Ken K Y Ho

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. doi request reprint Gender difference in the neuroendocrine regulation of growth hormone axis by selective estrogen receptor modulators
    Vita Birzniece
    Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    J Clin Endocrinol Metab 97:E521-7. 2012
  2. doi request reprint Modulatory effect of raloxifene and estrogen on the metabolic action of growth hormone in hypopituitary women
    Vita Birzniece
    Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
    J Clin Endocrinol Metab 95:2099-106. 2010
  3. ncbi request reprint Regulation of growth hormone signaling by selective estrogen receptor modulators occurs through suppression of protein tyrosine phosphatases
    Kin Chuen Leung
    Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Endocrinology 148:2417-23. 2007
  4. doi request reprint Paracrine regulation of growth hormone secretion by estrogen in women
    Vita Birzniece
    Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, The University of New South Wales, Sydney, NSW, Australia
    J Clin Endocrinol Metab 95:3771-6. 2010
  5. doi request reprint The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trial
    Udo Meinhardt
    Garvan Institute of Medical Research and St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Ann Intern Med 152:568-77. 2010
  6. doi request reprint Neuroendocrine regulation of growth hormone and androgen axes by selective estrogen receptor modulators in healthy men
    Vita Birzniece
    Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, and The University of New South Wales, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 95:5443-8. 2010
  7. ncbi request reprint Comparison of the metabolic effects of raloxifene and oral estrogen in postmenopausal and growth hormone-deficient women
    James Gibney
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 90:3897-903. 2005
  8. ncbi request reprint Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary men
    Gudmundur Johannsson
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 90:3989-94. 2005
  9. doi request reprint Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary men
    Vita Birzniece
    Pituitary Research Unit, Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Clin Endocrinol (Oxf) 71:715-21. 2009
  10. doi request reprint Interaction between testosterone and growth hormone on whole-body protein anabolism occurs in the liver
    Vita Birzniece
    Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 96:1060-7. 2011

Collaborators

Detail Information

Publications34

  1. doi request reprint Gender difference in the neuroendocrine regulation of growth hormone axis by selective estrogen receptor modulators
    Vita Birzniece
    Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    J Clin Endocrinol Metab 97:E521-7. 2012
    ..The relative impact of SERMs on the GH-IGF-I axis in men and women has not been investigated...
  2. doi request reprint Modulatory effect of raloxifene and estrogen on the metabolic action of growth hormone in hypopituitary women
    Vita Birzniece
    Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
    J Clin Endocrinol Metab 95:2099-106. 2010
    ..Selective estrogen receptor modulators lower IGF-I to a lesser degree than 17beta-estradiol in GH-deficient women, and their effect on fat and protein metabolism is unknown...
  3. ncbi request reprint Regulation of growth hormone signaling by selective estrogen receptor modulators occurs through suppression of protein tyrosine phosphatases
    Kin Chuen Leung
    Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Endocrinology 148:2417-23. 2007
    ..We provide the first evidence for a novel mechanism regulating GH signaling, in which SERMs enhance GH activation of the JAK2/STAT5 pathway in a cell-type-dependent manner by attenuating protein tyrosine phosphatase activities...
  4. doi request reprint Paracrine regulation of growth hormone secretion by estrogen in women
    Vita Birzniece
    Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, The University of New South Wales, Sydney, NSW, Australia
    J Clin Endocrinol Metab 95:3771-6. 2010
    ..The aim was to investigate whether local estrogens produced from aromatization regulate GH secretion...
  5. doi request reprint The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trial
    Udo Meinhardt
    Garvan Institute of Medical Research and St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Ann Intern Med 152:568-77. 2010
    ..Growth hormone is widely abused by athletes, frequently with androgenic steroids. Its effects on performance are unclear...
  6. doi request reprint Neuroendocrine regulation of growth hormone and androgen axes by selective estrogen receptor modulators in healthy men
    Vita Birzniece
    Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, and The University of New South Wales, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 95:5443-8. 2010
    ..Thus, tamoxifen is likely to perturb the neuroendocrine regulation of GH and gonadal axes. Raloxifene, a SERM, is used for therapy of osteoporosis in both sexes. Its neuroendocrine effects in men are poorly understood...
  7. ncbi request reprint Comparison of the metabolic effects of raloxifene and oral estrogen in postmenopausal and growth hormone-deficient women
    James Gibney
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 90:3897-903. 2005
    ..The aim of this study was to determine whether selective estrogen receptor modulators display similar effects and whether these effects are magnified in GH-deficient (GHD) women because of the loss of GH feedback...
  8. ncbi request reprint Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary men
    Gudmundur Johannsson
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 90:3989-94. 2005
    ..The mechanisms underlying the sodium-retaining effects of GH are poorly understood...
  9. doi request reprint Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary men
    Vita Birzniece
    Pituitary Research Unit, Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Clin Endocrinol (Oxf) 71:715-21. 2009
    ..Fat mass is increased in hypogonadal men and the changes are reversed by testosterone replacement. Testosterone administration enhances whole body fat oxidation (Fox). Fat is oxidized in the liver and in extra-hepatic tissues...
  10. doi request reprint Interaction between testosterone and growth hormone on whole-body protein anabolism occurs in the liver
    Vita Birzniece
    Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 96:1060-7. 2011
    ..GH and testosterone both exert protein-anabolic effects and may act synergistically. Liver and muscle are major sites of protein metabolism...
  11. doi request reprint Identification of novel GH-regulated pathway of lipid metabolism in adipose tissue: a gene expression study in hypopituitary men
    Jing Ting Zhao
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Sydney, Australia
    J Clin Endocrinol Metab 96:E1188-96. 2011
    ..Adipose tissue is a major target of GH action. GH stimulates lipolysis and reduces fat mass. The molecular mechanism underlying cellular and metabolic effects of GH in adipose tissue is not well understood...
  12. doi request reprint Detection of growth hormone doping by gene expression profiling of peripheral blood
    Christopher J Mitchell
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst New South Wales 2010, Sydney, Australia
    J Clin Endocrinol Metab 94:4703-9. 2009
    ..GH abuse is a significant problem in many sports, and there is currently no robust test that allows detection of doping beyond a short window after administration...
  13. doi request reprint Impact of growth hormone and dehydroepiandrosterone on protein metabolism in glucocorticoid-treated patients
    Morton G Burt
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Clin Endocrinol Metab 93:688-95. 2008
    ..Chronic pharmacological glucocorticoid (GC) use causes substantial morbidity from protein wasting. GH and androgens are anabolic agents that may potentially reverse GC-induced protein loss...
  14. ncbi request reprint Growth hormone regulation of metabolic gene expression in muscle: a microarray study in hypopituitary men
    Klara Sjögren
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
    Am J Physiol Endocrinol Metab 293:E364-71. 2007
    ..GH may regulate circadian function in skeletal muscle by modulating circadian gene expression with possible metabolic consequences...
  15. ncbi request reprint Regulating of growth hormone sensitivity by sex steroids: implications for therapy
    Ken K Y Ho
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Road, Darlinghurst, Sydney, NSE 2010, Australia
    Front Horm Res 35:115-28. 2006
    ..In the management of hypopituitarism, estrogens should be administered by the parenteral route in women and testosterone be replaced in men to optimize the benefits of GH replacement...
  16. ncbi request reprint Impact of acute and chronic low-dose glucocorticoids on protein metabolism
    Morton G Burt
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Clin Endocrinol Metab 92:3923-9. 2007
    ..High-dose glucocorticoids cause acute protein loss by increasing protein breakdown and oxidation. Whether lower glucocorticoid doses, typical of therapeutic use, induce sustained catabolism has not been studied...
  17. ncbi request reprint Protein metabolism in glucocorticoid excess: study in Cushing's syndrome and the effect of treatment
    Morton G Burt
    Pituitary Research Unit, Garvan Institute of Medical Research, New South Wales, Australia
    Am J Physiol Endocrinol Metab 292:E1426-32. 2007
    ..Enhanced protein oxidation is a likely explanation for the reduced protein mass in CS. Successful treatment of CS reduces protein oxidation and increases protein synthesis to prevent ongoing protein loss...
  18. ncbi request reprint Relationship between GH-induced metabolic changes and changes in body composition: a dose and time course study in GH-deficient adults
    Morton G Burt
    Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, NSW, Sydney, Australia
    Growth Horm IGF Res 18:55-64. 2008
    ..The aim was to study the effects of dose and time course on substrate metabolism and relate to body compositional changes during GH treatment...
  19. ncbi request reprint Modulation of growth hormone action by sex steroids
    Udo J Meinhardt
    Pituitary Research Unit, Garvan Institute of Medical Research, Sydney, Australia
    Clin Endocrinol (Oxf) 65:413-22. 2006
    ..In the general population, the metabolic consequences of long-term treatment of women with oral oestrogen compounds, including selective oestrogen receptor modulators, are largely unknown and warrant study...
  20. ncbi request reprint Estrogen regulation of growth hormone action
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Endocr Rev 25:693-721. 2004
    ..This represents a novel paradigm of steroid regulation of cytokine receptors and is likely to have significance for a diverse range of cytokine function...
  21. doi request reprint Demographic factors influencing the GH system: Implications for the detection of GH doping in sport
    Anne E Nelson
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst 2010, NSW, Australia
    Growth Horm IGF Res 19:327-32. 2009
    ..Therefore, a test based on IGF-I and the collagen markers must take age into account for men and women, and ethnicity and sport type are unlikely to be confounders for these markers...
  22. doi request reprint Growth hormone administration: is it safe and effective for athletic performance
    Vita Birzniece
    Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Endocrinol Metab Clin North Am 39:11-23, vii. 2010
    ..There are risks of adverse effects of long-term abuse of GH. Sustained abuse of GH may lead to a state mimicking acromegaly, a condition with increased morbidity and mortality...
  23. ncbi request reprint Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men
    James Gibney
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Am J Physiol Endocrinol Metab 289:E266-71. 2005
    ..T and GH exerted independent and additive effects on protein metabolism, F(ox) and REE. The anabolic effects of T are independent of circulating IGF-I...
  24. doi request reprint Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women
    Vita Birzniece
    Pituitary Research Unit, Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, and The University of New South Wales, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 97:1005-12. 2012
    ..Whether this translates to a long-term detrimental effect on body composition is unknown...
  25. ncbi request reprint Characterization of the metabolic phenotypes of Cushing's syndrome and growth hormone deficiency: a study of body composition and energy metabolism
    Morton G Burt
    Pituitary Research Unit, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Clin Endocrinol (Oxf) 64:436-43. 2006
    ..The aim of this study was to investigate the impact of Cushing's syndrome (CS) and GHD on whole and regional body composition and energy metabolism...
  26. ncbi request reprint Regulation of growth hormone action by gonadal steroids
    Udo J Meinhardt
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Sydney, Australia
    Endocrinol Metab Clin North Am 36:57-73. 2007
    ....
  27. doi request reprint Growth hormone in sports: detecting the doped or duped
    Ken K Y Ho
    Pituitary Research Unit, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Horm Res Paediatr 76:84-90. 2011
    ....
  28. doi request reprint Inducible brown adipogenesis of supraclavicular fat in adult humans
    Paul Lee
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, 2010 New South Wales, Australia
    Endocrinology 152:3597-602. 2011
    ..This study provides the first evidence of inducible brown adipogenesis in the supraclavicular region in adult humans...
  29. ncbi request reprint Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, J
    Ken K Y Ho
    Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Eur J Endocrinol 157:695-700. 2007
    ..The GH Research Society held a Consensus Workshop in Sydney, Australia, 2007 to incorporate the important advances in the management of GH deficiency (GHD) in adults, which have taken place since the inaugural 1997 Consensus Workshop...
  30. ncbi request reprint Estrogen up-regulates hepatic expression of suppressors of cytokine signaling-2 and -3 in vivo and in vitro
    Gary M Leong
    Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
    Endocrinology 145:5525-31. 2004
    ..In summary, estrogen, via ERalpha, up-regulated hepatic expression of SOCS-2 and -3, probably through transcriptional activation. This indicates a novel mechanism of estrogen regulation of cytokine action...
  31. ncbi request reprint Growth hormone measurements in the diagnosis and monitoring of acromegaly
    Akira Sata
    Department of Endocrinology, St Vincent s Hospital and the Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Pituitary 10:165-72. 2007
    ..These approaches give useful information on diagnosis, therapy, and prognosis. There is a place for measuring GH in the management of acromegaly although it complements that of IGF-I...
  32. ncbi request reprint Modulation by progestogens of the effects of oestrogen on hepatic endocrine function in postmenopausal women
    Ailish G Nugent
    Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Clin Endocrinol (Oxf) 59:690-8. 2003
    ..As progestogens attenuate the effects of oestrogen on circulating lipid levels according to their androgenic properties, we have investigated the impact of progestogen types on the hepatic endocrine effects of oestrogen...
  33. doi request reprint High prevalence of brown adipose tissue in adult humans
    Paul Lee
    Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Clin Endocrinol Metab 96:2450-5. 2011
    ..However, PET-CT has estimated a prevalence of BAT as low as 5% in adult humans, casting doubt on its significance. The true prevalence of BAT is unknown because of the suboptimal sensitivity of standard PET-CT...
  34. ncbi request reprint Physiological and pharmacological regulation of 20-kDa growth hormone
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Am J Physiol Endocrinol Metab 283:E836-43. 2002
    ..The 20-kDa GH level is reduced by administration of exogenous 22-kDa GH, suggesting rapid negative feedback regulation on pituitary release...