Gerard F Hoyne

Summary

Affiliation: University of Notre Dame
Country: Australia

Publications

  1. doi request reprint Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes
    Gerard F Hoyne
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Immunol 186:2024-32. 2011
  2. pmc Mechanisms that regulate peripheral immune responses to control organ-specific autoimmunity
    Gerard F Hoyne
    School of Health Sciences, University of Notre Dame Australia, 19 Mouat Street, Fremantle, WA 6959, Australia
    Clin Dev Immunol 2011:294968. 2011
  3. doi request reprint A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development
    Gerard F Hoyne
    The Laboratory of T Cell Development and Regulation, John Curtin School of Medical Research, Australian National University Canberra, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 89:696-705. 2011
  4. pmc Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells
    Mehmet Yabas
    Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    PLoS ONE 6:e26440. 2011
  5. ncbi request reprint The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity
    Gerard F Hoyne
    Australian Cancer Research Foundation Genetics Laboratory and Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Immunol Rev 210:27-39. 2006
  6. doi request reprint Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation
    Zuopeng Wu
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 185:231-8. 2010
  7. doi request reprint Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL
    Yovina Sontani
    Immunology Department, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Leuk Res 35:1512-9. 2011

Collaborators

Detail Information

Publications7

  1. doi request reprint Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes
    Gerard F Hoyne
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Immunol 186:2024-32. 2011
    ..These results reveal a role for peripheral T cell anergy in organ-specific self-tolerance and illuminate the interplay between Cblb-dependent anergy and other mechanisms for preventing organ-specific autoimmunity...
  2. pmc Mechanisms that regulate peripheral immune responses to control organ-specific autoimmunity
    Gerard F Hoyne
    School of Health Sciences, University of Notre Dame Australia, 19 Mouat Street, Fremantle, WA 6959, Australia
    Clin Dev Immunol 2011:294968. 2011
    ..This paper will examine the role of a range of E3 ubiquitin ligases and signaling pathways that influence the development of T-cell effector responses and the development of organ-specific autoimmune diseases such as type 1 diabetes...
  3. doi request reprint A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development
    Gerard F Hoyne
    The Laboratory of T Cell Development and Regulation, John Curtin School of Medical Research, Australian National University Canberra, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 89:696-705. 2011
    ....
  4. pmc Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells
    Mehmet Yabas
    Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    PLoS ONE 6:e26440. 2011
    ..In both cell subsets it is required as a trans-acting factor to regulate alternative splicing of the Ptprc mRNA, but it is only required for survival of conventional T cells...
  5. ncbi request reprint The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity
    Gerard F Hoyne
    Australian Cancer Research Foundation Genetics Laboratory and Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Immunol Rev 210:27-39. 2006
    ..The successful propagation and identification of the new gene variants will shed light on the various developmental checkpoints in lymphocyte development that are crucial for establishing tolerance to self-antigens...
  6. doi request reprint Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation
    Zuopeng Wu
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 185:231-8. 2010
    ..In T cells with no CD45 protein, hnRNPLL mutation still diminished peripheral T cell accumulation, demonstrating that hnRNPLL regulates T cell longevity independently from its effects on CD45 splicing...
  7. doi request reprint Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL
    Yovina Sontani
    Immunology Department, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Leuk Res 35:1512-9. 2011
    ..These findings illuminate the early stages of leukemogenesis by demonstrating progressive exaggeration of Notch1 responsiveness at the DP thymocyte stage brought about by multiple mutations acting in concert upon the Notch1 pathway...