Benjamin M Hogan
Affiliation: University of Queensland
Okuda K, Baek S, Hogan B. Visualization and Tools for Analysis of Zebrafish Lymphatic Development. Methods Mol Biol. 2018;1846:55-70 pubmed publisher
..These methods offer researchers the opportunity to experimentally dissect developmental lymphangiogenesis with outstanding resolution. ..
Lagendijk A, Hogan B. VE-cadherin in vascular development: a coordinator of cell signaling and tissue morphogenesis. Curr Top Dev Biol. 2015;112:325-52 pubmed publisher
..We describe key studies that highlight VE-cadherin as a regulatory hub in endothelial cell signaling during angiogenesis, vessel morphogenesis, and vascular development. ..
Bower N, Hogan B. Brain drains: new insights into brain clearance pathways from lymphatic biology. J Mol Med (Berl). 2018;96:383-390 pubmed publisher
..These systems may play important individual and collective roles in draining and clearing wastes from the brain. ..
Lagendijk A, Yap A, Hogan B. Notching a New Pathway in Vascular Flow Sensing. Trends Cell Biol. 2018;28:173-175 pubmed publisher
..A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms controlling the endothelial barrier. ..
Koltowska K, Lagendijk A, Pichol Thievend C, Fischer J, Francois M, Ober E, et al
. Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Rep. 2015;13:1828-41 pubmed publisher
..Vegfc drives cell division and Prox1 expression in lymphatic daughter cells, coupling signaling dynamics with daughter cell fate restriction and precursor division. ..
Koenig A, Baltrunaite K, Bower N, Rossi A, Stainier D, Hogan B, et al
. Vegfa signaling promotes zebrafish intestinal vasculature development through endothelial cell migration from the posterior cardinal vein. Dev Biol. 2016;411:115-27 pubmed publisher
..It is likely that a similar mechanism is utilized during vascularization of other organs. ..
Bower N, Vogrin A, Le Guen L, Chen H, Stacker S, Achen M, et al
. Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development. Development. 2017;144:507-518 pubmed publisher
..These data demonstrate that, rather than being dispensable during development, Vegfd plays context-specific indispensable and also compensatory roles during both blood vessel angiogenesis and lymphangiogenesis. ..
De Angelis J, Lagendijk A, Chen H, Tromp A, Bower N, Tunny K, et al
. Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover. Dev Cell. 2017;40:123-136 pubmed publisher
..Based on these data, and the known structure of Tmem2, we find that Tmem2 regulates HA turnover to promote normal Vegf signaling during developmental angiogenesis. ..
Hogan B, Schulte Merker S. How to Plumb a Pisces: Understanding Vascular Development and Disease Using Zebrafish Embryos. Dev Cell. 2017;42:567-583 pubmed publisher
..Here, we highlight key mechanisms controlling formation of the zebrafish vasculature and investigate how knowledge from this highly tractable model system has informed our understanding of vascular disease in humans. ..