G S Howarth

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi request reprint Enhancement of intestinal growth and repair by growth factors
    G S Howarth
    Child Health Research Institute, North Adelaide, South Australia
    Curr Opin Pharmacol 1:568-74. 2001
  2. pmc Role of endogenous microbiota, probiotics and their biological products in human health
    Gordon S Howarth
    School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, South Australia 5371, Australia
    Nutrients 5:58-81. 2013
  3. ncbi request reprint Betacellulin promotes growth of the gastrointestinal organs and effects a diuresis in normal rats
    Gordon S Howarth
    Cooperative Research Centre for Tissue Growth and Repair, University of Adelaide, Adelaide, Australia
    Growth Factors 21:79-86. 2003
  4. doi request reprint Optimization of the non-invasive 13C-sucrose breath test in a rat model of methotrexate-induced mucositis
    K L Tooley
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, SA 5006, Australia
    Cancer Chemother Pharmacol 65:913-21. 2010
  5. ncbi request reprint Predisposition to colonic dysplasia is unaffected by continuous administration of insulin-like growth factor-I for twenty weeks in a rat model of chronic inflammatory bowel disease
    G S Howarth
    Cooperative Research Centre for Tissue Growth and Repair, and Child Health Research Institute, North Adelaide, South Australia, Australia
    Growth Factors 18:119-33. 2000
  6. doi request reprint Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats
    E Southcott
    Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, SA 5006, Australia
    Dig Dis Sci 53:1837-41. 2008
  7. ncbi request reprint Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate
    G S Howarth
    Cooperative Research Center for Tissue Growth and Repair, North Adelaide, South Australia
    Growth Factors 15:279-92. 1998
  8. ncbi request reprint Pre-treatment with insulin-like growth factor-I partially ameliorates 5-fluorouracil-induced intestinal mucositis in rats
    Johanna C Cool
    Cooperative Research Centre for Tissue Growth and Repair, Australia
    Growth Horm IGF Res 15:72-82. 2005
  9. pmc Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis
    C J Xian
    Child Health Research Institute, University of Adelaide Department of Paediatrics, and Cooperative Research Centre for Tissue Growth and Repair, Australia
    Br J Cancer 82:945-52. 2000
  10. doi request reprint The effects of formula feeding on physiological and immunological parameters in the gut of neonatal rats
    K L Tooley
    Women s and Children s Health Research Institute, 72 King William Road, North Adelaide, South Australia
    Dig Dis Sci 54:1432-9. 2009

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Enhancement of intestinal growth and repair by growth factors
    G S Howarth
    Child Health Research Institute, North Adelaide, South Australia
    Curr Opin Pharmacol 1:568-74. 2001
    ....
  2. pmc Role of endogenous microbiota, probiotics and their biological products in human health
    Gordon S Howarth
    School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, South Australia 5371, Australia
    Nutrients 5:58-81. 2013
    ....
  3. ncbi request reprint Betacellulin promotes growth of the gastrointestinal organs and effects a diuresis in normal rats
    Gordon S Howarth
    Cooperative Research Centre for Tissue Growth and Repair, University of Adelaide, Adelaide, Australia
    Growth Factors 21:79-86. 2003
    ..Betacellulin further stimulated a diuresis suggesting an additional role in fluid homeostasis...
  4. doi request reprint Optimization of the non-invasive 13C-sucrose breath test in a rat model of methotrexate-induced mucositis
    K L Tooley
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, SA 5006, Australia
    Cancer Chemother Pharmacol 65:913-21. 2010
    ..In order to determine the sensitivity and specificity of the test and to optimize experimental conditions utilizing the SBT in a rat model of chemotherapy-induced small intestinal damage...
  5. ncbi request reprint Predisposition to colonic dysplasia is unaffected by continuous administration of insulin-like growth factor-I for twenty weeks in a rat model of chronic inflammatory bowel disease
    G S Howarth
    Cooperative Research Centre for Tissue Growth and Repair, and Child Health Research Institute, North Adelaide, South Australia, Australia
    Growth Factors 18:119-33. 2000
    ..We investigated the safety of long-term IGF-I administration in a rat model of inflammatory bowel disease which predisposes to the development of dysplasia...
  6. doi request reprint Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats
    E Southcott
    Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, SA 5006, Australia
    Dig Dis Sci 53:1837-41. 2008
    ..Probiotics containing SY and CY may be useful in preventing disruption to intestinal barrier function in MTX-induced mucositis...
  7. ncbi request reprint Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate
    G S Howarth
    Cooperative Research Center for Tissue Growth and Repair, North Adelaide, South Australia
    Growth Factors 15:279-92. 1998
    ..IGF-I was infused concurrent with methotrexate administration and compared to IGF-I administered following the withdrawal of methotrexate...
  8. ncbi request reprint Pre-treatment with insulin-like growth factor-I partially ameliorates 5-fluorouracil-induced intestinal mucositis in rats
    Johanna C Cool
    Cooperative Research Centre for Tissue Growth and Repair, Australia
    Growth Horm IGF Res 15:72-82. 2005
    ..We conclude that IGF-I pre-treatment only partially attenuates features of intestinal mucositis when assessed 48 h after 5-FU chemotherapy...
  9. pmc Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis
    C J Xian
    Child Health Research Institute, University of Adelaide Department of Paediatrics, and Cooperative Research Centre for Tissue Growth and Repair, Australia
    Br J Cancer 82:945-52. 2000
    ..The crypt epithelial localization of HGF and c-met implies an autocrine or paracrine mechanism of HGF action...
  10. doi request reprint The effects of formula feeding on physiological and immunological parameters in the gut of neonatal rats
    K L Tooley
    Women s and Children s Health Research Institute, 72 King William Road, North Adelaide, South Australia
    Dig Dis Sci 54:1432-9. 2009
    ..05). We have developed a new rat model of artificial feeding which possesses important immunological and biological similarities to the premature human infant...
  11. ncbi request reprint Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventative treatment modality for inflammatory bowel disease
    Danik Tenikoff
    Child Health Research Institute, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Gastroenterol 40:361-5. 2005
    ..We investigated the effect of pretreatment with Lyprinol (LYP) on experimentally induced inflammatory bowel disease (IBD) in mice...
  12. doi request reprint Dipeptidyl peptidase expression during experimental colitis in mice
    Roger Yazbeck
    School of Biological Sciences, Flinders University, Adelaide, South Australia, Australia
    Inflamm Bowel Dis 16:1340-51. 2010
    ..We have previously demonstrated that inhibition of dipeptidyl peptidase (DP) activity partially attenuates dextran sulfate sodium (DSS) colitis in mice. The aim of this study was to further investigate the mechanisms of this protection...
  13. ncbi request reprint Lyprinol only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis
    Diana M Torres
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, University of Adelaide, Adelaide, South Australia
    Cancer Biol Ther 7:295-302. 2008
    ..We assessed the effects of Lyprinol on the severity of 5-fluorouracil (5-FU)-induced mucositis in female Dark Agouti rats...
  14. ncbi request reprint Development and resolution of experimental colitis in mice with targeted deletion of dipeptidyl peptidase IV
    Mark S Geier
    Child Health Research Institute and Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Cell Physiol 204:687-92. 2005
    ..We conclude that loss of DPIV activity does not increase resistance to experimental colitis and hypothesize that other DPIV family members may also be involved in the cleavage of GLP-2...
  15. ncbi request reprint Effects of acute 5-fluorouracil chemotherapy and insulin-like growth factor-I pretreatment on growth plate cartilage and metaphyseal bone in rats
    C J Xian
    Department of Orthopaedic Surgery, University of Adelaide Department of Paediatrics, North Adelaide, SA, Australia
    Bone 35:739-49. 2004
    ....
  16. ncbi request reprint Lactobacillus rhamnosus GG exacerbates intestinal ulceration in a model of indomethacin-induced enteropathy
    Rasha Kamil
    entre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, South Australia, Australia
    Dig Dis Sci 52:1247-52. 2007
    ..Bb12 did not reduce indomethacin-induced intestinal ulceration, whereas LGG actually increased some indicators of injury. LGG and Bb12, at the doses tested, cannot alleviate indomethacin-induced intestinal injury...
  17. ncbi request reprint Short-chain fatty acid modulation of apoptosis in the Kato III human gastric carcinoma cell line
    Geoffrey M Matthews
    Gastroenterology Department, Children, Youth and Women s Health Service, North Adelaide, SA Australia
    Cancer Biol Ther 6:1051-7. 2007
    ..The inclusion of butyrate and propionate as adjunctive cancer therapies has the potential to enhance the efficacy of current chemotherapeutics in the treatment of gastric cancer...
  18. ncbi request reprint Lactobacillus fermentum BR11, a potential new probiotic, alleviates symptoms of colitis induced by dextran sulfate sodium (DSS) in rats
    Mark S Geier
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, South Australia, 5006, Australia
    Int J Food Microbiol 114:267-74. 2007
    ..Bb12 had minimal effects, whilst TH-4 did not prevent DSS-colitis and LGG actually exacerbated some indicators of colitis. Further studies into the potential benefits of L. fermentum BR11 are indicated...
  19. doi request reprint A small-scale, low-cost isolation system for the incubation and rearing of low bacterial load chicks as a model to study microbial-intestinal interactions
    Rebecca E A Forder
    Discipline of Agricultural and Animal Science, School of Agriculture, Food and Wine, Roseworthy Campus, University of Adelaide, Roseworthy, SA 5371, Australia
    Lab Anim 42:185-92. 2008
    ..Despite the presence of bacterial species, the isolator system was successful in producing low bacterial load chicks for comparison studies with conventionally raised chicks...
  20. ncbi request reprint Inflammatory bowel disease: current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics
    Mark S Geier
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, South Australia, Australia
    Int J Food Microbiol 115:1-11. 2007
    ....
  21. ncbi request reprint Probiotics, prebiotics and synbiotics: a role in chemoprevention for colorectal cancer?
    Mark S Geier
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, North Adelaide, South Australia
    Cancer Biol Ther 5:1265-9. 2006
    ..Probiotics and prebiotics have the potential to impact significantly on the development, progression and treatment of colorectal cancer and may have a valuable role in cancer prevention...
  22. ncbi request reprint A non-invasive method for detection of intestinal mucositis induced by different classes of chemotherapy drugs in the rat
    Gordon S Howarth
    Centre for Pediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, Adelaide, Australia
    Cancer Biol Ther 5:1189-95. 2006
    ..The Sucrose Breath Test (SBT) is a simple noninvasive technique for the detection of small intestinal mucositis...
  23. ncbi request reprint Effects of etoposide and cyclophosphamide acute chemotherapy on growth plate and metaphyseal bone in rats
    Cory J Xian
    Department of Orthopaedic Surgery, University of Adelaide Department of Paediatrics, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
    Cancer Biol Ther 6:170-7. 2007
    ....
  24. ncbi request reprint Dipeptidyl peptidases and inflammatory bowel disease
    Catherine A Abbott
    School of Biological Sciences, Flinders University, Adelaide, SA, Australia
    Adv Exp Med Biol 575:155-62. 2006
  25. ncbi request reprint Effects of TGF-alpha gene knockout on epithelial cell kinetics and repair of methotrexate-induced damage in mouse small intestine
    Cory J Xian
    Child Health Research Institute and Cooperative Research Centre for Tissue Growth and Repair, North Adelaide, South Australia, Australia
    J Cell Physiol 191:105-15. 2002
    ....
  26. doi request reprint Lactobacillus fermentum BR11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model of intestinal mucositis in rats
    Cassie L Smith
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, North Adelaide, South Australia
    Nutr Cancer 60:757-67. 2008
    ..05). We conclude that L. fermentum BR11 has the potential to reduce inflammation of the upper small intestine. However, its combination with FOS does not appear to confer any further therapeutic benefit for the alleviation of mucositis...
  27. ncbi request reprint Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine
    Cuong D Tran
    Gastroenterology Unit, Women s and Children s Hospital, University of Adelaide, Adelaide, Australia
    Am J Clin Nutr 77:1296-303. 2003
    ..Oral administration of zinc or bovine whey-derived growth factor extract (WGFE) is known to reduce intestinal permeability and ameliorate methotrexate (MTX)-induced mucositis, respectively...
  28. ncbi request reprint Insulin-like growth factor-I and the gastrointestinal system: therapeutic indications and safety implications
    Gordon S Howarth
    Child Health Research Institute and Gastroenterology Department, Women s and Children s Hospital, and Disciplines of Physiology and Paediatrics, University of Adelaide, Adelaide, South Australia
    J Nutr 133:2109-12. 2003
    ....
  29. ncbi request reprint Mucositis and non-invasive markers of small intestinal function
    Katie L Tooley
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service and Discipline of Physiology, University of Adelaide, 72 King William Road, North Adelaide, SA, Australia
    Cancer Biol Ther 8:753-8. 2009
    ..We propose the SBT a superior biomarker of small intestinal function that could be successfully applied in clinical practice for monitoring the development of mucositis in cancer patients undergoing chemotherapy...
  30. ncbi request reprint Prebiotic and synbiotic fructooligosaccharide administration fails to reduce the severity of experimental colitis in rats
    Mark S Geier
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, South Australia, Australia
    Dis Colon Rectum 50:1061-9. 2007
    ..01). No protection from dextran sulfate sodium-colitis was accorded by fructooligosaccharide alone or in synbiotic combination with L. fermentum BR11, whereas fructooligosaccharide actually increased some indicators of colonic injury...
  31. ncbi request reprint Expression of B7 costimulatory molecules by cells infiltrating the colon in experimental colitis induced by oral dextran sulfate sodium in the mouse
    R H Grose
    Cooperative Research Centre for Tissue Growth and Repair, Child Health Research Institute, North Adelaide, South Australia
    J Gastroenterol Hepatol 16:1228-34. 2001
    ..These results suggest an intervention strategy based on the blockade of the B7-costimulatory axis could find application in the treatment of inflammatory bowel disease...
  32. ncbi request reprint Bacterial modulation of small intestinal goblet cells and mucin composition during early posthatch development of poultry
    R E A Forder
    Discipline of Agricultural and Animal Science, School of Agriculture, Food and Wine, University of Adelaide, Roseworthy, 5371, South Australia
    Poult Sci 86:2396-403. 2007
    ..04 +/- 0.02 x10(3) cells/mm(2)). This change in mucin profile in response to bacterial colonization suggests a potential role as a protective mechanism against pathogenic invasion of the intestinal mucosa during early development...
  33. ncbi request reprint Dietary zinc supplementation and methotrexate-induced small intestinal mucositis in metallothionein-knockout and wild-type mice
    Cuong D Tran
    Gastroenterology Unit, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, SA, Australia
    Cancer Biol Ther 8:1662-7. 2009
    ..Zn induces metallothionein (MT) which has been shown to sequester free radicals. The aim of this study was to determine the capacity for dietary Zn supplementation to ameliorate methotrexate (MTX)-induced intestinal mucositis...
  34. pmc Increased responsiveness of rat colonic splanchnic afferents to 5-HT after inflammation and recovery
    Jonathan R Coldwell
    Nerve Gut Research Laboratory, Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, Australia
    J Physiol 579:203-13. 2007
    ..This is associated with alterations in the roles of 5-HT3 receptors and mast cells...
  35. ncbi request reprint Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis
    Ker Y Cheah
    Disciplines of Wine and Horticulture, School of Agriculture, Food and Wine, University of Adelaide, Adelaide, South Australia
    Cancer Biol Ther 8:382-90. 2009
    ..GSE may represent a promising prophylactic adjunct to conventional chemotherapy for preventing intestinal mucositis...
  36. ncbi request reprint The herbal extract, Iberogast, improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis
    Tessa H Wright
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, Adelaide, SA, Australia
    Cancer Biol Ther 8:923-9. 2009
    ..05). We conclude that although Iberogast partially improved the histopathological features of 5-FU induced mucositis, it conferred no significant protection as indicated by the assessed endpoints...
  37. ncbi request reprint A novel breath test for the non-invasive assessment of small intestinal mucosal injury following methotrexate administration in the rat
    N S Pelton
    Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, Adelaide, South Australia
    Scand J Gastroenterol 39:1015-6. 2004
  38. ncbi request reprint The role of zinc and metallothionein in the dextran sulfate sodium-induced colitis mouse model
    C D Tran
    Gastroenterology Unit, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, SA 5006, Australia
    Dig Dis Sci 52:2113-21. 2007
    ..Zn partially prevented the distal colon of MT+/+ by 47% from DSS-induced damage compared to MT-/- mice. MT did not prevent DSS-induced colitis and Zn was partially effective in amelioration of DSS-induced colitis...
  39. ncbi request reprint Use of the 13C-sucrose breath test to assess chemotherapy-induced small intestinal mucositis in the rat
    Julie M Clarke
    Child Health Research Institute, University of Adelaide, South Australia
    Cancer Biol Ther 5:34-8. 2006
    ....
  40. ncbi request reprint Probiotic effects on 5-fluorouracil-induced mucositis assessed by the sucrose breath test in rats
    Chad A Mauger
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, South Australia, Australia
    Dig Dis Sci 52:612-9. 2007
    ..The SBT detected damage induced by 5-FU and is a simple, noninvasive indicator of small bowel injury. The probiotics assessed offered no protection from mucositis at the dose tested...
  41. ncbi request reprint Inhibiting dipeptidyl peptidase activity partially ameliorates colitis in mice
    Roger Yazbeck
    School of Biological Sciences, Flinders University, Adelaide, South Australia, Australia
    Front Biosci 13:6850-8. 2008
    ..Crypt hyperplasia (p<0.05) was observed in the saline group compared to P32/98 treatment at day 9. This preliminary study shows that novel inhibitors of DP activity may provide a new treatment strategy for IBD...
  42. ncbi request reprint Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats
    Katie L Tooley
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, North Adelaide, South Australia
    Cancer Biol Ther 5:593-600. 2006
    ..This study investigated the effects of orally ingested Streptococcus thermophilus (TH-4) on chemotherapy-induced small intestinal damage in rats using the noninvasive (13)C-sucrose breath test (SBT)...
  43. doi request reprint Small-intestinal manifestations of dextran sulfate sodium consumption in rats and assessment of the effects of Lactobacillus fermentum BR11
    Mark S Geier
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, North Adelaide, Adelaide, SA, Australia
    Dig Dis Sci 54:1222-8. 2009
    ..05). BR11 normalized these parameters. While DSS predominantly induces colonic damage, minor morphological alterations were also detected in the distal small intestine. L. fermentum BR11 normalized these features...
  44. ncbi request reprint Applicability of the Ussing chamber technique to permeability determinations in functionally distinct regions of the gastrointestinal tract in the rat
    B H Bajka
    Child Health Research Institute and Cooperative Research Centre for Tissue Growth and Repair, Adelaide, South Australia, Australia
    Scand J Gastroenterol 38:732-41. 2003
    ..Ussing chambers are commonly utilized for in vitro investigations into gastrointestinal permeability. However, their sensitivity and applicability to the small intestine have not been well characterized...
  45. doi request reprint Gastrointestinal pathology in a mouse model of mucopolysaccharidosis type IIIA
    Ainslie L K Derrick Roberts
    Department of Genetic Medicine, Matrix Biology Unit, Children, Youth and Women s Health Service, North Adelaide, SA, Australia
    J Cell Physiol 219:259-64. 2009
    ..Sucrase activity was higher than normal in MPS IIIA at all ages tested. These abnormalities in GI structure and function observed in MPS IIIA may contribute to weight gain in this disorder...
  46. doi request reprint Orally administered emu oil decreases acute inflammation and alters selected small intestinal parameters in a rat model of mucositis
    Ruth J Lindsay
    School of Animal and Veterinary Sciences, Roseworthy Campus, University of Adelaide, Roseworthy, SA, Australia
    Br J Nutr 104:513-9. 2010
    ..Further studies investigating the potential benefits of emu oil as a nutritional supplement for the treatment of intestinal disorders are indicated...
  47. ncbi request reprint Effects of insulin-like growth factor-I and its analogue, long-R3-IGF-I, on intestinal absorption of 3-O-methyl-D-glucose are less pronounced than gut mucosal growth responses
    Sonja M Garnaut
    Cooperative Research Center for Tissue Growth and Repair, Child Health Research Institute, North Adelaide, South Australia, Australia
    Growth Factors 20:17-25. 2002
    ..Long-R3-IGF-I, but not native IGF-I, enhanced 3MG absorption from the intestinal lumen, presumably reflecting an increased mucosal mass rather than an up-regulation of specific epithelial glucose transporters...
  48. doi request reprint Growth factor based therapies and intestinal disease: is glucagon-like peptide-2 the new way forward?
    Roger Yazbeck
    School of Biological Sciences, Flinders University, Adelaide, South Australia, Australia
    Cytokine Growth Factor Rev 20:175-84. 2009
    ..This review outlines evidence for the clinical application of GLP-2, its degradation resistant analogue, Teduglutide, and novel DPIV inhibitors in efficacy studies utilizing pre-clinical models of intestinal damage, in particular IBD...
  49. doi request reprint Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
    Roger Yazbeck
    School of Biological Sciences, Flinders University, Adelaide, South Australia, Australia
    Trends Pharmacol Sci 30:600-7. 2009
    ..This review highlights recent insights into the applicability of DPP inhibitors as novel pharmacological agents for inflammatory disease...
  50. ncbi request reprint Nutrient and antioxidant modulation of apoptosis in gastric and colon cancer cells
    Geoffrey M Matthews
    Centre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, North Adelaide, SA, Australia
    Cancer Biol Ther 5:569-72. 2006
    ..Moreover, we hypothesize that the short-chain fatty acid, butyrate, will induce apoptosis in gastric cancer cells and, secondly, that differences in butyrate metabolism will exist between these cancer cell lines...
  51. ncbi request reprint The use of GLP-2 and related growth factors in intestinal diseases
    Roger Yazbeck
    Women s and Children s Hospital, Centre for Paediatric and Adolescent Gastroenterology, 72 King William Road, Adelaide, SA 5006, Australia
    Curr Opin Investig Drugs 11:440-6. 2010
    ....