ncbi A comparison of the nitrogen requirements of the eastern pygmy possum, Cercartetus nanus, on a pollen and on a mealworm diet
    I G van Tets
    Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia za
    Physiol Biochem Zool 72:127-37. 1999
    ..nanus than the composition of the mealworm protein did. Pollen is an excellent source of nitrogen for C. nanus, and it should be considered as a potential nitrogen source for other flower-feeding animals...
  52. ncbi Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birds
    Martin D Brand
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 376:741-8. 2003
    ..These correlations echo those seen in mammalian liver mitochondria, suggesting that they too are general for endotherms...
  53. ncbi Limits to physical performance and metabolism across species
    Nigel Turner
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Curr Opin Clin Nutr Metab Care 9:691-6. 2006
    ..The factors that determine each type of metabolic rate are not the same; however, all levels of energy expenditure are strongly linked with body size...
  54. ncbi Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice
    A J Hulbert
    Department of Biology, City College of the City University of New York, Convent Ave. at 138 St, New York, NY 10031, USA
    J Gerontol A Biol Sci Med Sci 61:1009-18. 2006
    ....
  55. ncbi Why are some mitochondria more powerful than others: insights from comparisons of muscle mitochondria from three terrestrial vertebrates
    Helga Guderley
    Helga Guderley, Dép de Biologie, Universite Laval, Quebec, P Q Canada
    Comp Biochem Physiol B Biochem Mol Biol 142:172-80. 2005
    ..We suggest that the numbers of CCO and ANT together with the poly-unsaturation of phospholipids explain the higher oxidative capacities in muscle mitochondria from rats and cane toads...
  56. ncbi Developmental profile of thyroid hormone distributor proteins in a marsupial, the tammar wallaby Macropus eugenii
    Samantha J Richardson
    Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    Gen Comp Endocrinol 125:92-103. 2002
    ....