V J Higgins

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. doi request reprint Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the involvement of the SWI6 transcription factor
    Chii Shyang Fong
    Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, UNSW, NSW, Australia
    FEMS Yeast Res 8:386-99. 2008
  2. pmc Yeast genome-wide expression analysis identifies a strong ergosterol and oxidative stress response during the initial stages of an industrial lager fermentation
    Vincent J Higgins
    Clive and Vera Ramaciotti Centre for Gene Function Analysis School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia
    Appl Environ Microbiol 69:4777-87. 2003
  3. pmc Application of genome-wide expression analysis to identify molecular markers useful in monitoring industrial fermentations
    Vincent J Higgins
    Clive and Vera Ramaciotti Centre for Gene Function Analysis, University of New South Wales, Sydney, New South Wales 2052, Australia
    Appl Environ Microbiol 69:7535-40. 2003
  4. pmc Generation of a novel Saccharomyces cerevisiae strain that exhibits strong maltose utilization and hyperosmotic resistance using nonrecombinant techniques
    V J Higgins
    School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, New South Wales 2052, Australia
    Appl Environ Microbiol 67:4346-8. 2001
  5. ncbi request reprint Phenotypic analysis of gene deletant strains for sensitivity to oxidative stress
    Vincent J Higgins
    Clive and Vera Ramaciotti Centre for Gene Function Analysis, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia
    Yeast 19:203-14. 2002
  6. ncbi request reprint Comparison of fermentative capacities of industrial baking and wild-type yeasts of the species Saccharomyces cerevisiae in different sugar media
    P J Bell
    Department of Biological Sciences, Macquarie University, Sydney, Australia
    Lett Appl Microbiol 32:224-9. 2001
  7. ncbi request reprint The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain
    J C Lee
    School of Biochemistry and Molecular Genetics, The CRC for Food Industry Innovation, University of New South Wales, Sydney, NSW 2052, Australia
    FEMS Yeast Res 1:57-65. 2001
  8. ncbi request reprint Leu343Phe substitution in the Malx3 protein of Saccharomyces cerevisiae increases the constitutivity and glucose insensitivity of MAL gene expression
    V J Higgins
    School of Biochemistry and Molecular Genetics and Cooperative Research Centre for Food Industry Innovation, University of New South Wales, Sydney 2052, New South Wales, Australia
    Curr Genet 35:491-8. 1999
  9. pmc Identification of a Saccharomyces cerevisiae gene that is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide
    N Alic
    School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, New South Wales 2052, Australia
    Mol Biol Cell 12:1801-10. 2001
  10. ncbi request reprint Characterization of the putative maltose transporters encoded by YDL247w and YJR160c
    Rachel E Day
    Clive and Vera Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Yeast 19:1015-27. 2002

Collaborators

  • P V Attfield
  • Michael Breitenbach
  • C M Grant
  • Ian W Dawes
  • Nazif Alic
  • Geoffrey W Thorpe
  • Rachel E Day
  • Chong Han Ng
  • Chii Shyang Fong
  • Mark D Temple
  • Pierre J Dilda
  • Peter J Rogers
  • I W Dawes
  • J C Lee
  • N Alic
  • P J Bell
  • Gabriel G Perrone
  • Joyce Chiu
  • Moritz Durchdewald
  • Shi Xiong Tan
  • Anthony S Don
  • John D Allen
  • Philip J Hogg
  • Kara M Tanabe
  • Christian Gloeckner
  • Peter Briza
  • Thomas Felder
  • Chii S Fong
  • Alena Pichova
  • M J Straffon
  • T Y Jang

Detail Information

Publications16

  1. doi request reprint Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the involvement of the SWI6 transcription factor
    Chii Shyang Fong
    Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, UNSW, NSW, Australia
    FEMS Yeast Res 8:386-99. 2008
    ..These data show that functions such as heat shock response, and glucose transport are involved in the response...
  2. pmc Yeast genome-wide expression analysis identifies a strong ergosterol and oxidative stress response during the initial stages of an industrial lager fermentation
    Vincent J Higgins
    Clive and Vera Ramaciotti Centre for Gene Function Analysis School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia
    Appl Environ Microbiol 69:4777-87. 2003
    ..Here we show that genome-wide expression analysis can be used in the commercial environment and was successful in identifying environmental conditions that are important in industrial yeast fermentation...
  3. pmc Application of genome-wide expression analysis to identify molecular markers useful in monitoring industrial fermentations
    Vincent J Higgins
    Clive and Vera Ramaciotti Centre for Gene Function Analysis, University of New South Wales, Sydney, New South Wales 2052, Australia
    Appl Environ Microbiol 69:7535-40. 2003
    ..Induction was specific for zinc deficiency and was dependent on Zap1p. The results indicate that these sequences may be valuable molecular markers for detecting zinc deficiency in industrial fermentations...
  4. pmc Generation of a novel Saccharomyces cerevisiae strain that exhibits strong maltose utilization and hyperosmotic resistance using nonrecombinant techniques
    V J Higgins
    School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, New South Wales 2052, Australia
    Appl Environ Microbiol 67:4346-8. 2001
    ..Therefore, we used strong selection and screening systems in conjunction with traditional mass mating techniques to develop a strain of Saccharomyces cerevisiae that efficiently leavens both types of dough...
  5. ncbi request reprint Phenotypic analysis of gene deletant strains for sensitivity to oxidative stress
    Vincent J Higgins
    Clive and Vera Ramaciotti Centre for Gene Function Analysis, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia
    Yeast 19:203-14. 2002
    ..Further analysis of these genes may reveal unknown mechanisms protecting the cell against reactive oxygen species...
  6. ncbi request reprint Comparison of fermentative capacities of industrial baking and wild-type yeasts of the species Saccharomyces cerevisiae in different sugar media
    P J Bell
    Department of Biological Sciences, Macquarie University, Sydney, Australia
    Lett Appl Microbiol 32:224-9. 2001
    ..To compare the fermentative capacity of wild and domesticated isolates of the genus Saccharomyces...
  7. ncbi request reprint The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain
    J C Lee
    School of Biochemistry and Molecular Genetics, The CRC for Food Industry Innovation, University of New South Wales, Sydney, NSW 2052, Australia
    FEMS Yeast Res 1:57-65. 2001
    ..Interestingly, the gsh1 sgr1 mutant generated petites at a lower rate than the gsh1 mutant. Thus, it is suggested that the essential role of GSH is involved in the maintenance of the mitochondrial genome...
  8. ncbi request reprint Leu343Phe substitution in the Malx3 protein of Saccharomyces cerevisiae increases the constitutivity and glucose insensitivity of MAL gene expression
    V J Higgins
    School of Biochemistry and Molecular Genetics and Cooperative Research Centre for Food Industry Innovation, University of New South Wales, Sydney 2052, New South Wales, Australia
    Curr Genet 35:491-8. 1999
    ..These results demonstrate that not only Mig1p modulation of MALx3 expression, but also the MALx3 protein structure, is involved in the glucose-insensitive expression of the MAL genes...
  9. pmc Identification of a Saccharomyces cerevisiae gene that is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide
    N Alic
    School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, New South Wales 2052, Australia
    Mol Biol Cell 12:1801-10. 2001
    ..Identification of OCA1 establishes cell cycle arrest as an actively regulated response to oxidative stress and will enable further elucidation of oxidative stress-responsive signaling pathways in yeast...
  10. ncbi request reprint Characterization of the putative maltose transporters encoded by YDL247w and YJR160c
    Rachel E Day
    Clive and Vera Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Yeast 19:1015-27. 2002
    ....
  11. ncbi request reprint Lipid hydroperoxides activate the mitogen-activated protein kinase Mpk1p in Saccharomyces cerevisiae
    Nazif Alic
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, 2052 New South Wales, Australia
    J Biol Chem 278:41849-55. 2003
    ..Furthermore, it revealed that Mpk1p is required for the regulation of 97 LoaOOH-responsive transcripts. Evidence is presented that the activation of Mpk1p may be caused by the activation of protein kinase C by LoaOOH...
  12. pmc Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes
    Geoffrey W Thorpe
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney NSW 2052, Australia
    Proc Natl Acad Sci U S A 101:6564-9. 2004
    ..Core functions required for a broad range of oxidative-stress resistance include transcription, protein trafficking, and vacuolar function...
  13. ncbi request reprint Genome-wide transcriptional responses to a lipid hydroperoxide: adaptation occurs without induction of oxidant defenses
    Nazif Alic
    Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, 2052 NSW, Australia
    Free Radic Biol Med 37:23-35. 2004
    ..Surprisingly, the cellular response to adaptive doses did not include induction of oxidative-stress defense enzymes nor of transcripts involved in general cellular defense systems...
  14. ncbi request reprint Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains
    Pierre J Dilda
    Center for Vascular Research, University of New South Wales, Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    J Natl Cancer Inst 97:1539-47. 2005
    ..Normal endothelial cells are much more sensitive to GSAO than tumor cells. To elucidate the mechanism of tumor cell resistance, we identified yeast genes that are necessary for resistance to GSAO...
  15. doi request reprint Adaptation to hydrogen peroxide in Saccharomyces cerevisiae: the role of NADPH-generating systems and the SKN7 transcription factor
    Chong Han Ng
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Free Radic Biol Med 44:1131-45. 2008
    ..These mutants overproduced reduced glutathione (GSH) but maintained normal cellular redox homeostasis. This overproduction of GSH was not regulated at transcription of the gene encoding gamma-glutamylcysteine synthetase...
  16. pmc Molecular analysis of maltotriose transport and utilization by Saccharomyces cerevisiae
    Rachel E Day
    Clive and Vera Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia 2052
    Appl Environ Microbiol 68:5326-35. 2002
    ..Here we identify molecular mechanisms regulating the uptake of maltotriose and determine the role of each of the transporter genes in the cells...