Hubert Hondermarck


Affiliation: University of Newcastle
Country: Australia


  1. Faulkner S, Jobling P, March B, Jiang C, Hondermarck H. Tumor Neurobiology and the War of Nerves in Cancer. Cancer Discov. 2019;: pubmed publisher
    ..b>Significance: Nerves are emerging regulators of cancer initiation, progression, and metastasis. Here, we review the evidence to date and explore the basic and clinical ramifications of these findings. ..
  2. Sahoo S, Zhang X, Hondermarck H, Tanwar P. The Emerging Role of the Microenvironment in Endometrial Cancer. Cancers (Basel). 2018;10: pubmed publisher
    ..We also suggest that the inhibition of microenvironment-derived signals may suppress metastatic EC progression and offer novel potential therapeutic interventions. ..
  3. Jobling P, Pundavela J, Oliveira S, Roselli S, Walker M, Hondermarck H. Nerve-Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression. Cancer Res. 2015;75:1777-81 pubmed publisher
    ..This review will discuss our evolving understanding of the cross-talk between nerves and cancer cells. ..
  4. Pundavela J, Roselli S, Faulkner S, Attia J, Scott R, Thorne R, et al. Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer. Mol Oncol. 2015;9:1626-35 pubmed publisher
    ..The potential participation of nerve fibers in breast cancer progression needs to be further considered. ..
  5. Pundavela J, Demont Y, Jobling P, Lincz L, Roselli S, Thorne R, et al. ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer. Am J Pathol. 2014;184:3156-62 pubmed publisher
    ..These data reveal that ProNGF is a biomarker associated with high-risk prostate cancers and a potential driver of infiltration by nerves. ..
  6. Dun M, Chalkley R, Faulkner S, Keene S, Avery Kiejda K, Scott R, et al. Proteotranscriptomic Profiling of 231-BR Breast Cancer Cells: Identification of Potential Biomarkers and Therapeutic Targets for Brain Metastasis. Mol Cell Proteomics. 2015;14:2316-30 pubmed publisher
    ..The clinicopathological significance of these major proteomic changes to predict the occurrence of brain metastases, and their potential value as therapeutic targets, warrants further investigation. ..
  7. Bradshaw R, Pundavela J, Biarc J, Chalkley R, Burlingame A, Hondermarck H. NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling. Adv Biol Regul. 2015;58:16-27 pubmed publisher
  8. Gao F, Griffin N, Faulkner S, Rowe C, Williams L, Roselli S, et al. The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung. Sci Rep. 2018;8:8135 pubmed publisher
    ..In conclusion, these data suggest a preferential therapeutic value of targeting the NGF-TrkA axis in squamous cell carcinomas of the lung. ..
  9. Griffin N, Faulkner S, Jobling P, Hondermarck H. Targeting neurotrophin signaling in cancer: The renaissance. Pharmacol Res. 2018;135:12-17 pubmed publisher
    ..Therefore, pharmacological interventions against neurotrophin signaling have the potential not only to target cancer cells directly, but also to inhibit neurogenesis and its stimulatory impact on cancer progression and pain. ..

More Information


  1. Shargh V, Hondermarck H, Liang M. Albumin hybrid nanoparticles loaded with tyrosine kinase A inhibitor GNF-5837 for targeted inhibition of breast cancer cell growth and invasion. Int J Pharm. 2016;515:527-534 pubmed publisher
    ..These results show that the GNF-Alb-HNPs may represent a novel approach for targeted breast cancer therapy. ..
  2. Hondermarck H, Jobling P. The Sympathetic Nervous System Drives Tumor Angiogenesis. Trends Cancer. 2018;4:93-94 pubmed publisher
    ..These findings suggest that the sympathetic nervous system is a higher-level control of tumor angiogenesis that could be targeted in clinical oncology. ..
  3. Boilly B, Faulkner S, Jobling P, Hondermarck H. Nerve Dependence: From Regeneration to Cancer. Cancer Cell. 2017;31:342-354 pubmed publisher
    ..Thus, the neurobiology of cancer is an emerging discipline that opens new perspectives in oncology. ..
  4. Faulkner S, Jobling P, Rowe C, Rodrigues Oliveira S, Roselli S, Thorne R, et al. Neurotrophin Receptors TrkA, p75NTR, and Sortilin Are Increased and Targetable in Thyroid Cancer. Am J Pathol. 2018;188:229-241 pubmed publisher
    ..Together, these data reveal TrkA, p75NTR, and sortilin as potential therapeutic targets in thyroid cancer. ..
  5. Rutledge A, Jobling P, Walker M, Denham J, Hondermarck H. Spinal Cord Injuries and Nerve Dependence in Prostate Cancer. Trends Cancer. 2017;3:812-815 pubmed publisher
    ..Patients with spinal cord injuries (SCIs) resulting in functional denervation of the prostate have a lower incidence of prostate cancer. This may constitute a clinical evidence for nerve dependence in human prostate tumorigenesis. ..