Janet E Holt

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi APC(FZR1) prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Biol Cell 23:3970-81. 2012
  2. ncbi The control of meiotic maturation in mammalian oocytes
    Janet E Holt
    Center for Reproductive Sciences and School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Curr Top Dev Biol 102:207-26. 2013
  3. ncbi The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 138:905-13. 2011
  4. ncbi Control of homologous chromosome division in the mammalian oocyte
    Janet E Holt
    University of Newcastle, Callaghan, NSW, Australia
    Mol Hum Reprod 15:139-47. 2009
  5. ncbi Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 137:1297-304. 2010
  6. ncbi Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis I in mouse oocytes
    Janet E Holt
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia
    Methods Mol Biol 957:91-106. 2013
  7. ncbi Reduced chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young mice
    Julie A Merriman
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 88:31. 2013
  8. ncbi Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline
    Janet E Holt
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Genomics 87:490-9. 2006
  9. ncbi The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development
    Michelle K Y Seah
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    J Cell Sci 125:6030-7. 2012
  10. ncbi CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary
    Janet E Holt
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Dev Biol 293:449-60. 2006

Collaborators

Detail Information

Publications12

  1. ncbi APC(FZR1) prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Biol Cell 23:3970-81. 2012
    ..This study implicates FZR1 as a major regulator of prometaphase whose activity helps to prevent chromosome nondisjunction...
  2. ncbi The control of meiotic maturation in mammalian oocytes
    Janet E Holt
    Center for Reproductive Sciences and School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Curr Top Dev Biol 102:207-26. 2013
    ..This is achieved by APC(CDC20), whose activity is critically regulated by the spindle assembly checkpoint, and which induces both a loss in CDK1 activity as well as the cohesive ties holding chromosomes together...
  3. ncbi The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 138:905-13. 2011
    ..Thus, APC/C(FZR1) activity is required to repress cyclin B1 levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption...
  4. ncbi Control of homologous chromosome division in the mammalian oocyte
    Janet E Holt
    University of Newcastle, Callaghan, NSW, Australia
    Mol Hum Reprod 15:139-47. 2009
    ..In particular, we examine the role played by the spindle assembly checkpoint in controlling the APC/C activity, and in so doing ensuring accurate disjunction of homologs...
  5. ncbi Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 137:1297-304. 2010
    ..We propose a simple spatial model of G2 arrest in which nuclear APC(Cdh1)-proteasomal activity guards against any cyclin B1 accumulation mediated by nuclear import...
  6. ncbi Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis I in mouse oocytes
    Janet E Holt
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia
    Methods Mol Biol 957:91-106. 2013
    ..Here we describe the process of microinjecting cRNA to proteins of interest that have been coupled to a fluorescent protein using cyclin B1 as an example...
  7. ncbi Reduced chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young mice
    Julie A Merriman
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 88:31. 2013
    ..Based on these results, we propose that individual oocytes undergo loss in chromosomal cohesion at different rates and that the greater this loss, the greater the risk for becoming aneuploid...
  8. ncbi Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline
    Janet E Holt
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Genomics 87:490-9. 2006
    ..Together with in silico data, we predict Mtfull plays an essential role in folliculogenesis through regulation of gene expression...
  9. ncbi The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development
    Michelle K Y Seah
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    J Cell Sci 125:6030-7. 2012
    ....
  10. ncbi CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary
    Janet E Holt
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Dev Biol 293:449-60. 2006
    ..By retaining follicles in an unactivated state, SDF1/CXCR4 signaling may play an important role in maintaining the size and longevity of the primordial follicle pool...
  11. ncbi Characterization of structure and expression of the Dzip1 gene in the rat and mouse
    Benjamin J Curry
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Genomics 87:275-85. 2006
    ....
  12. ncbi Biosynthesis of the canine zona pellucida requires the integrated participation of both oocytes and granulosa cells
    Daniel G Blackmore
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 71:661-8. 2004
    ....