Research Topics
| Ken K Y HoSummaryAffiliation: University of Queensland Country: Australia Publications
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Detail Information
Publications
Gender difference in the neuroendocrine regulation of growth hormone axis by selective estrogen receptor modulatorsVita Birzniece
Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
J Clin Endocrinol Metab 97:E521-7. 2012..The relative impact of SERMs on the GH-IGF-I axis in men and women has not been investigated...- Modulatory effect of raloxifene and estrogen on the metabolic action of growth hormone in hypopituitary womenVita Birzniece
Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
J Clin Endocrinol Metab 95:2099-106. 2010..Selective estrogen receptor modulators lower IGF-I to a lesser degree than 17beta-estradiol in GH-deficient women, and their effect on fat and protein metabolism is unknown... 
Regulation of growth hormone signaling by selective estrogen receptor modulators occurs through suppression of protein tyrosine phosphatasesKin Chuen Leung
Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
Endocrinology 148:2417-23. 2007..We provide the first evidence for a novel mechanism regulating GH signaling, in which SERMs enhance GH activation of the JAK2/STAT5 pathway in a cell-type-dependent manner by attenuating protein tyrosine phosphatase activities...- Paracrine regulation of growth hormone secretion by estrogen in womenVita Birzniece
Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, The University of New South Wales, Sydney, NSW, Australia
J Clin Endocrinol Metab 95:3771-6. 2010..The aim was to investigate whether local estrogens produced from aromatization regulate GH secretion... - The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trialUdo Meinhardt
Garvan Institute of Medical Research and St Vincent s Hospital, Darlinghurst, New South Wales, Australia
Ann Intern Med 152:568-77. 2010..Growth hormone is widely abused by athletes, frequently with androgenic steroids. Its effects on performance are unclear... - Neuroendocrine regulation of growth hormone and androgen axes by selective estrogen receptor modulators in healthy menVita Birzniece
Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, and The University of New South Wales, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 95:5443-8. 2010..Thus, tamoxifen is likely to perturb the neuroendocrine regulation of GH and gonadal axes. Raloxifene, a SERM, is used for therapy of osteoporosis in both sexes. Its neuroendocrine effects in men are poorly understood... - Comparison of the metabolic effects of raloxifene and oral estrogen in postmenopausal and growth hormone-deficient womenJames Gibney
Pituitary Research Unit, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 90:3897-903. 2005..CONCLUSION: E2 and raloxifene exert different hepatic endocrine, but not lipid oxidative, effects. The greater effects seen in GHD women may be explained by the loss of endogenous GH feedback... - Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary menGudmundur Johannsson
Pituitary Research Unit, Garvan Institute of Medical Research, St. Vincent's Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 90:3989-94. 2005..The mechanisms of fluid retention for both hormones are likely to be exerted on the renal tubules. This is the first direct evidence that testosterone increases ECW... - Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary menVita Birzniece
Pituitary Research Unit, Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
Clin Endocrinol (Oxf) 71:715-21. 2009..Fat mass is increased in hypogonadal men and the changes are reversed by testosterone replacement. Testosterone administration enhances whole body fat oxidation (Fox). Fat is oxidized in the liver and in extra-hepatic tissues... - Interaction between testosterone and growth hormone on whole-body protein anabolism occurs in the liverVita Birzniece
Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 96:1060-7. 2011..GH and testosterone both exert protein-anabolic effects and may act synergistically. Liver and muscle are major sites of protein metabolism... - Identification of novel GH-regulated pathway of lipid metabolism in adipose tissue: a gene expression study in hypopituitary menJing Ting Zhao
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Sydney, Australia
J Clin Endocrinol Metab 96:E1188-96. 2011..Adipose tissue is a major target of GH action. GH stimulates lipolysis and reduces fat mass. The molecular mechanism underlying cellular and metabolic effects of GH in adipose tissue is not well understood... - Detection of growth hormone doping by gene expression profiling of peripheral bloodChristopher J Mitchell
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst New South Wales 2010, Sydney, Australia
J Clin Endocrinol Metab 94:4703-9. 2009..GH abuse is a significant problem in many sports, and there is currently no robust test that allows detection of doping beyond a short window after administration... - Impact of growth hormone and dehydroepiandrosterone on protein metabolism in glucocorticoid-treated patientsMorton G Burt
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
J Clin Endocrinol Metab 93:688-95. 2008..Chronic pharmacological glucocorticoid (GC) use causes substantial morbidity from protein wasting. GH and androgens are anabolic agents that may potentially reverse GC-induced protein loss... - Growth hormone regulation of metabolic gene expression in muscle: a microarray study in hypopituitary menKlara Sjögren
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
Am J Physiol Endocrinol Metab 293:E364-71. 2007..GH may regulate circadian function in skeletal muscle by modulating circadian gene expression with possible metabolic consequences... - Regulating of growth hormone sensitivity by sex steroids: implications for therapyKen K Y Ho
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Road, Darlinghurst, Sydney, NSE 2010, Australia
Front Horm Res 35:115-28. 2006..In the management of hypopituitarism, estrogens should be administered by the parenteral route in women and testosterone be replaced in men to optimize the benefits of GH replacement... - Impact of acute and chronic low-dose glucocorticoids on protein metabolismMorton G Burt
Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
J Clin Endocrinol Metab 92:3923-9. 2007..High-dose glucocorticoids cause acute protein loss by increasing protein breakdown and oxidation. Whether lower glucocorticoid doses, typical of therapeutic use, induce sustained catabolism has not been studied... - Protein metabolism in glucocorticoid excess: study in Cushing's syndrome and the effect of treatmentMorton G Burt
Pituitary Research Unit, Garvan Institute of Medical Research, New South Wales, Australia
Am J Physiol Endocrinol Metab 292:E1426-32. 2007..Enhanced protein oxidation is a likely explanation for the reduced protein mass in CS. Successful treatment of CS reduces protein oxidation and increases protein synthesis to prevent ongoing protein loss... - Relationship between GH-induced metabolic changes and changes in body composition: a dose and time course study in GH-deficient adultsMorton G Burt
Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, NSW, Sydney, Australia
Growth Horm IGF Res 18:55-64. 2008..The aim was to study the effects of dose and time course on substrate metabolism and relate to body compositional changes during GH treatment... - Modulation of growth hormone action by sex steroidsUdo J Meinhardt
Pituitary Research Unit, Garvan Institute of Medical Research, Sydney, Australia
Clin Endocrinol (Oxf) 65:413-22. 2006..In the general population, the metabolic consequences of long-term treatment of women with oral oestrogen compounds, including selective oestrogen receptor modulators, are largely unknown and warrant study... - Estrogen regulation of growth hormone actionKin-Chuen Leung
Pituitary Research Unit, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, New South Wales 2010, Australia
Endocr Rev 25:693-721. 2004..This represents a novel paradigm of steroid regulation of cytokine receptors and is likely to have significance for a diverse range of cytokine function... - Demographic factors influencing the GH system: Implications for the detection of GH doping in sportAnne E Nelson
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst 2010, NSW, Australia
Growth Horm IGF Res 19:327-32. 2009..Therefore, a test based on IGF-I and the collagen markers must take age into account for men and women, and ethnicity and sport type are unlikely to be confounders for these markers... - Growth hormone administration: is it safe and effective for athletic performanceVita Birzniece
Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Endocrinol Metab Clin North Am 39:11-23, vii. 2010..There are risks of adverse effects of long-term abuse of GH. Sustained abuse of GH may lead to a state mimicking acromegaly, a condition with increased morbidity and mortality... - Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary menJames Gibney
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Am J Physiol Endocrinol Metab 289:E266-71. 2005..T and GH exerted independent and additive effects on protein metabolism, F(ox) and REE. The anabolic effects of T are independent of circulating IGF-I... - Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary womenVita Birzniece
Pituitary Research Unit, Garvan Institute of Medical Research and Department of Endocrinology, St Vincent s Hospital, and The University of New South Wales, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 97:1005-12. 2012..Whether this translates to a long-term detrimental effect on body composition is unknown... - Characterization of the metabolic phenotypes of Cushing's syndrome and growth hormone deficiency: a study of body composition and energy metabolismMorton G Burt
Pituitary Research Unit, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
Clin Endocrinol (Oxf) 64:436-43. 2006..Reduced REE and Fox contribute to increased adiposity in GHD. As REE and Fox are not perturbed in CS, other mechanisms must explain the marked gain in truncal and total fat... - Regulation of growth hormone action by gonadal steroidsUdo J Meinhardt
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Sydney, Australia
Endocrinol Metab Clin North Am 36:57-73. 2007.... - Growth hormone in sports: detecting the doped or dupedKen K Y Ho
Pituitary Research Unit, Garvan Institute of Medical Research, Sydney, NSW, Australia
Horm Res Paediatr 76:84-90. 2011.... - Inducible brown adipogenesis of supraclavicular fat in adult humansPaul Lee
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, 2010 New South Wales, Australia
Endocrinology 152:3597-602. 2011..This study provides the first evidence of inducible brown adipogenesis in the supraclavicular region in adult humans... - Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, JKen K Y Ho
Pituitary Research Unit, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Eur J Endocrinol 157:695-700. 2007..The GH Research Society held a Consensus Workshop in Sydney, Australia, 2007 to incorporate the important advances in the management of GH deficiency (GHD) in adults, which have taken place since the inaugural 1997 Consensus Workshop... - Estrogen up-regulates hepatic expression of suppressors of cytokine signaling-2 and -3 in vivo and in vitroGary M Leong
Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
Endocrinology 145:5525-31. 2004..In summary, estrogen, via ERalpha, up-regulated hepatic expression of SOCS-2 and -3, probably through transcriptional activation. This indicates a novel mechanism of estrogen regulation of cytokine action... - Growth hormone measurements in the diagnosis and monitoring of acromegalyAkira Sata
Department of Endocrinology, St Vincent s Hospital and the Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Pituitary 10:165-72. 2007..These approaches give useful information on diagnosis, therapy, and prognosis. There is a place for measuring GH in the management of acromegaly although it complements that of IGF-I... - Modulation by progestogens of the effects of oestrogen on hepatic endocrine function in postmenopausal womenAilish G Nugent
Garvan Institute of Medical Research, Department of Endocrinology, St Vincent's Hospital, Darlinghurst, NSW, Australia
Clin Endocrinol (Oxf) 59:690-8. 2003..The modulatory effects of progestogens on IGF-I during oestrogen therapy may have long-term implications for lean body mass... - High prevalence of brown adipose tissue in adult humansPaul Lee
Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 96:2450-5. 2011..However, PET-CT has estimated a prevalence of BAT as low as 5% in adult humans, casting doubt on its significance. The true prevalence of BAT is unknown because of the suboptimal sensitivity of standard PET-CT... - Physiological and pharmacological regulation of 20-kDa growth hormoneKin Chuen Leung
Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
Am J Physiol Endocrinol Metab 283:E836-43. 2002..The 20-kDa GH level is reduced by administration of exogenous 22-kDa GH, suggesting rapid negative feedback regulation on pituitary release...